PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TADA2A	1	KRT8	3	affinity chromatography technology	Krebs AR (2010)	1
IKBKG	0	KRT8	3	pull down, affinity chromatography technology, two hybrid	Fenner BJ (2010), Wang J (2011), Wang J (2011)	3
NOS2	6	KRT18	2	affinity chromatography technology	Foster MW (2013)	1
VCAM1	2	KPNA2	0	affinity chromatography technology	Humphries JD (2009)	1
ATF2	1	ANXA1	1	affinity chromatography technology	Lau E (2012)	1
GRB2	2	KRT15	2	affinity chromatography technology	Brehme M (2009)	1
VCAM1	2	ANXA1	1	affinity chromatography technology	Humphries JD (2009)	1
BYSL	3	TROAP	4	two hybrid, two hybrid, pull down	Suzuki N (1998), Suzuki N (1998), Suzuki N (1998)	3
GRB2	2	KRT17	0	affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Brehme M (2009)	2
TES	1	KRT17	0	affinity chromatography technology	Sala S (2017)	1
MAPK14	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Sanz-Moreno V (2003), Tanoue T (2001), Srivastav RK (2011), Chan PM (2008)	4
CYLD	2	KRT8	3	affinity chromatography technology	Elliott PR (2016)	1
NOS2	6	KRT8	3	affinity chromatography technology	Foster MW (2013)	1
ITGA4	4	EED	1	two hybrid	Rietzler M (1998)	1
WBP2	0	KRT18	2	pull down	Lim SK (2016)	1
USP32	0	KRT8	3	affinity chromatography technology	Sowa ME (2009)	1
CDH1	4	CRK	0	bioid	Guo Z (2014)	1
VCAM1	2	GRB2	2	affinity chromatography technology	Humphries JD (2009)	1
ESR1	0	TRAF6	0	affinity chromatography technology	Robinson LJ (2009)	1
CYLD	2	BSG	1	affinity chromatography technology	Elliott PR (2016)	1
APEX1	1	KRT8	3	affinity chromatography technology	Vascotto C (2009)	1
CAV1	0	MAPK1	1	affinity chromatography technology	Hua H (2003)	1
NOS2	6	HSPA5	0	affinity chromatography technology	Foster MW (2013)	1
FN1	17	KPNA2	0	affinity chromatography technology, two hybrid	Humphries JD (2009), Wang J (2011)	2
PPP6C	7	KRT8	3	affinity chromatography technology	St-Denis N (2016)	1
CDH1	4	ANXA1	1	bioid	Guo Z (2014)	1
IQCB1	3	KRT18	2	affinity chromatography technology	Sang L (2011)	1
ESR1	0	HSPA5	0	affinity chromatography technology	Dhamad AE (2016)	1
KRT8	3	CLN5	1	affinity chromatography technology	Ewing RM (2007)	1
KRT8	3	KRT40	0	two hybrid	Rolland T (2014)	1
GRB2	2	KRT8	3	affinity chromatography technology, two hybrid	Blagoev B (2003), Bandyopadhyay S (2010)	2
FN1	17	KRT8	3	affinity chromatography technology	Humphries JD (2009)	1
KRT17	0	KRT8	3	two hybrid	Schnabel J (1998)	1
CYLD	2	HSPA5	0	affinity chromatography technology	Elliott PR (2016)	1
UBASH3B	4	KRT17	0	affinity chromatography technology	Brehme M (2009)	1
BYSL	3	KRT8	3	two hybrid	Suzuki N (1998)	1
IKBKG	0	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Brummelkamp TR (2003), Trompouki E (2003), Chu L (2006), Shibata Y (2012), Wang J (2011), Zilberman-Rudenko J (2016), Zilberman-Rudenko J (2016)	11
PAN2	3	KRT18	2	affinity chromatography technology	Bett JS (2013)	1
BYSL	3	KRT31	0	two hybrid	Rolland T (2014)	1
ESR1	0	KRT18	2	pull down	Nalvarte I (2010)	1
IKBKG	0	ANXA1	1	affinity chromatography technology, biochemical, affinity chromatography technology	Bist P (2011), Bist P (2011), Bist P (2011)	3
FBXO25	1	HSPA5	0	affinity chromatography technology	Teixeira FR (2010)	1
QRSL1	3	KRT8	3	two hybrid	Vinayagam A (2011)	1
EED	1	HSPA5	0	affinity chromatography technology	Cao Q (2014)	1
BSG	1	HSPA5	0	affinity chromatography technology	Wu B (2017)	1
CYLD	2	PKP1	2	affinity chromatography technology	Elliott PR (2016)	1
ITGA4	4	GRB2	2	affinity chromatography technology	Byron A (2012)	1
PPL	6	KRT8	3	two hybrid, pull down	Kazerounian S (2002), Kazerounian S (2002)	2
CYLD	2	TRAF6	0	enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Bremm A (2010), Wu J (2015), Wu J (2015)	4
TADA2A	1	HSPA5	0	affinity chromatography technology	Krebs AR (2010)	1
ITGA4	4	KPNA2	0	affinity chromatography technology	Byron A (2012)	1
ATF2	1	KRT18	2	affinity chromatography technology	Lau E (2012)	1
VCAM1	2	KRT8	3	affinity chromatography technology	Humphries JD (2009)	1
CYLD	2	KRT17	0	affinity chromatography technology	Elliott PR (2016)	1
FN1	17	ANXA1	1	affinity chromatography technology	Humphries JD (2009)	1
PPEF2	0	KRT8	3	affinity chromatography technology	St-Denis N (2016)	1
GRB2	2	KPNA2	0	two hybrid	Wang J (2011)	1
CDH1	4	TES	1	bioid	Guo Z (2014)	1
FAF2	4	CAV1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GRB2	2	FN1	17	two hybrid, affinity chromatography technology	Wang J (2008), Humphries JD (2009)	2
FN1	17	YWHAQ	0	affinity chromatography technology	Humphries JD (2009)	1
CDH1	4	KRT18	2	affinity chromatography technology, bioid	Catimel B (2005), Guo Z (2014)	2
ATF2	1	MAPK8	3	pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study	Raingeaud J (1995), Fuchs SY (1997), Chen Z (2001), Tournier C (1997), Pipaon C (2004), Pipaon C (2004), Pillai VB (2011), Jensen LE (2003), Jensen LE (2003), Deacon K (1997), Bustelo XR (1997), Gupta S (1996), Yao K (2007), Li H (2001), Sanna MG (2002)	15
KRT8	3	HSPA4L	1	affinity chromatography technology	Ewing RM (2007)	1
TES	1	KRT18	2	affinity chromatography technology	Sala S (2017)	1
WBP2	0	KRT8	3	pull down	Lim SK (2016)	1
CDH1	4	BSG	1	bioid	Guo Z (2014)	1
ATF2	1	KRT8	3	affinity chromatography technology	Lau E (2012)	1
KPNA2	0	KRT40	0	two hybrid	Rolland T (2014)	1
ESR1	0	HSPA4L	1	affinity chromatography technology	Dhamad AE (2016)	1
KRT31	0	TROAP	4	two hybrid	Rolland T (2014)	1
KRT8	3	PRKCE	6	affinity chromatography technology	Omary MB (1992)	1
IKBKG	0	PRKCE	6	affinity chromatography technology	Yang W (2012)	1
ANXA1	1	KRT8	3	affinity chromatography technology	Croxtall JD (1998)	1
OTUD4	2	KRT8	3	affinity chromatography technology	Sowa ME (2009)	1
BSG	1	IQCB1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KRT8	3	KRT15	2	two hybrid	Rolland T (2014)	1
TROAP	4	KRT40	0	two hybrid	Rolland T (2014)	1
UBASH3B	4	CRK	0	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
KRT8	3	STAM2	0	biochemical	Havugimana PC (2012)	1
KRT8	3	KRT31	0	two hybrid	Rolland T (2014)	1
KRT8	3	CAV1	0	biochemical	Boettcher JP (2010)	1
PNN	2	KRT8	3	two hybrid, pull down	Shi J (2000), Shi J (2000)	2
KPNA2	0	KRT8	3	two hybrid	Wang J (2011)	1
CYLD	2	YWHAQ	0	affinity chromatography technology	Elliott PR (2016)	1
HSPA5	0	HSPA4L	1	affinity chromatography technology	Hein MY (2015)	1
YWHAQ	0	KRT8	3	affinity chromatography technology	Pozuelo-Rubio M (2010)	1
RCHY1	0	KRT18	2	pull down, affinity chromatography technology, affinity chromatography technology	Duan S (2009), Duan S (2009), Duan S (2009)	3
KRT8	3	KRT38	4	two hybrid	Rolland T (2014)	1
RMND5A	0	KRT8	3	affinity chromatography technology	Lampert F (2018)	1
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
YWHAQ	0	ESR1	0	pull down	Zilliacus J (2001)	1
FN1	17	ITGA4	4	affinity chromatography technology	Humphries JD (2009)	1
IQCB1	3	HSPA5	0	affinity chromatography technology	Sang L (2011)	1
IQCB1	3	KRT8	3	affinity chromatography technology	Sang L (2011)	1
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
KRT8	3	PLAT	2	pull down	Kralovich KR (1998)	1
CYLD	2	OTUD4	2	affinity chromatography technology	Elliott PR (2016)	1
FN1	17	HSPA5	0	affinity chromatography technology	Humphries JD (2009)	1
FN1	17	KRT31	0	affinity chromatography technology	Humphries JD (2009)	1
CDH1	4	HSPA5	0	affinity chromatography technology, bioid	Catimel B (2005), Guo Z (2014)	2
MAPK8	3	CRK	0	affinity chromatography technology, pull down, imaging technique	Girardin SE (2001), Girardin SE (2001), Chen TC (2014)	3
MAPK14	0	MAPK8	3	affinity chromatography technology	Chan PM (2008)	1
GRB2	2	HSPA5	0	two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Brehme M (2009)	2
FGFR3	7	KRT8	3	two hybrid	Stelzl U (2005)	1
CRK	0	KRT15	2	affinity chromatography technology	Brehme M (2009)	1
CDH1	4	KRT8	3	affinity chromatography technology	Catimel B (2005)	1
TRAF6	0	BSG	1	affinity chromatography technology, affinity chromatography technology	Luo Z (2016), Luo Z (2016)	2
CYLD	2	KRT13	2	affinity chromatography technology	Elliott PR (2016)	1
CDH1	4	PPL	6	bioid	Guo Z (2014)	1
YWHAQ	0	KRT17	0	affinity chromatography technology	Pozuelo-Rubio M (2010)	1
FN1	17	KRT18	2	affinity chromatography technology	Humphries JD (2009)	1
YWHAQ	0	ANXA1	1	pull down	Meek SE (2004)	1
CRK	0	KRT8	3	affinity chromatography technology	Brehme M (2009)	1
MAPK1	1	ATF2	1	enzymatic study, enzymatic study, enzymatic study	Livingstone C (1995), Sanna MG (2002), Krump E (1997)	3
ESR1	0	KRT8	3	pull down	Nalvarte I (2010)	1
MAPK14	0	ATF2	1	enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Raingeaud J (1995), Raingeaud J (1995), Chen Z (2001), Pillai VB (2011), Pillai VB (2011), Gianni M (2006), Deacon K (1997), Sudo T (2000), Mo JS (2010), Uddin S (2002), Stein B (1997), Yuan ZQ (2003), Coxon PY (2003), Li H (2001), Sun L (2007), Grimsey NJ (2015), Tang J (2008), Dixon DA (2006), Chen G (2000), Frantz B (1998), Tesker M (2016), Hwang SG (2014), Camps M (1998), Bakin AV (2002), Bulavin DV (1999)	25
ATF2	1	BSG	1	affinity chromatography technology	Lau E (2012)	1
FBXO25	1	KRT8	3	enzymatic study	Teixeira FR (2013)	1
FN1	17	PLAT	2	pull down	Moser TL (1993)	1
KPNA2	0	TADA2A	1	two hybrid	Rolland T (2014)	1
KRT8	3	KRT13	2	two hybrid	Rolland T (2014)	1
KRT18	2	KRT8	3	two hybrid, two hybrid	Schnabel J (1998), Wang J (2011)	2
MAPK1	1	PRKCE	6	affinity chromatography technology	Bourbon NA (2001)	1
PAN2	3	TJP1	2	affinity chromatography technology	Bett JS (2013)	1
PAN2	3	HSPA5	0	affinity chromatography technology	Bett JS (2013)	1
NOS2	6	YWHAQ	0	affinity chromatography technology	Foster MW (2013)	1
BYSL	3	KRT40	0	two hybrid	Rolland T (2014)	1
TES	1	KRT8	3	affinity chromatography technology	Sala S (2017)	1
IQCB1	3	KRT17	0	affinity chromatography technology	Sang L (2011)	1
CAV1	0	NOS2	6	biochemical, pull down	Felley-Bosco E (2000), Felley-Bosco E (2000)	2
VCAM1	2	BYSL	3	affinity chromatography technology	Humphries JD (2009)	1
VCAM1	2	ITGA4	4	affinity chromatography technology, affinity chromatography technology	Humphries JD (2009), Byron A (2012)	2
USP32	0	KRT18	2	affinity chromatography technology	Sowa ME (2009)	1
IKBKG	0	KRT17	0	biochemical	Kristensen AR (2012)	1
PAN2	3	KRT8	3	affinity chromatography technology	Bett JS (2013)	1
KPNA2	0	KRT18	2	two hybrid	Wang J (2011)	1
KRT18	2	PRKCE	6	affinity chromatography technology	Omary MB (1992)	1
FGFR3	7	GRB2	2	affinity chromatography technology, biochemical	Kanai M (1997), Wan C (2015)	2
TRAF6	0	KRT8	3	affinity chromatography technology	Dong XM (2016)	1
RCHY1	0	KRT8	3	pull down, affinity chromatography technology, affinity chromatography technology	Duan S (2009), Duan S (2009), Duan S (2009)	3
MAPK14	0	KRT8	3	enzymatic study, pull down	Ku NO (2002), Ku NO (2002)	2
RMND5A	0	HSPA4L	1	affinity chromatography technology	Lampert F (2018)	1
WBP2	0	ESR1	0	pull down, affinity chromatography technology	Dhananjayan SC (2006), Dhananjayan SC (2006)	2
GRB2	2	CYLD	2	affinity chromatography technology	Huttlin EL (2017)	1
EED	1	KRT8	3	affinity chromatography technology	Cao Q (2014)	1
PKP1	2	KRT8	3	pull down	Hofmann I (2000)	1
CRK	0	KRT17	0	affinity chromatography technology	Brehme M (2009)	1
RCHY1	0	UBASH3B	4	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
CRK	0	YWHAQ	0	affinity chromatography technology	Brehme M (2009)	1
UBASH3B	4	HSPA5	0	affinity chromatography technology	Brehme M (2009)	1
HSPA5	0	KRT8	3	pull down	Liao J (1997)	1
OTUD4	2	KRT31	0	affinity chromatography technology	Sowa ME (2009)	1
KRT18	2	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Ku NO (1998), Pozuelo-Rubio M (2010)	2
VCAM1	2	KRT18	2	affinity chromatography technology	Humphries JD (2009)	1
PRKCE	6	ATF2	1	enzymatic study	Lau E (2012)	1
HSPA5	0	FAF2	4	affinity chromatography technology	Hein MY (2015)	1
NOS2	6	PPP6C	7	affinity chromatography technology	Foster MW (2013)	1
TJP1	2	KRT8	3	affinity chromatography technology	Chen VC (2006)	1
ITGA4	4	KRT8	3	affinity chromatography technology	Byron A (2012)	1
GRB2	2	KRT18	2	affinity chromatography technology	Blagoev B (2003)	1
ASB12	0	KRT8	3	affinity chromatography technology	Andresen CA (2014)	1
UBASH3B	4	KRT8	3	affinity chromatography technology	Brehme M (2009)	1
CRK	0	HSPA5	0	affinity chromatography technology	Brehme M (2009)	1
ESR1	0	CAV1	0	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Schlegel A (2001), Schlegel A (2001), Ramirez CM (2009), Watson CS (2012)	4
GRB2	2	YWHAQ	0	affinity chromatography technology	Bisson N (2011)	1
ITGA4	4	ANXA1	1	affinity chromatography technology	Byron A (2012)	1
ESR1	0	MAPK1	1	pull down, enzymatic study	Metivier R (2002), Tremblay A (2001)	2
IKBKG	0	KRT18	2	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
FAF2	4	KRT8	3	affinity chromatography technology	Christianson JC (2012)	1
MAPK1	1	KRT8	3	enzymatic study	Ku NO (2002)	1
CLK1	1	KRT8	3	enzymatic study	Lipp JJ (2015)	1
PNN	2	KRT18	2	two hybrid, pull down	Shi J (2000), Shi J (2000)	2
TES	1	IKBKG	0	affinity chromatography technology	Sala S (2017)	1
FAF2	4	KRT18	2	affinity chromatography technology	Christianson JC (2012)	1
KRT15	2	KRT18	2	two hybrid	Rual JF (2005)	1
BSG	1	KRT8	3	affinity chromatography technology	Wu B (2017)	1
CDH1	4	TJP1	2	bioid	Guo Z (2014)	1
TROAP	4	KRT8	3	pull down	Suzuki N (1998)	1
ITGA4	4	KRT18	2	affinity chromatography technology	Byron A (2012)	1
UBASH3B	4	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), Li J (2013), Li J (2013)	3
EED	1	KRT18	2	affinity chromatography technology	Cao Q (2014)	1
MAPK8	3	KRT8	3	affinity chromatography technology	He T (2002)	1
KRT8	3	TFIP11	5	two hybrid	Rolland T (2014)	1