PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FBXO7	1	RBBP4	3	affinity chromatography technology	Teixeira FR (2016)	1
ADAMTS4	1	LOXL2	5	affinity chromatography technology	Huttlin EL (2017)	1
IL12RB1	2	LOXL2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EZH2	4	HIST1H3A	3	enzymatic study, enzymatic study, affinity chromatography technology	Martin C (2006), Cha TL (2005), Cha TL (2005)	3
IDS	0	TAZ	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TINAGL1	0	LOXL2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PSG8	4	LOXL2	5	affinity chromatography technology	Huttlin EL (2017)	1
EZH2	4	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	van der Vlag J (1999), van der Vlag J (1999), Caretti G (2004), Tong ZT (2012), Tong ZT (2012), Su L (2012), Su L (2012), Wan C (2015)	8
HDAC1	4	MTA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Yao YL (2003), Yao YL (2003), Yao YL (2003), Mazumdar A (2001), Mazumdar A (2001), Yoo YG (2006), Liu XF (2004), Khaleque MA (2008), Terhune SS (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Millard CJ (2016), Millard CJ (2016)	21
TRIM25	5	LOXL2	5	affinity chromatography technology	Choudhury NR (2017)	1
HDAC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Yao YL (2003), Fleischer TC (2003), Fleischer TC (2003), Yang L (2003), Grozinger CM (1999), Zhang J (2002), Zhang J (2002), You A (2001), Zhang Y (1999), Zhang Y (2002), Tong JK (1998), Hassig CA (1998), Yasui D (2002), Huang EY (2000), Huang EY (2000), Kuzmichev A (2002), Kuzmichev A (2002), Martinowich K (2003), Martinowich K (2003), Suzuki M (2003), Suzuki M (2006), Nakamura T (2002), Wei Q (2005), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Skowyra D (2001), Humphrey GW (2001), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Oh YM (2009), Wan C (2015), Hein MY (2015), Hsu DS (2014), Huttlin EL (2017)	45
HIST1H3A	3	MTA2	1	affinity chromatography technology	Nishioka K (2002)	1
PDIA3	0	LOXL2	5	affinity chromatography technology	Jessop CE (2007)	1
TRIM25	5	FBXO7	1	affinity chromatography technology	Choudhury NR (2017)	1
TAZ	1	LOXL2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LOXL2	5	RBM14-RBM4	0	affinity chromatography technology	Huttlin EL (2017)	1
EZH2	4	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao Q (2014), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
EZH2	4	SIN3A	13	affinity chromatography technology	Hauri S (2016)	1
LOXL2	5	RBBP7	1	affinity chromatography technology	Herranz N (2012)	1
SCGB2A2	0	LOXL2	5	affinity chromatography technology	Huttlin EL (2017)	1
MTA1	3	SIN3A	13	affinity chromatography technology	Yao YL (2003)	1
INSL5	0	LOXL2	5	affinity chromatography technology	Huttlin EL (2017)	1
LRP1	25	PLAUR	0	affinity chromatography technology, pull down	Czekay RP (2001), Czekay RP (2001)	2
HNRNPL	3	OS9	4	affinity chromatography technology	Fei T (2017)	1
HIST1H3A	3	RBBP7	1	affinity chromatography technology	Foltz DR (2009)	1
LOXL2	5	EZH2	4	affinity chromatography technology, affinity chromatography technology	Herranz N (2012), Herranz N (2012)	2
DEFA5	1	LOXL2	5	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	MTA1	3	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Zang HL (2017)	2
RBBP4	3	RBBP7	1	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
LOXL2	5	FBXO7	1	affinity chromatography technology	Huttlin EL (2017)	1
LOXL2	5	SIN3A	13	affinity chromatography technology, affinity chromatography technology	Herranz N (2012), Herranz N (2012)	2
PLAUR	0	LOXL2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
MTA1	3	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Roche AE (2008), Huttlin EL (2015), Huttlin EL (2017), Millard CJ (2016), Hauri S (2016)	6
LOXL2	5	MTA1	3	affinity chromatography technology	Herranz N (2012)	1
HNRNPL	3	LRP1	25	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	LOXL2	5	affinity chromatography technology	Fei T (2017)	1
IDS	0	LOXL2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RBBP4	3	PDIA3	0	biochemical	Kristensen AR (2012)	1
LOXL2	5	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Herranz N (2012), Herranz N (2012)	2
EZH2	4	TRIM25	5	affinity chromatography technology	Cao Q (2014)	1
MTA2	1	MTA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Yao YL (2003), Yao YL (2003), Cui S (2011), Wan C (2015)	4
LOXL2	5	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Herranz N (2012), Herranz N (2012)	2
OS9	4	LOXL2	5	affinity chromatography technology	Huttlin EL (2017)	1
TMEM25	0	TAZ	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MTA1	3	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology	Yao YL (2003), Roche AE (2008), Cui S (2011), Cui S (2011), Rolland T (2014), Huttlin EL (2015), Alqarni SS (2014), Alqarni SS (2014), Alqarni SS (2014), Wan C (2015), Huttlin EL (2017), Millard CJ (2016), Millard CJ (2016), Millard CJ (2016), Hauri S (2016)	15
WNT7A	0	LOXL2	5	affinity chromatography technology	Huttlin EL (2017)	1
EZH2	4	RBBP4	3	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li G (2010), Kaneko S (2010), Kaneko S (2010), Cao Q (2014), Hein MY (2015), Hauri S (2016), Hauri S (2016)	7
LOXL2	5	IK	6	affinity chromatography technology	Huttlin EL (2017)	1
RBBP7	1	SIN3A	13	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (1998), Kuzmichev A (2002), Nakamura T (2002), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	6
LRP1	25	LOXL2	5	affinity chromatography technology	Huttlin EL (2017)	1
KLK5	1	OS9	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MTA2	1	RBBP7	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Yao YL (2003), Zhang Y (1999), Feng Q (2001), Wang Y (2009), Fu J (2011), Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017), Brasen C (2017), Brasen C (2017), Hauri S (2016)	11
HNRNPL	3	RBBP4	3	affinity chromatography technology	Fei T (2017)	1
DEFA1	0	LOXL2	5	affinity chromatography technology	Huttlin EL (2017)	1
LOXL2	5	HIST1H3A	3	enzymatic study	Herranz N (2012)	1
TRIM25	5	SIN3A	13	affinity chromatography technology	Choudhury NR (2017)	1
SIN3A	13	RBBP4	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hassig CA (1997), Zhang Y (1998), Nakamura T (2002), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Bantscheff M (2011), Hauri S (2016)	8
LOXL2	5	MTA2	1	affinity chromatography technology	Herranz N (2012)	1
LYZL2	0	LOXL2	5	affinity chromatography technology	Huttlin EL (2017)	1
MTA2	1	RBBP4	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, x-ray crystallography, affinity chromatography technology	Yao YL (2003), Zhang Y (1999), Banach-Orlowska M (2009), Pflum MK (2001), Feng Q (2001), Wang Y (2009), Cui S (2011), Havugimana PC (2012), Wan C (2015), Brasen C (2017), Brasen C (2017), Brasen C (2017), Hauri S (2016)	13
HDAC1	4	RBBP7	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Ng HH (1999), Zhang Y (1999), Zhang Y (1997), Banach-Orlowska M (2009), Humphrey GW (2001), Zhang Y (1998), Zhang Y (1998), Xue Y (1998), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Yeh HH (2015), Yeh HH (2015), Huttlin EL (2017), Hauri S (2016)	19
RBBP4	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Nicolas E (2001), Nicolas E (2001), Grozinger CM (1999), You A (2001), Hassig CA (1997), Hassig CA (1997), Ng HH (1999), Zhang Y (1999), Zhang Y (2002), Hassig CA (1998), Zhang Y (1997), Banach-Orlowska M (2009), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Humphrey GW (2001), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	35
HDAC1	4	MTA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Yao YL (2003), You A (2001), Zhang Y (1999), Zhang Y (1999), Yasui D (2002), Banach-Orlowska M (2009), Banach-Orlowska M (2009), Cui Y (2006), Pflum MK (2001), Feng Q (2001), Humphrey GW (2001), Humphrey GW (2001), Humphrey GW (2001), Zhang Y (1998), Terhune SS (2010), Opsahl JA (2010), Wang Y (2009), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	27
KLK5	1	LOXL2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MTA2	1	SIN3A	13	affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Pflum MK (2001)	2
LYZL2	0	OS9	4	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H3A	3	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Wysocka J (2006), Nishioka K (2002), Tagami H (2004), Foltz DR (2009), Millard CJ (2016)	5
HIST1H3A	3	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology	Nishioka K (2002), Li X (2014), Hein MY (2015)	3
TMEM25	0	LOXL2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KLK11	0	LOXL2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	RBBP4	3	affinity chromatography technology	Choudhury NR (2017)	1
PLAUR	0	TAZ	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2