PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
HIST1H4A	0	CUL1	7	biochemical	Kristensen AR (2012)	1
ELAVL1	0	CSNK1A1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
KMT5A	2	EED	1	biochemical	Cao R (2002)	1
KMT5A	2	CSNK1D	3	affinity chromatography technology	Wang Z (2015)	1
CUL4A	2	EED	1	affinity chromatography technology	Higa LA (2006)	1
UBE2I	0	HIST1H4A	0	pull down, enzymatic study	Shiio Y (2003), Shiio Y (2003)	2
SUZ12	0	SKP1	0	affinity chromatography technology	Cao Q (2014)	1
CUL1	7	EZH2	4	affinity chromatography technology	Sahasrabuddhe AA (2014)	1
CUL4A	2	TP53	0	affinity chromatography technology	Banks D (2006)	1
CUL4A	2	BTRC	1	affinity chromatography technology	He YJ (2006)	1
KMT5A	2	TCF7L2	12	affinity chromatography technology, pull down, affinity chromatography technology	Li Z (2011), Li Z (2011), Li Z (2011)	3
CUL1	7	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Cenciarelli C (1999), Sowa ME (2009), Megumi Y (2005), Davis M (2002), Kawakami T (2001), Read MA (2000), Suzuki H (1999), Kumar KG (2007), Schweitzer K (2007), Chua YS (2011), Winston JT (1999), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Latres E (1999), Yoshida Y (2007), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), Chung FZ (2014), Chen ZW (2015), Kim TY (2014), Read MA (2000), Coyaud E (2015), Low TY (2014), Coyaud E (2015), He N (2005), Huttlin EL (2017), Kuang P (2016), Reitsma JM (2017), Reitsma JM (2017)	34
EED	1	CUL1	7	affinity chromatography technology	Cao Q (2014)	1
FZR1	1	DDB1	6	affinity chromatography technology, affinity chromatography technology	Lv XB (2010), Lv XB (2010)	2
CUL4A	2	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Bennett EJ (2010), Sertic S (2013), Rossi M (2013), Jin J (2006), Shibata E (2011), Higa LA (2006)	7
TWIST1	0	BTRC	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Guo W (2016), Guo W (2016), Guo W (2016), Zhong J (2013), Ruan D (2017)	5
TWIST1	0	CUL4A	2	imaging technique	Govindarajalu G (2018)	1
SUZ12	0	HIST4H4	1	affinity chromatography technology	Cao Q (2014)	1
KMT5A	2	PCNA	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Huen MS (2008), Huen MS (2008), Jorgensen S (2007), Oda H (2010), Oda H (2010), Takawa M (2012), Takawa M (2012), Takawa M (2012), Wang Z (2015)	9
BTRC	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Strack P (2000), Margottin F (1998), Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Watanabe N (2004), Wu G (2003), Kawakami T (2001), Hattori K (1999), Hattori K (1999), Hattori K (1999), Kitagawa M (1999), Hart M (1999), Su Y (2008), Banerjee S (2010), Winston JT (1999), Winston JT (1999), Estrabaud E (2007), Latres E (1999), Latres E (1999), Liu J (2004), Lievens S (2009), Yoshida Y (2007), Yoshida Y (2007), Busino L (2012), Li T (2005), da Silva Almeida AC (2013), Sahasrabuddhe AA (2014), Choi BH (2014), Chong RA (2014), Kim TY (2014), Coyaud E (2015), Deng W (2015), Coyaud E (2015), Liu YQ (2015), He N (2005), Kuchay S (2017), Hauri S (2016)	40
ELAVL1	0	KMT5A	2	affinity chromatography technology	Abdelmohsen K (2009)	1
KMT5A	2	CUL1	7	affinity chromatography technology	Wang Z (2015)	1
BTRC	1	EZH2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sahasrabuddhe AA (2014), Sahasrabuddhe AA (2014), Huttlin EL (2017)	3
SKP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Kumar R (2005), Wang W (2004), Ohta T (2001), Oshikawa K (2003), Liu J (2002), Li X (2003), Zhou W (2014), Zhou W (2014), Hao J (2015), Hauri S (2016)	11
TWIST1	0	HDAC6	0	imaging technique	Govindarajalu G (2018)	1
KMT5A	2	DTL	0	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Centore RC (2010), Centore RC (2010), Abbas T (2010), Oda H (2010)	4
HDAC6	0	PCNA	0	affinity chromatography technology	New M (2013)	1
ELAVL1	0	SUZ12	0	affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Cao Q (2014)	2
KMT5A	2	TP53BP1	3	imaging technique	Oda H (2010)	1
KMT5A	2	EZH2	4	biochemical	Cao R (2002)	1
TP53	0	CSNK1A1	1	affinity chromatography technology, affinity chromatography technology	Huart AS (2009), Wei X (2016)	2
L3MBTL1	1	TP53	0	pull down, x-ray crystallography, affinity chromatography technology	West LE (2010), West LE (2010), West LE (2010)	3
DDB1	6	PCNA	0	affinity chromatography technology	Angers S (2006)	1
TP53	0	DDB1	6	affinity chromatography technology	Fogeron ML (2013)	1
L3MBTL1	1	KMT5A	2	affinity chromatography technology	West LE (2010)	1
BTRC	1	AEBP2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loveless TB (2015), Loveless TB (2015), Huttlin EL (2017)	3
EED	1	AEBP2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao R (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
L3MBTL1	1	PCNA	0	affinity chromatography technology	Gurvich N (2010)	1
TP53BP1	3	UBE2I	0	imaging technique	Galanty Y (2009)	1
KMT5A	2	FZR1	1	affinity chromatography technology, affinity chromatography technology	Wu S (2010), Wu S (2010)	2
TCF7L2	12	LEF1	3	affinity chromatography technology	Jia Y (2014)	1
PCNA	0	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Jascur T (2011), Jascur T (2011), Dar A (2014), Terai K (2010), Higa LA (2006), Higa LA (2006)	6
EZH2	4	HIST4H4	1	affinity chromatography technology	Cao Q (2014)	1
DDB1	6	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down	Wang H (2006), Kapetanaki MG (2006), Hu J (2004), Ahn J (2010), Fischer ES (2011), Groisman R (2006)	6
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
HIST1H4A	0	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Saade E (2009), Verreault A (1996), Huttlin EL (2017), Millard CJ (2016), Kleiner RE (2018)	5
EED	1	RBBP4	3	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2004), Cao R (2004), Hein MY (2015), Hauri S (2016), Hauri S (2016)	5
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
KMT5A	2	DDB1	6	affinity chromatography technology	Abbas T (2010)	1
ELAVL1	0	SKP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
KMT5A	2	SUZ12	0	biochemical	Cao R (2002)	1
TP53	0	RBX1	2	affinity chromatography technology	Fogeron ML (2013)	1
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
DDB1	6	RBBP4	3	affinity chromatography technology, affinity chromatography technology	He YJ (2006), Mouysset J (2015)	2
ELAVL1	0	AEBP2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TP53	0	SKP1	0	affinity chromatography technology	Fogeron ML (2013)	1
KMT5A	2	RBX1	2	affinity chromatography technology	Wang Z (2015)	1
ELAVL1	0	BTRC	1	affinity chromatography technology, affinity chromatography technology	Chu PC (2012), Chu PC (2012)	2
DDB1	6	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2006), Jin J (2006), Jin J (2006), Higa LA (2006), Rossi M (2013), Shibata E (2011), Higa LA (2006), Higa LA (2006)	8
CUL1	7	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
UBE2I	0	DTL	0	affinity chromatography technology	Hein MY (2015)	1
KMT5A	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Wang Z (2015), Wang Z (2015), Wang Z (2015), Wang Z (2015), Wang Z (2015)	5
ELAVL1	0	HDAC6	0	affinity chromatography technology, affinity chromatography technology	Scott GK (2008), Scott GK (2008)	2
UBE2I	0	SUZ12	0	pull down, affinity chromatography technology	Riising EM (2008), Riising EM (2008)	2
CUL1	7	FZR1	1	affinity chromatography technology, affinity chromatography technology	Fukushima H (2013), Fukushima H (2013)	2
FAM9A	0	KMT5A	2	two hybrid	Weimann M (2013)	1
RBX1	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, bioid	Tan M (2010), Oshikawa K (2003), Coyaud E (2015)	3
KMT5A	2	SKP1	0	affinity chromatography technology	Wang Z (2015)	1
CUL1	7	DDB1	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Gastaldello S (2012)	2
EED	1	SUZ12	0	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2004), Cao R (2004), Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2008), Sarma K (2008), Pasini D (2010), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Hein MY (2015), Chan YS (2013), Huttlin EL (2017), Zhang H (2016), Zhang H (2016), Wang X (2017), Hauri S (2016), Hauri S (2016)	22
KMT5A	2	TP53	0	enzymatic study	Shi X (2007)	1
HIST1H4A	0	RBX1	2	biochemical	Kristensen AR (2012)	1
LEF1	3	KMT5A	2	affinity chromatography technology, pull down, affinity chromatography technology	Li Z (2011), Li Z (2011), Li Z (2011)	3
EZH2	4	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Su IH (2005), Aoto T (2008), Hansen KH (2008), Li G (2010), Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2008), Pasini D (2008), Sarma K (2008), Xu B (2011), Xu B (2011), Avdic V (2011), Kaneko S (2010), Kaneko S (2010), Yap DB (2011), Lee ST (2011), Havugimana PC (2012), Sahasrabuddhe AA (2014), Wang L (2013), Wu L (2013), Pasini D (2010), Pasini D (2010), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Wan C (2015), Hein MY (2015), Bhatnagar S (2014), Bhatnagar S (2014), Zhao R (2015), Wienken M (2016), Huttlin EL (2017), Zhang H (2016), Zhang H (2016), Mahara S (2016), Hauri S (2016), Hauri S (2016)	40
TP53	0	TP53BP1	3	x-ray crystallography, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, x-ray crystallography, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method	Derbyshire DJ (2002), Sengupta S (2004), Sengupta S (2004), Ekblad CM (2004), Lo KW (2005), Joo WS (2002), Derbyshire DJ (2002), Iwabuchi K (1994), Iwabuchi K (1994), Iwabuchi K (1994), Roy S (2010), Dai C (2011), Tembe V (2015), Cuella-Martin R (2016), Cuella-Martin R (2016), Tong Q (2015), Tong Q (2015)	17
EZH2	4	AEBP2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao Q (2014), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
KMT5A	2	HIST4H4	1	affinity chromatography technology, pull down	Yin Y (2008), Yin Y (2008)	2
ELAVL1	0	E2F2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
KMT5A	2	HIST1H4A	0	enzymatic study, enzymatic study, x-ray crystallography, x-ray crystallography, unspecified method, x-ray crystallography	Fang J (2002), Yin Y (2005), Couture JF (2005), Xiao B (2005), Xiao B (2005), Zhang X (2008)	6
BTRC	1	SUZ12	0	affinity chromatography technology, affinity chromatography technology	Sahasrabuddhe AA (2014), Huttlin EL (2017)	2
KMT5A	2	UBE2I	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Spektor TM (2011), Spektor TM (2011), Spektor TM (2011), Spektor TM (2011), Spektor TM (2011), Spektor TM (2011)	6
ELAVL1	0	RBBP4	3	affinity chromatography technology	Abdelmohsen K (2009)	1
CSNK1D	3	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique	Kulikov R (2006), Alsheich-Bartok O (2008), Alsheich-Bartok O (2008), Wolff S (2006), Chen TC (2014)	5
TWIST1	0	KMT5A	2	affinity chromatography technology, pull down, pull down	Yang F (2012), Yang F (2012), Yang F (2012)	3
TP53	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Banks D (2006), Banks D (2006), Hampp S (2016), Hampp S (2016)	4
EED	1	DDB1	6	affinity chromatography technology	Higa LA (2006)	1
E2F2	0	KMT5A	2	two hybrid	Schlisio S (2002)	1
EZH2	4	RBBP4	3	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li G (2010), Kaneko S (2010), Kaneko S (2010), Cao Q (2014), Hein MY (2015), Hauri S (2016), Hauri S (2016)	7
DTL	0	RBX1	2	affinity chromatography technology	Shibata E (2011)	1
BTRC	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Xia Y (2009), Verma S (2011)	2
KMT5A	2	CSNK1A1	1	affinity chromatography technology	Wang Z (2015)	1
EZH2	4	EED	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, pull down, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van Lohuizen M (1998), van Lohuizen M (1998), van Lohuizen M (1998), van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), Denisenko O (1998), Denisenko O (1998), Denisenko O (1998), Denisenko O (1998), Pasini D (2004), Cao R (2004), Su IH (2005), Hansen KH (2008), Margueron R (2008), Margueron R (2008), Shen X (2008), Shen X (2008), Hernandez-Munoz I (2005), Sarma K (2008), Sarma K (2008), Han Z (2007), Avdic V (2011), Kaneko S (2010), Kaneko S (2010), Yap DB (2011), Satijn DP (2001), Satijn DP (2001), Sewalt RG (1998), Sewalt RG (1998), Sewalt RG (1998), Sewalt RG (1998), Wang L (2013), Wu L (2013), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Wan C (2015), Hein MY (2015), Hein MY (2015), Chan YS (2013), Zhang H (2016), Zhang H (2016), Wang X (2017), Hauri S (2016), Hauri S (2016)	49
FZR1	1	TP53	0	enzymatic study	Gmachl M (2000)	1
CSNK1A1	1	CSNK1D	3	affinity chromatography technology	Varjosalo M (2013)	1
DTL	0	TP53	0	affinity chromatography technology, enzymatic study	Banks D (2006), Banks D (2006)	2
DDB1	6	BTRC	1	affinity chromatography technology	He YJ (2006)	1
TP53	0	TWIST1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Shiota M (2008), Shiota M (2008), Piccinin S (2012), Piccinin S (2012), Kotlyar M (2015)	5
KMT5A	2	RBBP4	3	biochemical	Cao R (2002)	1
EED	1	TP53BP1	3	affinity chromatography technology	Cao Q (2014)	1
CUL4A	2	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Lo YH (2012), Banks D (2006)	3
TP53	0	RBBP4	3	affinity chromatography technology	Fogeron ML (2013)	1
SUZ12	0	RBBP4	3	pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao R (2004), Cao R (2004), Havugimana PC (2012), Pasini D (2010), Cao Q (2014), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	8
KMT5A	2	CUL4A	2	affinity chromatography technology	Wang Z (2015)	1
CUL4A	2	CUL1	7	biochemical	He YJ (2006)	1
SUZ12	0	AEBP2	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao R (2004), Cao R (2004), Pasini D (2010), Cao Q (2014), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	8
ELAVL1	0	TCF7L2	12	affinity chromatography technology	Abdelmohsen K (2009)	1
EED	1	SKP1	0	affinity chromatography technology	Cao Q (2014)	1
KMT5A	2	AEBP2	1	biochemical	Cao R (2002)	1
BTRC	1	FZR1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Fukushima H (2013), Fukushima H (2013), Fukushima H (2013)	3
RBBP4	3	AEBP2	1	pull down, affinity chromatography technology, affinity chromatography technology	Cao R (2004), Hauri S (2016), Hauri S (2016)	3
BTRC	1	EED	1	affinity chromatography technology	Huttlin EL (2017)	1
EZH2	4	RBX1	2	affinity chromatography technology	Hein MY (2015)	1
CUL4A	2	RBBP4	3	affinity chromatography technology	He YJ (2006)	1
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
CUL1	7	PCNA	0	affinity chromatography technology	Bennett EJ (2010)	1
BTRC	1	CSNK1A1	1	affinity chromatography technology, bioid	Coyaud E (2015), Coyaud E (2015)	2
HDAC6	0	HIST4H4	1	unspecified method	Hard RL (2010)	1
TCF7L2	12	UBE2I	0	two hybrid, affinity chromatography technology	Wang J (2011), Hsieh YL (2013)	2
HDAC6	0	KMT5A	2	affinity chromatography technology	New M (2013)	1
RBX1	2	CUL4A	2	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, biochemical, enzymatic study, pull down, biochemical	Dias DC (2002), Ohta T (1999), Guerrero-Santoro J (2008), Hu J (2004), Furukawa M (2002), Maddika S (2009), Tron AE (2012), Tron AE (2012), He YJ (2006), Gastaldello S (2012), Olma MH (2009), Kristensen AR (2012), Huang DT (2009), Pick E (2007), Yang Y (2016), Scherer PC (2016), Nguyen TV (2016)	17
ELAVL1	0	RBX1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CUL4A	2	SKP1	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Gastaldello S (2012)	2
EED	1	HIST4H4	1	affinity chromatography technology	Cao Q (2014)	1
HIST4H4	1	RBBP4	3	pull down	Alqarni SS (2014)	1
EZH2	4	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1
TP53BP1	3	HIST1H4A	0	unspecified method, x-ray crystallography, pull down	Botuyan MV (2006), Botuyan MV (2006), Jacquet K (2016)	3
EED	1	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1