Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
ASIC2 40 CHEMBL482796 CHEMBL482796 agonist GuideToPharmacologyInteractions
ASIC2 40 AMILORIDE CHEMBL945 channel blocker GuideToPharmacologyInteractions
ASIC2 40 PYRIMETHAMINE CHEMBL36 channel blocker GuideToPharmacologyInteractions
ASIC2 40 NAFAMOSTAT CHEMBL273264 channel blocker GuideToPharmacologyInteractions
ASIC2 40 CHEMBL185515 CHEMBL185515 channel blocker GuideToPharmacologyInteractions
ASIC2 40 GADOBENATE DIMEGLUMINE CHEMBL1200571 activator GuideToPharmacologyInteractions
ASIC2 40 LIPOXIN A4 CHEMBL392438 agonist GuideToPharmacologyInteractions
ASIC2 40 LITHIUM CHEMBL2146126 PharmGKB

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
ASIC2 rs11869731 CC lithium efficacy yes P value for quantitative trait analysis of long-term treatment response scale comparing all three genotypes. Please note: the ACCN1 gene is found on the minus chromosomal strand. The G allele was reported in this study as the minor allele - genotype GG was associated with response to lithium. Here we give the association with the complementary C allele on the plus chromosomal strand. Genotype CC is associated with increased response to lithium in people with Bipolar Disorder as compared to genotypes CG + GG. 21961650 827816621