PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LIPE	6	PLIN2	0	fluorescent resonance energy transfe, affinity chromatography technology	Wang H (2009), Wang H (2009)	2
NSFL1C	1	LIPE	6	two hybrid	Stelzl U (2005)	1
LIPE	6	PLIN1	4	fluorescent resonance energy transfe, protein complementation assay, fluorescent resonance energy transfe, affinity chromatography technology	Granneman JG (2007), Granneman JG (2007), Wang H (2009), Wang H (2009)	4
FABP4	3	LIPE	6	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Smith AJ (2004), Smith AJ (2007)	2
LIPE	6	PLIN5	0	fluorescent resonance energy transfe, affinity chromatography technology	Wang H (2009), Wang H (2009)	2
LIPE	6	PLIN3	3	affinity chromatography technology	Wang H (2009)	1
CAVIN1	0	LIPE	6	biochemical, affinity chromatography technology, affinity chromatography technology	Aboulaich N (2006), Aboulaich N (2006), Aboulaich N (2006)	3
MTNR1A	1	LIPE	6	two hybrid	Benleulmi-Chaachoua A (2016)	1