PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAD2L1	0	APP	1	pull down	Olah J (2011)	1
ZW10	2	APP	1	pull down	Olah J (2011)	1
PYM1	3	MAD2L1	0	affinity chromatography technology	Huttlin EL (2017)	1
CDC27	2	CDC26	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Gmachl M (2000), Kraft C (2003), Dube P (2005), Holzmann J (2011), Gmachl M (2000), Vodermaier HC (2003), Vodermaier HC (2003), Masuda K (2015)	8
CHFR	5	MAD2L1	0	affinity chromatography technology	Privette LM (2008)	1
BUB1B	0	TRIP13	0	affinity chromatography technology, pull down	Wang K (2014), Miniowitz-Shemtov S (2015)	2
CDC20	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
DAXX	5	MAD2L1	0	affinity chromatography technology	Kwan PS (2013)	1
EGLN3	0	BUB1B	0	affinity chromatography technology	Rodriguez J (2016)	1
MAD2L1	0	ANAPC2	0	affinity chromatography technology	Zhang Y (2001)	1
CDC20	1	ANAPC1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nilsson J (2008), Hein JB (2014), Lischetti T (2014), Kelly A (2014), Craney A (2016), Qiao R (2016), Qiao R (2016), Hein JB (2016)	8
MAD2L1	0	TRIP13	0	affinity chromatography technology, pull down, affinity chromatography technology	Wang K (2014), Miniowitz-Shemtov S (2015), Sedgwick GG (2016)	3
MAD2L1	0	DYNLL1	0	affinity chromatography technology	Hein MY (2015)	1
BCL7C	0	APP	1	pull down	Olah J (2011)	1
BUB1B	0	NEK2	2	affinity chromatography technology	Boekhout M (2015)	1
BUB1B	0	TP73	2	affinity chromatography technology, pull down	Tomasini R (2009), Tomasini R (2009)	2
MAD2L1	0	ADAM17	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Nelson KK (1999), Nelson KK (1999), Nelson KK (1999), Poghosyan Z (2002)	4
BUB1B	0	CDC16	2	affinity chromatography technology, affinity chromatography technology	Chan GK (1999), Tipton AR (2013)	2
CDC20	1	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	DAngiolella V (2003), Kallio MJ (2002), Wassmann K (1998), Kramer ER (1998), Kallio M (1998), Kallio M (1998), Nilsson J (2008), Jeganathan KB (2006), Nath S (2011), Lee YJ (2008), Lara-Gonzalez P (2011), Mansfeld J (2011), Braunstein I (2007), Visconti R (2010), Ma HT (2011), Lee YJ (2008), DAngiolella V (2003), Lee SJ (2012), Fang G (1998), Fang G (1998), Wolthuis R (2008), Ban KH (2007), Ge S (2009), Tipton AR (2011), Westhorpe FG (2011), Uzunova K (2012), Kwan PS (2013), Sedgwick GG (2012), Eytan E (2013), Hyun SY (2013), Lim HJ (2013), Choi BH (2014), Fogeron ML (2013), Sackton KL (2014), Shoji S (2014), Han JS (2014), Lara-Gonzalez P (2011), Hein JB (2014), Vodermaier HC (2003), Yen AH (2010), Voets E (2015), Boekhout M (2015), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016), Craney A (2016), Listovsky T (2013), Qiao R (2016), Qiao R (2016), Qiao R (2016), Qiao R (2016), Qiao R (2016), Hein JB (2016)	54
ANAPC2	0	ANAPC7	2	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Gmachl M (2000), Vodermaier HC (2003)	3
OXSR1	2	APP	1	pull down	Olah J (2011)	1
DAXX	5	CUL3	17	affinity chromatography technology, affinity chromatography technology	Kwon JE (2006), Kwon JE (2006)	2
BUB1B	0	TUBB	3	biochemical, genetic interference	Izumi H (2009), Horlbeck MA (2018)	2
TRIP13	0	CDC20	1	pull down, pull down	Miniowitz-Shemtov S (2015), Miniowitz-Shemtov S (2015)	2
RNF2	1	MAD2L1	0	affinity chromatography technology	Cao Q (2014)	1
ZW10	2	MAD1L1	2	imaging technique	Kops GJ (2005)	1
MAD2L1	0	IPO7	3	affinity chromatography technology	Hein MY (2015)	1
CDC26	0	CDC16	2	pull down, x-ray crystallography, two hybrid, two hybrid, biochemical, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology	Wang J (2009), Wang J (2009), Wang J (2011), Rolland T (2014), Wan C (2015), Yu H (2011), Hein MY (2015), Masuda K (2015), Masuda K (2015), Masuda K (2015), Huttlin EL (2017)	11
ANAPC4	0	NUP98	5	affinity chromatography technology	Salsi V (2016)	1
ANAPC4	0	CDC26	0	biochemical, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang Z (2012), Chang L (2014), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Masuda K (2015)	6
CDC27	2	ANAPC2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kraft C (2003), Lara-Gonzalez P (2011), Dube P (2005), Dube P (2005), Holzmann J (2011), Lee SJ (2012), Hayes MJ (2006), Havugimana PC (2012), Gmachl M (2000), Cotto-Rios XM (2011), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Gmachl M (2000), Kelly A (2014), Craney A (2016), Qiao R (2016)	17
MAD2L1	0	BCL7C	0	affinity chromatography technology	Hein MY (2015)	1
CDC16	2	ANAPC7	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Havugimana PC (2012), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	5
MAD2L1	0	TSC22D4	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	4
ANAPC4	0	CCNA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Izawa D (2011), Di Fiore B (2015), Voets E (2015)	3
BUB1	3	NSL1	3	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Hutchins JR (2010), Kiyomitsu T (2010), Kiyomitsu T (2010), Kiyomitsu T (2011)	4
ANAPC4	0	BUB3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mansfeld J (2011), Sedgwick GG (2012), Hein JB (2014), Tipton AR (2013), Izawa D (2012), Salsi V (2016)	6
MAD2L1	0	TRAP1	0	imaging technique, affinity chromatography technology	Sisinni L (2017), Sisinni L (2017)	2
MAD2L1	0	RPS3A	1	affinity chromatography technology	Hein MY (2015)	1
CDC27	2	ANAPC1	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Sumara I (2000), Lara-Gonzalez P (2011), Tran K (2008), Dube P (2005), Holzmann J (2011), Havugimana PC (2012), Vodermaier HC (2003), Tran K (2010), Wan C (2015), Qiao R (2016), Qiao R (2016)	12
BUB1	3	BUB1B	0	affinity chromatography technology, imaging technique, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Jablonski SA (1998), DArcy S (2010), So J (2015), Huttlin EL (2015), Vleugel M (2015), Huttlin EL (2017)	7
MAD2L1	0	PSMD8	1	affinity chromatography technology, affinity chromatography technology	Sedgwick GG (2016), Sedgwick GG (2016)	2
EGLN3	0	KEAP1	0	affinity chromatography technology	Rodriguez J (2016)	1
PPM1E	4	MAD2L1	0	affinity chromatography technology	St-Denis N (2016)	1
CUL3	17	KLHL13	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maerki S (2009), Sumara I (2007), Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Maerki S (2009)	7
CDC20	1	ANAPC2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Stewart S (2005), Jia L (2011), Zhang Y (2001), Fogeron ML (2013), Lee SB (2015), Kelly A (2014), Craney A (2016), Qiao R (2016), Qiao R (2016)	9
EGLN3	0	DYNLL1	0	affinity chromatography technology	Rodriguez J (2016)	1
HIST1H3A	3	DAXX	5	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	TRIP13	0	affinity chromatography technology	Rodriguez J (2016)	1
BUB1B	0	MAD2L1BP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miniowitz-Shemtov S (2012), Westhorpe FG (2011), Westhorpe FG (2011)	3
CUL3	17	CAD	10	affinity chromatography technology	Bennett EJ (2010)	1
CUEDC2	0	CDC27	2	affinity chromatography technology, affinity chromatography technology	Gao YF (2011), Zhang WN (2013)	2
RNF2	1	RPS3A	1	affinity chromatography technology	Cao Q (2014)	1
BUB1	3	MAD2L1	0	unspecified method, affinity chromatography technology	Di Fiore B (2015), Theng SS (2014)	2
CUL3	17	AAR2	2	affinity chromatography technology	Bennett EJ (2010)	1
CDC20	1	BUB1B	0	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Fang G (2002), Fang G (2002), Wu H (2000), Wu H (2000), Wu H (2000), Kallio MJ (2002), Sudakin V (2001), Sudakin V (2001), Skoufias DA (2001), Nilsson J (2008), Ho CY (2010), Ho CY (2010), Garnett MJ (2009), Hutchins JR (2010), Di Fiore B (2010), Di Fiore B (2010), Mansfeld J (2011), Jia L (2011), Braunstein I (2007), Eytan E (2008), Eytan E (2008), Ma HT (2011), Miniowitz-Shemtov S (2012), Tang Z (2001), Tang Z (2001), Tang Z (2001), Tang Z (2001), Bolanos-Garcia VM (2011), Ge S (2009), Liu L (2007), Westhorpe FG (2011), Westhorpe FG (2011), Kwan PS (2013), Tian W (2012), Tian W (2012), Tian W (2012), Santaguida S (2011), Hyun SY (2013), Han JS (2013), Rodriguez-Bravo V (2014), Fogeron ML (2013), Wang K (2014), Han JS (2014), Izawa D (2014), Hein JB (2014), So J (2015), Scialpi F (2015), Scialpi F (2015), Diaz-Martinez LA (2015), Diaz-Martinez LA (2015), Di Fiore B (2015), Di Fiore B (2015), Di Fiore B (2015), Di Fiore B (2015), Voets E (2015), Chen TC (2014), Lischetti T (2014), Lischetti T (2014), Lischetti T (2014), Tipton AR (2013), Boekhout M (2015), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016), Sedgwick GG (2016), Qiao R (2016), Huttlin EL (2017), Izawa D (2012), Jia L (2016), Jia L (2016), Hein JB (2016), Kaisari S (2017)	73
ANAPC1	1	CDC26	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CDC20	1	CDC16	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kallio MJ (2002), Kallio M (1998), Nilsson J (2008), Hutchins JR (2010), Fogeron ML (2013), Hein JB (2014), Hein MY (2015), Kelly A (2014), Craney A (2016), Listovsky T (2013), Qiao R (2016), Izawa D (2012)	12
EGLN3	0	BSG	1	affinity chromatography technology	Rodriguez J (2016)	1
CDC27	2	MAD1L1	2	affinity chromatography technology	Westhorpe FG (2011)	1
EGLN3	0	TUBB	3	affinity chromatography technology	Rodriguez J (2016)	1
MAD2L1	0	TUBB	3	affinity chromatography technology	Hein MY (2015)	1
HSF1	1	DAXX	5	two hybrid, affinity chromatography technology, pull down	Boellmann F (2004), Boellmann F (2004), Zhang J (2010)	3
MAD2L1	0	SDCBP	0	two hybrid	Rolland T (2014)	1
ANAPC2	0	ANAPC4	0	biochemical, biochemical, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Gmachl M (2000), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Boekhout M (2015)	11
PYM1	3	APP	1	pull down	Olah J (2011)	1
CDC20	1	ANAPC4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Mansfeld J (2011), Mansfeld J (2011), Izawa D (2011), Ma HT (2011), Wolthuis R (2008), Sedgwick GG (2012), Zhang Z (2012), Chang L (2014), Fogeron ML (2013), Hein JB (2014), Hein JB (2014), Voets E (2015), Voets E (2015), Tipton AR (2013), Boekhout M (2015), Kelly A (2014), Craney A (2016), Craney A (2016), Sedgwick GG (2016), Qiao R (2016), Izawa D (2012), Izawa D (2012), Izawa D (2012), Izawa D (2012), Salsi V (2016)	25
ADAM15	2	TRIP13	0	two hybrid	Rual JF (2005)	1
NUP98	5	MAD2L1	0	affinity chromatography technology	Salsi V (2016)	1
MAD2L1	0	FAT1	12	affinity chromatography technology	Theng SS (2014)	1
DSTYK	1	MAD2L1	0	affinity chromatography technology	Ewing RM (2007)	1
BAG5	0	MAD2L1	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
BSG	1	DSTYK	1	affinity chromatography technology	Huttlin EL (2017)	1
MAD2L1	0	REV3L	8	pull down	Murakumo Y (2000)	1
DAXX	5	MACF1	12	affinity chromatography technology	Hein MY (2015)	1
CDC20	1	HSF1	1	affinity chromatography technology, pull down, affinity chromatography technology	Lee YJ (2008), Lee YJ (2008), Lee YJ (2008)	3
ANAPC4	0	NEK2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sedgwick GG (2013), Sedgwick GG (2013), Voets E (2015), Boekhout M (2015), Boekhout M (2015)	5
BUB1B	0	NSL1	3	imaging technique	Kiyomitsu T (2010)	1
CCNA2	1	CDC20	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mateo F (2009), Di Fiore B (2010), Di Fiore B (2010), Di Fiore B (2010), Wolthuis R (2008), Wolthuis R (2008), Ge S (2009), Townsend K (2009), Di Fiore B (2010), Mateo F (2009), Mateo F (2009), Huttlin EL (2015), Di Fiore B (2015), Di Fiore B (2015), Di Fiore B (2015), Di Fiore B (2015), Hein MY (2015), Voets E (2015), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016), Huttlin EL (2017), Izawa D (2012), Hein JB (2016)	25
CDC20	1	NUP98	5	affinity chromatography technology	Salsi V (2016)	1
CUL3	17	TRAP1	0	affinity chromatography technology	Bennett EJ (2010)	1
KEAP1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang XJ (2008), Rachakonda G (2008), Rachakonda G (2008), Nioi P (2007), Chew EH (2007), Chew EH (2007), Zhang DD (2005), Furukawa M (2005), Furukawa M (2005), Furukawa M (2005), Zhang DD (2004), Cullinan SB (2004), Kobayashi A (2004), Kobayashi A (2004), McMahon M (2006), Ichikawa T (2009), Lee DF (2009), Wong DP (2010), Wong DP (2010), Lau A (2010), Lau A (2010), Hur W (2010), Bennett EJ (2010), Yao JW (2012), Li Y (2012), Choo YY (2012), Kansanen E (2011), Kansanen E (2011), Niture SK (2013), Hast BE (2014), Cleasby A (2014), Kaspar JW (2012), Kaspar JW (2012), Su C (2015), Su C (2015), Huo L (2015), Dubiel D (2015), Lo SC (2006), Wu G (2017), Villeneuve NF (2013), Villeneuve NF (2013), Villeneuve NF (2013), Dong T (2016)	43
MAD2L1	0	MACF1	12	affinity chromatography technology	Hein MY (2015)	1
BUB1B	0	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chan GK (1999), Hutchins JR (2010), Lara-Gonzalez P (2011), Mansfeld J (2011), Tipton AR (2011), Westhorpe FG (2011), Uzunova K (2012), Eytan E (2013), Wang K (2014), Han JS (2014), Han JS (2014), Lara-Gonzalez P (2011), So J (2015), Boekhout M (2015), Kelly A (2014), Craney A (2016), Qiao R (2016)	17
CUEDC2	0	CDC20	1	affinity chromatography technology, affinity chromatography technology	Gao YF (2011), Gao YF (2011)	2
ANAPC1	1	ANAPC2	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Sumara I (2000), Havugimana PC (2012), Gmachl M (2000), Vodermaier HC (2003)	4
CDC20	1	BUB1	3	affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, imaging technique	Fogeron ML (2013), Huttlin EL (2015), Di Fiore B (2015), Hein MY (2015), Kelly A (2014), Craney A (2016), Huttlin EL (2017), Jia L (2016), Jia L (2016), Jia L (2016)	10
MAD2L2	0	MAD2L1	0	pull down, pull down	Murakumo Y (2000), Murakumo Y (2000)	2
UBD	0	MAD2L1	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Liu YC (1999), Liu YC (1999), Liu YC (1999), Ren J (2006), Ren J (2006), Theng SS (2014), Theng SS (2014), Theng SS (2014)	8
UBE2C	1	MAD2L1	0	biochemical	Reddy SK (2007)	1
EGLN3	0	MAD2L1	0	affinity chromatography technology	Rodriguez J (2016)	1
CDC20	1	NEK2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Sedgwick GG (2012), Boekhout M (2015), Boekhout M (2015), Kelly A (2014)	4
TOR1AIP1	2	MAD2L1BP	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	TUBB	3	affinity chromatography technology	Bennett EJ (2010)	1
ANAPC4	0	MAD2L1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mansfeld J (2011), Ma HT (2011), Sedgwick GG (2012), Voets E (2015), Tipton AR (2013), Boekhout M (2015), Sedgwick GG (2016), Izawa D (2012), Salsi V (2016)	9
ANAPC2	0	CDC26	0	affinity chromatography technology, affinity chromatography technology	Gmachl M (2000), Vodermaier HC (2003)	2
EGLN3	0	ANAPC1	1	affinity chromatography technology	Rodriguez J (2016)	1
MAD2L1	0	FLG2	2	affinity chromatography technology	Hein MY (2015)	1
CDC27	2	MAD2L1BP	0	affinity chromatography technology	Westhorpe FG (2011)	1
BUB1B	0	MAD2L1	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sudakin V (2001), Sudakin V (2001), Ho CY (2010), Bolanos-Garcia VM (2011), Tipton AR (2011), Tipton AR (2011), Tipton AR (2011), Westhorpe FG (2011), Eytan E (2013), Han JS (2013), Wang K (2014), Wang K (2014), So J (2015), Di Fiore B (2015), Di Fiore B (2015), Di Fiore B (2015), Lischetti T (2014), Tipton AR (2013), Tipton AR (2013), Boekhout M (2015), Sedgwick GG (2016), Sedgwick GG (2016), Sedgwick GG (2016)	23
ANAPC1	1	ANAPC7	2	biochemical, biochemical, biochemical	Sumara I (2000), Havugimana PC (2012), Wan C (2015)	3
CDC20	1	CUL3	17	affinity chromatography technology	Wu F (2017)	1
MAD2L1	0	TRMT10A	0	affinity chromatography technology	Hein MY (2015)	1
CHFR	5	CDC20	1	affinity chromatography technology	Oh YM (2009)	1
BUB1B	0	ANAPC1	1	affinity chromatography technology, affinity chromatography technology	So J (2015), Lischetti T (2014)	2
ANAPC4	0	CDC16	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mansfeld J (2011), Ma HT (2011), Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Hein MY (2015), Masuda K (2015), Boekhout M (2015), Huttlin EL (2017)	14
MAD1L1	2	TRIP13	0	affinity chromatography technology	Wang K (2014)	1
EGLN3	0	CDC20	1	affinity chromatography technology	Rodriguez J (2016)	1
CUL3	17	MACF1	12	affinity chromatography technology	Bennett EJ (2010)	1
MAD1L1	2	CDC20	1	affinity chromatography technology, affinity chromatography technology	Rodriguez-Bravo V (2014), Kelly A (2014)	2
BUB1	3	HSF1	1	affinity chromatography technology	Boldt K (2016)	1
BSG	1	ZW10	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL3	17	WDR35	3	affinity chromatography technology	Wimuttisuk W (2014)	1
MAD2L1	0	MAD1L1	2	two hybrid, pull down, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Sironi L (2001), Murakumo Y (2000), Chen J (2001), Sironi L (2001), Sironi L (2001), Tipton AR (2011), De Antoni A (2005), De Antoni A (2005), Fava LL (2011), Fava LL (2011), Wang J (2011), Rodriguez-Bravo V (2014), Wang K (2014), Hein MY (2015), Sedgwick GG (2016), Sedgwick GG (2016), Yang M (2008), Kim S (2010), Kim S (2010), Theng SS (2014)	21
TP73	2	MAD2L1	0	affinity chromatography technology	Katayama H (2012)	1
APC	5	MACF1	12	two hybrid	Bandyopadhyay S (2010)	1
CUL3	17	BAG5	0	affinity chromatography technology	Bennett EJ (2010)	1
MAD2L1	0	BUB3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tipton AR (2011), Tipton AR (2013), Sedgwick GG (2016), Sedgwick GG (2016)	4
DAXX	5	CDC20	1	affinity chromatography technology	Kwan PS (2013)	1
NEK2	2	MAD2L1	0	affinity chromatography technology	Boekhout M (2015)	1
CDC26	0	MAD2L1	0	biochemical	Masuda K (2015)	1
MAD2L1	0	RABAC1	0	two hybrid	Wang J (2011)	1
EGLN3	0	ANAPC7	2	affinity chromatography technology	Rodriguez J (2016)	1
CCNA2	1	CDC27	2	affinity chromatography technology	Mateo F (2009)	1
HSF1	1	MAD2L1	0	affinity chromatography technology	Lee YJ (2008)	1
ANAPC2	0	CDC16	2	biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Gmachl M (2000), Vodermaier HC (2003), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	6
CUL3	17	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
BAG5	0	MAD1L1	2	biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	6
MAD2L1	0	CAD	10	affinity chromatography technology	Hein MY (2015)	1
CDC20	1	CDC26	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Masuda K (2015), Kelly A (2014), Craney A (2016)	4
TP73	2	CDC20	1	affinity chromatography technology, affinity chromatography technology	Katayama H (2012), Katayama H (2012)	2
AAR2	2	MAD2L1	0	affinity chromatography technology	Cloutier P (2017)	1
ADAM15	2	MAD2L1	0	affinity chromatography technology	Poghosyan Z (2002)	1
BUB1B	0	CCNA2	1	pull down	Di Fiore B (2015)	1
MAD2L1	0	CDC16	2	affinity chromatography technology	Li Y (1997)	1
MAD2L1	0	PPP1R9A	4	affinity chromatography technology	Hein MY (2015)	1
MAD2L1	0	CHMP2B	0	affinity chromatography technology	Hein MY (2015)	1
CDC27	2	CDC16	2	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Ollendorff V (1997), Kallio M (1998), Gmachl M (2000), Kraft C (2003), Li Y (1997), Lara-Gonzalez P (2011), Binne UK (2007), van Zon W (2010), Dube P (2005), Holzmann J (2011), Hayes MJ (2006), Tugendreich S (1995), Havugimana PC (2012), Vodermaier HC (2003), Wan C (2015), Hein MY (2015), Kelly A (2014), Listovsky T (2013), Qiao R (2016), Huttlin EL (2017), Boldt K (2016)	22
KLHL13	0	MAD2L1	0	affinity chromatography technology	Sowa ME (2009)	1
EGLN3	0	TOR1AIP1	2	affinity chromatography technology	Rodriguez J (2016)	1
CDC20	1	BUB3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mansfeld J (2011), Hyun SY (2013), Fogeron ML (2013), Hein JB (2014), Scialpi F (2015), Lischetti T (2014), Kelly A (2014), Craney A (2016), Qiao R (2016), Huttlin EL (2017)	10
PYM1	3	MAD2L1BP	0	affinity chromatography technology	Huttlin EL (2017)	1
CDC27	2	ANAPC4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Gmachl M (2000), Kraft C (2003), Mansfeld J (2011), Lara-Gonzalez P (2011), Mansfeld J (2011), Izawa D (2011), Ma HT (2011), Ma HT (2011), Ma HT (2011), Dube P (2005), Holzmann J (2011), Wolthuis R (2008), Havugimana PC (2012), Uzunova K (2012), Song MS (2011), Zhang Z (2012), Chang L (2014), Hein JB (2014), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Tran K (2010), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Hein MY (2015), Voets E (2015), Masuda K (2015), Boekhout M (2015), Craney A (2016), Qiao R (2016), Izawa D (2012), Hein JB (2016)	34
MAD2L1BP	0	CDC20	1	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miniowitz-Shemtov S (2012), Westhorpe FG (2011), Westhorpe FG (2011), Lischetti T (2014), Kelly A (2014), Huttlin EL (2017), Izawa D (2012), Jia L (2016)	8
CDC27	2	ANAPC7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Gmachl M (2000), Kraft C (2003), Lara-Gonzalez P (2011), Tran K (2008), Dube P (2005), Holzmann J (2011), Havugimana PC (2012), Sedgwick GG (2012), Song MS (2011), Vodermaier HC (2003), Tran K (2010), Yamaguchi M (2015), Yamaguchi M (2015), Wan C (2015), Kelly A (2014), Craney A (2016), Qiao R (2016), Boldt K (2016)	19
EGLN3	0	APC	5	affinity chromatography technology	Rodriguez J (2016)	1
CUL3	17	TRIP13	0	affinity chromatography technology	Bennett EJ (2010)	1
MAD2L1	0	MAD2L1BP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Habu T (2002), Westhorpe FG (2011), Fava LL (2011), Mapelli M (2006), Rolland T (2014), Hein MY (2015)	6
ANAPC1	1	ANAPC4	0	biochemical, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Sumara I (2000), Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Hein JB (2014), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015)	9
CDC27	2	BUB3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lara-Gonzalez P (2011), Mansfeld J (2011), Qiao R (2016), Huttlin EL (2017)	4
MAD2L2	0	REV3L	8	pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down	Murakumo Y (2000), Murakumo Y (2000), Murakumo Y (2001), Murakumo Y (2001), Murakumo Y (2001), Hashimoto K (2012), Sharma S (2012), Sharma S (2012), Hara K (2010), Hara K (2010), Hara K (2010), Hara K (2009), Kikuchi S (2012)	13
CDC27	2	NEK2	2	affinity chromatography technology, affinity chromatography technology	Hayes MJ (2006), Boekhout M (2015)	2
EGLN3	0	CDC27	2	affinity chromatography technology	Rodriguez J (2016)	1
MAD2L1	0	ANAPC7	2	affinity chromatography technology, affinity chromatography technology	Sedgwick GG (2016), Sedgwick GG (2016)	2
PYM1	3	RPS3A	1	biochemical	Kristensen AR (2012)	1
ADAM10	2	MAD2L1	0	affinity chromatography technology	Poghosyan Z (2002)	1
BUB1B	0	ANAPC7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chan GK (1999), Hutchins JR (2010), Sedgwick GG (2012), Sedgwick GG (2016)	4
CDC16	2	NEK2	2	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	CAD	10	affinity chromatography technology	Rodriguez J (2016)	1
UBE2C	1	BUB1B	0	biochemical	Reddy SK (2007)	1
ANAPC4	0	PSMD8	1	affinity chromatography technology	Sedgwick GG (2016)	1
BUB1B	0	APC	5	enzymatic study	Kaplan KB (2001)	1
MAD2L1	0	SLC39A7	0	affinity chromatography technology	Hein MY (2015)	1
BUB1	3	APC	5	affinity chromatography technology, enzymatic study, imaging technique	Kaplan KB (2001), Kaplan KB (2001), Chen TC (2014)	3
ZW10	2	MAD2L1	0	imaging technique	Kops GJ (2005)	1
EGLN3	0	AAR2	2	affinity chromatography technology	Rodriguez J (2016)	1
CDC20	1	MAD2L1	0	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, unspecified method, pull down, affinity chromatography technology	Zhang Y (2001), Sihn CR (2003), Luo X (2000), Sironi L (2001), DAngiolella V (2003), Kallio MJ (2002), Wassmann K (1998), Kallio M (1998), Fang G (1998), Fang G (1998), Skoufias DA (2001), Nilsson J (2008), Privette LM (2008), Stegmeier F (2007), Ho CY (2010), Ho CY (2010), Mansfeld J (2011), Gao YF (2011), Braunstein I (2007), Visconti R (2010), Ma HT (2011), Townsend K (2009), Lee YJ (2008), DAngiolella V (2003), Tang Z (2001), Tang Z (2001), Sironi L (2001), Sironi L (2001), Ge S (2009), Mapelli M (2007), Tipton AR (2011), Mondal G (2006), Mondal G (2006), Westhorpe FG (2011), De Antoni A (2005), De Antoni A (2005), Kwan PS (2013), Katayama H (2012), Fava LL (2011), Santaguida S (2011), Mapelli M (2006), Eytan E (2013), Eytan E (2013), Hyun SY (2013), Han JS (2013), Rodriguez-Bravo V (2014), Fogeron ML (2013), Wang K (2014), Eytan E (2014), Hein JB (2014), Yen AH (2010), Yen AH (2010), Di Fiore B (2015), Hein MY (2015), Voets E (2015), Lischetti T (2014), Tipton AR (2013), Boekhout M (2015), Kelly A (2014), Craney A (2016), Sedgwick GG (2016), Sedgwick GG (2016), Izawa D (2012), Izawa D (2012), Jia L (2016), Jia L (2016), Kaisari S (2017), Yang M (2008), Kim S (2010), Kim S (2010)	70
CCNA2	1	MAD2L1	0	unspecified method	Di Fiore B (2015)	1
MAD2L1	0	MAD2L1	0	x-ray crystallography, pull down, pull down, pull down, x-ray crystallography, pull down, x-ray crystallography	Mapelli M (2007), Mapelli M (2007), De Antoni A (2005), Mapelli M (2006), Mapelli M (2006), Yang M (2008), Yang M (2008)	7
BUB1	3	BUB3	0	affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qi W (2006), DArcy S (2010), Wang J (2011), Rolland T (2014), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Vleugel M (2015), Huttlin EL (2017)	9
CUL3	17	MAD2L1	0	affinity chromatography technology	Bennett EJ (2010)	1
MAD2L1BP	0	MAD1L1	2	affinity chromatography technology	Westhorpe FG (2011)	1
CSF2RB	6	MAD2L1	0	affinity chromatography technology, pull down	Takeda M (2001), Takeda M (2001)	2
CUL3	17	BUB3	0	affinity chromatography technology	Bennett EJ (2010)	1
RNF2	1	APP	1	affinity chromatography technology	Cao Q (2014)	1
TP73	2	DAXX	5	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Kim EJ (2003), Kim EJ (2003), Kim EJ (2003), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004)	6
APP	1	KEAP1	0	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	BUB3	0	affinity chromatography technology	Rodriguez J (2016)	1
MAD2L1	0	ANAPC1	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Sedgwick GG (2016)	2
RNF2	1	KIF20A	3	affinity chromatography technology	Cao Q (2014)	1
RNF2	1	IPO7	3	affinity chromatography technology	Cao Q (2014)	1
MAD2L2	0	TRIP13	0	two hybrid	Venkatesan K (2009)	1
OXSR1	2	MAD2L1	0	affinity chromatography technology	Varjosalo M (2013)	1
CUL3	17	RPS3A	1	affinity chromatography technology	Bennett EJ (2010)	1
CDC20	1	ANAPC7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nilsson J (2008), Townsend K (2009), Townsend K (2009), Townsend K (2009), Sedgwick GG (2012), Fogeron ML (2013), Hein JB (2014), Vodermaier HC (2003), Kelly A (2014), Craney A (2016), Craney A (2016), Qiao R (2016), Hein JB (2016)	13
BUB1B	0	BUB3	0	affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sudakin V (2001), Sudakin V (2001), Taylor SS (1998), Cayrol C (2002), Jia L (2011), Tang Z (2001), Tang Z (2001), Bolanos-Garcia VM (2011), Westhorpe FG (2011), DArcy S (2010), DArcy S (2010), Han JS (2013), Wang J (2011), Wang K (2014), Han JS (2014), Han JS (2014), So J (2015), Huttlin EL (2015), Scialpi F (2015), Diaz-Martinez LA (2015), Di Fiore B (2015), Hein MY (2015), Lischetti T (2014), Tipton AR (2013), Huttlin EL (2017)	25
MAD2L1	0	TOR1AIP1	2	affinity chromatography technology	Hein MY (2015)	1
CDC27	2	NUP98	5	affinity chromatography technology	Salsi V (2016)	1
ANAPC2	0	UBE2C	1	pull down, biochemical, pull down, x-ray crystallography, pull down	Tang Z (2001), Reddy SK (2007), Tang Z (2001), Brown NG (2015), Brown NG (2015)	5
TSC22D4	1	MAD2L1BP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAD2L1	0	RAF1	3	affinity chromatography technology	Hein MY (2015)	1
ANAPC4	0	ANAPC7	2	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Mansfeld J (2011), Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Sedgwick GG (2013), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Sedgwick GG (2016)	10
BUB1B	0	ANAPC4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Mansfeld J (2011), Izawa D (2011), Sedgwick GG (2012), Hein JB (2014), Di Fiore B (2015), Voets E (2015), Tipton AR (2013), Boekhout M (2015), Boekhout M (2015), Sedgwick GG (2016), Izawa D (2012), Salsi V (2016)	13
MAD2L2	0	CDC20	1	pull down, affinity chromatography technology	Chen J (2001), Chen J (2001)	2
EGLN3	0	SLC39A7	0	affinity chromatography technology	Rodriguez J (2016)	1
DAXX	5	BUB1B	0	affinity chromatography technology	Kwan PS (2013)	1
MAD2L1	0	NSL1	3	imaging technique	Kiyomitsu T (2010)	1
CDC26	0	ANAPC7	2	biochemical	Wan C (2015)	1
MAD2L1	0	NUDT5	0	affinity chromatography technology	Hein MY (2015)	1
ANAPC1	1	CDC16	2	biochemical, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Sumara I (2000), Hutchins JR (2010), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	6
KEAP1	0	TSC22D4	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Sowa ME (2009), Hast BE (2013), Wang J (2011), Huttlin EL (2015)	4
TRIP13	0	MAD2L1BP	0	two hybrid, affinity chromatography technology, two hybrid, two hybrid, pull down	Rual JF (2005), Rual JF (2005), Stelzl U (2005), Venkatesan K (2009), Miniowitz-Shemtov S (2015)	5
APC	5	MAD1L1	2	affinity chromatography technology	Hein MY (2015)	1
MAD2L1	0	BSG	1	affinity chromatography technology	Hein MY (2015)	1
TRAP1	0	APP	1	pull down	Olah J (2011)	1
TUBB	3	APP	1	pull down	Olah J (2011)	1
DYNLL1	0	RAF1	3	affinity chromatography technology	Boldt K (2016)	1
CDC16	2	BUB1	3	affinity chromatography technology	Huttlin EL (2017)	1
MAD2L1	0	ESR2	1	two hybrid, pull down	Poelzl G (2000), Poelzl G (2000)	2
BUB3	0	APC	5	affinity chromatography technology	Kaplan KB (2001)	1
MAD2L1	0	APC	5	affinity chromatography technology	Fang G (1998)	1
MAD2L1	0	KIF20A	3	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Sedgwick GG (2016)	2
CDC27	2	MAD2L2	0	affinity chromatography technology	Uzunova K (2012)	1
RAF1	3	KEAP1	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CUEDC2	0	MAD2L1	0	affinity chromatography technology	Gao YF (2011)	1
MAD2L1	0	ABCF2	3	affinity chromatography technology	Hein MY (2015)	1
MAD2L1	0	HIST1H3A	3	pull down	Schibler A (2016)	1
MAD2L1	0	WDR35	3	affinity chromatography technology	Hein MY (2015)	1
UBE2C	1	CDC20	1	biochemical, pull down	Reddy SK (2007), Garnett MJ (2009)	2
KEAP1	0	MAD2L1	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Sowa ME (2009), Hast BE (2013), Rolland T (2014)	3
CUL3	17	BSG	1	affinity chromatography technology	Bennett EJ (2010)	1
CDC27	2	MAD2L1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wassmann K (1998), Kallio M (1998), Li Y (1997), Li Y (1997), Lara-Gonzalez P (2011), Mansfeld J (2011), Visconti R (2010), Ma HT (2011), Sironi L (2001), Tipton AR (2011), Tipton AR (2011), Westhorpe FG (2011), Eytan E (2013), Lara-Gonzalez P (2011), Yen AH (2010), Hein MY (2015), Craney A (2016), Sedgwick GG (2016)	18
MAD2L2	0	ADAM15	2	two hybrid	Nelson KK (1999)	1
CDC20	1	TUBB	3	affinity chromatography technology	Fogeron ML (2013)	1
CCNA2	1	TP73	2	enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Gaiddon C (2003), Gaiddon C (2003), Gaiddon C (2003), Gaiddon C (2003)	4
EGLN3	0	RAF1	3	affinity chromatography technology	Rodriguez J (2016)	1
APC	5	NUP98	5	two hybrid	Bandyopadhyay S (2010)	1
BUB1B	0	ANAPC2	0	affinity chromatography technology	So J (2015)	1