Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
SUMO4 rs237025 AA tacrolimus metabolism/PK yes DONOR genotype, significant at weeks 1-3 of treatment in study Cohort A (n=200; p=0.014, 0.03 and 0.006) and weeks 1-2 of treatment in study Cohort B (n=97; p=0.025, 0.049). 3 months of treatment were analyzed total. No significant associations were seen when considering recipient genotype. Genotype AA is associated with decreased dose-adjusted trough concentrations of tacrolimus in people with liver transplantation as compared to genotypes AG + GG. 28941036 1449165643