Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
LRP5	rs3736228	T	risedronate		not stated		Allele T is not associated with response to risedronate in people with Osteoporosis as compared to allele C.	19148563	769170898
LRP5	rs3736228	TT	ranibizumab	efficacy	no	Response was measured by improvement in mean visual acuity, using either Snellen or Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity tests. Visual acuity was measured at baseline and after three monthly intravitreal ranibizumab injections.	Genotype TT is not associated with response to ranibizumab in people with Macular Degeneration as compared to genotype CC.	22840423	981755354
LRP5	rs3736228	CT	ranibizumab	efficacy	no	Response was measured by improvement in mean visual acuity, using either Snellen or Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity tests. Visual acuity was measured at baseline and after three monthly intravitreal ranibizumab injections.	Genotype CT is not associated with response to ranibizumab in people with Macular Degeneration as compared to genotype CC.	22840423	981755362