PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TMEM17	0	PARD3	5	bioid	Gupta GD (2015)	1
PRKCZ	5	NPM1	0	affinity chromatography technology, affinity chromatography technology	Chen R (2013), Chen R (2013)	2
CDH1	4	LLGL1	9	bioid	Guo Z (2014)	1
CHEK2	2	CHEK1	2	genetic interference	Srivas R (2016)	1
NPM1	0	SQSTM1	0	affinity chromatography technology	Chen R (2013)	1
LLGL1	9	STX3	3	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	PRKCI	1	affinity chromatography technology	Abdelmohsen K (2009)	1
PARD3	5	PRKCI	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kohjima M (2002), Kohjima M (2002), Brajenovic M (2004), Brajenovic M (2004), Yang Z (2012)	5
PRKCI	1	SQSTM1	0	two hybrid, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, fluorescent resonance energy transfe	Sanchez P (1998), Sanchez P (1998), Sanchez P (1998), Sanchez P (1998), Behrends C (2010), Brajenovic M (2004), Lamark T (2003), Lamark T (2003), Lamark T (2003), Yang JQ (2010), Yang JQ (2010), Erdogan E (2006), Milan E (2015), Tsai LC (2015), Tsai LC (2015), Tsai LC (2015)	16
NTRK1	1	NPM1	0	affinity chromatography technology	Emdal KB (2015)	1
TUBA1A	13	CHEK2	2	genetic interference	Srivas R (2016)	1
EGLN3	0	ALDH1B1	2	affinity chromatography technology	Rodriguez J (2016)	1
KBTBD7	3	PRKCI	1	affinity chromatography technology	Huttlin EL (2017)	1
TERF2	2	LLGL1	9	affinity chromatography technology	Giannone RJ (2010)	1
PRKCI	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Taipale M (2012)	2
ELAVL1	0	TERF2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
PARD6G	0	LLGL1	9	affinity chromatography technology	Brajenovic M (2004)	1
TOP2A	2	TOP1	1	biochemical	Wan C (2015)	1
CUL3	17	ALDH1B1	2	affinity chromatography technology	Bennett EJ (2010)	1
NPM1	0	COPB1	0	affinity chromatography technology	Chen R (2013)	1
LLGL1	9	HTT	14	affinity chromatography technology	Hein MY (2015)	1
TOP1	1	ELAVL1	0	affinity chromatography technology	Czubaty A (2005)	1
TERF2	2	TOP2A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bhattacharyya S (2009), Bhattacharyya S (2009), Bhattacharyya S (2009)	3
NTRK1	1	TOP3A	0	affinity chromatography technology	Emdal KB (2015)	1
PARD6G	0	PARD6B	0	affinity chromatography technology	Brajenovic M (2004)	1
TOP1	1	NPM1	0	affinity chromatography technology	Czubaty A (2005)	1
LLGL1	9	COPB1	0	affinity chromatography technology	Hein MY (2015)	1
PARD3	5	PARD6A	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kohjima M (2002), Brajenovic M (2004), Suzuki A (2001), Yang Z (2012), Hein MY (2015)	5
NTRK1	1	RANBP9	5	affinity chromatography technology	Emdal KB (2015)	1
TERF2	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bhattacharyya S (2009), Bhattacharyya S (2009), Bhattacharyya S (2009)	3
PARD6B	0	PRKCI	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004), Waaijers S (2013), Waaijers S (2013), Hayase J (2013), Rolland T (2014), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	10
CDH1	4	PARD3	5	bioid	Guo Z (2014)	1
HSP90AA1	7	CHEK1	2	affinity chromatography technology, pull down, affinity chromatography technology	Ha K (2011), Arlander SJ (2006), Taipale M (2012)	3
TMEM17	0	PRKCI	1	bioid	Gupta GD (2015)	1
TUBA1A	13	SQSTM1	0	affinity chromatography technology	Seiberlich V (2012)	1
EGLN3	0	TOP3A	0	affinity chromatography technology	Rodriguez J (2016)	1
PARD6G	0	PRKCZ	5	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Noda Y (2001), Brajenovic M (2004), So J (2015), Huttlin EL (2017)	4
HSP90AA1	7	TUBA1A	13	affinity chromatography technology, affinity chromatography technology	Hu Y (2003), Skarra DV (2011)	2
TOP1	1	CHEK1	2	genetic interference	Srivas R (2016)	1
NPM1	0	PARD6B	0	affinity chromatography technology	Chen R (2013)	1
PRKCZ	5	PRKCI	1	affinity chromatography technology, affinity chromatography technology	So J (2015), Huttlin EL (2017)	2
CUL3	17	TOP1	1	affinity chromatography technology	Bennett EJ (2010)	1
NPM1	0	LLGL1	9	affinity chromatography technology	Chen R (2013)	1
CUL3	17	LLGL1	9	affinity chromatography technology	Bennett EJ (2010)	1
PARD3	5	LLGL1	9	affinity chromatography technology	Brajenovic M (2004)	1
NPM1	0	HSP90AA1	7	affinity chromatography technology	Chen R (2013)	1
PARD6B	0	KBTBD7	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NTRK1	1	CUL3	17	affinity chromatography technology	Emdal KB (2015)	1
TOP3A	0	TERF2	2	affinity chromatography technology	Temime-Smaali N (2008)	1
FBXW11	2	ELAVL1	0	affinity chromatography technology	Low TY (2014)	1
EGLN3	0	LLGL1	9	affinity chromatography technology	Rodriguez J (2016)	1
NTRK1	1	ALDH1B1	2	affinity chromatography technology	Emdal KB (2015)	1
GABARAPL1	0	PRKCI	1	affinity chromatography technology	Behrends C (2010)	1
GABARAPL1	0	LLGL1	9	affinity chromatography technology	Behrends C (2010)	1
SQSTM1	0	PRKCZ	5	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, imaging technique, affinity chromatography technology	Sanz L (2000), Hirano Y (2004), Chang S (2002), Wilson MI (2003), Feng Y (2005), Kim GY (2012), Urbanczyk A (2011), Linares JF (2011), So J (2015), Tsai LC (2015), Huttlin EL (2017), Tobias IS (2016), Tobias IS (2016)	13
TOP3A	0	CHEK1	2	genetic interference	Srivas R (2016)	1
EGLN3	0	RANBP9	5	affinity chromatography technology	Rodriguez J (2016)	1
HSP90AA1	7	FBXW11	2	affinity chromatography technology	Taipale M (2012)	1
LLGL1	9	ALDH1B1	2	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	PRKCZ	5	two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Noda Y (2001), Noda Y (2001), Brajenovic M (2004), Wilson MI (2003), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	7
EGLN3	0	PARD3	5	affinity chromatography technology	Rodriguez J (2016)	1
NTRK1	1	COPB1	0	affinity chromatography technology	Emdal KB (2015)	1
SQSTM1	0	LLGL1	9	affinity chromatography technology	Behrends C (2010)	1
LLGL1	9	RANBP9	5	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Suresh B (2010), Suresh B (2010), Suresh B (2010), Suresh B (2010)	4
ELAVL1	0	LLGL1	9	affinity chromatography technology	Abdelmohsen K (2009)	1
TUBA1A	13	LLGL1	9	genetic interference	Srivas R (2016)	1
PRKCZ	5	HSP90AA1	7	two hybrid, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Taipale M (2012), Taipale M (2012)	3
GABARAPL1	0	CUL3	17	affinity chromatography technology, pull down	Behrends C (2010), Genau HM (2015)	2
SQSTM1	0	CUL3	17	imaging technique, affinity chromatography technology	Lau A (2010), Mori Y (2015)	2
HSP90AA1	7	KBTBD7	3	affinity chromatography technology	Taipale M (2012)	1
PARD6B	0	PARD6A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004), Hein MY (2015)	3
PRKCI	1	LLGL1	9	affinity chromatography technology, biochemical, affinity chromatography technology	Brajenovic M (2004), Wan C (2015), Hein MY (2015)	3
NTRK1	1	TOP1	1	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	LLGL1	9	affinity chromatography technology	Emdal KB (2015)	1
CACNA1A	21	LLGL1	9	two hybrid	Kahle JJ (2011)	1
SQSTM1	0	NTRK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wooten MW (2001), Geetha T (2003), Jadhav T (2008), Wooten MW (2008), Wooten MW (2008), Zheng C (2015)	6
CUL3	17	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
FBXW11	2	LLGL1	9	affinity chromatography technology	Low TY (2014)	1
TUBA1A	13	CHEK1	2	genetic interference	Srivas R (2016)	1
NTRK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rao R (2010), Taipale M (2012), Emdal KB (2015)	3
TOP2A	2	LLGL1	9	genetic interference	Srivas R (2016)	1
GABARAPL1	0	KBTBD7	3	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, unspecified method	Behrends C (2010), Rolland T (2014), Genau HM (2015), Genau HM (2015), Genau HM (2015)	5
EGLN3	0	SQSTM1	0	affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology	Rantanen K (2013), Rantanen K (2013), Rantanen K (2013), Rodriguez J (2016)	4
LLGL1	9	SERPINB12	2	affinity chromatography technology	Hein MY (2015)	1
PRKCZ	5	LLGL1	9	affinity chromatography technology, affinity chromatography technology	So J (2015), Huttlin EL (2017)	2
CHEK2	2	LLGL1	9	genetic interference	Srivas R (2016)	1
LLGL1	9	TIMM13	0	affinity chromatography technology	Hein MY (2015)	1
PARD6B	0	LLGL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	5
CUL3	17	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
EGLN3	0	COPB1	0	affinity chromatography technology	Rodriguez J (2016)	1
KBTBD7	3	LLGL1	9	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Huttlin EL (2017)	2
HTT	14	TUBA1A	13	affinity chromatography technology	Mitsui K (2002)	1
HTT	14	HSP90AA1	7	pull down, unspecified method	He WT (2017), He WT (2017)	2
HSP90AA1	7	LLGL1	9	genetic interference	Srivas R (2016)	1
PARD6G	0	PRKCI	1	affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004)	2
ELAVL1	0	TRIB1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CDH1	4	HSP90AA1	7	affinity chromatography technology	Catimel B (2005)	1
TOP1	1	LLGL1	9	genetic interference	Srivas R (2016)	1
TOP2A	2	CHEK1	2	genetic interference	Srivas R (2016)	1
CHEK1	2	LLGL1	9	genetic interference	Srivas R (2016)	1
CUL3	17	TUBA1A	13	affinity chromatography technology	Bennett EJ (2010)	1
PRKCI	1	PARD6A	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Brajenovic M (2004), Suzuki A (2001), Suzuki A (2001), Suzuki A (2001), Lamark T (2003), Lamark T (2003), Lamark T (2003), Lamark T (2003), Erdogan E (2006), Rolland T (2014), Yu H (2011), Hein MY (2015)	13
PARD6A	0	LLGL1	9	affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Hein MY (2015)	2
EGLN3	0	TIMM13	0	affinity chromatography technology	Rodriguez J (2016)	1
TMEM17	0	LLGL1	9	bioid	Gupta GD (2015)	1
TMEM17	0	SQSTM1	0	bioid	Gupta GD (2015)	1
PARD3	5	PARD6G	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kohjima M (2002), Brajenovic M (2004), Brajenovic M (2004)	3
NTRK1	1	TUBA1A	13	affinity chromatography technology	Emdal KB (2015)	1
HTT	14	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Filimonenko M (2010), Zhou L (2014), Rui YN (2015), Rui YN (2015)	4
LLGL1	9	TRIB1	1	affinity chromatography technology	Hein MY (2015)	1
PARD3	5	PARD6B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kohjima M (2002), Brajenovic M (2004), Brajenovic M (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
ELAVL1	0	CHEK2	2	affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study	Abdelmohsen K (2009), Abdelmohsen K (2007), Abdelmohsen K (2007), Abdelmohsen K (2007)	4
KBTBD7	3	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Bennett EJ (2010), Genau HM (2015), Genau HM (2015), Huttlin EL (2017)	5
PARD3	5	PRKCZ	5	affinity chromatography technology	Kohjima M (2002)	1
NTRK1	1	ELAVL1	0	affinity chromatography technology	Emdal KB (2015)	1
PRKCZ	5	PARD6A	0	two hybrid, pull down, two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Rual JF (2005), Liu XF (2004), Noda Y (2001), Brajenovic M (2004), Lamark T (2003), Lamark T (2003), So J (2015), Huttlin EL (2017), Tobias IS (2016), Tobias IS (2016)	10
CUL3	17	TIMM13	0	affinity chromatography technology	Bennett EJ (2010)	1
SQSTM1	0	GABARAPL1	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, two hybrid	Rual JF (2005), Behrends C (2010), Wild P (2011), Kirkin V (2009), Zhang Y (2011), Zhang Y (2011), Rolland T (2014)	7
TOP3A	0	LLGL1	9	genetic interference	Srivas R (2016)	1
ELAVL1	0	TIMM13	0	affinity chromatography technology	Abdelmohsen K (2009)	1
NPM1	0	PRKCI	1	affinity chromatography technology	Chen R (2013)	1