PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ARRB1	2	GNMT	0	two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Wang J (2011), Wang J (2011)	3
ARR3	0	RHO	3	pull down	Orsini MJ (1998)	1
ARR3	0	PLK4	1	two hybrid	Rolland T (2014)	1
ARR3	0	ZNF496	1	two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Rual JF (2005), Rolland T (2014)	3
ARRB2	5	RHO	3	pull down	Orsini MJ (1998)	1
ARRB2	5	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Huttlin EL (2017)	4
ARR3	0	CAPNS1	0	two hybrid	Stelzl U (2005)	1
ARRB1	2	ZBTB43	1	two hybrid	Rual JF (2005)	1
ARR3	0	ZBTB43	1	two hybrid	Rolland T (2014)	1
ARR3	0	GNMT	0	two hybrid	Rual JF (2005)	1
ARRB1	2	DVL2	5	two hybrid, affinity chromatography technology	Chen W (2001), Chen W (2001)	2
ARRB1	2	ARR3	0	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007)	2
ARR3	0	DVL2	5	two hybrid, two hybrid	Rual JF (2005), Yu H (2011)	2
ARR3	0	RNASE6	0	two hybrid	Stelzl U (2005)	1
ARRB2	5	ARR3	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Huttlin EL (2017)	2