PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	TUBB2A	2	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
LAMA4	8	TP53	0	two hybrid, imaging technique	Stelzl U (2005), Chen TC (2014)	2
LAMA4	8	BRD7	2	two hybrid	Stelzl U (2005)	1
BRD7	2	LRIF1	3	two hybrid	Goehler H (2004)	1
CLEC14A	1	LAMA4	8	affinity chromatography technology	Zanivan S (2013)	1
LAMA4	8	UNC119	4	two hybrid	Stelzl U (2005)	1
EEF1A1	0	GAPDH	0	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
LGALS3	0	LAMA4	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LGALS8	4	LAMA4	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LAMA4	8	ZHX1	1	two hybrid	Stelzl U (2005)	1
LAMA4	8	LRIF1	3	two hybrid	Stelzl U (2005)	1
MCAM	5	LAMA4	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRD7	2	TP53	0	affinity chromatography technology, pull down, imaging technique	Drost J (2010), Drost J (2010), Drost J (2010)	3
TP53	0	EEF1A1	0	affinity chromatography technology	Fogeron ML (2013)	1
LAMA4	8	RTN4	4	two hybrid	Wang J (2011)	1
LAMA4	8	EEF1A1	0	two hybrid	Stelzl U (2005)	1
LAMA4	8	COPS6	0	two hybrid	Stelzl U (2005)	1
LAMA4	8	PTN	0	two hybrid	Stelzl U (2005)	1
LGALS9	0	LAMA4	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP53	0	GAPDH	0	affinity chromatography technology	Sen N (2008)	1
LAMA4	8	MED31	0	two hybrid	Stelzl U (2005)	1
LAMA4	8	UBR1	3	two hybrid	Stelzl U (2005)	1
LGALS9	0	LGALS3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LGALS8	4	MCAM	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP53	0	ZHX1	1	two hybrid	Goehler H (2004)	1
APC	5	LAMA4	8	two hybrid	Bandyopadhyay S (2010)	1
COPS6	0	GAPDH	0	affinity chromatography technology	Bennett EJ (2010)	1
PILRA	0	LAMA4	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BCAM	4	LAMA4	8	affinity chromatography technology	Huttlin EL (2017)	1
LAMA4	8	GAPDH	0	two hybrid	Stelzl U (2005)	1
LAMA4	8	TUBB2A	2	two hybrid	Stelzl U (2005)	1