Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
LTA	4049	ADALIMUMAB	CHEMBL1201580		PharmGKB
LTA	4049	PATECLIZUMAB	CHEMBL1743056	inhibitor	ChemblInteractions
LTA	4049	ETANERCEPT	CHEMBL1201572		PharmGKB, DrugBank	1328224, 11302411, 15005015, 15033655, 15695296
LTA	4049	INFLIXIMAB	CHEMBL1201581		PharmGKB
LTA	4049	BAMINERCEPT	CHEMBL1742988	inhibitor	TdgClinicalTrial, ChemblInteractions
LTA	4049	CARBAMAZEPINE	CHEMBL108		PharmGKB

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
LTA	rs909253	AA	rituximab	efficacy	no	No significant association was seen between genotype and whether a patient was a "responder" or a "non-responder". "Responders" had a post-rituximab disease activity score (DAS28) of lower than 5.1 and a DAS28 variation between baseline and post-treatment higher than 0.6. Please note alleles have been complemented to the plus chromosomal strand.	Genotype AA is not associated with response to rituximab in people with Arthritis, Rheumatoid as compared to genotypes AG + GG.	22129793	982047076
LTA	rs1041981	C	etanercept	efficacy	no	No significant difference in the frequency of the alleles was seen when comparing responders to non-responders, when using 1) American College of Rheumatology (ACR) 20 criteria, 2) ACR70 criteria or 3) ACR20 criteria non-responders vs ACR70 criteria responders at 12 weeks of treatment.	Allele C is not associated with response to etanercept in people with Arthritis, Rheumatoid as compared to allele A.	15695296	1444668362
LTA	rs1041981	CC	rituximab	efficacy	no	No significant association was seen between genotype and whether a patient was a "responder" or a "non-responder". "Responders" had a post-rituximab disease activity score (DAS28) of lower than 5.1 and a DAS28 variation between baseline and post-treatment higher than 0.6.	Genotype CC is not associated with response to rituximab in people with Arthritis, Rheumatoid as compared to genotypes AA + AC.	22129793	982047062