PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NTRK1	1	EZR	8	affinity chromatography technology	Emdal KB (2015)	1
EGFR	5	CNTN2	4	protein complementation assay	Deribe YL (2009)	1
L1CAM	3	NUMB	1	affinity chromatography technology, affinity chromatography technology	Nishimura T (2003), Nishimura T (2003)	2
TRIM25	5	RABGEF1	1	affinity chromatography technology	Choudhury NR (2017)	1
NTRK1	1	CANX	4	affinity chromatography technology	Emdal KB (2015)	1
TRIM25	5	CANX	4	affinity chromatography technology	Choudhury NR (2017)	1
ERBB2	6	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Scaltriti M (2009), Graus-Porta D (1997), Le XF (2005), Chen TC (2014), Ritch PS (2005)	5
CNTN2	4	L1CAM	3	pull down	Pavlou O (2002)	1
RABGEF1	1	L1CAM	3	affinity chromatography technology, affinity chromatography technology	Aikawa Y (2012), Aikawa Y (2012)	2
FBXO6	0	ITGA5	7	affinity chromatography technology	Liu B (2012)	1
L1CAM	3	ITGAV	7	pull down	Silletti S (2000)	1
EGFR	5	EZR	8	protein complementation assay	Petschnigg J (2014)	1
TRIM25	5	AP2A1	1	affinity chromatography technology	Choudhury NR (2017)	1
EGFR	5	AP2A1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Foerster S (2013), Tong J (2014), Li J (2013)	4
L1CAM	3	RANBP9	5	two hybrid	Cheng L (2005)	1
EGFR	5	FBXO6	0	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Liu B (2012)	2
NTRK1	1	RANBP9	5	affinity chromatography technology	Emdal KB (2015)	1
HAX1	1	L1CAM	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
L1CAM	3	ERBB3	3	affinity chromatography technology, imaging technique	Donier E (2012), Donier E (2012)	2
FGFR1	2	ERBB3	3	unspecified method	Jones RB (2006)	1
ERBB2	6	ITGAV	7	affinity chromatography technology, affinity chromatography technology	Lal S (2015), Lal S (2015)	2
ERBB3	3	CANX	4	affinity chromatography technology	Li J (2013)	1
FGFR1	2	CANX	4	affinity chromatography technology	Vecchione A (2007)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
NTRK1	1	AP2A1	1	affinity chromatography technology	Emdal KB (2015)	1
L1CAM	3	AP2A1	1	affinity chromatography technology	Nishimura T (2003)	1
L1CAM	3	NRP1	2	pull down	Stoeck A (2006)	1
DGUOK	1	L1CAM	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NTRK1	1	RABGEF1	1	affinity chromatography technology	Emdal KB (2015)	1
TRIM25	5	ITGAV	7	affinity chromatography technology	Choudhury NR (2017)	1
FBXO6	0	EZR	8	affinity chromatography technology	Liu B (2012)	1
L1CAM	3	NCAN	4	pull down	Friedlander DR (1994)	1
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
L1CAM	3	FGFR1	2	imaging technique, pull down	Mohanan V (2013), Kulahin N (2008)	2
FBXO6	0	ITGAV	7	affinity chromatography technology	Liu B (2012)	1
TRIM25	5	EZR	8	affinity chromatography technology	Choudhury NR (2017)	1
L1CAM	3	CANX	4	affinity chromatography technology	Marx M (2012)	1
L1CAM	3	EGFR	5	affinity chromatography technology	Donier E (2012)	1
L1CAM	3	ITGA5	7	pull down	Silletti S (2000)	1
EGFR	5	CANX	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tong J (2014), Li J (2013), Yao Z (2017)	3
L1CAM	3	ERBB2	6	affinity chromatography technology	Donier E (2012)	1
FBXO6	0	CANX	4	affinity chromatography technology	Liu B (2012)	1
L1CAM	3	EZR	8	pull down, affinity chromatography technology	Dickson TC (2002), Aikawa Y (2012)	2
CNTN2	4	NCAN	4	pull down	Milev P (1996)	1
DNAAF2	2	L1CAM	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EZR	8	ERBB2	6	fluorescent resonance energy transfe, imaging technique	Asp N (2016), Asp N (2016)	2
L1CAM	3	PEA15	0	two hybrid	Stelzl U (2005)	1
FBXO6	0	L1CAM	3	affinity chromatography technology	Liu B (2012)	1
TRIM25	5	L1CAM	3	affinity chromatography technology	Choudhury NR (2017)	1
NUFIP1	0	L1CAM	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RABGEF1	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Penengo L (2006), Yao Z (2017)	2
NTRK1	1	HAX1	1	affinity chromatography technology	Emdal KB (2015)	1
NUMB	1	AP2A1	1	affinity chromatography technology, pull down	Nishimura T (2003), Nishimura T (2003)	2
EGFR	5	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marques MM (1999), Li J (2013), Li J (2013), Sharif A (2009)	4
EGFR	5	NUMB	1	unspecified method	Jones RB (2006)	1
NTRK1	1	L1CAM	3	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	ITGAV	7	affinity chromatography technology	Emdal KB (2015)	1