PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EXOSC10	1	LCAT	2	two hybrid	Lehner B (2004)	1
APOA1	0	APOA2	1	pull down, pull down, biochemical	Clay MA (2000), Clay MA (2000), Cheung MC (1986)	3
APOA2	1	LCAT	2	biochemical	Cheung MC (1986)	1
LCAT	2	APOE	1	enzymatic study	Zhao Y (2005)	1
A2M	8	APOE	1	affinity chromatography technology, pull down, two hybrid	Krimbou L (1998), Krimbou L (1998), Soler-Lopez M (2011)	3
A2M	8	LCAT	2	affinity chromatography technology, pull down	Krimbou L (2001), Krimbou L (2001)	2
LCAT	2	PIKFYVE	13	x-ray crystallography	Piper DE (2015)	1
APOA1	0	LCAT	2	pull down, pull down, biochemical, enzymatic study, pull down, enzymatic study, pull down	Minnich A (1992), Furukawa Y (1992), Cheung MC (1986), Fielding CJ (1972), Collet X (1999), Zhao Y (2005), Sparks DL (1999)	7