Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
LYN 4067 NINTEDANIB CHEMBL502835 inhibitor, Inhibitor TALC, DrugBank 18559524
LYN 4067 TOLIMIDONE CHEMBL8030 allosteric modulator GuideToPharmacologyInteractions
LYN 4067 IBRUTINIB CHEMBL1873475 inhibitor GuideToPharmacologyInteractions
LYN 4067 DASATINIB CHEMBL1421 inhibitor ChemblInteractions
LYN 4067 CHEMBL406845 CHEMBL406845 DrugBank 10592235
LYN 4067 BOSUTINIB CHEMBL288441 inhibitor GuideToPharmacologyInteractions, ChemblInteractions, DrugBank
LYN 4067 CHEMBL605003 CHEMBL605003 inhibitor GuideToPharmacologyInteractions
LYN 4067 ENMD-981693 CHEMBL52885 inhibitor ChemblInteractions
LYN 4067 ACALABRUTINIB CHEMBL3707348 inhibitor GuideToPharmacologyInteractions
LYN 4067 BAFETINIB CHEMBL206834 inhibitor MyCancerGenome, GuideToPharmacologyInteractions, ChemblInteractions
LYN 4067 ILORASERTIB CHEMBL1980297 inhibitor ChemblInteractions
LYN 4067 JNJ-26483327 CHEMBL3545133 inhibitor ChemblInteractions
LYN 4067 XL-228 CHEMBL3545085 inhibitor ChemblInteractions
LYN 4067 MASITINIB CHEMBL1908391 inhibitor TdgClinicalTrial, MyCancerGenomeClinicalTrial
LYN 4067 TG100-801 CHEMBL403989 inhibitor ChemblInteractions
LYN 4067 PONATINIB CHEMBL1171837 inhibitor DrugBank 19878872

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
LYN rs1546519 G ziprasidone efficacy yes as measured by changes in PANSS-T (positive and negative syndrome scale total score), using a mixed model repeated measures approach. Examined 6789 SNPs - p-value of p< or equal to 5x10-4 was considered significant. Please note: reported allele was C, this has been complemented to the plus chromosomal strand. It was unclear whether the allele was associated with an increased or decreased response to drug. Allele G is associated with response to ziprasidone in people with Schizophrenia. 22920393 981238789