PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MOV10	6	EHMT2	4	affinity chromatography technology	Castello A (2012)	1
PCNA	0	UHRF1	3	affinity chromatography technology	Hein MY (2015)	1
LIG1	4	CHTF18	3	biochemical	Wan C (2015)	1
NTRK1	1	HSPB1	2	affinity chromatography technology	Emdal KB (2015)	1
LIG1	4	DDB1	6	affinity chromatography technology, affinity chromatography technology	Peng Z (2016), Peng Z (2016)	2
PCNA	0	LIG1	4	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Ohta S (2002), Montecucco A (1998), Han J (2014), Ferry L (2017)	4
PRMT3	1	LIG1	4	biochemical	Kristensen AR (2012)	1
EHMT2	4	EHMT1	18	affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Hauri S (2016)	2
RNF166	0	LIG1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LIG1	4	STKLD1	3	biochemical	Wan C (2015)	1
NTRK1	1	SKIV2L2	0	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	PRMT3	1	affinity chromatography technology	Emdal KB (2015)	1
POLA1	0	PCNA	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
EHMT2	4	LIG1	4	enzymatic study	Ferry L (2017)	1
AURKA	1	LIG1	4	affinity chromatography technology	Hein MY (2015)	1
AURKA	1	DDB1	6	affinity chromatography technology	Fogeron ML (2013)	1
RGS2	2	LIG1	4	two hybrid	Vinayagam A (2011)	1
DDB1	6	PCNA	0	affinity chromatography technology	Angers S (2006)	1
MOV10	6	POLA1	0	affinity chromatography technology	Castello A (2012)	1
MOV10	6	FEN1	1	affinity chromatography technology	Castello A (2012)	1
HSPB1	2	LIG1	4	two hybrid	Katsogiannou M (2014)	1
NTRK1	1	UHRF1	3	affinity chromatography technology	Emdal KB (2015)	1
LIG1	4	CUL4A	2	affinity chromatography technology, affinity chromatography technology	Peng Z (2016), Peng Z (2016)	2
LIG1	4	DCAF7	4	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Peng Z (2016), Peng Z (2016), Peng Z (2016), Peng Z (2016)	4
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
PCNA	0	FEN1	1	pull down, pull down, pull down, pull down, two hybrid, pull down, pull down, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, x-ray crystallography, unspecified method, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, x-ray crystallography, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Hasan S (2001), Jonsson ZO (1998), Gary R (1997), Chen U (1996), Chen U (1996), Chen U (1996), Chen U (1996), Chen U (1996), Dianova II (2001), Dianova II (2001), Yu P (2001), Friedrich-Heineken E (2005), Wang SC (2006), Warbrick E (1997), Warbrick E (1997), Bruning JB (2004), Bruning JB (2004), Zhang Z (2012), Pichler G (2012), Takawa M (2012), Wu X (1996), Wu X (1996), Sakurai S (2005), Sharma S (2004), Han J (2014), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	30
NTRK1	1	POLA1	0	affinity chromatography technology	Emdal KB (2015)	1
RGS2	2	DDB1	6	affinity chromatography technology	Sjoegren B (2015)	1
NTRK1	1	FEN1	1	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	LIG1	4	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	CHTF18	3	affinity chromatography technology	Emdal KB (2015)	1
PCNA	0	CHTF18	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Ohta S (2002), Ohta S (2002), Han J (2014), Wan C (2015), Merkle CJ (2003)	5
LIG1	4	MRE11	3	two hybrid	Petrini JH (1995)	1
CUL4A	2	DCAF7	4	affinity chromatography technology	Bennett EJ (2010)	1
MOV10	6	LIG1	4	affinity chromatography technology	Castello A (2012)	1
CUL4A	2	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Lo YH (2012), Banks D (2006)	3
MRE11	3	POLA1	0	genetic interference	van Pel DM (2013)	1
EHMT1	18	LIG1	4	enzymatic study	Ferry L (2017)	1
DDB1	6	DCAF7	4	affinity chromatography technology	Jin J (2006)	1
SKIV2L2	0	LIG1	4	biochemical	Wan C (2015)	1
MRE11	3	FEN1	1	biochemical, genetic interference	Wan C (2015), Ward TA (2017)	2
UHRF1	3	LIG1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, imaging technique	Ferry L (2017), Ferry L (2017), Ferry L (2017), Ferry L (2017), Ferry L (2017), Ferry L (2017)	6
NTRK1	1	MRE11	3	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	DDB1	6	affinity chromatography technology	Emdal KB (2015)	1
POLA1	0	LIG1	4	biochemical	Wan C (2015)	1
EHMT2	4	UHRF1	3	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin W (2010), Kim JK (2009), Kim JK (2009), Zhang J (2011)	4
LIG1	4	FEN1	1	biochemical	Wan C (2015)	1
NTRK1	1	PCNA	0	affinity chromatography technology	Emdal KB (2015)	1
AURKA	1	DCAF7	4	affinity chromatography technology	Fogeron ML (2013)	1
NTRK1	1	MOV10	6	affinity chromatography technology	Emdal KB (2015)	1