PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GSK3B	1	VTA1	1	affinity chromatography technology	Pilot-Storck F (2010)	1
MAP1LC3A	0	TOLLIP	3	affinity chromatography technology	Lu K (2014)	1
CALM1	0	SQSTM1	0	pull down	Shen X (2005)	1
NBR1	0	MAP1LC3C	0	affinity chromatography technology	Kirkin V (2009)	1
HNRNPL	3	TNK2	7	affinity chromatography technology	Fei T (2017)	1
LTBR	0	NBR1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FEZ1	0	HTT	14	pull down, two hybrid, affinity chromatography technology	Goehler H (2004), Goehler H (2004), Huttlin EL (2017)	3
TTN	102	NBR1	0	two hybrid, affinity chromatography technology, enzymatic study	Lange S (2005), Lange S (2005), Lange S (2005)	3
UBC	7	TOLLIP	3	pull down, pull down, pull down, biochemical, pull down, pull down, pull down, pull down	Fenner BJ (2009), Nathan JA (2013), Mitra S (2013), Mitra S (2013), Shih SC (2003), Lu K (2014), Lu K (2014), Zhang X (2017)	8
CORO6	2	NBR1	0	affinity chromatography technology	Huttlin EL (2017)	1
MAP1LC3C	0	UBC	7	imaging technique	Liu X (2017)	1
GSK3B	1	JUN	0	enzymatic study, imaging technique	Chen BK (2007), Chen TC (2014)	2
HNRNPL	3	SPPL2B	0	affinity chromatography technology	Fei T (2017)	1
USP8	7	HTT	14	biochemical	Kristensen AR (2012)	1
NBR1	0	CIB1	2	two hybrid	Whitehouse C (2002)	1
JUNB	0	JUN	0	affinity chromatography technology	Huttlin EL (2017)	1
GABARAPL1	0	GABARAP	0	affinity chromatography technology	Behrends C (2010)	1
MAP3K3	3	NBR1	0	affinity chromatography technology, affinity chromatography technology	Hernandez ED (2014), Hernandez ED (2014)	2
SQSTM1	0	NBR1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	DAgostino C (2011), Lange S (2005), Lamark T (2003), Lamark T (2003), Yang JQ (2010), Erdogan E (2006), Yamashita SI (2014), Nicot AS (2014)	8
SQSTM1	0	UBC	7	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, affinity chromatography technology, unspecified method, pull down, pull down, pull down, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, imaging technique, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Vinayagam A (2011), Vadlamudi RK (1996), Tanji K (2012), Matsumoto G (2011), Long J (2008), Long J (2008), Najat D (2009), Najat D (2009), Hocking LJ (2004), Boh BK (2011), Long J (2010), Seibenhener ML (2004), Seibenhener ML (2004), Seibenhener ML (2004), Fenner BJ (2009), Nathan JA (2013), Ciani B (2003), Shi J (2013), Goode A (2014), Bish RA (2007), Lu K (2014), Zhou L (2014), Zhou L (2014), Vadlamudi RK (1996), Long J (2008), Cavey JR (2006), Cavey JR (2006), Kirkin V (2009), Nakayasu ES (2013), Nakayasu ES (2013), Lim J (2015), Milan E (2015), Milan E (2015), Ordureau A (2015), Wurzer B (2015), Zhang X (2017), Wang L (2017), Liu X (2017), Peng H (2017), Donohue E (2014), Nibe Y (2017), Nibe Y (2017), Govindaraju VK (2017)	43
NBR1	0	UBE2D3	1	pull down	Peng H (2017)	1
SSH3	3	NBR1	0	bioid	St-Denis N (2016)	1
SQSTM1	0	UBE2D3	1	two hybrid, affinity chromatography technology, pull down, enzymatic study, pull down	Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017)	5
MAP1LC3B	1	SQSTM1	0	two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Behrends C (2010), Vinayagam A (2011), Kirkin V (2009), Kirkin V (2009), Liang X (2013), Liang X (2013), Novak I (2010), Novak I (2010), Rogov VV (2012), Gao W (2013), Maruyama Y (2014), Maruyama Y (2014), Maruyama Y (2014), Yamashita SI (2014), Wurzer B (2015), Wurzer B (2015), Wurzer B (2015), Sun A (2017), Cohen-Kaplan V (2016), Dou Z (2015), Galindo-Moreno M (2017)	22
USP8	7	UBC	7	enzymatic study, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, pull down	Faesen AC (2011), Ernst A (2013), Row PE (2007), Ernst A (2013), Wauer T (2015), Reincke M (2015), Kwasna D (2018)	7
UBC	7	HNRNPL	3	affinity chromatography technology	Matsumoto M (2005)	1
CEP135	2	SQSTM1	0	bioid	Gupta GD (2015)	1
UBC	7	ITSN2	7	pull down	Zhang X (2017)	1
NBR1	0	UBC	7	pull down, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down	Waters S (2009), Kirkin V (2009), Walinda E (2014), Walinda E (2014), Nicot AS (2014), Nakayasu ES (2013), Nakayasu ES (2013), Zhang X (2017)	8
SQSTM1	0	MAP3K3	3	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Nakamura K (2010), Nakamura K (2010), Nakamura K (2010), Nakamura K (2010), Nakamura K (2010), Yamazaki K (2009)	6
UBC	7	MAP2K4	3	pull down	Zhang X (2017)	1
HNRNPL	3	MRPL41	2	biochemical	Wan C (2015)	1
CEP135	2	NBR1	0	bioid	Gupta GD (2015)	1
MAP1LC3B	1	UBC	7	imaging technique	Liu X (2017)	1
GTSE1	3	NBR1	0	affinity chromatography technology	Hein MY (2015)	1
MAP1LC3B	1	GABARAPL2	0	pull down	Maruyama Y (2014)	1
JUNB	0	NBR1	0	affinity chromatography technology	Huttlin EL (2017)	1
MAP2K4	3	JUN	0	enzymatic study	Sundarrajan M (2003)	1
SPRED2	12	NBR1	0	affinity chromatography technology	Mardakheh FK (2009)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
MAP1LC3A	0	UBC	7	biochemical, imaging technique	Fujita N (2013), Govindaraju VK (2017)	2
HTT	14	MAP1LC3A	0	affinity chromatography technology	Filimonenko M (2010)	1
NBR1	0	NBR1	0	two hybrid	Lange S (2005)	1
LYPD4	1	NBR1	0	affinity chromatography technology	Huttlin EL (2017)	1
MAP1LC3C	0	GABARAP	0	affinity chromatography technology	Behrends C (2010)	1
GABARAPL2	0	NBR1	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Behrends C (2010), Kirkin V (2009), Kirkin V (2009)	3
TNK2	7	NBR1	0	imaging technique	Jones S (2014)	1
GABARAP	0	GABARAPL2	0	affinity chromatography technology	Behrends C (2010)	1
SPPL2B	0	NBR1	0	affinity chromatography technology	Huttlin EL (2017)	1
CEP135	2	CEP55	2	bioid	Gupta GD (2015)	1
SQSTM1	0	MAP1LC3C	0	affinity chromatography technology	Kirkin V (2009)	1
GABARAP	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Behrends C (2010), Kirkin V (2009), Maruyama Y (2014), Dunlop EA (2014), Wurzer B (2015), Wurzer B (2015)	6
SQSTM1	0	GABARAPL2	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Rual JF (2005), Behrends C (2010), Vinayagam A (2011), Shvets E (2011), Kirkin V (2009), Kirkin V (2009), Maruyama Y (2014), Rolland T (2014), Yu H (2011)	9
VAPB	2	NBR1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GABARAP	0	NBR1	0	affinity chromatography technology, affinity chromatography technology, pull down	Behrends C (2010), Kirkin V (2009), Nicot AS (2014)	3
MAP1LC3A	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, biochemical, imaging technique, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, pull down, affinity chromatography technology	Shvets E (2008), Shvets E (2008), Behrends C (2010), Gao Z (2010), Pan JA (2011), Pankiv S (2007), Pankiv S (2007), Shvets E (2011), Tung YT (2010), Bjorkoy G (2005), Kirkin V (2009), Lim J (2011), Lim J (2011), Pan JA (2012), Lee DY (2013), Wang BS (2013), Wang BS (2013), Sansanwal P (2012), Shi J (2013), Fujita N (2013), Chen X (2014), Liu XD (2014), Noda NN (2008), Noda NN (2008), Matsuzawa Y (2015), Matsuzawa Y (2015), Rui YN (2015), Rui YN (2015), Ciuffa R (2015), Wang N (2013), Hua F (2015), Rui YN (2015), Cha-Molstad H (2015), Paul S (2012), Puvirajesinghe TM (2016), Wang L (2017), Cha-Molstad H (2017), Peng H (2017), Lee Y (2017)	39
NBR1	0	UBE2D2	0	pull down	Peng H (2017)	1
NBR1	0	FEZ1	0	two hybrid, affinity chromatography technology	Whitehouse C (2002), Whitehouse C (2002)	2
VAPB	2	UBC	7	affinity chromatography technology	Baron Y (2014)	1
NBR1	0	USP8	7	two hybrid, pull down	Waters S (2009), Waters S (2009)	2
GSK3A	1	VTA1	1	affinity chromatography technology	Pilot-Storck F (2010)	1
MAP1LC3A	0	NBR1	0	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	DAgostino C (2011), Waters S (2009), Waters S (2009), Kirkin V (2009)	4
GTSE1	3	TNK2	7	affinity chromatography technology	Hein MY (2015)	1
ITSN2	7	NBR1	0	two hybrid	Wong KA (2012)	1
MAP3K3	3	MAP2K4	3	enzymatic study, affinity chromatography technology, pull down	Deacon K (1997), Hernandez ED (2014), Hernandez ED (2014)	3
MAP1LC3B	1	GABARAP	0	affinity chromatography technology	Behrends C (2010)	1
NBR1	0	VTA1	1	two hybrid	Rual JF (2005)	1
HNRNPL	3	HTT	14	affinity chromatography technology	Fei T (2017)	1
MAP1LC3C	0	GABARAPL2	0	affinity chromatography technology	Behrends C (2010)	1
TOLLIP	3	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Lu K (2014), Jongsma ML (2016)	2
CEP55	2	NBR1	0	affinity chromatography technology	Kuo TC (2011)	1
TTN	102	CALM1	0	affinity chromatography technology	Gautel M (1995)	1
JUN	0	NBR1	0	affinity chromatography technology	Li X (2015)	1
HNRNPL	3	LTBR	0	affinity chromatography technology	Fei T (2017)	1
UBC	7	CEP55	2	pull down	Zhang X (2017)	1
HTT	14	NBR1	0	affinity chromatography technology	Filimonenko M (2010)	1
SPRED2	12	SQSTM1	0	affinity chromatography technology	Mardakheh FK (2009)	1
CALM1	0	NBR1	0	pull down	Shen X (2005)	1
HNRNPL	3	NBR1	0	affinity chromatography technology	Fei T (2017)	1
TOLLIP	3	NBR1	0	affinity chromatography technology	Lu K (2014)	1
NBR1	0	SYT4	3	two hybrid	Rolland T (2014)	1
MAP2K4	3	NBR1	0	affinity chromatography technology, affinity chromatography technology, pull down	Hernandez ED (2014), Hernandez ED (2014), Hernandez ED (2014)	3
GSK3B	1	NBR1	0	enzymatic study, affinity chromatography technology	Nicot AS (2014), Nicot AS (2014)	2
TTN	102	SQSTM1	0	enzymatic study	Lange S (2005)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
MAP1LC3A	0	GABARAPL1	0	imaging technique	Tanida I (2006)	1
MRPL41	2	NBR1	0	affinity chromatography technology	Huttlin EL (2017)	1
SCGN	1	NBR1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HTT	14	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Filimonenko M (2010), Zhou L (2014), Rui YN (2015), Rui YN (2015)	4
GSK3A	1	NBR1	0	affinity chromatography technology, enzymatic study, affinity chromatography technology	Pilot-Storck F (2010), Nicot AS (2014), Nicot AS (2014)	3
LTBR	0	VAPB	2	affinity chromatography technology	Huttlin EL (2015)	1
SQSTM1	0	UBE2D2	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017)	5
GABARAPL1	0	GABARAPL2	0	affinity chromatography technology	Behrends C (2010)	1
TNK2	7	SQSTM1	0	affinity chromatography technology, imaging technique	Jones S (2014), Jones S (2014)	2
NBR1	0	MAP1LC3B	1	affinity chromatography technology, pull down	Kirkin V (2009), Nicot AS (2014)	2
UBC	7	CALM1	0	affinity chromatography technology	Bish RA (2007)	1
SQSTM1	0	GABARAPL1	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, two hybrid	Rual JF (2005), Behrends C (2010), Wild P (2011), Kirkin V (2009), Zhang Y (2011), Zhang Y (2011), Rolland T (2014)	7
NBR1	0	GABARAPL1	0	affinity chromatography technology	Kirkin V (2009)	1
MAP1LC3B	1	MAP1LC3A	0	affinity chromatography technology	Behrends C (2010)	1
JUN	0	UBC	7	two hybrid, protein complementation assay	Bandyopadhyay S (2010), Fang D (2004)	2
ATXN1L	0	NBR1	0	two hybrid	Lim J (2006)	1