PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2V2	0	UBC	7	x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, pull down	McKenna S (2003), McKenna S (2003), McKenna S (2003), Lewis MJ (2006), McKenna S (2001)	5
CASP8	1	HDAC7	4	enzymatic study	Scott FL (2008)	1
RHOA	0	CAV1	0	pull down	Nethe M (2010)	1
SMURF1	4	SLC25A5	1	affinity chromatography technology	Xie Y (2013)	1
ARHGDIA	3	MSN	0	biochemical, biochemical	Gajate C (2005), Wan C (2015)	2
KRAS	1	PON2	0	genetic interference	Luo J (2009)	1
PTEN	24	PKN2	6	affinity chromatography technology	Crockett DK (2005)	1
BAIAP2	6	RAP1GDS1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MDM2	2	S100A4	0	pull down	van Dieck J (2010)	1
ICMT	1	RHOA	0	enzymatic study	Dai Q (1998)	1
EGLN3	0	NUBP2	0	affinity chromatography technology	Rodriguez J (2016)	1
RHOA	0	RIPK4	0	two hybrid	Gebbink MF (1997)	1
AGAP1	6	LIMA1	4	affinity chromatography technology	Boldt K (2016)	1
RAP1GDS1	0	RHOA	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Vikis HG (2002), Vikis HG (2002), Berg TJ (2010), Huttlin EL (2017)	4
RHOA	0	RPN2	0	two hybrid	Wang J (2011)	1
EZR	8	TNFRSF1A	3	biochemical	Gajate C (2005)	1
PTEN	24	CASP8	1	affinity chromatography technology, affinity chromatography technology	Crockett DK (2005), Crockett DK (2005)	2
OTUB1	0	RACK1	2	affinity chromatography technology, affinity chromatography technology	Edelmann MJ (2009), Edelmann MJ (2009)	2
BID	1	FASLG	0	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
CUL3	17	NVL	5	affinity chromatography technology	Bennett EJ (2010)	1
GOSR1	1	RHOA	0	genetic interference	Blomen VA (2015)	1
MED20	2	RHOA	0	affinity chromatography technology	Lambert JP (2015)	1
OTUB1	0	UBE2V2	0	pull down	Sato Y (2012)	1
LIMA1	4	CAV1	0	affinity chromatography technology	Hein MY (2015)	1
SOD1	0	PRDX6	0	affinity chromatography technology	Malty RH (2017)	1
BID	1	TNFRSF1A	3	biochemical	Gajate C (2005)	1
FAS	2	MAPK8	3	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
RHOA	0	CTSA	2	affinity chromatography technology	Huttlin EL (2017)	1
DEF6	0	RHOA	0	pull down	Mavrakis KJ (2004)	1
TNFRSF1A	3	UBC	7	affinity chromatography technology	Nakazawa S (2016)	1
PTEN	24	ARHGAP26	3	affinity chromatography technology	Crockett DK (2005)	1
SMAD2	5	RPS27A	1	two hybrid	Colland F (2004)	1
RHOA	0	BID	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
NFKBIA	0	BIRC2	1	affinity chromatography technology	Huttlin EL (2015)	1
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
EGLN3	0	TRIP6	2	affinity chromatography technology	Rodriguez J (2016)	1
DCUN1D1	0	RHOA	0	pull down	Huang G (2014)	1
IKBKG	0	ARHGDIA	3	pull down	Kim HJ (2014)	1
IKBKG	0	NFKBIA	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Stempin CC (2011), Pringle LM (2011), Wu CJ (2006), Higashimoto T (2008), Ducut Sigala JL (2004), Shibata Y (2011), Liu L (2002), Xiao G (2000), Chan H (2005), Funakoshi-Tago M (2005), Wu X (2007), Kato T (2008), Niu J (2011), Neumann M (2011), Keusekotten K (2013), Fu J (2013), Dan HC (2008), Criollo A (2010), Hein MY (2015), Baratchian M (2016)	20
CUL3	17	HSD17B10	1	affinity chromatography technology	Bennett EJ (2010)	1
RHOA	0	MARK2	6	affinity chromatography technology	Yamahashi Y (2011)	1
RIPK4	0	CPT1A	1	affinity chromatography technology	Rodriguez J (2016)	1
MAP3K1	4	NOTCH1	25	enzymatic study, affinity chromatography technology	Ahn JS (2016), Ahn JS (2016)	2
CLNS1A	2	PLIN3	3	biochemical	Havugimana PC (2012)	1
PRRC1	2	SHMT2	3	biochemical	Wan C (2015)	1
CASP10	1	TNFRSF10B	1	biochemical, affinity chromatography technology	Gajate C (2005), MacFarlane M (1997)	2
TNFRSF1A	3	TRPC1	0	affinity chromatography technology	Mace KE (2010)	1
LRRK2	5	MPRIP	2	affinity chromatography technology	Meixner A (2011)	1
EGLN3	0	AKAP13	11	affinity chromatography technology	Rodriguez J (2016)	1
ARHGDIA	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
DIRAS3	0	RHOA	0	affinity chromatography technology	Huttlin EL (2015)	1
DPYSL2	3	GORASP2	1	two hybrid	Rolland T (2014)	1
BID	1	CRMP1	0	two hybrid	Vinayagam A (2011)	1
MSN	0	BID	1	biochemical	Gajate C (2005)	1
CASP10	1	FASLG	0	biochemical	Gajate C (2005)	1
IKBKG	0	HSPA1A	0	pull down	Agou F (2002)	1
UBC	7	LIMA1	4	pull down	Nathan JA (2013)	1
DIRAS3	0	MDM2	2	affinity chromatography technology	Huttlin EL (2015)	1
SMURF1	4	UBC	7	affinity chromatography technology, enzymatic study, pull down	Xie Y (2013), Kristariyanto YA (2015), Zhang Y (2017)	3
KCTD13	1	RHOA	0	affinity chromatography technology, pull down, enzymatic study, enzymatic study	Chen Y (2009), Chen Y (2009), Chen Y (2009), Ibeawuchi SR (2015)	4
FAS	2	FADD	1	biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Gajate C (2005), MacFarlane M (1997), Pan G (1997), Huang B (1996), Huang B (1996), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Thomas LR (2002), Kumar A (2001), Lee EW (2012), Zhang M (2011), Huttlin EL (2015), Chen TC (2014), Jeong M (2017), Huttlin EL (2017), Kleber S (2008), Torii S (1999), Torii S (1999), Chang HY (1999)	20
DCUN1D1	0	RPL18	0	affinity chromatography technology	Bennett EJ (2010)	1
PLXNB1	12	PLCG1	6	affinity chromatography technology, affinity chromatography technology	Swiercz JM (2009), Swiercz JM (2009)	2
OPHN1	4	RHOA	0	enzymatic study	Billuart P (1998)	1
CASP8	1	FADD	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Srinivasula SM (1997), Srinivasula SM (1997), Henshall DC (2003), Boldin MP (1996), Oshima S (2009), Thomas LR (2002), Ikner A (2011), Tenev T (2011), Ramakrishnan P (2011), Mahul-Mellier AL (2011), Won M (2010), Ryu SW (2003), Sinha SK (2004), Biton S (2011), Fu K (2012), Fu K (2012), Gonzalvez F (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Wang J (2011), Puliyappadamba VT (2013), Choi H (2011), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Saitoh Y (2016), Moquin DM (2013), Ranjan K (2016), Nakazawa S (2016), Jeong M (2017), Jeong M (2017), Pescatore A (2016)	35
PTEN	24	SLC25A5	1	pull down	Verrastro I (2015)	1
SLC25A5	1	RHOA	0	biochemical	Havugimana PC (2012)	1
RHOA	0	CRMP1	0	genetic interference	Leung T (2002)	1
EGLN3	0	PDHA1	7	affinity chromatography technology	Rodriguez J (2016)	1
ARHGEF2	4	PLCG1	6	affinity chromatography technology	Swiercz JM (2009)	1
FAS	2	ARHGDIA	3	biochemical	Gajate C (2005)	1
BIRC2	1	CASP10	1	affinity chromatography technology	McDonald ER (2004)	1
RHOA	0	ARHGAP35	12	pull down, affinity chromatography technology, pull down	Zhang B (1998), Ling L (2004), Zhang B (1998)	3
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
ARHGAP26	3	ARHGAP10	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
PTEN	24	UBC	7	protein complementation assay, affinity chromatography technology	Li Y (2014), Li Y (2014)	2
DLST	3	SLC25A5	1	affinity chromatography technology	Malty RH (2017)	1
VASH1	1	RAP1GDS1	0	affinity chromatography technology	Huttlin EL (2017)	1
ARHGEF2	4	RHOA	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Ren Y (1998), Yamahashi Y (2011), Huttlin EL (2017)	3
RABL3	0	RHOA	0	affinity chromatography technology	Huttlin EL (2017)	1
RHOA	0	KTN1	1	two hybrid, two hybrid, two hybrid, two hybrid	Riento K (2003), Neudauer CL (2001), Hotta K (1996), Vignal E (2001)	4
CAV1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology	Dubiel D (2017), Dubiel D (2017)	2
SMURF2	3	UBC	7	enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down	Maspero E (2013), Zhang L (2013), Kristariyanto YA (2015), Mari S (2014), Zhang Y (2017)	5
HDAC7	4	RHOA	0	affinity chromatography technology	Huttlin EL (2017)	1
RHOC	0	ARHGEF12	2	affinity chromatography technology	Huttlin EL (2017)	1
RACK1	2	TSC22D4	1	two hybrid	Rual JF (2005)	1
HSD17B10	1	BID	1	affinity chromatography technology	Malty RH (2017)	1
RHOA	0	SHMT2	3	biochemical	Wan C (2015)	1
PDE6D	0	RHOA	0	two hybrid	Nancy V (2002)	1
RHOA	0	BIRC2	1	pull down	Marivin A (2013)	1
PSMD10	1	MDM2	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Qiu W (2008), Qiu W (2008), Higashitsuji H (2005), Higashitsuji H (2005), Higashitsuji H (2005), Higashitsuji H (2007)	6
AGAP2	14	MPRIP	2	affinity chromatography technology	Pilot-Storck F (2010)	1
LIMA1	4	TNFAIP1	4	affinity chromatography technology	Hein MY (2015)	1
LRRK2	5	LIMA1	4	affinity chromatography technology	Meixner A (2011)	1
MAPK8	3	GORASP2	1	enzymatic study	Jesch SA (2001)	1
RHOC	0	RIPOR2	1	two hybrid	Rolland T (2014)	1
SMURF1	4	ARHGAP5	3	affinity chromatography technology	Xie Y (2013)	1
CUL3	17	DDX1	6	affinity chromatography technology	Bennett EJ (2010)	1
CNKSR1	2	RHPN1	2	affinity chromatography technology, pull down, affinity chromatography technology	Jaffe AB (2004), Jaffe AB (2004), Jaffe AB (2004)	3
EZR	8	HSD17B10	1	biochemical	Wan C (2015)	1
RHOA	0	VAV3	4	pull down	Movilla N (1999)	1
CAV1	0	SMAD2	5	biochemical	Razani B (2001)	1
RPGR	0	PDE6D	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Linari M (1999), Linari M (1999), Huttlin EL (2017), Boldt K (2016)	4
RHOA	0	GLB1	3	affinity chromatography technology	Huttlin EL (2017)	1
SRGAP1	3	RHOA	0	affinity chromatography technology, affinity chromatography technology	Tang YA (2010), Tang YA (2010)	2
MAPK8	3	RABL3	0	affinity chromatography technology	Hein MY (2015)	1
RHOA	0	CIT	14	pull down, two hybrid, two hybrid, far western blotting	Riento K (2003), Riento K (2003), Madaule P (1995), Madaule P (1995)	4
LIMA1	4	MPRIP	2	affinity chromatography technology	Hein MY (2015)	1
U2AF2	7	ARHGDIA	3	affinity chromatography technology	Whisenant TC (2015)	1
RPS27A	1	MDM2	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Sun XX (2011), Sun XX (2011), Sun XX (2011), Sun XX (2011), Wang J (2011)	5
LRRK2	5	PPP1R12A	6	affinity chromatography technology	Meixner A (2011)	1
RASL10A	0	RAP1GDS1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NFKBIA	0	RHOA	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	CDKN1B	1	affinity chromatography technology	Huang G (2014)	1
RHOC	0	ARHGEF11	8	affinity chromatography technology	Huttlin EL (2017)	1
EZR	8	CASP8	1	biochemical	Gajate C (2005)	1
RHOC	0	CTSA	2	affinity chromatography technology	Huttlin EL (2017)	1
PLIN3	3	RHOA	0	biochemical	Havugimana PC (2012)	1
BID	1	TNFRSF10B	1	biochemical	Gajate C (2005)	1
EGLN3	0	HSD17B10	1	affinity chromatography technology	Rodriguez J (2016)	1
RHOA	0	RPS27A	1	biochemical	Havugimana PC (2012)	1
CAV1	0	PLCG1	6	affinity chromatography technology	Boettcher JP (2010)	1
LDB3	2	RHOA	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	DLST	3	affinity chromatography technology	Matsumoto M (2005)	1
RHOA	0	FADD	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
SERPINB5	0	PRDX6	0	biochemical	Wan C (2015)	1
ARHGDIA	3	EZR	8	biochemical, biochemical	Gajate C (2005), Wan C (2015)	2
ARHGAP26	3	OPHN1	4	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	RHOA	0	affinity chromatography technology	Huang G (2014)	1
ANLN	2	CIT	14	affinity chromatography technology	Hein MY (2015)	1
PKN2	6	RABL3	0	affinity chromatography technology	Hein MY (2015)	1
MAPK8	3	CASP10	1	biochemical	Gajate C (2005)	1
MAPK8	3	FASLG	0	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
RACK1	2	PLCG1	6	far western blotting	Disatnik MH (1994)	1
NUTF2	0	RHOA	0	biochemical	Wan C (2015)	1
SMURF1	4	HSPA1A	0	affinity chromatography technology	Xie Y (2013)	1
MSN	0	FASLG	0	biochemical	Gajate C (2005)	1
RHOA	0	ARHGDIB	1	biochemical	Wan C (2015)	1
PRDX6	0	RHOA	0	biochemical	Havugimana PC (2012)	1
UBC	7	CAV1	0	affinity chromatography technology, imaging technique	Luo X (2017), Luo X (2017)	2
RHOA	0	ITPR1	25	affinity chromatography technology, pull down	Mehta D (2003), Mehta D (2003)	2
RHOC	0	RTKN	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	ARHGDIA	3	affinity chromatography technology	Bennett EJ (2010)	1
PRDX6	0	CASP8	1	pull down, affinity chromatography technology, affinity chromatography technology, protein complementation assay	Choi H (2011), Choi H (2011), Choi H (2011), Choi H (2011)	4
RPE	3	NUTF2	0	biochemical	Wan C (2015)	1
BCR	3	RHOA	0	pull down	Zhang B (1998)	1
TNFRSF1A	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
LIMA1	4	RAP2C	0	affinity chromatography technology	Hein MY (2015)	1
CASP8	1	TNFRSF1A	3	biochemical	Gajate C (2005)	1
KLHL20	2	CRMP1	0	two hybrid	Stelzl U (2005)	1
SMAD2	5	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Runyan CE (2009), Runyan CE (2009), Chong PA (2010), Brown KA (2008), Colland F (2004), Colland F (2004), Zhang Y (2017), Zhou F (2017), Zhou F (2017)	16
KRAS	1	DIRAS3	0	genetic interference, two hybrid	Vizeacoumar FJ (2013), Arroyo R (2015)	2
SLC25A5	1	RPL18	0	biochemical	Havugimana PC (2012)	1
DCUN1D1	0	DDX1	6	affinity chromatography technology	Bennett EJ (2010)	1
KLHL20	2	ARHGEF12	2	enzymatic study	Lin MY (2011)	1
ARHGDIA	3	RHOA	0	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, biochemical, pull down, x-ray crystallography	Ewing RM (2007), Gajate C (2005), Michaelson D (2001), Gorvel JP (1998), Faure J (2001), Man JH (2010), Rolland T (2014), Wan C (2015), Jaffe AB (2004), Kuhlmann N (2016), Kuhlmann N (2016), Kuhlmann N (2016)	12
ARHGEF4	3	RHOA	0	pull down	Kawasaki Y (2000)	1
LIMA1	4	RHOA	0	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	SLC25A12	2	affinity chromatography technology	Rodriguez J (2016)	1
CASP10	1	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Micheau O (2003), Guo Y (2002), Srinivasula SM (1996), Srinivasula SM (1996), Sinha SK (2004), Lee EW (2012), Feoktistova M (2011)	9
RHOA	0	ARHGAP5	3	affinity chromatography technology, pull down	Wennerberg K (2003), Wennerberg K (2003)	2
ANLN	2	MPRIP	2	affinity chromatography technology	Hein MY (2015)	1
SMAD2	5	PLIN3	3	two hybrid	Colland F (2004)	1
EGLN3	0	RTKN	0	affinity chromatography technology	Rodriguez J (2016)	1
VASH1	1	RHOA	0	affinity chromatography technology	Huttlin EL (2017)	1
COX15	3	PRDX6	0	affinity chromatography technology	Malty RH (2017)	1
DIAPH1	4	PLXNB1	12	affinity chromatography technology	Hein MY (2015)	1
CLNS1A	2	TRIP6	2	biochemical	Havugimana PC (2012)	1
CUL3	17	FADD	1	affinity chromatography technology	Gonzalvez F (2012)	1
ARHGDIB	1	RHOC	0	biochemical	Wan C (2015)	1
SOD1	0	RPE	3	biochemical	Wan C (2015)	1
CDKN1B	1	RHOA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Larrea MD (2009), Larrea MD (2009), Wei Z (2013)	3
SMURF1	4	MSN	0	enzymatic study	Andrews PS (2010)	1
ANLN	2	LIMA1	4	affinity chromatography technology	Hein MY (2015)	1
BID	1	CASP10	1	biochemical	Gajate C (2005)	1
MAPK8	3	CASP8	1	biochemical	Gajate C (2005)	1
PTEN	24	LIMA1	4	pull down	Verrastro I (2015)	1
NOTCH1	25	RHOA	0	two hybrid	Daakour S (2016)	1
RHOC	0	ARHGEF1	5	affinity chromatography technology	Huttlin EL (2017)	1
RHOA	0	SMURF1	4	pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Asanuma K (2006), Tian M (2011), Tian M (2011), Tian M (2011), Lee MG (2016), He S (2017)	6
FAS	2	CRMP1	0	two hybrid	Stelzl U (2005)	1
GORASP2	1	SHMT2	3	biochemical	Wan C (2015)	1
PTEN	24	NOTCH1	25	genetic interference	Vizeacoumar FJ (2013)	1
BID	1	CASP8	1	biochemical, enzymatic study	Gajate C (2005), Guo Y (2002)	2
RHOA	0	NAXE	2	biochemical	Wan C (2015)	1
PDHA1	7	RHOA	0	affinity chromatography technology	Malty RH (2017)	1
EZR	8	CASP10	1	biochemical	Gajate C (2005)	1
RHOA	0	CASP8	1	biochemical	Gajate C (2005)	1
DLST	3	RPN2	0	affinity chromatography technology	Malty RH (2017)	1
EZR	8	MAPK8	3	biochemical	Gajate C (2005)	1
MBD5	14	RHOA	0	affinity chromatography technology	Huttlin EL (2015)	1
RHOA	0	RPL18	0	biochemical	Havugimana PC (2012)	1
EGLN3	0	SLC25A5	1	affinity chromatography technology	Rodriguez J (2016)	1
FAS	2	CASP10	1	biochemical, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Vincenz C (1997), MacFarlane M (1997)	3
RHOA	0	UBE2V2	0	affinity chromatography technology	Hein MY (2015)	1
UBC	7	PSMD10	1	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
TM4SF20	1	RHOA	0	affinity chromatography technology	Huttlin EL (2015)	1
ARHGAP26	3	RHOA	0	enzymatic study	Shibata H (2001)	1
DCUN1D1	0	HSPA1A	0	affinity chromatography technology	Bennett EJ (2010)	1
PDHA1	7	LIMA1	4	affinity chromatography technology	Malty RH (2017)	1
RHOA	0	RHPN1	2	affinity chromatography technology, pull down	Jaffe AB (2004), Jaffe AB (2004)	2
HDAC7	4	PPP1R12A	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Parra M (2007), Parra M (2007), Parra M (2007)	3
RHOA	0	KCNA2	6	affinity chromatography technology, pull down, two hybrid	Cachero TG (1998), Cachero TG (1998), Cachero TG (1998)	3
TNFRSF1A	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1996), Vince JE (2009), Vince JE (2007), Wang YB (2015)	4
SOD1	0	NUTF2	0	biochemical	Wan C (2015)	1
EGLN3	0	BIRC2	1	affinity chromatography technology	Fu J (2016)	1
FASLG	0	TRIP6	2	two hybrid	Rolland T (2014)	1
ROCK2	2	ROCK1	6	affinity chromatography technology	Huttlin EL (2017)	1
CASP8	1	FASLG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Legler DF (2003), Tao RH (2011)	4
OTUB1	0	HSPA1A	0	affinity chromatography technology	Scholz CC (2016)	1
PTEN	24	RHOA	0	affinity chromatography technology, affinity chromatography technology	Chang CC (2012), Chang CC (2012)	2
RHOA	0	MAPK8	3	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
TSC22D4	1	RHOA	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPL18	0	U2AF2	7	biochemical	Havugimana PC (2012)	1
TSC22D4	1	RAP1GDS1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RHOA	0	PKN1	4	pull down, two hybrid, pull down, two hybrid, far western blotting, pull down, x-ray crystallography	Riento K (2003), Riento K (2003), Alberts AS (1998), Flynn P (1998), Flynn P (1998), Flynn P (1998), Maesaki R (1999)	7
RHOA	0	ROCK1	6	pull down, two hybrid, affinity chromatography technology, pull down, far western blotting, two hybrid	Riento K (2003), Riento K (2003), Riento K (2003), Leung T (1996), Fujisawa K (1996), Fujisawa K (1996)	6
U2AF2	7	RHOA	0	affinity chromatography technology	Whisenant TC (2015)	1
KLHL20	2	RHOA	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNAL1	1	RHOA	0	affinity chromatography technology	Huttlin EL (2017)	1
MBD5	14	BID	1	affinity chromatography technology	Huttlin EL (2017)	1
RTKN	0	AGAP1	6	affinity chromatography technology	Boldt K (2016)	1
RHOA	0	CASP10	1	biochemical	Gajate C (2005)	1
LRRK2	5	RHOA	0	affinity chromatography technology	Chan D (2011)	1
SMAD2	5	SMURF1	4	affinity chromatography technology, affinity chromatography technology, two hybrid	Komuro A (2004), Ito I (2010), Colland F (2004)	3
HSD17B10	1	ARHGDIA	3	biochemical, affinity chromatography technology	Wan C (2015), Malty RH (2017)	2
TBXA2R	1	RACK1	2	two hybrid, pull down, affinity chromatography technology	Parent A (2008), Parent A (2008), Parent A (2008)	3
FAS	2	EZR	8	biochemical	Gajate C (2005)	1
CASP8	1	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin Z (2009), Jin Z (2009), Gonzalvez F (2012), Xu J (2015)	4
ARHGDIA	3	MAPK8	3	biochemical	Gajate C (2005)	1
RHOA	0	HTR1A	1	affinity chromatography technology	Guilluy C (2007)	1
U2AF2	7	SHMT2	3	affinity chromatography technology	Whisenant TC (2015)	1
MSN	0	FADD	1	biochemical	Gajate C (2005)	1
PDHA1	7	SHMT2	3	affinity chromatography technology	Malty RH (2017)	1
RHOC	0	DAAM1	3	affinity chromatography technology	Huttlin EL (2017)	1
GORASP2	1	CUL3	17	biochemical	Kristensen AR (2012)	1
DLST	3	HSD17B10	1	affinity chromatography technology	Malty RH (2017)	1
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
EGLN3	0	RHOA	0	affinity chromatography technology	Rodriguez J (2016)	1
LIMA1	4	HDAC7	4	affinity chromatography technology	Boldt K (2016)	1
DNAL1	1	RAP1GDS1	0	affinity chromatography technology	Huttlin EL (2017)	1
RHOA	0	FUBP3	0	affinity chromatography technology	Hein MY (2015)	1
MARK2	6	BAIAP2	6	enzymatic study	Lazaro-Dieguez F (2013)	1
RIPOR2	1	RHOA	0	two hybrid, two hybrid, two hybrid	Wang J (2011), Rolland T (2014), Yu H (2011)	3
MSN	0	CASP8	1	biochemical	Gajate C (2005)	1
RHOA	0	PKN2	6	pull down, far western blotting, affinity chromatography technology	Quilliam LA (1996), Flynn P (1998), Huttlin EL (2017)	3
SHMT2	3	DDX1	6	biochemical	Wan C (2015)	1
NVL	5	CRMP1	0	two hybrid	Stelzl U (2005)	1
PKN3	4	ARHGAP10	1	two hybrid, affinity chromatography technology, pull down	Shibata H (2001), Shibata H (2001), Shibata H (2001)	3
RHOA	0	MCF2	1	pull down	Zhu K (2000)	1
TNFRSF10B	1	CUL3	17	affinity chromatography technology	Gonzalvez F (2012)	1
RHOA	0	SMAD2	5	pull down	Miyamoto-Sato E (2010)	1
MED20	2	PSMD10	1	affinity chromatography technology	Lambert JP (2015)	1
U2AF2	7	MSN	0	affinity chromatography technology	Whisenant TC (2015)	1
RHOA	0	SLC25A12	2	biochemical	Wan C (2015)	1
NOTCH1	25	IKZF3	1	affinity chromatography technology	Yatim A (2012)	1
KCTD13	1	TNFAIP1	4	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Sowa ME (2009), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	5
ARHGEF25	0	RHOA	0	enzymatic study, pull down	Lutz S (2004), Lutz S (2004)	2
LIMA1	4	KRAS	1	affinity chromatography technology	Hein MY (2015)	1
SMAD2	5	BAZ1A	5	two hybrid	Colland F (2004)	1
CASP8	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Feoktistova M (2012), McDonald ER (2004), Zinngrebe J (2016)	4
TNFRSF1A	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Zhang SQ (2000), Nakazawa S (2016)	2
RHOA	0	BAZ1A	5	affinity chromatography technology	Hein MY (2015)	1
RHOA	0	RAP2C	0	affinity chromatography technology	Huttlin EL (2017)	1
ATP6AP2	2	KTN1	1	affinity chromatography technology	Hein MY (2015)	1
RHOA	0	TRPC1	0	affinity chromatography technology, pull down	Mehta D (2003), Mehta D (2003)	2
MAP3K1	4	DCUN1D1	0	enzymatic study	Charlaftis N (2014)	1
ATP6AP2	2	RHOA	0	affinity chromatography technology	Hein MY (2015)	1
PDHA1	7	RPN2	0	affinity chromatography technology	Malty RH (2017)	1
RIPK4	0	SLC25A12	2	affinity chromatography technology	Rodriguez J (2016)	1
TNFAIP1	4	RHOA	0	affinity chromatography technology, pull down, enzymatic study	Chen Y (2009), Chen Y (2009), Chen Y (2009)	3
MSN	0	PAFAH1B2	2	biochemical	Kristensen AR (2012)	1
COX15	3	RPN2	0	affinity chromatography technology	Malty RH (2017)	1
CUL3	17	RPL18	0	affinity chromatography technology	Bennett EJ (2010)	1
SMURF2	3	SLC25A5	1	affinity chromatography technology	Zhang L (2013)	1
CUL3	17	PON2	0	affinity chromatography technology	Bennett EJ (2010)	1
TNFRSF1A	3	CAV1	0	biochemical	Legler DF (2003)	1
ARHGAP32	11	SMURF1	4	affinity chromatography technology, affinity chromatography technology	Kannan M (2012), Kannan M (2012)	2
ARHGAP32	11	PLCG1	6	affinity chromatography technology	Moon SY (2003)	1
RHOC	0	RHOA	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	U2AF2	7	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	SHMT2	3	affinity chromatography technology	Bennett EJ (2010)	1
RHOA	0	GORASP2	1	biochemical	Wan C (2015)	1
SMAD2	5	ROCK1	6	two hybrid	Colland F (2004)	1
SHMT2	3	DGKQ	4	affinity chromatography technology	Castello A (2012)	1
NUBP2	0	RHOA	0	biochemical	Havugimana PC (2012)	1
PLXNB1	12	RHOA	0	affinity chromatography technology	Swiercz JM (2009)	1
CLNS1A	2	RHOA	0	biochemical	Havugimana PC (2012)	1
CASP10	1	FADD	1	biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, pull down, pull down	Gajate C (2005), Vincenz C (1997), Vincenz C (1997), Srinivasula SM (1997), Srinivasula SM (1997), Wang J (2001), McDonald ER (2004), Choi H (2011), Choi H (2011)	9
DCUN1D1	0	SLC25A5	1	affinity chromatography technology	Bennett EJ (2010)	1
U2AF2	7	HSPA1A	0	affinity chromatography technology	Whisenant TC (2015)	1
ARHGDIA	3	CASP8	1	biochemical	Gajate C (2005)	1
BID	1	FADD	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
ARHGEF12	2	PLXNB1	12	affinity chromatography technology, two hybrid	Hirotani M (2002), Hirotani M (2002)	2
CASP10	1	PRDX6	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, protein complementation assay	Choi H (2011), Choi H (2011), Choi H (2011), Choi H (2011), Choi H (2011), Choi H (2011)	6
EGLN3	0	DIAPH3	7	affinity chromatography technology	Rodriguez J (2016)	1
MAP3K1	4	MAPK8	3	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique	Xu S (1997), Xu S (1997), Xu S (1997), Xu S (1997), Ryoo K (2004), Tu Z (2003), Sun BK (2011), Gallagher ED (2002), Chen TC (2014)	9
FAS	2	MSN	0	biochemical	Gajate C (2005)	1
ITPR1	25	TRPC1	0	affinity chromatography technology	Yuan JP (2003)	1
NAXE	2	FADD	1	biochemical	Wan C (2015)	1
IRGC	1	RHOA	0	affinity chromatography technology	Huttlin EL (2017)	1
RTKN	0	AKAP13	11	pull down	Baisamy L (2009)	1
ARHGDIA	3	BID	1	biochemical	Gajate C (2005)	1
CUL3	17	RPN2	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	RHOA	0	affinity chromatography technology, affinity chromatography technology	Chen Y (2009), Dubiel D (2017)	2
RTKN	0	HDAC7	4	affinity chromatography technology	Boldt K (2016)	1
RHOA	0	TNFRSF10B	1	biochemical	Gajate C (2005)	1
RACK1	2	RHOA	0	two hybrid	Wang J (2011)	1
RHOC	0	GLB1	3	affinity chromatography technology	Huttlin EL (2017)	1
MSN	0	HSD17B10	1	biochemical	Wan C (2015)	1
RASSF1	3	RHOA	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Lee MG (2016), Lee MG (2016), Lee MG (2016), Lee MG (2016)	4
MAPK8	3	TNFRSF1A	3	biochemical	Gajate C (2005)	1
FADD	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Chaudhary PM (1997), Kim Y (2002), Guo F (2005), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017)	8
CTSA	2	GLB1	3	affinity chromatography technology	Boldt K (2016)	1
SMURF2	3	RHOA	0	pull down, enzymatic study, enzymatic study	Ogunjimi AA (2010), Lu K (2011), Wiesner S (2007)	3
RHOA	0	TNFRSF1A	3	biochemical	Gajate C (2005)	1
EZR	8	FASLG	0	biochemical, affinity chromatography technology	Gajate C (2005), Parlato S (2000)	2
SMURF1	4	ROCK1	6	affinity chromatography technology	Xie Y (2013)	1
RHOA	0	FASLG	0	biochemical	Gajate C (2005)	1
RHOA	0	CNKSR1	2	two hybrid, pull down, affinity chromatography technology	Jaffe AB (2004), Jaffe AB (2004), Jaffe AB (2004)	3
LRRK2	5	FADD	1	affinity chromatography technology	Ho CC (2009)	1
TRIP6	2	PAFAH1B2	2	biochemical	Kristensen AR (2012)	1
SHMT2	3	ARHGEF3	3	affinity chromatography technology	Castello A (2012)	1
EGLN3	0	BCR	3	affinity chromatography technology	Rodriguez J (2016)	1
PSMD10	1	ARHGDIA	3	affinity chromatography technology, affinity chromatography technology	Man JH (2010), Man JH (2010)	2
HDAC7	4	RAP1GDS1	0	affinity chromatography technology	Huttlin EL (2015)	1
RABL3	0	RAP1GDS1	0	affinity chromatography technology	Huttlin EL (2017)	1
RHOA	0	ARHGAP1	0	two hybrid, enzymatic study, pull down, pull down, pull down, affinity chromatography technology, two hybrid, pull down	Rual JF (2005), Zhang B (1998), Zhang B (1998), Li R (1997), Zhang B (1998), Zhou YT (2010), Jaffe AB (2004), Jaffe AB (2004)	8
S100A4	0	SMAD2	5	affinity chromatography technology	Matsuura I (2010)	1
RHOA	0	DIAPH1	4	pull down, two hybrid	Riento K (2003), Riento K (2003)	2
DCUN1D1	0	ARHGEF1	5	affinity chromatography technology	Bennett EJ (2010)	1
GORASP2	1	TSC22D4	1	two hybrid	Rual JF (2005)	1
SMURF1	4	CLNS1A	2	affinity chromatography technology	Xie Y (2013)	1
SHMT2	3	LIMA1	4	affinity chromatography technology	Castello A (2012)	1
TBXA2R	1	PKN1	4	two hybrid, pull down, affinity chromatography technology	Turner EC (2011), Turner EC (2011), Turner EC (2011)	3
DCUN1D1	0	CUL3	17	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Monda JK (2013), Wan C (2015), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Huttlin EL (2017)	19
HSD17B10	1	TRIP6	2	biochemical	Wan C (2015)	1
FAS	2	TNFRSF1A	3	biochemical	Gajate C (2005)	1
AKAP13	11	RHOA	0	affinity chromatography technology, affinity chromatography technology	Klussmann E (2001), Baisamy L (2009)	2
FAS	2	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Shu HB (1997), MacFarlane M (1997), Huttlin EL (2015), Jeong M (2017), Huttlin EL (2017), Kleber S (2008)	7
NUTF2	0	NAXE	2	biochemical	Wan C (2015)	1
PDHA1	7	FUBP3	0	affinity chromatography technology	Malty RH (2017)	1
DCUN1D1	0	TNFAIP1	4	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D1	0	UBC	7	affinity chromatography technology, pull down, affinity chromatography technology	Bennett EJ (2010), Huang G (2014), Huang G (2014)	3
RHOA	0	PKN3	4	affinity chromatography technology	Huttlin EL (2017)	1
FAS	2	BID	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
MDM2	2	SMURF1	4	pull down, affinity chromatography technology, affinity chromatography technology	Nie J (2010), Nie J (2010), Nie J (2010)	3
IKBKG	0	RHOA	0	pull down	Kim HJ (2014)	1
TRPC1	0	CAV1	0	affinity chromatography technology, affinity chromatography technology	Singh BB (2000), Sundivakkam PC (2009)	2
PLCG1	6	PKN2	6	pull down	Quilliam LA (1996)	1
IKZF3	1	HDAC7	4	affinity chromatography technology	Koipally J (2002)	1
SMAD2	5	DCUN1D1	0	two hybrid	Colland F (2004)	1
IRGC	1	RAP1GDS1	0	affinity chromatography technology	Huttlin EL (2017)	1
RASSF1	3	SMURF1	4	pull down, affinity chromatography technology, affinity chromatography technology	Lee MG (2016), Lee MG (2016), Lee MG (2016)	3
MCF2L	4	RHOA	0	x-ray crystallography	Snyder JT (2002)	1
RHOC	0	CAV1	0	pull down	Nethe M (2010)	1
DDX1	6	HSPA1A	0	biochemical	Havugimana PC (2012)	1
PPP1R12A	6	RHOA	0	biochemical	Havugimana PC (2012)	1
MSN	0	TNFRSF1A	3	biochemical	Gajate C (2005)	1
CAV1	0	BID	1	affinity chromatography technology, affinity chromatography technology	Zhang M (2011), Zhang M (2011)	2
IKBKG	0	FADD	1	affinity chromatography technology	Biton S (2011)	1
CUL3	17	HSPA1A	0	affinity chromatography technology	Bennett EJ (2010)	1
AGAP2	14	RHOA	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Luo R (2012), Luo R (2012), Luo R (2012), Luo R (2012)	4
RHOA	0	NVL	5	affinity chromatography technology	Hein MY (2015)	1
NOTCH1	25	CUL3	17	affinity chromatography technology, affinity chromatography technology	Ren K (2014), Ren K (2014)	2
MAP3K1	4	NFKBIA	0	enzymatic study	Tu Z (2003)	1
PLD1	5	RHOA	0	enzymatic study, pull down, affinity chromatography technology, pull down, unspecified method	Genth H (2003), Genth H (2003), Cai S (2001), Cai S (2001), Cai S (2001)	5
PTEN	24	CAV1	0	affinity chromatography technology	Caselli A (2002)	1
HSD17B10	1	RHOA	0	affinity chromatography technology	Malty RH (2017)	1
ATP6AP2	2	PON2	0	affinity chromatography technology	Hein MY (2015)	1
PKN3	4	ARHGAP26	3	two hybrid, affinity chromatography technology, pull down	Shibata H (2001), Shibata H (2001), Shibata H (2001)	3
MPV17	2	RHOA	0	biochemical	Havugimana PC (2012)	1
SMAD2	5	SOD1	0	pull down	Miyamoto-Sato E (2010)	1
ARHGDIG	1	RHOA	0	pull down, biochemical	Adra CN (1997), Wan C (2015)	2
U2AF2	7	RACK1	2	affinity chromatography technology	Whisenant TC (2015)	1
U2AF2	7	ARHGDIB	1	affinity chromatography technology	Whisenant TC (2015)	1
KRAS	1	ICMT	1	genetic interference	Wang T (2017)	1
CASP8	1	SERPINB5	0	two hybrid	Arroyo R (2015)	1
SHMT2	3	NUTF2	0	affinity chromatography technology	Castello A (2012)	1
CPT1A	1	RHOA	0	biochemical	Havugimana PC (2012)	1
FADD	1	FASLG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Gajate C (2005), Micheau O (2003), Legler DF (2003), Tao RH (2011), Chen TC (2014)	5
UBC	7	CPT1A	1	pull down	Zhang X (2017)	1
ANLN	2	RHOA	0	pull down, x-ray crystallography	Sun L (2015), Sun L (2015)	2
FASLG	0	TNFRSF10B	1	biochemical	Gajate C (2005)	1
U2AF2	7	SLC25A5	1	affinity chromatography technology	Whisenant TC (2015)	1
MSN	0	CASP10	1	biochemical	Gajate C (2005)	1
CASP10	1	TNFRSF1A	3	biochemical, affinity chromatography technology	Gajate C (2005), Vincenz C (1997)	2
ARHGEF11	8	PLXNB1	12	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, two hybrid	Perrot V (2002), Oinuma I (2003), Swiercz JM (2002), Swiercz JM (2002), Swiercz JM (2002), Hirotani M (2002), Hirotani M (2002), Hirotani M (2002)	8
BIRC2	1	RIPK4	0	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
SMAD2	5	SLC25A5	1	affinity chromatography technology	Brown KA (2008)	1
CUL3	17	ARHGEF12	2	two hybrid, affinity chromatography technology, pull down	Lin MY (2011), Lin MY (2011), Lin MY (2011)	3
RHOA	0	PAFAH1B2	2	biochemical	Wan C (2015)	1
HSD17B10	1	ARHGDIG	1	biochemical	Wan C (2015)	1
PKN2	6	RPE	3	biochemical	Wan C (2015)	1
RHOA	0	EZR	8	biochemical	Gajate C (2005)	1
FGB	2	RHOA	0	affinity chromatography technology	Huttlin EL (2017)	1
SMURF2	3	ARHGAP5	3	two hybrid, affinity chromatography technology	Colland F (2004), Huttlin EL (2017)	2
MAPK8	3	FADD	1	biochemical	Gajate C (2005)	1
RAP2C	0	RAP1GDS1	0	affinity chromatography technology	Huttlin EL (2017)	1
CRMP1	0	DPYSL2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Leung T (2002), Leung T (2002), Vinayagam A (2011), Corominas R (2014)	4
PDHA1	7	CPT1A	1	affinity chromatography technology	Malty RH (2017)	1
FGB	2	ARHGAP1	0	affinity chromatography technology	Huttlin EL (2017)	1
ARHGDIA	3	RHOC	0	affinity chromatography technology, biochemical	Ewing RM (2007), Wan C (2015)	2
RHOA	0	ARHGEF18	3	pull down	Blomquist A (2000)	1
ARHGDIA	3	TNFRSF1A	3	biochemical	Gajate C (2005)	1
CUL3	17	KCTD13	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Bennett EJ (2010), Chen Y (2009), Rolland T (2014), Ibeawuchi SR (2015), Huttlin EL (2017), Pinkas DM (2017)	6
EGLN3	0	OTUB1	0	affinity chromatography technology	Rodriguez J (2016)	1
RHOA	0	SYNPO2	1	affinity chromatography technology	Hein MY (2015)	1
ARHGEF3	3	RHOA	0	enzymatic study, pull down	Arthur WT (2002), Arthur WT (2002)	2
FGB	2	OTUB1	0	affinity chromatography technology	Huttlin EL (2017)	1
DDX1	6	RHOA	0	biochemical	Havugimana PC (2012)	1
ARHGEF1	5	RHOA	0	enzymatic study, affinity chromatography technology	Bourguignon LY (2003), Huttlin EL (2017)	2
PSMD10	1	RHOA	0	affinity chromatography technology	Man JH (2010)	1
MDM2	2	U2AF2	7	affinity chromatography technology	Jacob AG (2014)	1
PTEN	24	MPRIP	2	pull down	Verrastro I (2015)	1
SOD1	0	RHOA	0	affinity chromatography technology	Malty RH (2017)	1
BIRC2	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Hinz M (2010), Hinz M (2010), Shibata Y (2012), Goncharov T (2013), Fu J (2013)	6
RHOA	0	MSN	0	biochemical	Gajate C (2005)	1
MARK2	6	ARHGEF2	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Yoshimura Y (2011), Yamahashi Y (2011), Yoshimura Y (2011), Yoshimura Y (2011), Yoshimura Y (2011)	6
RHOA	0	RPE	3	biochemical	Wan C (2015)	1
RHOA	0	PLEKHG2	5	pull down	Himmel KL (2002)	1
CASP8	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), MacFarlane M (1997), Kim Y (2002), Kaunisto A (2009), Kaunisto A (2009), Guo F (2005), Gonzalvez F (2012), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017), Xu L (2017)	12
PLCG1	6	RHOA	0	affinity chromatography technology, pull down	Thodeti CK (2002), Thodeti CK (2002)	2
CUL3	17	PDHA1	7	affinity chromatography technology	Bennett EJ (2010)	1
RHOA	0	NET1	1	two hybrid	Alberts AS (1998)	1
FAS	2	TNFRSF10B	1	biochemical	Gajate C (2005)	1
DLST	3	RHOA	0	affinity chromatography technology	Malty RH (2017)	1
SOD1	0	SERPINB5	0	biochemical	Wan C (2015)	1
NOTCH1	25	ROCK1	6	affinity chromatography technology	Yatim A (2012)	1
SH3GLB2	1	RHOA	0	pull down, affinity chromatography technology	Liang ZD (2006), Liang ZD (2006)	2
SMAD2	5	U2AF2	7	affinity chromatography technology	Brown KA (2008)	1
PAFAH1B2	2	SHMT2	3	biochemical	Wan C (2015)	1
ANLN	2	TNFAIP1	4	affinity chromatography technology	Hein MY (2015)	1
RHOA	0	STK39	3	affinity chromatography technology	Hein MY (2015)	1
OTUB1	0	SLC25A5	1	affinity chromatography technology	Scholz CC (2016)	1
RHOC	0	DIAPH1	4	affinity chromatography technology	Huttlin EL (2017)	1
PRRC1	2	PAFAH1B2	2	biochemical	Wan C (2015)	1
BID	1	MAPK8	3	biochemical	Gajate C (2005)	1
FASLG	0	SRGAP1	3	unspecified method	Voss M (2009)	1
TNFAIP1	4	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Hu X (2012), Bennett EJ (2010), Chen Y (2009), Rolland T (2014), Huttlin EL (2017)	5
SERPINB5	0	RHOA	0	affinity chromatography technology	Huttlin EL (2015)	1
EZR	8	FADD	1	biochemical, affinity chromatography technology, imaging technique	Gajate C (2005), Young JA (2011), Chen TC (2014)	3
FADD	1	TNFRSF1A	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Hsu H (1996), Kumar A (2001), Zheng L (2006)	4
HSD17B10	1	OTUB1	0	affinity chromatography technology	Malty RH (2017)	1
DIAPH3	7	RHOA	0	pull down	Yasuda S (2004)	1
RHOA	0	ROCK2	2	affinity chromatography technology	Singh US (2001)	1
AGAP1	6	RHOA	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Luo R (2012), Luo R (2012), Luo R (2012), Luo R (2012)	4
MAPK8	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
CNKSR1	2	RASSF1	3	two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Rabizadeh S (2004), Rabizadeh S (2004), Rabizadeh S (2004), Rabizadeh S (2004)	4
RHOC	0	CIT	14	two hybrid	Madaule P (1995)	1
RTKN	0	LIMA1	4	affinity chromatography technology	Boldt K (2016)	1
RIPK4	0	IKBKG	0	affinity chromatography technology	Rodriguez J (2016)	1
RHOA	0	PRRC1	2	biochemical	Wan C (2015)	1
RHOC	0	ARHGAP1	0	two hybrid	Rual JF (2005)	1
RHOA	0	MPRIP	2	two hybrid, pull down	Gebbink MF (1997), Gebbink MF (1997)	2
MDM2	2	EZR	8	pull down	Miyamoto-Sato E (2010)	1
ARHGDIA	3	CASP10	1	biochemical	Gajate C (2005)	1
FAS	2	RHOA	0	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
SOD1	0	UBC	7	affinity chromatography technology	Urushitani M (2004)	1
OTUB1	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, unspecified method, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Wang T (2009), Bremm A (2010), Juang YC (2012), Ernst A (2013), Ernst A (2013), Nakasone MA (2013), Wiener R (2013), Edelmann MJ (2009), Bish RA (2007), Mevissen TE (2013), Juang YC (2012), Herhaus L (2013), Ernst A (2013), Herhaus L (2015), Herhaus L (2015), Herhaus L (2015), Wauer T (2015), Michel MA (2015), Kristariyanto YA (2015), Scholz CC (2016), Scholz CC (2016), Altun M (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	26
RIPK4	0	SLC25A5	1	affinity chromatography technology	Rodriguez J (2016)	1
ATP6AP2	2	GLB1	3	affinity chromatography technology	Hein MY (2015)	1
MSN	0	EZR	8	biochemical, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Gary R (1995), Gary R (1993), Gary R (1993), Hein MY (2015)	5
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
PON2	0	RHOA	0	biochemical	Havugimana PC (2012)	1
EGLN3	0	NFKBIA	0	affinity chromatography technology	Rodriguez J (2016)	1
CASP8	1	UBC	7	pull down	Bellail AC (2012)	1
EZR	8	SHMT2	3	biochemical	Wan C (2015)	1
TSC22D4	1	STK39	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RAP1GDS1	0	PAFAH1B2	2	biochemical	Kristensen AR (2012)	1
RHOA	0	DPYSL2	3	genetic interference	Leung T (2002)	1
COX15	3	SLC25A5	1	affinity chromatography technology	Malty RH (2017)	1
DGKQ	4	EZR	8	biochemical	Havugimana PC (2012)	1
ARHGEF11	8	RHOA	0	enzymatic study, pull down, two hybrid, affinity chromatography technology	Ruemenapp U (1999), Ruemenapp U (1999), Wang J (2011), Huttlin EL (2017)	4
RHOA	0	DAAM1	3	imaging technique, affinity chromatography technology	Chen TC (2014), Huttlin EL (2017)	2
UBC	7	PDHA1	7	affinity chromatography technology	Matsumoto M (2005)	1
NOTCH1	25	ARHGEF2	4	affinity chromatography technology	Yatim A (2012)	1
UBC	7	BCR	3	affinity chromatography technology, two hybrid	Chen R (2013), Chen R (2013)	2
MSN	0	TNFRSF10B	1	biochemical	Gajate C (2005)	1
TBXA2R	1	RHOA	0	affinity chromatography technology	Turner EC (2011)	1
BAIAP2	6	RHOA	0	affinity chromatography technology	Govind S (2001)	1
HSPA1A	0	RHOA	0	affinity chromatography technology	Liu TS (2003)	1
ARHGDIA	3	CDKN1B	1	two hybrid	Stelzl U (2005)	1
RHOA	0	DGKQ	4	affinity chromatography technology, pull down	Houssa B (1999), Houssa B (1999)	2
RHOA	0	TRIO	31	affinity chromatography technology, pull down, imaging technique, biochemical	Medley QG (2000), Medley QG (2000), Medley QG (2000), Wan C (2015)	4
SHMT2	3	TRIP6	2	affinity chromatography technology	Castello A (2012)	1
RHOC	0	RAP1GDS1	0	affinity chromatography technology	Huttlin EL (2017)	1
CDKN1B	1	MAPK8	3	pull down, affinity chromatography technology, affinity chromatography technology	Chang TS (2003), Chang TS (2003), Chang TS (2003)	3
DIRAS3	0	RAP1GDS1	0	affinity chromatography technology	Huttlin EL (2015)	1
RPL18	0	RPS27A	1	biochemical	Havugimana PC (2012)	1
MAP3K1	4	RHOA	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gallagher ED (2004), Gallagher ED (2004), Pearlman A (2010), Loke J (2014)	4
ARHGAP10	1	RHOA	0	enzymatic study	Shibata H (2001)	1
MSN	0	MAPK8	3	biochemical	Gajate C (2005)	1
KRAS	1	RHOA	0	two hybrid	Daakour S (2016)	1
ATP6AP2	2	PLD1	5	affinity chromatography technology	Hein MY (2015)	1
OTUB1	0	RHOA	0	enzymatic study	Edelmann MJ (2010)	1
ATP6AP2	2	RABL3	0	affinity chromatography technology	Hein MY (2015)	1
RHOA	0	IKZF3	1	two hybrid	Rolland T (2014)	1
SMURF1	4	MARK2	6	enzymatic study	Andrews PS (2010)	1
RHOA	0	ARHGEF12	2	pull down, affinity chromatography technology, affinity chromatography technology	Reuther GW (2001), Yang Y (2013), Huttlin EL (2017)	3
LRRK2	5	CASP8	1	affinity chromatography technology	Ho CC (2009)	1
EGLN3	0	ARHGAP32	11	affinity chromatography technology	Rodriguez J (2016)	1
KLHL20	2	CUL3	17	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Lee YR (2010), Bennett EJ (2010), Yuan WC (2014), Chen HY (2015), Chen HY (2015), Huttlin EL (2017)	6
NFKBIA	0	OTUB1	0	affinity chromatography technology	Huttlin EL (2015)	1
PTEN	24	RPS27A	1	pull down	Verrastro I (2015)	1
LDB3	2	HSPA1A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SHMT2	3	HDAC7	4	affinity chromatography technology	Castello A (2012)	1
ATP6AP2	2	GOSR1	1	affinity chromatography technology	Hein MY (2015)	1
FASLG	0	TNFRSF1A	3	biochemical, affinity chromatography technology	Gajate C (2005), Legler DF (2003)	2
U2AF2	7	EZR	8	affinity chromatography technology	Whisenant TC (2015)	1
FAS	2	FASLG	0	biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Gajate C (2005), Micheau O (2003), Starling GC (1997), Schneider P (1997), Legler DF (2003), Tao RH (2011), Chen TC (2014)	7
RPGR	0	RHOA	0	bioid	Gupta GD (2015)	1
MSN	0	PDHA1	7	biochemical	Kristensen AR (2012)	1
CUL3	17	RACK1	2	affinity chromatography technology	Bennett EJ (2010)	1
RASL10A	0	RHOA	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IKBKG	0	MPRIP	2	two hybrid	Wang J (2011)	1
IKBKG	0	EGLN3	0	affinity chromatography technology, affinity chromatography technology, pull down	Fu J (2013), Fu J (2013), Fu J (2013)	3
CTSA	2	NAXE	2	biochemical	Wan C (2015)	1
PLD1	5	PKN1	4	affinity chromatography technology, pull down	Oishi K (2001), Oishi K (2001)	2
CUL3	17	SLC25A5	1	affinity chromatography technology	Bennett EJ (2010)	1
OTUB1	0	SMAD2	5	affinity chromatography technology, affinity chromatography technology, pull down	Herhaus L (2013), Herhaus L (2013), Herhaus L (2013)	3
HSD17B10	1	PRDX6	0	affinity chromatography technology	Malty RH (2017)	1
COX15	3	RHOA	0	affinity chromatography technology	Malty RH (2017)	1
HDAC7	4	MARK2	6	affinity chromatography technology, enzymatic study	Dequiedt F (2006), Dequiedt F (2006)	2
RHOA	0	RHPN2	3	two hybrid	Riento K (2003)	1
PTEN	24	HSPA1A	0	affinity chromatography technology	Maddika S (2011)	1
RAP1GDS1	0	KRAS	1	two hybrid, affinity chromatography technology	Vikis HG (2002), Berg TJ (2010)	2
RHOA	0	TRIP6	2	two hybrid	Rolland T (2014)	1
MSN	0	RAP1GDS1	0	biochemical	Kristensen AR (2012)	1
HSD17B10	1	PDHA1	7	two hybrid	Narayan SB (2012)	1
MDM2	2	NOTCH1	25	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Lim SO (2011), Lim SO (2011), Pettersson S (2012), Pettersson S (2012), Pettersson S (2012)	5
RHOA	0	MDM2	2	affinity chromatography technology, affinity chromatography technology	Ma J (2012), Ma J (2012)	2
ANLN	2	PPP1R12A	6	affinity chromatography technology	Hein MY (2015)	1
AK9	6	RHOA	0	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	RABL3	0	affinity chromatography technology	Rodriguez J (2016)	1
BIRC2	1	OTUB1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Goncharov T (2013), Goncharov T (2013), Goncharov T (2013)	3
EZR	8	TNFRSF10B	1	biochemical	Gajate C (2005)	1
ARHGDIA	3	FASLG	0	biochemical	Gajate C (2005)	1
EZR	8	BID	1	biochemical	Gajate C (2005)	1
CAV1	0	FAS	2	affinity chromatography technology, affinity chromatography technology	Zhang M (2011), Zhang M (2011)	2
ARHGAP32	11	RHOA	0	enzymatic study, enzymatic study, enzymatic study	Nakazawa T (2003), Nakamura T (2002), Moon SY (2003)	3
TRIO	31	RPE	3	biochemical	Wan C (2015)	1
KRAS	1	SERPINB5	0	genetic interference, two hybrid	Luo J (2009), Arroyo R (2015)	2
RHOA	0	S100A4	0	affinity chromatography technology	Lee MG (2016)	1
PKN2	6	KTN1	1	affinity chromatography technology	Hein MY (2015)	1
MDM2	2	RASSF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Song MS (2008), Zhang H (2013), Zhang H (2013)	3
ARHGDIA	3	FADD	1	biochemical	Gajate C (2005)	1
CASP8	1	CDKN1B	1	genetic interference	Shen JP (2017)	1
LUM	0	RHOA	0	affinity chromatography technology	Huttlin EL (2017)	1
RTKN	0	RHOA	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Genth H (2003), Swiercz JM (2009), Edlund S (2004), Baisamy L (2009), Jaffe AB (2004), Lee MG (2016), Lee MG (2016), Du X (2012), Brozzi F (2009)	9
UBC	7	IKZF3	1	affinity chromatography technology	Gandhi AK (2014)	1