Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
LEPR 3953 METRELEPTIN CHEMBL2107857 agonist ChemblInteractions, DrugBank 25249580

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
LEPR rs1137101 GG simvastatin efficacy yes Subjects with the GG genotype (Arg/Arg) had smaller reductions in serum total cholesterol levels when treated with simvastatin as compared to subjects with genotype AA+AG (Arg/Gln+Gln/Gln). Genotype GG is associated with decreased response to simvastatin in men with Hyperlipidemias as compared to genotypes AA + AG. 14625131 982037581