PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ARL3	1	UNC119B	1	affinity chromatography technology	Boldt K (2016)	1
ARL3	1	TP53	0	two hybrid, genetic interference	Stelzl U (2005), Xie L (2013)	2
UNC119	4	UNC119B	1	affinity chromatography technology	Huttlin EL (2017)	1
ARL3	1	LRIF1	3	two hybrid	Stelzl U (2005)	1
ARL3	1	UNC119	4	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Van Valkenburgh H (2001), Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	5
ARL3	1	WRN	6	affinity chromatography technology	Boldt K (2016)	1
SPRR2A	2	ARL3	1	affinity chromatography technology	Boldt K (2016)	1
GOLGA4	6	ARL3	1	two hybrid	Van Valkenburgh H (2001)	1
ARL3	1	UBR1	3	two hybrid	Stelzl U (2005)	1
UNC119	4	ARL2	0	two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Kobayashi A (2003), Kobayashi A (2003), Kobayashi A (2003), Rolland T (2014), Boldt K (2016)	5
ARL2	0	ARL3	1	affinity chromatography technology	Boldt K (2016)	1
ARL2	0	PDE6D	0	two hybrid, x-ray crystallography, two hybrid, two hybrid	Rual JF (2005), Hanzal-Bayer M (2002), Rolland T (2014), Yu H (2011)	4
ARL3	1	ESF1	2	affinity chromatography technology	Boldt K (2016)	1
CAMK2A	6	ARL3	1	affinity chromatography technology	Boldt K (2016)	1
ARL2	0	ARL2BP	0	biochemical, two hybrid, two hybrid, pull down, pull down	Sharer JD (2002), Wang J (2011), Rolland T (2014), Sharer JD (1999), Sharer JD (1999)	5
ARL3	1	ARL2BP	0	two hybrid, affinity chromatography technology	Van Valkenburgh H (2001), Boldt K (2016)	2
ARL3	1	PDE6D	0	two hybrid	Stelzl U (2005)	1
ARL3	1	TLE1	6	two hybrid	Stelzl U (2005)	1
WRN	6	TP53	0	affinity chromatography technology, pull down, pull down	Yang Q (2002), Yang Q (2002), Brosh RM (2001)	3
RP2	3	ARL3	1	pull down, pull down	Bartolini F (2002), Kuehnel K (2006)	2
UNC119	4	NPHP3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	3
NPHP3	2	ARL3	1	affinity chromatography technology	Boldt K (2016)	1
ALKBH2	0	ARL3	1	affinity chromatography technology	Boldt K (2016)	1
NPHP3	2	UNC119B	1	affinity chromatography technology	Huttlin EL (2017)	1