PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EIF4A3	1	HNRNPM	1	affinity chromatography technology	Singh G (2012)	1
CUL3	17	CUL1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Bennett EJ (2010), Bennett EJ (2010), Wan C (2015)	3
CBL	7	KRT16	2	affinity chromatography technology	Brehme M (2009)	1
COPS5	0	DSP	8	affinity chromatography technology	Bennett EJ (2010)	1
GRB2	2	AP2M1	5	affinity chromatography technology	Blagoev B (2003)	1
CAND1	2	DSP	8	affinity chromatography technology	Bennett EJ (2010)	1
KRT5	1	KRT16	2	biochemical	Wan C (2015)	1
CUL2	3	KRT10	7	affinity chromatography technology	Bennett EJ (2010)	1
ITGA4	4	EPS15	1	affinity chromatography technology	Byron A (2012)	1
CUL4B	8	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
SHC1	0	AP2M1	5	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
CUL4B	8	KRT16	2	affinity chromatography technology	Bennett EJ (2010)	1
CAND1	2	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	AP2M1	5	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Foerster S (2013), Li J (2013), Tong J (2014), Li J (2013)	5
AP2M1	5	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
PIK3R2	3	KRT16	2	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	GRB2	2	far western blotting, affinity chromatography technology, affinity chromatography technology, pull down	Schumacher C (1995), Parachoniak CA (2009), Parachoniak CA (2009), Parachoniak CA (2009)	4
CBL	7	PIK3R2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Lin H (2001), Hartley D (1995), Feshchenko EA (2004), Alcazar I (2009), Brehme M (2009), Brehme M (2009), Grossmann A (2015)	7
COPS5	0	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
MAPK6	1	ALB	1	affinity chromatography technology	Huttlin EL (2017)	1
ALB	1	KRT5	1	affinity chromatography technology	Zhou M (2004)	1
ITGA4	4	INPPL1	6	affinity chromatography technology	Byron A (2012)	1
PIK3R2	3	SHC1	0	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
CUL3	17	PIK3R2	3	affinity chromatography technology	Bennett EJ (2010)	1
IQCB1	3	DSP	8	affinity chromatography technology	Sang L (2011)	1
CUL3	17	HNRNPM	1	affinity chromatography technology	Bennett EJ (2010)	1
FN1	17	KRT10	7	affinity chromatography technology	Humphries JD (2009)	1
CYLD	2	KRT10	7	affinity chromatography technology	Elliott PR (2016)	1
APOA1	0	FN1	17	affinity chromatography technology	Zhou M (2004)	1
EPS15	1	KRT82	7	affinity chromatography technology	Brehme M (2009)	1
DSP	8	KRT16	2	biochemical	Wan C (2015)	1
GRB2	2	KRT16	2	affinity chromatography technology	Brehme M (2009)	1
CUL1	7	HNRNPM	1	affinity chromatography technology	Bennett EJ (2010)	1
CCDC8	1	KRT5	1	affinity chromatography technology	Hanson D (2014)	1
FN1	17	KRT16	2	affinity chromatography technology	Humphries JD (2009)	1
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
EGFR	5	PIK3R2	3	affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid, pull down, protein complementation assay	Tong J (2009), Jones RB (2006), Foerster S (2013), Kotlyar M (2015), Gout I (1992), Petschnigg J (2014)	6
COPS5	0	CAND1	2	biochemical, affinity chromatography technology	Bornstein G (2006), Bennett EJ (2010)	2
IQCB1	3	KRT16	2	affinity chromatography technology	Sang L (2011)	1
CAND1	2	HNRNPM	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	KRT16	2	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
CYLD	2	ALB	1	affinity chromatography technology	Elliott PR (2016)	1
ALB	1	FN1	17	affinity chromatography technology	Zhou M (2004)	1
ITGA4	4	KRT10	7	affinity chromatography technology	Byron A (2012)	1
RPS6KB2	3	KRT10	7	affinity chromatography technology	Roy R (2014)	1
CYLD	2	HNRNPM	1	affinity chromatography technology	Elliott PR (2016)	1
RPS6KB2	3	HNRNPA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Roy R (2014), Roy R (2014), Roy R (2014), Roy R (2014)	4
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
CYLD	2	KRT5	1	affinity chromatography technology	Elliott PR (2016)	1
UBASH3B	4	KRT10	7	affinity chromatography technology	Brehme M (2009)	1
KRT5	1	KRT10	7	biochemical	Wan C (2015)	1
CRK	0	KRT16	2	affinity chromatography technology	Brehme M (2009)	1
GRB2	2	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
ITGA4	4	GRB2	2	affinity chromatography technology	Byron A (2012)	1
IQCB1	3	ALB	1	affinity chromatography technology	Sang L (2011)	1
FN1	17	KRT5	1	affinity chromatography technology	Humphries JD (2009)	1
CBL	7	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	AP2M1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	5
CUL3	17	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
EIF4A3	1	KRT5	1	affinity chromatography technology	Singh G (2012)	1
ITGA4	4	AP2M1	5	affinity chromatography technology	Byron A (2012)	1
UBASH3B	4	INPPL1	6	affinity chromatography technology	Brehme M (2009)	1
RPS6KB2	3	HNRNPM	1	affinity chromatography technology	Roy R (2014)	1
COPS5	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	8
CRK	0	INPPL1	6	affinity chromatography technology	Brehme M (2009)	1
CUL3	17	CUL2	3	biochemical	Wan C (2015)	1
EPS15	1	CRK	0	far western blotting, pull down, affinity chromatography technology, affinity chromatography technology	Schumacher C (1995), Schumacher C (1995), Brehme M (2009), Brehme M (2009)	4
HNRNPA1	1	KRT16	2	affinity chromatography technology	Roy R (2014)	1
UBASH3B	4	EWSR1	2	affinity chromatography technology	Li J (2013)	1
ALB	1	APOA1	0	affinity chromatography technology	Zhou M (2004)	1
GRB2	2	FN1	17	two hybrid, affinity chromatography technology	Wang J (2008), Humphries JD (2009)	2
EGFR	5	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Schulze WX (2006), Sakaguchi K (1998), Tong J (2009), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Burke P (2001), Katayama H (1999), Tong J (2008), Zhang L (1999), Levkowitz G (1999), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Foerster S (2013), Gotoh N (1994), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Li J (2013), Prigent SA (1996), Prigent SA (1996), Grosse R (2000), Yao Z (2017), Wills MK (2014), Wills MK (2014), Kapoor GS (2010)	29
NEDD8	0	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
FN1	17	EIF4A3	1	affinity chromatography technology	Humphries JD (2009)	1
EGFR	5	EWSR1	2	affinity chromatography technology	Tong J (2014)	1
COPS5	0	KRT16	2	affinity chromatography technology	Bennett EJ (2010)	1
MAPK6	1	KRT16	2	affinity chromatography technology	Rodriguez J (2016)	1
KRT10	7	KRT16	2	biochemical	Wan C (2015)	1
CUL4B	8	KRT10	7	affinity chromatography technology	Bennett EJ (2010)	1
HNRNPA1	1	EIF4A3	1	affinity chromatography technology	Roy R (2014)	1
HNRNPM	1	KRT16	2	biochemical	Havugimana PC (2012)	1
IQCB1	3	KRT10	7	affinity chromatography technology	Sang L (2011)	1
EGFR	5	KRT5	1	affinity chromatography technology	Yao Z (2017)	1
CUL3	17	AP2M1	5	affinity chromatography technology	Bennett EJ (2010)	1
HNRNPA1	1	EWSR1	2	affinity chromatography technology, affinity chromatography technology	Close P (2012), Roy R (2014)	2
EGFR	5	UBASH3B	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kowanetz K (2004), Raguz J (2007), Raguz J (2007), Tong J (2008), Foerster S (2013), Li J (2013), Tong J (2014), Li J (2013)	8
CCDC8	1	DSP	8	affinity chromatography technology	Hanson D (2014)	1
CUL2	3	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	INPPL1	6	affinity chromatography technology, affinity chromatography technology	Pesesse X (2001), Sanada F (2009)	2
ITGA4	4	CBL	7	affinity chromatography technology	Byron A (2012)	1
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
UBASH3B	4	CRK	0	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
ITGA4	4	HNRNPA1	1	affinity chromatography technology	Byron A (2012)	1
BANF1	0	KRT16	2	affinity chromatography technology	Montes de Oca R (2009)	1
COPS5	0	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
AP2M1	5	CRK	0	affinity chromatography technology	Brehme M (2009)	1
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
CUL2	3	DSP	8	affinity chromatography technology	Bennett EJ (2010)	1
FN1	17	ITGA4	4	affinity chromatography technology	Humphries JD (2009)	1
EGFR	5	FN1	17	protein complementation assay	Deribe YL (2009)	1
HNRNPA1	1	DSP	8	affinity chromatography technology	Roy R (2014)	1
CUL3	17	KRT16	2	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012)	4
EPS15	1	KRT10	7	affinity chromatography technology	Brehme M (2009)	1
PIK3R2	3	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
RPS6KB2	3	KRT5	1	affinity chromatography technology	Roy R (2014)	1
CUL4B	8	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Min KW (2003), Bennett EJ (2010), Bennett EJ (2010), Hein MY (2015)	6
CBL	7	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park RK (1999), Gesbert F (1998), Erdreich-Epstein A (1997), Wang Y (1999), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Brizzi MF (1996), Fukazawa T (1996)	9
NEDD8	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
APOA1	0	KRT16	2	affinity chromatography technology	Zhou M (2004)	1
CUL2	3	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
SHC1	0	KRT10	7	affinity chromatography technology	Brehme M (2009)	1
EGFR	5	CUL4B	8	affinity chromatography technology	Tong J (2014)	1
INPPL1	6	KRT16	2	affinity chromatography technology	Brehme M (2009)	1
SHC1	0	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
COPS5	0	KRT10	7	affinity chromatography technology	Bennett EJ (2010)	1
FN1	17	HNRNPM	1	affinity chromatography technology	Humphries JD (2009)	1
CCDC8	1	HNRNPA1	1	affinity chromatography technology	Hanson D (2014)	1
EGFR	5	CRK	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Schulze WX (2006), Hashimoto Y (1998), Hashimoto Y (1998), Katayama H (1999), Ota S (1998), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	9
CUL4B	8	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
HNRNPA1	1	KRT5	1	affinity chromatography technology	Roy R (2014)	1
NEDD8	0	DSP	8	affinity chromatography technology	Bennett EJ (2010)	1
INPPL1	6	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
CAND1	2	KRT16	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	KRT10	7	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	KRT10	7	affinity chromatography technology	Bennett EJ (2010)	1
RPS6KB2	3	KRT16	2	affinity chromatography technology	Roy R (2014)	1
AP2M1	5	KRT16	2	affinity chromatography technology	Brehme M (2009)	1
CUL4B	8	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
MAPK6	1	APOA1	0	two hybrid, affinity chromatography technology	Vinayagam A (2011), Huttlin EL (2017)	2
UBASH3B	4	CBL	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kowanetz K (2004), Kowanetz K (2004), Raguz J (2007), Hoeller D (2006), Peruzzi G (2007), Brehme M (2009)	6
ALB	1	KRT10	7	affinity chromatography technology	Zhou M (2004)	1
ITGA4	4	PIK3R2	3	affinity chromatography technology	Byron A (2012)	1
AP2M1	5	KRT10	7	affinity chromatography technology	Brehme M (2009)	1
NEDD8	0	KRT16	2	affinity chromatography technology	Bennett EJ (2010)	1
MAPK6	1	SHC1	0	two hybrid	Vinayagam A (2011)	1
CUL3	17	KRT10	7	affinity chromatography technology	Bennett EJ (2010)	1
CCDC8	1	KRT16	2	affinity chromatography technology	Hanson D (2014)	1
EWSR1	2	KRT16	2	affinity chromatography technology	Elzi DJ (2014)	1
CAND1	2	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
PIK3R2	3	KRT10	7	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
CUL1	7	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
ALB	1	KRT16	2	affinity chromatography technology	Zhou M (2004)	1
CCDC8	1	EWSR1	2	affinity chromatography technology	Hanson D (2014)	1
CBL	7	INPPL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vandenbroere I (2003), Prasad NK (2005), De Schutter J (2009), De Schutter J (2009), Brehme M (2009)	5
CUL3	17	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
CAND1	2	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	HNRNPM	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	GRB2	2	affinity chromatography technology	Bennett EJ (2010)	1
CAND1	2	EIF4A3	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Menon S (2008), Mao X (2011), Chua YS (2011), Chua YS (2011), Tron AE (2012)	7
CUL1	7	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
SHC1	0	INPPL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wisniewski D (1999), Wisniewski D (1999), Pesesse X (2001), Habib T (1998), Brehme M (2009), Brehme M (2009)	6
CRK	0	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
CYLD	2	HNRNPA1	1	affinity chromatography technology	Elliott PR (2016)	1
SHC1	0	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Ota S (1998), Larsson H (1999)	4
CUL1	7	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
CCDC8	1	ALB	1	affinity chromatography technology	Hanson D (2014)	1
UBASH3B	4	CUL3	17	pull down	Krupina K (2016)	1
CUL2	3	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
PTPRN2	8	KRT16	2	bioid	St-Denis N (2016)	1
FN1	17	HNRNPA1	1	affinity chromatography technology	Humphries JD (2009)	1
GRB2	2	KRT82	7	affinity chromatography technology	Brehme M (2009)	1
CRK	0	KRT10	7	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	KRT16	2	affinity chromatography technology	Brehme M (2009)	1
IQCB1	3	KRT5	1	affinity chromatography technology	Sang L (2011)	1
MAPK6	1	DSP	8	affinity chromatography technology	Rodriguez J (2016)	1
CUL3	17	DSP	8	affinity chromatography technology	Bennett EJ (2010)	1
GRB2	2	CYLD	2	affinity chromatography technology	Huttlin EL (2017)	1
CCDC8	1	CAND1	2	affinity chromatography technology	Hanson D (2014)	1
EIF4A3	1	KRT10	7	affinity chromatography technology	Singh G (2012)	1
FN1	17	EWSR1	2	affinity chromatography technology	Humphries JD (2009)	1
ITGA4	4	EWSR1	2	affinity chromatography technology	Byron A (2012)	1
CYLD	2	DSP	8	affinity chromatography technology	Elliott PR (2016)	1
RPS6KB2	3	ALB	1	affinity chromatography technology	Roy R (2014)	1
COPS5	0	HNRNPM	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
FN1	17	EPS15	1	affinity chromatography technology	Humphries JD (2009)	1
CBL	7	KRT10	7	affinity chromatography technology	Brehme M (2009)	1
NEDD8	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
NEDD8	0	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	EIF4A3	1	affinity chromatography technology	Bennett EJ (2010)	1
SHC1	0	UBASH3B	4	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
GRB2	2	KRT10	7	affinity chromatography technology	Brehme M (2009)	1
GRB2	2	PIK3R2	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Brehme M (2009), Brehme M (2009), Bisson N (2011)	4
EGFR	5	KRT10	7	affinity chromatography technology	Yao Z (2017)	1
SHC1	0	KRT16	2	affinity chromatography technology	Brehme M (2009)	1
HNRNPA1	1	HNRNPM	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Close P (2012), Havugimana PC (2012), Roy R (2014), Hein MY (2015)	5
COPS5	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), He F (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
CAND1	2	KRT10	7	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	KRT16	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
CRK	0	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, two hybrid	Gesbert F (1998), Husson H (1997), Ingham RJ (1996), Ingham RJ (1996), Delehanty LL (2003), Garcia-Guzman M (2000), Garcia-Guzman M (2000), Barber DL (1997), Buday L (1996), Sawasdikosol S (1996), Sawasdikosol S (1996), Thien CB (1997), van Leeuwen JE (1999), Ribon V (1996), Lottin-Divoux S (2006), Reedquist KA (1996), Brehme M (2009), Brehme M (2009), Ota S (1998), Peterson ME (2008), Liu BA (2012), Fukazawa T (1996), Umehara H (2002), Grossmann A (2015)	24
CYLD	2	KRT16	2	affinity chromatography technology	Elliott PR (2016)	1
MAPK6	1	KRT10	7	affinity chromatography technology	Rodriguez J (2016)	1
INPPL1	6	PIK3R2	3	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
ITGA4	4	KRT16	2	affinity chromatography technology	Byron A (2012)	1
HNRNPA1	1	ALB	1	affinity chromatography technology	Roy R (2014)	1
UBASH3B	4	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
INPPL1	6	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Brehme M (2009), Bisson N (2011)	4
ITGA4	4	HNRNPM	1	affinity chromatography technology	Byron A (2012)	1
FN1	17	CAND1	2	affinity chromatography technology	Humphries JD (2009)	1
EGFR	5	KRT16	2	affinity chromatography technology	Yao Z (2017)	1
RPS6KB2	3	EWSR1	2	affinity chromatography technology	Roy R (2014)	1
CUL1	7	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Min KW (2003), Menon S (2008), Chew EH (2007), Min KW (2005), Min KW (2005), Min KW (2005), Hwang JW (2003), Hwang JW (2003), Mao X (2011), Chua YS (2011), Chua YS (2011), Tron AE (2012), Zheng J (2002), Zheng J (2002), Bornstein G (2006), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), He YJ (2006), Emberley ED (2012), Choo YY (2011), Jonason JH (2007), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Liu J (2002), Liu J (2002), Liu J (2002), Liu J (2002), Korzeniewski N (2012), Pierce NW (2013), Kim AY (2008), Zhang S (2016), Tikhmyanova N (2017), Tikhmyanova N (2017), Reitsma JM (2017), Reitsma JM (2017)	41
FN1	17	AP2M1	5	affinity chromatography technology	Humphries JD (2009)	1
COPS5	0	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
HNRNPA1	1	KRT10	7	affinity chromatography technology	Roy R (2014)	1
INPPL1	6	KRT10	7	affinity chromatography technology	Brehme M (2009)	1
CUL3	17	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Chua YS (2011), Chua YS (2011), Tron AE (2012), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Schumacher FR (2015), Schumacher FR (2015), Lo SC (2006), Lo SC (2006)	12
COPS5	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
EIF4A3	1	KRT16	2	affinity chromatography technology	Singh G (2012)	1
NEDD8	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Wimuttisuk W (2007)	4
UBASH3B	4	KRT16	2	affinity chromatography technology	Brehme M (2009)	1
UBASH3B	4	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), Li J (2013), Li J (2013)	3
COPS5	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Pick E (2012)	7
ITGA4	4	EIF4A3	1	affinity chromatography technology	Byron A (2012)	1
CUL3	17	EIF4A3	1	affinity chromatography technology	Bennett EJ (2010)	1
PIK3R2	3	CRK	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Brehme M (2009), Brehme M (2009), Grossmann A (2015)	3
EPS15	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	van Delft S (1997), Sigismund S (2005), Bertelsen V (2011), Parachoniak CA (2009), Parachoniak CA (2009), Hoeller D (2006)	6
KRT82	7	KRT16	2	biochemical	Wan C (2015)	1