PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RHOA	0	CAV1	0	pull down	Nethe M (2010)	1
ARHGAP1	0	RAC1	7	pull down, two hybrid, pull down	Zhang B (1998), Jaffe AB (2004), Jaffe AB (2004)	3
RAP1GDS1	0	RHOA	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Vikis HG (2002), Vikis HG (2002), Berg TJ (2010), Huttlin EL (2017)	4
ATF2	1	GNB2	3	affinity chromatography technology	Lau E (2012)	1
VHL	0	RHOC	0	affinity chromatography technology	Ewing RM (2007)	1
RHOA	0	CTSA	2	affinity chromatography technology	Huttlin EL (2017)	1
RHOC	0	ARHGEF12	2	affinity chromatography technology	Huttlin EL (2017)	1
RHOC	0	RIPOR2	1	two hybrid	Rolland T (2014)	1
RHOA	0	GLB1	3	affinity chromatography technology	Huttlin EL (2017)	1
RHOA	0	CIT	14	pull down, two hybrid, two hybrid, far western blotting	Riento K (2003), Riento K (2003), Madaule P (1995), Madaule P (1995)	4
RAC1	7	RAP1GDS1	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Vikis HG (2002), Bandyopadhyay S (2010), Berg TJ (2010), Huttlin EL (2017)	4
RHOC	0	ARHGEF11	8	affinity chromatography technology	Huttlin EL (2017)	1
RHOC	0	CTSA	2	affinity chromatography technology	Huttlin EL (2017)	1
RHOA	0	ARHGDIB	1	biochemical	Wan C (2015)	1
RHOC	0	RTKN	0	affinity chromatography technology	Huttlin EL (2017)	1
ARHGDIA	3	RHOA	0	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, biochemical, pull down, x-ray crystallography	Ewing RM (2007), Gajate C (2005), Michaelson D (2001), Gorvel JP (1998), Faure J (2001), Man JH (2010), Rolland T (2014), Wan C (2015), Jaffe AB (2004), Kuhlmann N (2016), Kuhlmann N (2016), Kuhlmann N (2016)	12
CDK2	0	RAP1GDS1	0	affinity chromatography technology	Hein MY (2015)	1
ARHGDIB	1	RHOC	0	biochemical	Wan C (2015)	1
RHOC	0	ARHGEF1	5	affinity chromatography technology	Huttlin EL (2017)	1
CDK2	0	ARHGDIA	3	affinity chromatography technology	Neganova I (2011)	1
RAC3	4	ARHGDIA	3	two hybrid	Vinayagam A (2011)	1
RHOC	0	RAC3	4	biochemical	Wan C (2015)	1
RHOC	0	GNB2	3	biochemical	Wan C (2015)	1
PPP3CA	3	RHOC	0	biochemical	Havugimana PC (2012)	1
CIT	14	RAC1	7	far western blotting	Madaule P (1995)	1
RHOC	0	DAAM1	3	affinity chromatography technology	Huttlin EL (2017)	1
RIPOR2	1	RHOA	0	two hybrid, two hybrid, two hybrid	Wang J (2011), Rolland T (2014), Yu H (2011)	3
ATF2	1	RHOC	0	affinity chromatography technology	Lau E (2012)	1
ARHGDIA	3	RAC1	7	affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, biochemical, two hybrid, biochemical, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Grizot S (2001), Grizot S (2001), Lian LY (2000), Gorvel JP (1998), Di-Poi N (2001), Di-Poi N (2001), Faure J (2001), Vinayagam A (2011), Yu J (2012), Sandrock K (2010), Boldt K (2016)	12
CDK2	0	RHOC	0	affinity chromatography technology	Neganova I (2011)	1
RHOC	0	RHOA	0	affinity chromatography technology	Huttlin EL (2017)	1
RHOC	0	GLB1	3	affinity chromatography technology	Huttlin EL (2017)	1
CTSA	2	GLB1	3	affinity chromatography technology	Boldt K (2016)	1
RHOA	0	ARHGAP1	0	two hybrid, enzymatic study, pull down, pull down, pull down, affinity chromatography technology, two hybrid, pull down	Rual JF (2005), Zhang B (1998), Zhang B (1998), Li R (1997), Zhang B (1998), Zhou YT (2010), Jaffe AB (2004), Jaffe AB (2004)	8
RHOA	0	DIAPH1	4	pull down, two hybrid	Riento K (2003), Riento K (2003)	2
RHOC	0	ZMYM4	4	affinity chromatography technology	Huttlin EL (2017)	1
LNX1	7	CIT	14	affinity chromatography technology	Lenihan JA (2017)	1
RHOC	0	DAAM2	2	affinity chromatography technology	Huttlin EL (2017)	1
RHOC	0	CAV1	0	pull down	Nethe M (2010)	1
RHOC	0	C1orf198	2	affinity chromatography technology	Huttlin EL (2017)	1
VHL	0	CDK2	0	affinity chromatography technology	Ewing RM (2007)	1
CDK2	0	CTSA	2	affinity chromatography technology	Huttlin EL (2015)	1
ARHGDIA	3	RHOC	0	affinity chromatography technology, biochemical	Ewing RM (2007), Wan C (2015)	2
ARHGEF1	5	RHOA	0	enzymatic study, affinity chromatography technology	Bourguignon LY (2003), Huttlin EL (2017)	2
RAC1	7	RAC3	4	affinity chromatography technology	Huttlin EL (2017)	1
RAC1	7	ARHGDIB	1	two hybrid	Vinayagam A (2011)	1
CDK2	0	RAC1	7	affinity chromatography technology	Neganova I (2011)	1
RHOC	0	DIAPH1	4	affinity chromatography technology	Huttlin EL (2017)	1
RHOC	0	CIT	14	two hybrid	Madaule P (1995)	1
RHOC	0	ARHGAP1	0	two hybrid	Rual JF (2005)	1
RAC3	4	ARHGDIB	1	two hybrid	Vinayagam A (2011)	1
ARHGEF11	8	RHOA	0	enzymatic study, pull down, two hybrid, affinity chromatography technology	Ruemenapp U (1999), Ruemenapp U (1999), Wang J (2011), Huttlin EL (2017)	4
RHOA	0	DAAM1	3	imaging technique, affinity chromatography technology	Chen TC (2014), Huttlin EL (2017)	2
RHOC	0	RAP1GDS1	0	affinity chromatography technology	Huttlin EL (2017)	1
LNX1	7	RHOC	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Zheng D (2010), Zheng D (2010), Zheng D (2010)	3
CDK2	0	GLB1	3	affinity chromatography technology	Huttlin EL (2017)	1
RHOA	0	ARHGEF12	2	pull down, affinity chromatography technology, affinity chromatography technology	Reuther GW (2001), Yang Y (2013), Huttlin EL (2017)	3
RAP1GDS1	0	RAC3	4	affinity chromatography technology	Huttlin EL (2017)	1
RHOC	0	ACTR10	0	affinity chromatography technology	Huttlin EL (2017)	1
RAC1	7	CAV1	0	pull down, pull down	Nethe M (2010), Nethe M (2010)	2
RHOC	0	RTKN2	2	affinity chromatography technology	Huttlin EL (2017)	1
RAC1	7	RHOC	0	biochemical	Wan C (2015)	1
RTKN	0	RHOA	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Genth H (2003), Swiercz JM (2009), Edlund S (2004), Baisamy L (2009), Jaffe AB (2004), Lee MG (2016), Lee MG (2016), Du X (2012), Brozzi F (2009)	9
CDK2	0	GNB2	3	affinity chromatography technology	Neganova I (2011)	1