PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GRB2	2	KRT15	2	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	GRB2	2	far western blotting, affinity chromatography technology, affinity chromatography technology, pull down	Schumacher C (1995), Parachoniak CA (2009), Parachoniak CA (2009), Parachoniak CA (2009)	4
CUL3	17	KRT33B	1	affinity chromatography technology	Bennett EJ (2010)	1
PIK3R2	3	SHC1	0	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
CUL3	17	PIK3R2	3	affinity chromatography technology	Bennett EJ (2010)	1
ATG4B	1	KRT4	0	affinity chromatography technology	Behrends C (2010)	1
CRK	0	KRT4	0	affinity chromatography technology	Brehme M (2009)	1
CUL3	17	USP25	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Xu D (2017)	2
SHC1	0	KRT4	0	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	CRK	0	far western blotting, pull down, affinity chromatography technology, affinity chromatography technology	Schumacher C (1995), Schumacher C (1995), Brehme M (2009), Brehme M (2009)	4
CUL3	17	KRT4	0	affinity chromatography technology	Bennett EJ (2010)	1
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
UBASH3B	4	CRK	0	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
KRT4	0	KRT40	0	two hybrid	Rolland T (2014)	1
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
KRT4	0	KRT38	4	two hybrid	Rolland T (2014)	1
PIK3R2	3	KRT38	4	two hybrid	Rolland T (2014)	1
KRT4	0	KRT15	2	two hybrid	Rolland T (2014)	1
GRB2	2	KRT4	0	affinity chromatography technology	Brehme M (2009)	1
CRK	0	KRT15	2	affinity chromatography technology	Brehme M (2009)	1
CYLD	2	KRT13	2	affinity chromatography technology	Elliott PR (2016)	1
THOC2	4	KRT4	0	affinity chromatography technology	Hein MY (2015)	1
EPS15	1	KRT38	4	affinity chromatography technology	Brehme M (2009)	1
PIK3R2	3	KRT4	0	affinity chromatography technology	Brehme M (2009)	1
UCHL1	1	KRT4	0	affinity chromatography technology	Sowa ME (2009)	1
UBASH3B	4	KRT4	0	affinity chromatography technology	Brehme M (2009)	1
CUL3	17	GRB2	2	affinity chromatography technology	Bennett EJ (2010)	1
SHC1	0	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Ota S (1998), Larsson H (1999)	4
EPS15	1	KRT4	0	affinity chromatography technology	Brehme M (2009)	1
UBASH3B	4	CUL3	17	pull down	Krupina K (2016)	1
GRB2	2	CYLD	2	affinity chromatography technology	Huttlin EL (2017)	1
WWOX	3	KRT4	0	affinity chromatography technology	Abu-Odeh M (2014)	1
CYLD	2	KRT4	0	affinity chromatography technology	Elliott PR (2016)	1
CUL3	17	KRT13	2	affinity chromatography technology	Bennett EJ (2010)	1
SHC1	0	UBASH3B	4	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
GRB2	2	PIK3R2	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Brehme M (2009), Brehme M (2009), Bisson N (2011)	4
USPL1	5	KRT4	0	affinity chromatography technology	Sowa ME (2009)	1
SHC1	0	KRT13	2	affinity chromatography technology	Brehme M (2009)	1
PIK3R2	3	KRT15	2	affinity chromatography technology, two hybrid	Brehme M (2009), Rolland T (2014)	2
USP25	0	KRT4	0	affinity chromatography technology	Sowa ME (2009)	1
USP1	4	KRT4	0	affinity chromatography technology	Sowa ME (2009)	1
KRT4	0	KRT13	2	two hybrid	Rolland T (2014)	1
GRB2	2	KRT33B	1	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	KRT33B	1	affinity chromatography technology	Brehme M (2009)	1
UBASH3B	4	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), Li J (2013), Li J (2013)	3
PIK3R2	3	CRK	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Brehme M (2009), Brehme M (2009), Grossmann A (2015)	3
KRT4	0	KRT33B	1	two hybrid	Rolland T (2014)	1