PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CUL7	4	PA2G4	1	affinity chromatography technology	Hanson D (2014)	1
IKBKG	0	KRT8	3	pull down, affinity chromatography technology, two hybrid	Fenner BJ (2010), Wang J (2011), Wang J (2011)	3
GRB2	2	AP2M1	5	affinity chromatography technology	Blagoev B (2003)	1
AP2M1	5	KRT17	0	affinity chromatography technology	Brehme M (2009)	1
UCHL1	1	COPS5	0	two hybrid, affinity chromatography technology	Caballero OL (2002), Caballero OL (2002)	2
KRT17	0	CCDC85B	0	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
GRB2	2	KRT17	0	affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Brehme M (2009)	2
TES	1	KRT17	0	affinity chromatography technology	Sala S (2017)	1
CUL7	4	CALR	1	affinity chromatography technology	Hanson D (2014)	1
SHC1	0	AP2M1	5	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
OBSL1	9	HNRNPA1	1	affinity chromatography technology	Hanson D (2014)	1
CYLD	2	KRT8	3	affinity chromatography technology	Elliott PR (2016)	1
OBSL1	9	YWHAQ	0	affinity chromatography technology	Hanson D (2014)	1
SHC1	0	KRT6A	1	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	GRB2	2	far western blotting, affinity chromatography technology, affinity chromatography technology, pull down	Schumacher C (1995), Parachoniak CA (2009), Parachoniak CA (2009), Parachoniak CA (2009)	4
INPPL1	6	KRT17	0	affinity chromatography technology	Brehme M (2009)	1
CBL	7	PIK3R2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Lin H (2001), Hartley D (1995), Feshchenko EA (2004), Alcazar I (2009), Brehme M (2009), Brehme M (2009), Grossmann A (2015)	7
ZNF598	6	KRT17	0	affinity chromatography technology	Garzia A (2017)	1
PA2G4	1	IKBKG	0	two hybrid	Ravasi T (2010)	1
PIK3R2	3	SHC1	0	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
COPS5	0	ILF3	5	affinity chromatography technology	Bennett EJ (2010)	1
TES	1	AP2M1	5	affinity chromatography technology	Sala S (2017)	1
HNRNPA1	1	KRT17	0	affinity chromatography technology	Roy R (2014)	1
EPS15	1	KRT17	0	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	KRT6A	1	affinity chromatography technology	Brehme M (2009)	1
UCHL1	1	KRT17	0	affinity chromatography technology	Sowa ME (2009)	1
KRT6A	1	CCDC85B	0	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
GRB2	2	KRT8	3	affinity chromatography technology, two hybrid	Blagoev B (2003), Bandyopadhyay S (2010)	2
KRT17	0	KRT8	3	two hybrid	Schnabel J (1998)	1
UBASH3B	4	KRT17	0	affinity chromatography technology	Brehme M (2009)	1
IKBKG	0	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Brummelkamp TR (2003), Trompouki E (2003), Chu L (2006), Shibata Y (2012), Wang J (2011), Zilberman-Rudenko J (2016), Zilberman-Rudenko J (2016)	11
CUL7	4	IGF2BP3	0	affinity chromatography technology	Hanson D (2014)	1
GRB2	2	KRT6A	1	affinity chromatography technology	Brehme M (2009)	1
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
COPS5	0	APC	5	affinity chromatography technology	Huang X (2009)	1
SHC1	0	KRT17	0	affinity chromatography technology	Brehme M (2009)	1
HNRNPA1	1	ILF3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Roy R (2014), Hein MY (2015)	3
IQCB1	3	UCHL1	1	affinity chromatography technology	Sang L (2011)	1
EPS15	1	AP2M1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	5
CUL7	4	KRT17	0	affinity chromatography technology	Hanson D (2014)	1
AP2M1	5	APC	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CYLD	2	KRT17	0	affinity chromatography technology	Elliott PR (2016)	1
IGF2BP3	0	CRYZ	1	biochemical	Kristensen AR (2012)	1
KRT17	0	KDM1A	2	two hybrid	Weimann M (2013)	1
UBASH3B	4	INPPL1	6	affinity chromatography technology	Brehme M (2009)	1
YWHAQ	0	CBL	7	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Pedraza-Alva G (2001), Liu YC (1996), Liu YC (1996), Melander F (2004), Subramanian RR (2001), Liu YC (1997), Liu YC (1997), Brehme M (2009)	8
CRK	0	INPPL1	6	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	CRK	0	far western blotting, pull down, affinity chromatography technology, affinity chromatography technology	Schumacher C (1995), Schumacher C (1995), Brehme M (2009), Brehme M (2009)	4
PIK3R2	3	KRT17	0	affinity chromatography technology	Brehme M (2009)	1
OBSL1	9	KDM1A	2	affinity chromatography technology	Hanson D (2014)	1
PTPRN2	8	KRT17	0	bioid	St-Denis N (2016)	1
CYLD	2	ILF3	5	affinity chromatography technology	Elliott PR (2016)	1
COPS5	0	KRT17	0	affinity chromatography technology	Bennett EJ (2010)	1
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
UBASH3B	4	CRK	0	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
CYLD	2	YWHAQ	0	affinity chromatography technology	Elliott PR (2016)	1
YWHAQ	0	PIK3R2	3	pull down, affinity chromatography technology, affinity chromatography technology	Bonnefoy-Berard N (1995), Bonnefoy-Berard N (1995), Bonnefoy-Berard N (1995)	3
COPS5	0	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
AP2M1	5	CRK	0	affinity chromatography technology	Brehme M (2009)	1
YWHAQ	0	KRT8	3	affinity chromatography technology	Pozuelo-Rubio M (2010)	1
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
IQCB1	3	KRT8	3	affinity chromatography technology	Sang L (2011)	1
AP2M1	5	KRT6A	1	affinity chromatography technology	Brehme M (2009)	1
YWHAQ	0	APC	5	pull down	Meek SE (2004)	1
CBL	7	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park RK (1999), Gesbert F (1998), Erdreich-Epstein A (1997), Wang Y (1999), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Brizzi MF (1996), Fukazawa T (1996)	9
OBSL1	9	ILF3	5	affinity chromatography technology	Hanson D (2014)	1
YWHAQ	0	HNRNPA1	1	pull down, affinity chromatography technology	Meek SE (2004), Roy R (2014)	2
UBASH3B	4	KRT6A	1	affinity chromatography technology	Brehme M (2009)	1
YWHAQ	0	KRT17	0	affinity chromatography technology	Pozuelo-Rubio M (2010)	1
ILF3	5	KRT17	0	biochemical	Havugimana PC (2012)	1
CRK	0	KRT8	3	affinity chromatography technology	Brehme M (2009)	1
IQCB1	3	KRT6A	1	affinity chromatography technology	Sang L (2011)	1
CYLD	2	KRT72	0	affinity chromatography technology	Elliott PR (2016)	1
KRT17	0	KRT72	0	two hybrid	Schnabel J (1998)	1
UBASH3B	4	CBL	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kowanetz K (2004), Kowanetz K (2004), Raguz J (2007), Hoeller D (2006), Peruzzi G (2007), Brehme M (2009)	6
CUL7	4	UCHL1	1	affinity chromatography technology	Hanson D (2014)	1
COPS5	0	KRT6A	1	affinity chromatography technology	Bennett EJ (2010)	1
NETO2	1	KRT17	0	affinity chromatography technology	Hein MY (2015)	1
KRT17	0	PA2G4	1	biochemical	Kristensen AR (2012)	1
CYLD	2	KRT6A	1	affinity chromatography technology	Elliott PR (2016)	1
CBL	7	INPPL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vandenbroere I (2003), Prasad NK (2005), De Schutter J (2009), De Schutter J (2009), Brehme M (2009)	5
TES	1	KRT8	3	affinity chromatography technology	Sala S (2017)	1
IQCB1	3	KRT17	0	affinity chromatography technology	Sang L (2011)	1
SHC1	0	INPPL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wisniewski D (1999), Wisniewski D (1999), Pesesse X (2001), Habib T (1998), Brehme M (2009), Brehme M (2009)	6
IKBKG	0	KRT17	0	biochemical	Kristensen AR (2012)	1
CUL7	4	HNRNPA1	1	affinity chromatography technology	Hanson D (2014)	1
CYLD	2	HNRNPA1	1	affinity chromatography technology	Elliott PR (2016)	1
SHC1	0	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Ota S (1998), Larsson H (1999)	4
KRT17	0	CRYZ	1	biochemical	Kristensen AR (2012)	1
CBL	7	KRT6A	1	affinity chromatography technology	Brehme M (2009)	1
KRT6A	1	KDM1A	2	two hybrid	Weimann M (2013)	1
CUL7	4	YWHAQ	0	affinity chromatography technology	Hanson D (2014)	1
OBSL1	9	IGF2BP3	0	affinity chromatography technology	Hanson D (2014)	1
HNRNPA1	1	IGF2BP3	0	affinity chromatography technology	Jeronimo C (2007)	1
KRT17	0	TRIM69	0	two hybrid	Rolland T (2014)	1
IGF2BP3	0	PA2G4	1	biochemical	Kristensen AR (2012)	1
GRB2	2	CYLD	2	affinity chromatography technology	Huttlin EL (2017)	1
CRK	0	KRT17	0	affinity chromatography technology	Brehme M (2009)	1
CRK	0	YWHAQ	0	affinity chromatography technology	Brehme M (2009)	1
KRT6A	1	KRT17	0	two hybrid	Rual JF (2005)	1
SHC1	0	UBASH3B	4	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
OBSL1	9	PA2G4	1	affinity chromatography technology	Hanson D (2014)	1
OBSL1	9	KRT17	0	affinity chromatography technology	Hanson D (2014)	1
GRB2	2	PIK3R2	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Brehme M (2009), Brehme M (2009), Bisson N (2011)	4
APC	5	KRT17	0	two hybrid	Bandyopadhyay S (2010)	1
UBASH3B	4	KRT8	3	affinity chromatography technology	Brehme M (2009)	1
USP1	4	KRT17	0	affinity chromatography technology	Sowa ME (2009)	1
GRB2	2	YWHAQ	0	affinity chromatography technology	Bisson N (2011)	1
IGF2BP3	0	KRT17	0	biochemical	Kristensen AR (2012)	1
CUL7	4	ILF3	5	affinity chromatography technology	Hanson D (2014)	1
CRK	0	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, two hybrid	Gesbert F (1998), Husson H (1997), Ingham RJ (1996), Ingham RJ (1996), Delehanty LL (2003), Garcia-Guzman M (2000), Garcia-Guzman M (2000), Barber DL (1997), Buday L (1996), Sawasdikosol S (1996), Sawasdikosol S (1996), Thien CB (1997), van Leeuwen JE (1999), Ribon V (1996), Lottin-Divoux S (2006), Reedquist KA (1996), Brehme M (2009), Brehme M (2009), Ota S (1998), Peterson ME (2008), Liu BA (2012), Fukazawa T (1996), Umehara H (2002), Grossmann A (2015)	24
CBL	7	KRT17	0	affinity chromatography technology	Brehme M (2009)	1
INPPL1	6	PIK3R2	3	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
COPS5	0	IGF2BP3	0	affinity chromatography technology	Bennett EJ (2010)	1
CRK	0	KRT6A	1	affinity chromatography technology	Brehme M (2009)	1
INPPL1	6	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Brehme M (2009), Bisson N (2011)	4
TES	1	IKBKG	0	affinity chromatography technology	Sala S (2017)	1
OBSL1	9	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litterman N (2011), Litterman N (2011), Hanson D (2011), Hanson D (2011), Nie J (2015)	5
ZNF598	6	KDM1A	2	affinity chromatography technology	Garzia A (2017)	1
UBASH3B	4	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), Li J (2013), Li J (2013)	3
HNRNPA1	1	KRT6A	1	affinity chromatography technology	Roy R (2014)	1
PIK3R2	3	CRK	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Brehme M (2009), Brehme M (2009), Grossmann A (2015)	3
CALR	1	KRT17	0	biochemical	Havugimana PC (2012)	1
ZDHHC17	1	KRT17	0	two hybrid	Butland SL (2014)	1