PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
VDR	2	CREBBP	29	imaging technique, pull down	Saramaeki A (2006), Jimenez-Lara AM (1999)	2
ATF3	0	ATF2	1	two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Ravasi T (2010), Reinke AW (2013), Reinke AW (2013)	3
EP300	36	FOXO3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li XN (2009), Li XN (2009), Mahmud DL (2002), Li X (2015)	4
SMAD2	5	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xi Q (2008), Xi Q (2008), Xi Q (2008), He W (2006)	4
HDAC1	4	STRAP	2	affinity chromatography technology	Jin L (2014)	1
FOXH1	1	SMAD3	1	affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology	Liu B (1999), Cui Q (2005), Cui Q (2005), Yoon SJ (2011), Cui Q (2005)	5
CSNK1D	3	SMAD4	9	affinity chromatography technology	Ding L (2009)	1
CDC25A	2	TRIB3	0	affinity chromatography technology	Sakai S (2010)	1
SMAD3	1	TSC22D4	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
MYC	2	SQSTM1	0	affinity chromatography technology	Koch HB (2007)	1
E2F4	0	RBL1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen CR (2002), Iavarone A (1999), Schmit F (2007), Moberg K (1996), Magae J (1996), Beijersbergen RL (1994), Ginsberg D (1994), Trimarchi JM (1998)	8
HDAC4	10	HNF4A	2	pull down	Torres-Padilla ME (2002)	1
NOTCH1	25	CBL	7	affinity chromatography technology, affinity chromatography technology	Jehn BM (2002), Platonova N (2015)	2
SMAD2	5	RUNX3	1	affinity chromatography technology	Hanai J (1999)	1
SMAD1	0	SKIL	3	affinity chromatography technology	Mizuide M (2003)	1
EP300	36	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qiu P (2006), Furumatsu T (2005), Itoh S (2000), Akiyoshi S (1999), Abecassis L (2004), Kaimori A (2010), Janknecht R (1998), Janknecht R (1998), Nishihara A (1999), Nishihara A (1999), Furumatsu T (2005), Ghosh AK (2004), Shen X (1998), Shen X (1998), Ghosh AK (2001), Postigo AA (2003), Postigo AA (2003), Yang WS (2005), Lim JY (2012), Lim JY (2012), Jinnin M (2007), Wang G (2005)	22
JUN	0	SMAD4	9	affinity chromatography technology	Li X (2015)	1
CDK2	0	USP7	14	affinity chromatography technology	Neganova I (2011)	1
SMAD4	9	HNF4A	2	pull down	Kardassis D (2000)	1
SMAD1	0	PIAS4	5	two hybrid, affinity chromatography technology, two hybrid	Long J (2003), Long J (2003), Colland F (2004)	3
NOTCH1	25	RUNX1	0	affinity chromatography technology	Yatim A (2012)	1
PIAS4	5	SMAD7	1	two hybrid, affinity chromatography technology, two hybrid	Imoto S (2003), Imoto S (2003), Colland F (2004)	3
SMAD7	1	CTNNB1	30	affinity chromatography technology, imaging technique, affinity chromatography technology	Edlund S (2005), Edlund S (2005), Tang Y (2008)	3
NEDD4	2	RBX1	2	affinity chromatography technology	Liu J (2014)	1
HIF1A	1	RUNX2	2	affinity chromatography technology, affinity chromatography technology, pull down	Lee SH (2012), Lee SH (2012), Lee SH (2012)	3
SP1	0	SMARCA4	19	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kadam S (2000), Liu H (2002), Liu H (2002), Ma Z (2004), Saladi SV (2010)	5
USP7	14	WWP2	7	two hybrid, affinity chromatography technology	Lim J (2006), Chaudhary N (2014)	2
WWP2	7	WWP1	3	affinity chromatography technology, affinity chromatography technology	Chaudhary N (2014), Chaudhary N (2014)	2
FOXM1	3	GSK3B	1	affinity chromatography technology	Chen Y (2016)	1
BRCA1	7	SMARCC2	9	biochemical, affinity chromatography technology	Bochar DA (2000), Ertych N (2016)	2
SMAD7	1	ERBIN	5	pull down	Warner DR (2003)	1
MYC	2	GSK3B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Gregory MA (2003), Gregory MA (2003), Arnold HK (2009), Zhou Z (2014)	4
EP300	36	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pao GM (2000), Pao GM (2000), Pao GM (2000), Pao GM (2000), Fan S (2002), Fan S (2002), Ma Y (2010), Subbaramaiah K (2011), Subbaramaiah K (2012)	9
ZFYVE9	5	ERBIN	5	two hybrid	Colland F (2004)	1
TP53	0	WWOX	3	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Chang NS (2001), Chang NS (2001), Chang NS (2005), Chang NS (2005), Chang NS (2005)	5
FHL2	0	SMAD3	1	pull down, affinity chromatography technology	Ding L (2009), Ding L (2009)	2
NR3C1	2	CREBBP	29	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Almloef T (1998), Almloef T (1998), Fryer CJ (1998), Govindan MV (2010), Govindan MV (2010), Govindan MV (2010), Carruthers CW (2015)	7
SMAD2	5	MYOCD	4	pull down	Qiu P (2005)	1
SMAD7	1	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mochizuki T (2004), Asano Y (2004), Koinuma D (2003), Kavsak P (2000), Hayashi H (1997), Hayashi H (1997), Datta PK (2000), Wicks SJ (2005), Lallemand F (2005), Seong HA (2007), Yan X (2011), Cai Y (2012), Cai Y (2012), Seo SR (2004), Zhu L (2012), Zhu L (2012), Nakao A (1997), Yan X (2009), Kamiya Y (2010), Suzuki C (2002), Hsu HY (2014)	21
SREBF2	5	SPTBN1	6	two hybrid	Bandyopadhyay S (2010)	1
BRCA1	7	AR	3	pull down, pull down, two hybrid	Park JJ (2000), Yeh S (2000), Yeh S (2000)	3
ERBIN	5	CBL	7	affinity chromatography technology	Yao S (2015)	1
PIN1	0	SMAD3	1	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, two hybrid	Nakano A (2009), Nakano A (2009), Nakano A (2009), Aragon E (2011), Matsuura I (2010), Matsuura I (2010), Wang J (2011)	7
SP1	0	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, two hybrid, imaging technique, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Gao J (2009), Goto T (2006), Hung JJ (2006), Hung JJ (2006), Hung JJ (2006), Choi HS (2002), Walker GE (2001), Kundu TK (2000), Suzuki T (2000), Suzuki T (2000), Wang X (2008), Wang X (2008), Wang X (2008), Chen YJ (2007), Chen YJ (2007), Azahri NS (2012), Azahri NS (2012), Li J (2013), Li J (2013), Wang SA (2014)	20
NR3C1	2	JUN	0	pull down	Lerner L (2003)	1
SMAD2	5	DAB2	1	pull down, affinity chromatography technology	Hocevar BA (2001), Hocevar BA (2001)	2
EP300	36	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Kim RH (2000), Luciakova K (2008), Janknecht R (1998), Chung CL (2011), Shen X (1998), Dornan D (2003), Yang Y (2015)	7
FOXO3	1	USP7	14	affinity chromatography technology, affinity chromatography technology	van der Horst A (2006), Bucur O (2014)	2
FHL1	1	SMAD3	1	pull down, affinity chromatography technology, affinity chromatography technology	Ding L (2009), Ding L (2009), Ding L (2009)	3
TGIF1	1	JUN	0	affinity chromatography technology, pull down	Pessah M (2001), Pessah M (2001)	2
STRAP	2	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Datta PK (1998), Datta PK (2000)	2
RUNX3	1	EP300	36	affinity chromatography technology, affinity chromatography technology	Jin YH (2004), Jin YH (2004)	2
CDK2	0	RBL1	1	enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Leng X (2002), Zhao J (1998), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	8
SMAD9	0	KAT2B	2	affinity chromatography technology	Kahata K (2004)	1
CEBPD	0	PIAS4	5	pull down	Zhou S (2008)	1
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
SMURF2	3	DAB2	1	two hybrid	Colland F (2004)	1
PIAS4	5	SMAD3	1	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Imoto S (2003), Long J (2003), Long J (2003), Long J (2003), Long J (2003), Long J (2003)	6
NOTCH1	25	USP15	4	affinity chromatography technology	Yatim A (2012)	1
ATF2	1	HDAC4	10	affinity chromatography technology, affinity chromatography technology	Rong Y (2010), Rong Y (2010)	2
EPAS1	6	TRIM33	4	affinity chromatography technology	Steunou AL (2012)	1
SMAD2	5	SH2D2A	2	pull down, affinity chromatography technology	Richard KC (2006), Richard KC (2006)	2
AKT1	1	AR	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin HK (2001), Lin HK (2001), Deep G (2008), Deep G (2008), Steely AM (2017)	5
SP1	0	HNF4A	2	affinity chromatography technology, affinity chromatography technology, pull down	Wang HY (2009), Wang HY (2009), Magenheim J (2005)	3
RNF111	2	SMAD7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Koinuma D (2003), Koinuma D (2003), Erker Y (2013), Elkouris M (2016)	4
OTUB1	0	SMAD4	9	affinity chromatography technology, pull down	Herhaus L (2013), Herhaus L (2013)	2
BRCA1	7	MYC	2	affinity chromatography technology, imaging technique, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Li H (2002), Xiong J (2003), Xiong J (2003), Wang Q (1998), Wang Q (1998), Wang Q (1998), Harte MT (2010), Harte MT (2010), Xiong J (2003), Xiong J (2003), Zhou C (2003)	11
HDAC1	4	RUNX1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Reed-Inderbitzin E (2006), Guo H (2011), Guo H (2011), Guo H (2011), Shia WJ (2012), Leong WY (2016)	6
FHL2	0	SMAD4	9	pull down, affinity chromatography technology	Ding L (2009), Ding L (2009)	2
RNF111	2	FHL2	0	affinity chromatography technology, affinity chromatography technology	Xia T (2013), Xia T (2013)	2
CREBBP	29	CITED2	0	affinity chromatography technology	Bhattacharya S (1999)	1
LEF1	3	SMAD3	1	pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology	Labbe E (2000), Labbe E (2000), Cui Q (2005), Cui Q (2005), Cui Q (2005)	5
TGFBR1	2	OTUB1	0	enzymatic study, affinity chromatography technology	Herhaus L (2015), Herhaus L (2015)	2
ERBIN	5	FOXO3	1	unspecified method	Boisguerin P (2004)	1
SMAD1	0	FOXO3	1	affinity chromatography technology	Sapkota G (2007)	1
CTNNB1	30	KAT2B	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ge X (2009), Ge X (2009), Ge X (2009), Ge X (2009), Ge X (2009)	5
TGFB1I1	2	NR3C1	2	two hybrid	Yang L (2000)	1
TRIM33	4	SMAD4	9	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Agricola E (2011), Fattet L (2013), Bellaye PS (2014), Xue J (2014), Xue J (2014), Wu Y (2017)	6
CREBBP	29	FOS	0	pull down, affinity chromatography technology, two hybrid	Fan S (2002), Bossis G (2005), Patel D (1999)	3
HIF1A	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang KL (2014), Zhang KL (2014), Xi Y (2013)	3
PIN1	0	CDK2	0	pull down	Yeh ES (2006)	1
SMAD4	9	YY1	7	imaging technique, pull down, affinity chromatography technology	Kurisaki K (2003), Kurisaki K (2003), Kurisaki K (2003)	3
CTNNB1	30	SP1	0	affinity chromatography technology	Ponce E (2014)	1
AR	3	HDAC1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gaughan L (2002), Gaughan L (2002), Gaughan L (2005), Gaughan L (2005), Gobinet J (2005), Peche LY (2015)	6
FOXO3	1	RBL1	1	affinity chromatography technology	Li X (2015)	1
SMAD2	5	TSC2	17	affinity chromatography technology, affinity chromatography technology	Birchenall-Roberts MC (2004), Birchenall-Roberts MC (2004)	2
AR	3	SMAD3	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Chipuk JE (2002), Hayes SA (2001), Hayes SA (2001), Hayes SA (2001), Chipuk JE (2002), Hayes SA (2001), Hayes SA (2001), Kang HY (2002), Kang HY (2002), Kang HY (2002), Kang HY (2002), Chipuk JE (2002)	12
MAPK1	1	HIF1A	1	enzymatic study	Sang N (2003)	1
SMAD7	1	SMURF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Asano Y (2004), Kavsak P (2000), Lee YS (2008), Komuro A (2004), Chong PA (2010), Chong PA (2010), Chong PA (2010), Cai Y (2012), Cai Y (2012), Chong PA (2006), Al-Salihi MA (2012), Ogunjimi AA (2005), Aragon E (2012), Aragon E (2012), Colland F (2004), Zhang L (2013), Chandhoke AS (2015), Iyengar PV (2015), Elkouris M (2016)	19
AKT1	1	CREBBP	29	pull down, enzymatic study	Drendall CI (2010), Drendall CI (2010)	2
JUNB	0	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Narayanan K (2004), Narayanan K (2004), Narayanan K (2004), Wang CC (2007), Wang WM (2011)	5
EPAS1	6	SQSTM1	0	affinity chromatography technology	Liu XD (2014)	1
PIN1	0	SMAD2	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakano A (2009), Nakano A (2009), Matsuura I (2010), Matsuura I (2010)	4
MAPK1	1	AR	3	pull down	Yeh S (1999)	1
ATF2	1	SMAD4	9	two hybrid, pull down, affinity chromatography technology	Sano Y (1999), Sano Y (1999), Sano Y (1999)	3
CTNNB1	30	CREBBP	29	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ma H (2005), Sustmann C (2008), Taurin S (2006), Zhao Y (2016), Benoit YD (2017)	5
BRCA2	6	SMAD3	1	pull down, affinity chromatography technology	Preobrazhenska O (2002), Preobrazhenska O (2002)	2
BRCA1	7	KPNB1	3	affinity chromatography technology	Ertych N (2016)	1
SMAD2	5	CITED2	0	affinity chromatography technology	Chou YT (2006)	1
FHL2	0	FHL3	0	two hybrid, two hybrid, fluorescent resonance energy transfe	Fimia GM (2000), Li HY (2001), Li HY (2001)	3
CDK4	2	RBL1	1	enzymatic study	Anders L (2011)	1
JUN	0	MYC	2	affinity chromatography technology	Levy S (2010)	1
GSK3B	1	JUN	0	enzymatic study, imaging technique	Chen BK (2007), Chen TC (2014)	2
TRIM33	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, enzymatic study	Xue J (2015), Xue J (2015), Xue J (2015)	3
NEDD4	2	SMURF2	3	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Huttlin EL (2017)	2
PIAS3	2	SMAD4	9	affinity chromatography technology, pull down	Long J (2004), Long J (2004)	2
SMAD2	5	DOCK9	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brown KA (2008), Brown KA (2008), Brown KA (2008)	3
BRCA2	6	SMAD2	5	affinity chromatography technology	Preobrazhenska O (2002)	1
ATF3	0	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henderson A (2004), Xu YZ (2011), Xu YZ (2011)	3
SMAD4	9	SMAD9	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Nishita M (1999), Li X (2015)	3
SMAD2	5	UCHL5	1	pull down	Wicks SJ (2005)	1
JUNB	0	ATF2	1	affinity chromatography technology	Huttlin EL (2017)	1
AR	3	HDAC4	10	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Franco PJ (2003), Yang Y (2011), Yang Y (2011), Yang Y (2011), Yang Y (2011), Yang Y (2011)	6
SMAD4	9	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moren A (2003), Wotton D (1999), Mori N (2001), Wu JW (2002), Wu JW (2002), Nakao A (1997), Wicks SJ (2000), Wu JW (2001), Chen X (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Razani B (2001), Razani B (2001), Wang B (2008), Moren A (2005), Kurisaki K (2003), Prunier C (2003), Kato Y (2002), Xu J (2000), Wang L (2011), He W (2006), He W (2006), Dupont S (2009), Brown JD (1999), Pardali K (2000), Fu G (2011), Chen W (2007), Gao S (2009), Lin X (2003), Seo SR (2006), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Barrios-Rodiles M (2005), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Ali A (2013), Yamakawa N (2002), Yamakawa N (2002), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Zhou F (2017)	56
KAT2B	2	AKT1	1	enzymatic study, affinity chromatography technology	Sundaresan NR (2011), Sundaresan NR (2011)	2
SMAD1	0	NEDD9	3	affinity chromatography technology, two hybrid	Liu X (2000), Colland F (2004)	2
RUNX1	0	JUN	0	pull down, affinity chromatography technology, pull down	Hess J (2001), Hess J (2001), DAlonzo RC (2002)	3
CREBBP	29	SREBF2	5	far western blotting, affinity chromatography technology, affinity chromatography technology	Oliner JD (1996), Oliner JD (1996), Nath S (2014)	3
CDK4	2	MYC	2	enzymatic study, two hybrid, fluorescent resonance energy transfe	Anders L (2011), Wang J (2011), Ivanov AA (2017)	3
SMURF1	4	FHL1	1	affinity chromatography technology	Xie Y (2013)	1
SMAD2	5	ZFYVE9	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Lin HK (2004), Tsukazaki T (1998), Tsukazaki T (1998), Faresse N (2008), Miura S (2000), Seo SR (2006), Brown KA (2008), Colland F (2004), Lu D (2013)	9
MYC	2	RUNX1	0	affinity chromatography technology	Agrawal P (2010)	1
BRCA1	7	NUP214	3	affinity chromatography technology	Ertych N (2016)	1
SMAD2	5	CSNK1D	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Brown KA (2008), Ding L (2009), Ding L (2009)	3
STRAP	2	SMAD2	5	affinity chromatography technology, affinity chromatography technology, genetic interference	Datta PK (2000), Datta PK (2000), Datta PK (2000)	3
SMARCA4	19	CTNNB1	30	affinity chromatography technology, two hybrid	Barker N (2001), Barker N (2001)	2
RUNX2	2	JUN	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Hess J (2001), Hess J (2001), DAlonzo RC (2002), DAlonzo RC (2002), DAlonzo RC (2002)	5
SMAD3	1	UCHL5	1	pull down, affinity chromatography technology	Wicks SJ (2005), Nan L (2016)	2
KPNB1	3	SMAD3	1	pull down, affinity chromatography technology	Xiao Z (2000), Xiao Z (2000)	2
E2F4	0	SMAD3	1	affinity chromatography technology, pull down	Chen CR (2002), Chen CR (2002)	2
SP1	0	AR	3	affinity chromatography technology, affinity chromatography technology	Yuan H (2005), Chen PH (2008)	2
MYC	2	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Faiola F (2005), Faiola F (2005), Faiola F (2005), Faiola F (2005), Faiola F (2005), Zhang K (2005), Covic M (2005), Fujii M (2006)	8
AR	3	PIAS3	2	two hybrid	Kotaja N (2000)	1
ATF2	1	FOS	0	pull down, fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hai T (1991), Reinke AW (2013), Reinke AW (2013), Miyamoto-Sato E (2010), Rolland T (2014), Huttlin EL (2015), Li X (2015), Huttlin EL (2017)	8
HIF1A	1	RBX1	2	affinity chromatography technology	Heir P (2013)	1
MAPK1	1	CREBBP	29	enzymatic study	Janknecht R (1996)	1
ZMIZ1	7	NOTCH1	25	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Pinnell N (2015), Pinnell N (2015), Pinnell N (2015), Pinnell N (2015)	4
HDAC1	4	HIF1A	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahon PC (2001), Yoo YG (2006), Kim SH (2007), Kim SH (2007), Bodily JM (2011), Yeh IJ (2013), Yeh IJ (2013)	7
TRIM62	4	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Chen N (2013), Chen N (2013), Chen N (2013), Chen N (2013)	4
JUNB	0	JUN	0	affinity chromatography technology	Huttlin EL (2017)	1
SMAD3	1	USP15	4	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Inui M (2011), Inui M (2011), Inui M (2011), Eichhorn PJ (2012), Wijnhoven P (2015)	5
FHL2	0	EP300	36	pull down, affinity chromatography technology	Labalette C (2004), Labalette C (2004)	2
MAX	0	JUN	0	affinity chromatography technology	Boldt K (2016)	1
RNF111	2	SKI	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nagano Y (2007), Le Scolan E (2008), Erker Y (2013)	3
KPNB1	3	NUP214	3	affinity chromatography technology	Hein MY (2015)	1
PIN1	0	TP53	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down	Wulf GM (2002), Wulf GM (2002), Zacchi P (2002), Zacchi P (2002), Vinayagam A (2011), Mantovani F (2007)	6
SMAD3	1	MYOCD	4	affinity chromatography technology, pull down	Qiu P (2005), Qiu P (2005)	2
NUP214	3	SMAD4	9	affinity chromatography technology, pull down	Xu L (2003), Xu L (2003)	2
CTNNB1	30	FOXM1	3	affinity chromatography technology	Chen Y (2016)	1
OTUB1	0	SMAD3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Herhaus L (2013), Herhaus L (2013), Herhaus L (2013)	3
NOTCH1	25	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yatim A (2012), Yatim A (2012), Yatim A (2012)	3
HIF1A	1	CREBBP	29	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Ema M (1999), Ema M (1999), Bhattacharya S (1999), Park YK (2008), Choi SM (2006), Matt T (2004), Hubbi ME (2012), Ruas JL (2010), Ruas JL (2010), Ruas JL (2010), Ruas JL (2010), Ruas JL (2005), Arany Z (1996), Ruas JL (2005), Gradin K (2002)	15
NUP214	3	SMAD3	1	affinity chromatography technology, pull down	Xu L (2003), Xu L (2003)	2
JUN	0	MAPK1	1	affinity chromatography technology, enzymatic study, pull down	Kumar NV (2001), Zuniga A (1999), Zuniga A (1999)	3
WWOX	3	SMAD3	1	pull down, affinity chromatography technology	Ferguson BW (2013), Ferguson BW (2013)	2
AKT1	1	TRIB3	0	pull down, affinity chromatography technology, two hybrid	Du K (2003), Du K (2003), Du K (2003)	3
HNF4A	2	TP53	0	pull down, affinity chromatography technology	Maeda Y (2002), Huttlin EL (2017)	2
ATF3	0	FHL2	0	two hybrid, two hybrid, affinity chromatography technology	Gao J (2008), Gao J (2008), Gao J (2008)	3
EP300	36	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Han Y (2008), Mayanil CS (2006), Simone C (2004), Simone C (2004), Simone C (2004), Liu Y (2012), Mizuguchi Y (2012)	7
YY1	7	MYC	2	two hybrid, pull down	Shrivastava A (1993), Shrivastava A (1993)	2
NOTCH1	25	KPNB1	3	affinity chromatography technology, affinity chromatography technology	Yatim A (2012), Mukherjee S (2016)	2
SMAD2	5	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Kuratomi G (2005)	2
BRCA2	6	KAT2B	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Lin HR (2003), Fuks F (1998), Fuks F (1998), Park I (2017)	4
SMAD3	1	HDAC4	10	affinity chromatography technology, pull down	Kang JS (2005), Kang JS (2005)	2
SMAD3	1	WWP1	3	affinity chromatography technology, affinity chromatography technology, two hybrid	Komuro A (2004), Seo SR (2004), Rolland T (2014)	3
HDAC1	4	SMAD7	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Simonsson M (2005), Simonsson M (2005), Simonsson M (2005), Laganiere J (2005)	4
USP15	4	USP7	14	enzymatic study	Loch CM (2012)	1
RUNX1	0	SMARCA4	19	affinity chromatography technology, affinity chromatography technology	Bakshi R (2010), Bakshi R (2010)	2
EID2	0	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down	Lee HJ (2004), Lee HJ (2004), Lee HJ (2004)	3
HDAC5	4	ATF3	0	pull down	Darlyuk-Saadon I (2012)	1
HIF1A	1	FHL2	0	affinity chromatography technology, affinity chromatography technology, pull down	Hubbi ME (2012), Hubbi ME (2012), Hubbi ME (2012)	3
SREBF2	5	PIAS3	2	two hybrid	Bandyopadhyay S (2010)	1
EP300	36	CITED2	0	two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, protein complementation assay	Bhattacharya S (1999), Braganca J (2003), Braganca J (2003), Braganca J (2002), Bhattacharya S (1999), Glenn DJ (1999), Matt T (2004), Freedman SJ (2003), Hein MY (2015), Machado-Oliveira G (2015)	10
SMURF2	3	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang L (2013), Zhou F (2017), Zhou F (2017)	3
SETD2	20	TP53	0	affinity chromatography technology, affinity chromatography technology	Xie P (2008), Xie P (2008)	2
SMAD3	1	RUNX1	0	affinity chromatography technology, affinity chromatography technology	Hanai J (1999), Nitta E (2005)	2
ZMIZ1	7	PIAS3	2	two hybrid	Peng Y (2010)	1
SNW1	0	SKIL	3	genetic interference	Leong GM (2001)	1
SNW1	0	SMAD2	5	genetic interference, two hybrid, pull down, affinity chromatography technology	Leong GM (2001), Leong GM (2001), Leong GM (2001), Brown KA (2008)	4
JUNB	0	YY1	7	affinity chromatography technology	Wang CC (2007)	1
AR	3	FHL2	0	two hybrid, pull down, affinity chromatography technology	Mueller JM (2000), Mueller JM (2000), Mueller JM (2000)	3
AKT1	1	GSK3B	1	pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Thimmaiah KN (2005), Drendall CI (2010), Connor MK (2005), Hunter MG (2004), Zhu QS (2011), Li L (2003), Nam SY (2010), Yang WL (2009), Zeng L (2013), Yang H (2005), Boehme KA (2008), Cross DA (1995), Hinton CV (2007), Kapoor GS (2004), Pitre A (2012), Guo J (2016)	16
CREBBP	29	MECOM	4	affinity chromatography technology, enzymatic study	Chakraborty S (2001), Chakraborty S (2001)	2
SKI	3	SKIL	3	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Cohen SB (1999), Cohen SB (1999), Tan R (2006), He J (2003), Ikeuchi Y (2014)	5
HIF1A	1	HDAC5	4	affinity chromatography technology, pull down	Seo HW (2009), Seo HW (2009)	2
HDAC5	4	NUP214	3	affinity chromatography technology	Gregoire S (2006)	1
SMAD1	0	SKI	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Harada J (2003), Takeda M (2004), Mizuide M (2003)	4
MAPK1	1	TSC2	17	pull down, affinity chromatography technology	Ma L (2005), Ma L (2005)	2
SNW1	0	KPNB1	3	affinity chromatography technology	Lleres D (2010)	1
FOS	0	SMARCC2	9	affinity chromatography technology	Li X (2015)	1
SMAD4	9	MAX	0	pull down	Grinberg AV (2003)	1
HDAC4	10	MECOM	4	affinity chromatography technology	Chakraborty S (2001)	1
SETD2	20	SMAD3	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
RUNX1	0	FOS	0	pull down, affinity chromatography technology, pull down	Hess J (2001), Hess J (2001), DAlonzo RC (2002)	3
SMAD4	9	AKT1	1	affinity chromatography technology	Song K (2006)	1
VDR	2	BRCA1	7	affinity chromatography technology	Deng C (2009)	1
TP53	0	YY1	7	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Groenroos E (2004), Groenroos E (2004), Sui G (2004), Sui G (2004), Sui G (2004), Wu S (2007), Wan M (2012), Kotlyar M (2015)	8
RNF31	3	SMAD3	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
WWOX	3	LACRT	1	affinity chromatography technology	Abu-Odeh M (2014)	1
SMAD7	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Asano Y (2004), Yamaguchi T (2006), Komuro A (2004), Ebisawa T (2001), Ebisawa T (2001), Al-Salihi MA (2012), Suzuki C (2002), Aragon E (2012), Aragon E (2012), Tajima Y (2003), Fei C (2013), Fei C (2014), Wan L (2011), Elkouris M (2016)	14
SMAD2	5	KPNB1	3	two hybrid	Colland F (2004)	1
SMAD1	0	SMAD7	1	affinity chromatography technology	Yan X (2016)	1
MAPK1	1	FHL2	0	two hybrid, pull down, pull down, affinity chromatography technology	Purcell NH (2004), Purcell NH (2004), Purcell NH (2004), Purcell NH (2004)	4
EP300	36	KAT2B	2	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012)	8
SMAD4	9	TGFB1I1	2	affinity chromatography technology	Wang H (2005)	1
SMAD7	1	WWP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004), Seo SR (2004), Al-Salihi MA (2012)	4
DAB2	1	TGFBR1	2	affinity chromatography technology	Hocevar BA (2001)	1
SMAD2	5	SMAD7	1	genetic interference, pull down, affinity chromatography technology	Lebrun JJ (1999), Zhang S (2007), Yan X (2016)	3
SMAD7	1	TP53	0	affinity chromatography technology	Zhang S (2006)	1
SMAD3	1	NR3C1	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li G (2003), Li G (2003), Song CZ (1999), Song CZ (1999)	4
SMAD2	5	WWP1	3	affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004)	2
SMAD7	1	SMAD3	1	genetic interference, genetic interference, affinity chromatography technology, protein complementation assay	Datta PK (2000), Lebrun JJ (1999), Yan X (2016), Yan X (2016)	4
ATF2	1	SMAD3	1	two hybrid, pull down, affinity chromatography technology	Sano Y (1999), Sano Y (1999), Sano Y (1999)	3
MAPK1	1	SMAD1	0	enzymatic study, enzymatic study, enzymatic study	Sapkota G (2007), Alarcon C (2009), Fuentealba LC (2007)	3
MYC	2	PIN1	0	affinity chromatography technology, affinity chromatography technology	Arnold HK (2009), Yeh E (2004)	2
MAX	0	HIF1A	1	affinity chromatography technology	Gordan JD (2007)	1
SMAD3	1	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Yan X (2009), Tang Y (2003), Tang Y (2003), Herhaus L (2015)	4
HDAC4	10	NUP214	3	affinity chromatography technology	Gregoire S (2006)	1
SMAD2	5	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Runyan CE (2009), Runyan CE (2009), Chong PA (2010), Brown KA (2008), Colland F (2004), Colland F (2004), Zhang Y (2017), Zhou F (2017), Zhou F (2017)	16
FHL3	0	SMAD2	5	pull down, affinity chromatography technology	Ding L (2009), Ding L (2009)	2
MECOM	4	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Kurokawa M (1998), Kurokawa M (1998), Alliston T (2005), Alliston T (2005)	4
SMAD7	1	LEF1	3	affinity chromatography technology, affinity chromatography technology	Edlund S (2005), Cui Q (2005)	2
LDLRAD4	1	SMAD3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD4	9	SKI	3	pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Ueki N (2003), Wu JW (2002), Stroschein SL (1999), Tabata T (2009), Prunier C (2003), Prunier C (2003), Takeda M (2004), Takeda M (2004), Ferrand N (2010), Wu K (2003), Wu K (2003), Barrios-Rodiles M (2005), Colland F (2004), He J (2003), He J (2003), Jinnin M (2007), Li X (2015), Rashidian J (2015), Rashidian J (2015), Zhou F (2017)	21
SMAD3	1	CDC25A	2	affinity chromatography technology, two hybrid	Ray D (2005), Wang J (2011)	2
JUN	0	SMARCC2	9	affinity chromatography technology	Li X (2015)	1
USP15	4	SMURF2	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Eichhorn PJ (2012), Iyengar PV (2015), Iyengar PV (2015)	3
HDAC4	10	MAPK1	1	affinity chromatography technology, enzymatic study	Zhou X (2000), Zhou X (2000)	2
SMAD3	1	JUN	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Verrecchia F (2000), Liberati NT (1999), Liberati NT (2001), Lee SY (2011)	7
GSK3B	1	ATF3	0	affinity chromatography technology	Lee SH (2010)	1
RNF111	2	SKIL	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Levy L (2007), Levy L (2007), Nagano Y (2007), Erker Y (2013)	4
SMAD3	1	DEDD	0	two hybrid, affinity chromatography technology, pull down	Xue JF (2010), Xue JF (2010), Xue JF (2010)	3
AR	3	RBL1	1	affinity chromatography technology	Su S (2013)	1
CDK2	0	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
SMAD3	1	JUNB	0	two hybrid, pull down	Liberati NT (1999), Liberati NT (1999)	2
NEDD4L	3	YY1	7	enzymatic study, affinity chromatography technology	Persaud A (2009), Persaud A (2009)	2
SP1	0	BRCA2	6	affinity chromatography technology	Tapias A (2008)	1
TP53	0	SMAD2	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Tateossian H (2009), Lu D (2013), Chen TC (2014)	5
SMAD3	1	IRF7	2	pull down, affinity chromatography technology, imaging technique	Qing J (2004), Qing J (2004), Qing J (2004)	3
RNF111	2	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koinuma D (2003), Yuzawa H (2009), Yuzawa H (2009), Levy L (2007), Erker Y (2013), Le Scolan E (2008)	6
TRIB3	0	SMURF1	4	two hybrid, affinity chromatography technology	Chan MC (2007), Chan MC (2007)	2
SMAD3	1	LEMD3	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Brown KA (2008), Gao S (2009), Huttlin EL (2015), Huttlin EL (2017)	4
CTNNB1	30	SMURF1	4	affinity chromatography technology, pull down	Boonanantanasarn K (2015), Boonanantanasarn K (2015)	2
TP53	0	PIAS4	5	two hybrid	Goehler H (2004)	1
TGFBR1	2	SMAD2	5	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Razani B (2001), Faresse N (2008), Bai Y (2004), Tang Y (2003), Tang Y (2003), Ding L (2009), Lu D (2013), Herhaus L (2015)	8
LEF1	3	HDAC1	4	affinity chromatography technology	Billin AN (2000)	1
MECOM	4	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology	Vinatzer U (2001), Vinatzer U (2001), Chakraborty S (2001)	3
MAX	0	YY1	7	affinity chromatography technology, affinity chromatography technology	de Nigris F (2007), de Nigris F (2007)	2
JUN	0	NEDD4	2	two hybrid, affinity chromatography technology	Camus G (2007), Camus G (2007)	2
SMAD4	9	MECOM	4	pull down	Alliston T (2005)	1
CSNK1D	3	FHL1	1	affinity chromatography technology, pull down, affinity chromatography technology	Ding L (2009), Ding L (2009), Ding L (2009)	3
TP53	0	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Lu D (2013), Ali A (2013)	4
SMAD2	5	SMARCC2	9	affinity chromatography technology, affinity chromatography technology	Xi Q (2008), He W (2006)	2
JUN	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alfranca A (2002), Yu B (2009), Yu B (2009)	3
CTNNB1	30	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vietor I (2005), Billin AN (2000), Iguchi H (2007), Iioka H (2009)	4
RNF111	2	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Levy L (2007), Erker Y (2013), Le Scolan E (2008)	3
YY1	7	CTCF	15	affinity chromatography technology	Donohoe ME (2007)	1
CDK4	2	SMAD2	5	enzymatic study	Matsuura I (2004)	1
SMAD7	1	KAT2B	2	affinity chromatography technology	Monteleone G (2005)	1
EP300	36	MAX	0	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Faiola F (2007), Faiola F (2005), Faiola F (2005), Zhang K (2005)	4
SMAD2	5	TGIF1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wotton D (1999), Wotton D (1999), Wotton D (1999), Pessah M (2001)	4
BRCA1	7	RUNX1	0	genetic interference	Shen JP (2017)	1
VDR	2	SNW1	0	two hybrid, pull down, far western blotting, pull down, two hybrid	Baudino TA (1998), Baudino TA (1998), Baudino TA (1998), Zhang C (2001), Zhang C (2001)	5
RBL1	1	SP1	0	affinity chromatography technology, affinity chromatography technology	Datta PK (1995), Datta PK (1995)	2
RUNX2	2	WWP1	3	affinity chromatography technology, affinity chromatography technology	Jones DC (2006), Jones DC (2006)	2
ATF3	0	FOS	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
ATF3	0	CREBBP	29	affinity chromatography technology, pull down	Kim HB (2010), Kim HB (2010)	2
ATF3	0	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kang Y (2003), Kang Y (2003), Yin X (2010), Yin X (2010)	4
SMAD3	1	SMAD3	1	affinity chromatography technology, two hybrid, pull down, x-ray crystallography	Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Qin BY (2002)	4
AKT1	1	SMARCC2	9	affinity chromatography technology	Foster KS (2006)	1
SMAD3	1	FOS	0	two hybrid, pull down, affinity chromatography technology	Zhang Y (1998), Zhang Y (1998), Lee SY (2011)	3
CTNNB1	30	GSK3B	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Davies G (2001), Kishida S (1999), Fischer L (2002), Kitagawa M (1999), Hart M (1999), Su Y (2008), Huang X (2009), Ding Q (2005), Piao S (2008), Varjosalo M (2013), Gao C (2014), Koo J (2015), Chen TC (2014), Lu D (2012), Kuslansky Y (2016), Novellasdemunt L (2017), Lu WJ (2015)	17
SMAD3	1	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Tang LY (2011), Brown KA (2008), Zhang L (2013), Li Y (2017), Zhang Y (2017)	12
PIN1	0	EP300	36	pull down	Yi P (2005)	1
CDK2	0	TP53	0	enzymatic study, enzymatic study, imaging technique	Luciani MG (2000), Tsai CH (2009), Chen TC (2014)	3
SMAD4	9	SMAD7	1	genetic interference, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Lebrun JJ (1999), Moren A (2005), Moren A (2005), Moren A (2005), Zhang S (2007), Yan X (2016)	6
BRCA2	6	TP53	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Dong Y (2003), Dong Y (2003), Dong Y (2003), Marmorstein LY (1998)	4
HDAC1	4	TGIF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Melhuish TA (2000), Melhuish TA (2001), Lo RS (2001)	3
SMAD3	1	ZC3H12A	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
CEBPD	0	HDAC4	10	pull down	Turgeon N (2008)	1
AKT1	1	CTNNB1	30	enzymatic study, enzymatic study	Tian Q (2004), Fang D (2007)	2
TSC2	17	AKT1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Dan HC (2002), Roux PP (2004), Dan HC (2002), Dan HC (2002)	4
SMAD9	0	SPTBN1	6	two hybrid	Colland F (2004)	1
SMURF2	3	YY1	7	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Jeong HM (2014), Jeong HM (2014), Jeong HM (2014), Jeong HM (2014)	4
SMAD2	5	SP1	0	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Poncelet AC (2001), Pardali K (2000), Pardali K (2000), Pardali K (2000), Barrasa JI (2011)	5
SMAD9	0	SMAD7	1	affinity chromatography technology	Yan X (2016)	1
NR3C1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Amat R (2007), Wang W (2012), Kino T (2002)	3
CTNNB1	30	LEF1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Edlund S (2005), Grueneberg DA (2003), Behrens J (1996), Behrens J (1996), Labbe E (2000), Sierra J (2006), Gomes NP (2006), Vietor I (2005), Billin AN (2000), Fischer L (2002), Tutter AV (2001), Sadot E (2002), Feigin ME (2008), Daniels DL (2005), Porfiri E (1997), Porfiri E (1997), Hamada F (2004), Vadlamudi U (2005), Lu D (2012), Lu D (2012)	20
SMAD3	1	HDAC1	4	two hybrid, pull down	Liberati NT (2001), Akiyoshi S (1999)	2
CDK2	0	BRCA2	6	enzymatic study	Esashi F (2005)	1
FOS	0	MAPK1	1	affinity chromatography technology	Kumar NV (2001)	1
SP1	0	EPAS1	6	affinity chromatography technology, affinity chromatography technology	Koizume S (2012), Koizume S (2012)	2
GSK3B	1	AR	3	pull down, affinity chromatography technology	Wang L (2004), Wang L (2004)	2
NEDD4	2	YY1	7	enzymatic study, affinity chromatography technology	Persaud A (2009), Persaud A (2009)	2
TP53	0	NOTCH4	7	affinity chromatography technology	Sun Y (2011)	1
JUNB	0	SMURF1	4	affinity chromatography technology, pull down	Zhao L (2010), Zhao L (2010)	2
BRCA1	7	FHL2	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Yan J (2003), Yan J (2003), Yan JH (2003), Yan JH (2003), Yan JH (2003), Yan J (2003), Wang J (2011), Hill SJ (2014)	8
HNF4A	2	SMAD3	1	affinity chromatography technology, pull down	Kardassis D (2000), Kardassis D (2000)	2
SMAD2	5	TRIM33	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xi Q (2008), He W (2006), He W (2006), Xi Q (2011), Fattet L (2013)	5
TP53	0	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li M (2002), Li M (2002), Li M (2002), Li M (2002), Brooks CL (2007), Brooks CL (2007), Becker K (2007), Hu M (2006), Hu M (2006), Sarkari F (2010), Marchenko ND (2007), Epping MT (2011), Qing P (2011), Tang J (2006), Ma J (2010), Dai C (2011), Holowaty MN (2003), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Yi P (2013), Yi P (2013), Zhang J (2014), Fang Z (2013), Ye M (2015), Lim KH (2015), Lim KH (2015), Reddy BA (2014), Reddy BA (2014)	29
VDR	2	HNF4A	2	affinity chromatography technology, affinity chromatography technology	Han S (2010), Han S (2010)	2
EP300	36	FOS	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Wang WM (2011), Pekarsky Y (2008), Wang C (2001)	3
SMAD3	1	BRCA1	7	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dubrovska A (2005), Dubrovska A (2005), Dubrovska A (2005), Li H (2009), Li H (2009)	5
MYC	2	RBL1	1	affinity chromatography technology	Beijersbergen RL (1994)	1
SMAD4	9	JUNB	0	pull down, two hybrid	Liberati NT (1999), Colland F (2004)	2
NUP214	3	SMAD2	5	affinity chromatography technology, pull down	Xu L (2003), Xu L (2003)	2
EPAS1	6	SMARCA4	19	affinity chromatography technology	Steunou AL (2012)	1
BRCA1	7	PIAS4	5	imaging technique, enzymatic study, imaging technique	Galanty Y (2009), Morris JR (2009), Morris JR (2009)	3
BRCA1	7	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2003), Maor S (2007), Maor S (2007), Abramovitch S (2003)	4
HIF1A	1	WWOX	3	affinity chromatography technology	Maroni P (2014)	1
SMAD3	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tian YC (2002), Dahle O (2010), Charbonney E (2011), Zhou B (2012)	4
LDLRAD4	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NOTCH1	25	USP7	14	affinity chromatography technology, affinity chromatography technology	Yatim A (2012), Yatim A (2012)	2
MYC	2	ERBIN	5	affinity chromatography technology	Agrawal P (2010)	1
SMAD2	5	ZEB2	7	two hybrid	Colland F (2004)	1
FOS	0	JUNB	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Rolland T (2014), Huttlin EL (2015), Hein MY (2015), Li X (2015), Huttlin EL (2017)	7
SMAD7	1	CBL	7	affinity chromatography technology, affinity chromatography technology, pull down	Ha Thi HT (2015), Ha Thi HT (2015), Ha Thi HT (2015)	3
SMAD3	1	USP7	14	affinity chromatography technology, two hybrid	Brown KA (2008), Wang J (2011)	2
FHL3	0	SNW1	0	affinity chromatography technology	Huttlin EL (2015)	1
BRCA1	7	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Li H (2010), Li H (2010), Li H (2010), Ertych N (2016)	4
SP1	0	SMAD3	1	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Botella LM (2001), Poncelet AC (2001), Pardali K (2000), Pardali K (2000), Pardali K (2000), Pardali K (2000), Barrasa JI (2011), Jungert K (2006), Sanchez-Elsner T (2002)	9
SMARCA4	19	MYOCD	4	affinity chromatography technology, affinity chromatography technology, pull down	Zhou J (2009), Zhou J (2009), Zhou J (2009)	3
E2F4	0	FHL2	0	two hybrid	Schlisio S (2002)	1
SMAD2	5	SMURF1	4	affinity chromatography technology, affinity chromatography technology, two hybrid	Komuro A (2004), Ito I (2010), Colland F (2004)	3
SMAD3	1	TRIM33	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Xi Q (2008), He W (2006), Xi Q (2011), Xue J (2014), Gao S (2009)	5
GSK3B	1	SMAD1	0	enzymatic study, imaging technique	Fuentealba LC (2007), Chen TC (2014)	2
AR	3	SMARCA4	19	affinity chromatography technology, two hybrid, affinity chromatography technology, bioid	Wang Q (2004), van de Wijngaart DJ (2009), Dai Y (2008), Lempiaeinen JK (2017)	4
SMAD2	5	SKI	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Luo K (1999), Tabata T (2009), Prunier C (2003), Prunier C (2003), Akiyoshi S (1999), Akiyoshi S (1999), Takeda M (2004), Inoue Y (2011), Ferrand N (2010), Chen W (2007), Brown KA (2008), He J (2003), Rashidian J (2015), Zhou F (2017)	15
SQSTM1	0	HIF1A	1	affinity chromatography technology	Liu XW (2013)	1
SMAD3	1	HIVEP1	13	two hybrid, two hybrid	Colland F (2004), Wang J (2011)	2
ERBIN	5	CTNNB1	30	unspecified method	Boisguerin P (2004)	1
SQSTM1	0	TRIB3	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, unspecified method	Hua F (2015), Hua F (2015), Hua F (2015), Hua F (2015), Hua F (2015)	5
FHL2	0	RUNX1	0	affinity chromatography technology	Bai S (2008)	1
SMAD1	0	SMAD4	9	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Hanai J (1999), Lopez-Rovira T (2002), Kato Y (2002), Wang L (2011), Li L (2004), Hata A (1998), Barrios-Rodiles M (2005), Wu RY (1997), Wu RY (1997), Colland F (2004), Qiu T (2007), Yan X (2016), Zhou F (2017)	14
GSK3B	1	HDAC4	10	enzymatic study	Cernotta N (2011)	1
MAPK1	1	HNF4A	2	enzymatic study	Han S (2010)	1
RUNX2	2	HDAC5	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeon EJ (2006), Kang JS (2005), Kang JS (2005)	3
TP53	0	RUNX2	2	affinity chromatography technology, affinity chromatography technology	Ozaki T (2013), Ozaki T (2013)	2
MYC	2	SMAD2	5	affinity chromatography technology, pull down, two hybrid, fluorescent resonance energy transfe	Feng XH (2002), Feng XH (2002), Feng XH (2002), Ivanov AA (2017)	4
SPTBN1	6	SMAD2	5	affinity chromatography technology	Tang Y (2003)	1
EP300	36	RUNX2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee HW (2006), Jeon EJ (2006), Jeon EJ (2006), Jun JH (2010)	4
MYC	2	KPNB1	3	affinity chromatography technology	Koch HB (2007)	1
SMAD1	0	RUNX3	1	affinity chromatography technology	Hanai J (1999)	1
STRAP	2	SMAD3	1	affinity chromatography technology, affinity chromatography technology, genetic interference, genetic interference	Datta PK (2000), Datta PK (2000), Datta PK (2000), Datta PK (2000)	4
SMURF2	3	RNF111	2	two hybrid	Colland F (2004)	1
SMAD1	0	WWP1	3	affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004)	2
SMAD3	1	DOCK9	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brown KA (2008), Brown KA (2008), Brown KA (2008)	3
BRCA1	7	HDAC1	4	pull down	Yarden RI (1999)	1
MYC	2	FOXO3	1	affinity chromatography technology	Chandramohan V (2008)	1
EPAS1	6	CREBBP	29	affinity chromatography technology	Steunou AL (2012)	1
CDK2	0	S100A4	0	affinity chromatography technology	Hein MY (2015)	1
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
ATF2	1	CTNNB1	30	affinity chromatography technology	Lau E (2012)	1
JUN	0	TRIM33	4	affinity chromatography technology	Li X (2015)	1
MAPK1	1	SP1	0	enzymatic study, enzymatic study	Milanini-Mongiat J (2002), Cramer T (2008)	2
RUNX3	1	SMURF2	3	affinity chromatography technology	Jin YH (2004)	1
SMAD3	1	KAT2B	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Prokova V (2005), Itoh S (2000), Itoh S (2000), Kahata K (2004), Dai M (2012)	5
LDLRAD4	1	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEBPD	0	CREBBP	29	pull down	Kovacs KA (2003)	1
SMAD3	1	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid	Brown KA (2008), Wu RY (1997), Wu RY (1997)	3
TP53	0	USP15	4	affinity chromatography technology, affinity chromatography technology	Liu WT (2016), Liu WT (2016)	2
KAT2B	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study	Jin Y (2002), Wang H (2008), Zhao Y (2006), Roe JS (2006), Perez RE (2010), Tang Y (2006), Zhao LY (2003), Liu L (1999), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Harrod R (2003), MacPartlin M (2005), Chen H (1999), Kang H (2009)	15
SP1	0	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mottet D (2009), Mottet D (2009), Wilson AJ (2008)	3
WWP2	7	SMAD7	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Soond SM (2011), Soond SM (2011), Soond SM (2011), Al-Salihi MA (2012)	4
SMAD2	5	ANAPC10	0	affinity chromatography technology, pull down	Nourry C (2004), Nourry C (2004)	2
TGFB1I1	2	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wang H (2005), Wang H (2005), Wang H (2005), Shibanuma M (2004)	4
TP53	0	RBX1	2	affinity chromatography technology	Fogeron ML (2013)	1
CDK2	0	SMAD2	5	enzymatic study	Matsuura I (2004)	1
CSNK1D	3	HIF1A	1	enzymatic study	Kalousi A (2010)	1
CDK2	0	SPTBN1	6	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Hein MY (2015)	2
LEF1	3	SMAD4	9	pull down	Labbe E (2000)	1
HDAC5	4	TP53	0	affinity chromatography technology	Greco TM (2011)	1
CTNNB1	30	CDK2	0	pull down, affinity chromatography technology	Park CS (2004), Park CS (2004)	2
SMAD3	1	MAX	0	pull down, imaging technique	Grinberg AV (2003), Chen TC (2014)	2
STRAP	2	SMAD7	1	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Datta PK (2000), Datta PK (2000), Datta PK (2000), Seong HA (2007)	4
TGIF1	1	SMAD1	0	affinity chromatography technology	Wotton D (1999)	1
WWP1	3	SKIL	3	affinity chromatography technology	Komuro A (2004)	1
KAT2B	2	RUNX2	2	affinity chromatography technology	Jeon EJ (2006)	1
JUN	0	SKI	3	affinity chromatography technology	Pessah M (2002)	1
TGFBR1	2	NOTCH1	25	affinity chromatography technology, affinity chromatography technology	Gudey SK (2014), Gudey SK (2014)	2
SMAD4	9	NOTCH4	7	affinity chromatography technology	Sun Y (2005)	1
ZMIZ1	7	CTNNB1	30	affinity chromatography technology	Pinnell N (2015)	1
MAPK1	1	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, imaging technique	Persons DL (2000), How PC (2011), Srivastav RK (2011), Fogeron ML (2013), Chen TC (2014)	5
SKIL	3	PIAS3	2	two hybrid	Colland F (2004)	1
PIAS4	5	MECOM	4	affinity chromatography technology, affinity chromatography technology	Singh S (2013), Singh S (2013)	2
KAT2B	2	JUN	0	affinity chromatography technology	Tsai LN (2008)	1
SMURF2	3	SKIL	3	affinity chromatography technology	Bonni S (2001)	1
BRCA1	7	JUN	0	affinity chromatography technology, pull down	Hu YF (2002), Hu YF (2002)	2
CSNK1D	3	BRCA1	7	two hybrid, affinity chromatography technology	Hill SJ (2014), Hill SJ (2014)	2
SMARCC2	9	HDAC1	4	affinity chromatography technology	Battaglioli E (2002)	1
BRCA2	6	BRCA1	7	affinity chromatography technology, two hybrid, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sarkisian CJ (2001), Reuter TY (2003), Dong Y (2003), Chen J (1998), Chen J (1998), Villarroel MC (2011), Kumaraswamy E (2007), Sy SM (2009), Sy SM (2009), Sy SM (2009), Johnson N (2013), Hill SJ (2014), Loke J (2015)	13
NR3C1	2	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sengupta S (2000), Sengupta S (2001), Sengupta S (2001), Sengupta S (2001)	4
HDAC1	4	PIN1	0	biochemical	Wan C (2015)	1
WWP2	7	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Soond SM (2011), Soond SM (2011), Brown KA (2008)	3
TGFBR1	2	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koinuma D (2003), Ebisawa T (2001), Murakami G (2003)	3
FHL3	0	SMAD3	1	pull down, affinity chromatography technology	Ding L (2009), Ding L (2009)	2
PIN1	0	TSC22D4	1	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
MYC	2	MAPK1	1	pull down, pull down	Jin Z (2004), Gupta S (1994)	2
LDLRAD4	1	SMURF2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AKT1	1	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Lin WN (2008), Lee IT (2010), Sundaresan NR (2011), Howie HL (2011), Chen J (2004), Chen J (2004)	6
NOTCH1	25	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Yatim A (2012), Yatim A (2012)	2
GSK3B	1	STRAP	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Kashikar ND (2011), Kashikar ND (2011)	3
MAX	0	EPAS1	6	affinity chromatography technology	Gordan JD (2007)	1
CDK4	2	FOXM1	3	enzymatic study	Anders L (2011)	1
SMAD3	1	DAB2	1	pull down, affinity chromatography technology	Hocevar BA (2001), Hocevar BA (2001)	2
BRCA1	7	RBL1	1	imaging technique, pull down	Fan S (2001), Fan S (2001)	2
SMURF1	4	CSNK1D	3	enzymatic study	Andrews PS (2010)	1
PIAS4	5	IRF7	2	affinity chromatography technology	Zhang J (2004)	1
KPNB1	3	SREBF2	5	pull down	Nagoshi E (2001)	1
MYD88	1	USP7	14	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
CTNNB1	30	HNF4A	2	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Mulholland DJ (2003), Mulholland DJ (2003), Mulholland DJ (2003), Chen TC (2014)	4
NR3C1	2	SMARCC2	9	bioid	Lempiaeinen JK (2017)	1
SMURF2	3	NEDD9	3	affinity chromatography technology, affinity chromatography technology	Moore FE (2010), Moore FE (2010)	2
SMURF1	4	USP15	4	affinity chromatography technology	Xie Y (2013)	1
SMAD2	5	YY1	7	pull down, affinity chromatography technology	Kurisaki K (2003), Brown KA (2008)	2
VDR	2	FOXO3	1	affinity chromatography technology, affinity chromatography technology, pull down	An BS (2010), An BS (2010), An BS (2010)	3
SMAD7	1	AKT1	1	affinity chromatography technology	Song K (2006)	1
ZEB2	7	HDAC1	4	affinity chromatography technology	Verstappen G (2008)	1
FHL1	1	SMAD4	9	pull down, affinity chromatography technology, affinity chromatography technology	Ding L (2009), Ding L (2009), Ding L (2009)	3
FOXH1	1	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wotton D (1999), Liu B (1999), Liu F (1997), Liu F (1997), Dou C (2000), Chen X (1997), Chen X (1997), Prunier C (2003), Yoon SJ (2011), Seo SR (2006), Cui Q (2005)	11
SP1	0	SMARCC2	9	pull down	Kadam S (2000)	1
CDK4	2	SMAD3	1	enzymatic study, imaging technique	Matsuura I (2004), Chen TC (2014)	2
SMAD2	5	MECOM	4	pull down	Alliston T (2005)	1
BRCA1	7	UCHL5	1	affinity chromatography technology	Ertych N (2016)	1
EP300	36	EPAS1	6	pull down, affinity chromatography technology, affinity chromatography technology	Kung AL (2004), Steunou AL (2012), Chen R (2012)	3
SMAD3	1	HDAC5	4	affinity chromatography technology, pull down	Kang JS (2005), Kang JS (2005)	2
EP300	36	SNW1	0	pull down	Leong GM (2004)	1
HDAC1	4	YY1	7	pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Yang WM (1997), He Y (2007), He G (2002), Sun JM (2007)	4
SPTBN1	6	SMAD4	9	affinity chromatography technology, affinity chromatography technology	Tang Y (2003), Tang Y (2003)	2
SMAD7	1	UCHL5	1	pull down, affinity chromatography technology	Wicks SJ (2005), Wicks SJ (2005)	2
SMAD2	5	RUNX2	2	affinity chromatography technology	Hanai J (1999)	1
SMAD3	1	SH2D2A	2	pull down, affinity chromatography technology	Richard KC (2006), Richard KC (2006)	2
FOS	0	JUN	0	pull down, two hybrid, pull down, x-ray crystallography, two hybrid, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, pull down, imaging technique, pull down, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, biochemical, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ito T (2001), Pognonec P (1997), Pognonec P (1997), Glover JN (1995), Yang X (1999), Nomura N (1993), Finkel T (1993), Finkel T (1993), Venugopal R (1998), Kumar NV (2001), Dumin E (2006), Bandyopadhyay S (2010), Asim M (2010), Asim M (2010), Srivastav RK (2011), Bossis G (2005), Bossis G (2005), Gupta K (2000), Bachmann M (2004), Reinke AW (2013), Miyagi M (2005), Subbaramaiah K (2007), Jang M (2012), Yamaguchi K (2005), Varjosalo M (2013), Miyamoto-Sato E (2010), Miyamoto-Sato E (2010), Varjosalo M (2013), Tang HY (2006), Marden NY (2005), Adler J (2010), Adler J (2010), Adler J (2010), Billiet L (2008), Huttlin EL (2015), Hein MY (2015), Li X (2015), Li X (2015), Huttlin EL (2017)	39
NEDD9	3	SMAD3	1	two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Feng L (2004), Nourry C (2004), Feng L (2004), Feng L (2004), Liu X (2000), Liu X (2000)	6
SMURF2	3	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kavsak P (2000), Yan X (2011), Cai Y (2012), Cai Y (2012), Zhang L (2013), Chandhoke AS (2015), Hsu HY (2014)	7
TP53	0	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Borellini F (1993), Jin W (2008), Dhar SK (2006), Lagger G (2003), Lagger G (2003), Lagger G (2003), Lagger G (2003), Sengupta S (2005), Sengupta S (2005), Lin RK (2010), Kim HA (2011), Sawaya BE (1998), St Clair S (2004), Innocente SA (2005), Innocente SA (2005), Ohlsson C (1998), Kong X (2013), Bocangel D (2009), Bocangel D (2009)	19
RUNX3	1	HDAC1	4	affinity chromatography technology	Jin YH (2004)	1
JUN	0	HDAC1	4	affinity chromatography technology	Tenbrock K (2006)	1
SMURF1	4	TP53	0	affinity chromatography technology	Nie J (2010)	1
RUNX1	0	CREBBP	29	affinity chromatography technology	Nguyen LA (2005)	1
LDLRAD4	1	SMAD2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CREBBP	29	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goto T (2006), Leclerc GJ (2010), Chuang JY (2012), Guo W (2014)	4
NOTCH1	25	LEF1	3	pull down	Ross DA (2001)	1
KPNB1	3	PIAS4	5	two hybrid	Goehler H (2004)	1
SMAD3	1	LACRT	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIF1A	1	SMARCA4	19	imaging technique	Wang F (2004)	1
SMAD9	0	SMAD2	5	two hybrid	Colland F (2004)	1
USP7	14	MYC	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Tavana O (2016), Tavana O (2016), Tavana O (2016), Tavana O (2016)	4
SMAD4	9	CEBPD	0	pull down, affinity chromatography technology	Choy L (2003), Choy L (2003)	2
BRCA1	7	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Yan Y (2008), Yan Y (2008)	2
SMAD7	1	NEDD4L	3	affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology	Al-Salihi MA (2012), Aragon E (2012), Aragon E (2012), Aragon E (2012)	4
SMAD2	5	TRIM62	4	two hybrid	Colland F (2004)	1
SMAD4	9	USP15	4	affinity chromatography technology, affinity chromatography technology	Inui M (2011), Eichhorn PJ (2012)	2
CREBBP	29	TP53	0	enzymatic study, pull down, genetic interference, pull down, enzymatic study, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Ito A (2002), Livengood JA (2002), Livengood JA (2002), Giebler HA (2000), Tang Y (2008), Jenkins LM (2009), Shi D (2009), Zhao Y (2006), Saifudeen Z (2005), Scolnick DM (1997), Scolnick DM (1997), Gu W (1997), Gu W (1997), Matsuda S (2004), Pasqualucci L (2011), Lee SK (1999), Dai C (2011), Lee CW (2010), Ferreon JC (2009), Ruas JL (2010), Ruas JL (2010), Huang WC (2007), Huang WC (2007), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Col E (2002), Jansma AL (2014), Jansma AL (2014), Krois AS (2016), Hasegawa K (2008), Huang X (2013), Huang X (2013), Piskacek M (2016)	35
ATF3	0	TP53	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down	Stelzl U (2005), Yan C (2002), Yan C (2002), Yan C (2005), Yan C (2005), Yan C (2005), Wei S (2014)	7
FOXO3	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Essers MA (2005), Essers MA (2005)	2
HIF1A	1	SMAD3	1	imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanchez-Elsner T (2001), Sanchez-Elsner T (2001), Sanchez-Elsner T (2001), Sanchez-Elsner T (2001), Sanchez-Elsner T (2002)	5
KAT2B	2	YY1	7	enzymatic study	Yao YL (2001)	1
KAT2B	2	MECOM	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chakraborty S (2001), Chakraborty S (2001), Shimahara A (2010), Shimahara A (2010)	4
SMURF1	4	SPTBN1	6	affinity chromatography technology	Xie Y (2013)	1
HNF4A	2	SREBF2	5	pull down	Inoue S (2011)	1
EP300	36	ZC3H12A	1	two hybrid	Wang J (2011)	1
FOXO3	1	BRCA1	7	affinity chromatography technology	Tsai WB (2008)	1
CTNNB1	30	AR	3	pull down, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Yang F (2002), Yang F (2002), Masiello D (2004), Song LN (2004), Amir AL (2003), Amir AL (2003), Mulholland DJ (2003), Mulholland DJ (2003), Pawlowski JE (2002), Mulholland DJ (2003), Levy L (2004)	11
SMAD1	0	MECOM	4	pull down	Alliston T (2005)	1
SMAD3	1	SMURF1	4	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Colland F (2004), Li Y (2017), Li Y (2017)	4
RUNX2	2	SMAD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Zhang YW (2000), Zhang YW (2000), Hanai J (1999), Jun JH (2010), Wang Q (2007)	5
CDC25A	2	CDK2	0	pull down, enzymatic study, affinity chromatography technology	Xu X (1996), Cheng A (2005), Li X (2016)	3
HDAC4	10	YY1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ren G (2009), Ren G (2009), Han S (2006), Wang X (2008), Wang X (2008)	5
JUN	0	ATF2	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Newell CL (1994), Newell CL (1994), Kara CJ (1990), Hai T (1991), Fuchs SY (1999), Reinke AW (2013), Reinke AW (2013), Miyamoto-Sato E (2010), Hayakawa J (2004), Hein MY (2015), Li X (2015), Huttlin EL (2017)	12
GSK3B	1	NOTCH1	25	enzymatic study, pull down	Foltz DR (2002), Foltz DR (2002)	2
SQSTM1	0	NOTCH1	25	affinity chromatography technology, affinity chromatography technology	Ahn JS (2016), Ahn JS (2016)	2
BRCA1	7	CDK4	2	pull down, enzymatic study, enzymatic study	Wang H (1997), Kehn K (2007), Miralem T (2003)	3
AR	3	SMARCC2	9	bioid	Lempiaeinen JK (2017)	1
HDAC5	4	USP7	14	affinity chromatography technology	Greco TM (2011)	1
SMAD3	1	ANAPC10	0	affinity chromatography technology, pull down, pull down	Nourry C (2004), Nourry C (2004), Nourry C (2004)	3
MYD88	1	IRF7	2	affinity chromatography technology, two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Zhao J (2006), Kawai T (2004), Kawai T (2004), Kawai T (2004)	4
ZMIZ1	7	BRCA1	7	affinity chromatography technology	Pinnell N (2015)	1
SMAD7	1	USP15	4	affinity chromatography technology	Eichhorn PJ (2012)	1
MAPK1	1	FOXO3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Yang JY (2008), Yang JY (2008), Yang JY (2008)	3
CDK2	0	FOXM1	3	affinity chromatography technology, enzymatic study	Major ML (2004), Luescher-Firzlaff JM (2006)	2
PCK2	3	SMAD3	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
SMAD4	9	SKIL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stroschein SL (1999), Stroschein SL (1999), Barrios-Rodiles M (2005), Colland F (2004), Colland F (2004), He J (2003), He J (2003), Ikeuchi Y (2014), Jinnin M (2007), Li X (2015)	10
RNF31	3	IRF7	2	affinity chromatography technology	Wang L (2017)	1
SP1	0	SMAD4	9	affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Luciakova K (2008), Pardali K (2000), Pardali K (2000), Pardali K (2000), Chung CL (2011), Jungert K (2006)	6
ATF3	0	JUNB	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Huttlin EL (2017)	3
SP1	0	PIN1	0	affinity chromatography technology, affinity chromatography technology	Yang HC (2014), Yang HC (2014)	2
SMAD3	1	NOTCH1	25	pull down, affinity chromatography technology	Blokzijl A (2003), Blokzijl A (2003)	2
CREBBP	29	PIAS3	2	affinity chromatography technology	Long J (2004)	1
AR	3	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Dai Y (2008), Minges JT (2013), Zhong J (2014), Fu M (2000), McClurg UL (2016), Tan G (2017)	6
WWP2	7	SMAD3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid	Soond SM (2011), Soond SM (2011), Soond SM (2011), Brown KA (2008), Soond SM (2013), Yu H (2011)	6
BRCA1	7	STRAP	2	affinity chromatography technology	Ertych N (2016)	1
ATF3	0	HDAC1	4	affinity chromatography technology, pull down	Li HF (2010), Darlyuk-Saadon I (2012)	2
EP300	36	SMAD7	1	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Groenroos E (2002), Groenroos E (2002), Groenroos E (2002), Groenroos E (2002)	4
SMAD3	1	ZFYVE9	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology	Lin HK (2004), Tsukazaki T (1998), Tsukazaki T (1998), Brown KA (2008), Colland F (2004), Qin BY (2002), Qin BY (2002), Huttlin EL (2015), Huttlin EL (2017)	9
SMAD9	0	ZEB2	7	two hybrid	Colland F (2004)	1
EP300	36	PIAS3	2	affinity chromatography technology	Long J (2004)	1
SMAD4	9	TFE3	4	pull down, pull down	Grinberg AV (2003), Hua X (1999)	2
SKI	3	SMURF2	3	affinity chromatography technology	Zhou F (2017)	1
SMAD2	5	LEMD3	4	affinity chromatography technology, two hybrid	Brown KA (2008), Hellemans J (2004)	2
HDAC5	4	KPNB1	3	affinity chromatography technology	Greco TM (2011)	1
KAT2B	2	MYC	2	enzymatic study	Patel JH (2004)	1
SP1	0	FHL1	1	affinity chromatography technology	Chuang JY (2012)	1
SMAD1	0	LEF1	3	affinity chromatography technology	Cui Q (2005)	1
SMAD1	0	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
RUNX3	1	SMURF1	4	affinity chromatography technology	Jin YH (2004)	1
CDK4	2	HDAC1	4	genetic interference	Shen JP (2017)	1
SMAD2	5	AKT1	1	affinity chromatography technology	Song K (2006)	1
SMAD3	1	RUNX3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hanai J (1999), Jin YH (2004), Kong Y (2016)	3
MAPK1	1	ATF2	1	enzymatic study, enzymatic study, enzymatic study	Livingstone C (1995), Sanna MG (2002), Krump E (1997)	3
SMAD2	5	NEDD9	3	affinity chromatography technology	Liu X (2000)	1
CTCF	15	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down	Bergstroem R (2010), Bergstroem R (2010), Bergstroem R (2010)	3
MYC	2	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Ewing RM (2007), Park J (2002), Pal S (2003), Ivanov AA (2017)	4
SMAD1	0	NUP214	3	affinity chromatography technology	Sapkota G (2007)	1
CDK4	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
S100A4	0	SMAD2	5	affinity chromatography technology	Matsuura I (2010)	1
SNW1	0	SKI	3	two hybrid, pull down, two hybrid, pull down, affinity chromatography technology, genetic interference	Prathapam T (2001), Prathapam T (2001), Dahl R (1998), Dahl R (1998), Dahl R (1998), Leong GM (2001)	6
ZMIZ1	7	SMAD4	9	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Li X (2006), Li X (2006), Li X (2006), Li X (2006)	4
EP300	36	EID2	0	pull down, affinity chromatography technology	Ji A (2003), Ji A (2003)	2
SMAD1	0	USP15	4	affinity chromatography technology, affinity chromatography technology	Inui M (2011), Eichhorn PJ (2012)	2
SMAD2	5	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Xi Q (2008), Chan EC (2010), He W (2006), Chen W (2007), Colland F (2004), Cui Q (2005)	6
CREBBP	29	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kang JS (2005), Alliston T (2005), Xi Q (2008), Cui Q (2005), Cui Q (2005), Chen W (2007), Nishihara A (1999), Tomita M (2004), Oussaief L (2009), Oussaief L (2009), Cui Q (2005)	11
HIF1A	1	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
WWP1	3	SMAD4	9	affinity chromatography technology	Seo SR (2004)	1
EP300	36	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Wotton D (1999), Pessah M (2001), Furumatsu T (2005), Wang J (2011), Suganuma T (2002)	5
SMAD3	1	FOXM1	3	pull down, affinity chromatography technology	Xue J (2014), Xue J (2014)	2
ZFYVE9	5	FHL2	0	two hybrid	Colland F (2004)	1
BRCA1	7	SPTBN1	6	affinity chromatography technology	Ertych N (2016)	1
AR	3	TGIF1	1	pull down	Sharma M (2001)	1
TP53	0	SQSTM1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Di Lello P (2006), Horikawa I (2014), Kang JH (2016), Kang JH (2016)	4
EP300	36	STRAP	2	affinity chromatography technology	Xu D (2008)	1
IRF7	2	CREBBP	29	pull down	Yang H (2003)	1
AR	3	TGFB1I1	2	two hybrid, affinity chromatography technology, pull down, two hybrid, unspecified method	Wang X (2002), Wang X (2002), Wang X (2002), He B (2002), He B (2002)	5
PIN1	0	RUNX3	1	affinity chromatography technology	Nicole Tsang YH (2012)	1
CDK2	0	SP1	0	enzymatic study	Fojas de Borja P (2001)	1
CDK2	0	KPNB1	3	affinity chromatography technology	Neganova I (2011)	1
VDR	2	RUNX1	0	pull down, affinity chromatography technology	Puccetti E (2002), Puccetti E (2002)	2
SMURF2	3	RUNX2	2	enzymatic study	Lu K (2011)	1
GSK3B	1	TP53	0	affinity chromatography technology, two hybrid	Watcharasit P (2002), Vinayagam A (2011)	2
MYC	2	CDK2	0	genetic interference, genetic interference	Toyoshima M (2012), Zhou Z (2014)	2
SMAD3	1	CEBPD	0	pull down, affinity chromatography technology	Choy L (2003), Choy L (2003)	2
SMAD1	0	LEMD3	4	two hybrid, two hybrid	Colland F (2004), Hellemans J (2004)	2
RUNX3	1	NOTCH1	25	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Gao J (2010), Gao J (2010), Gao J (2010), Gao J (2010)	4
AKT1	1	FOXO3	1	enzymatic study, imaging technique	Sundaresan NR (2011), Chen TC (2014)	2
CTNNB1	30	PIN1	0	pull down	Ryo A (2001)	1
FHL1	1	CREBBP	29	affinity chromatography technology	Hubbi ME (2012)	1
SMAD2	5	RUNX1	0	affinity chromatography technology	Hanai J (1999)	1
TGFBR1	2	EP300	36	affinity chromatography technology, affinity chromatography technology	Mu Y (2011), Mu Y (2011)	2
VDR	2	EP300	36	imaging technique, imaging technique	Kim S (2005), Kim S (2005)	2
SMURF1	4	KPNB1	3	affinity chromatography technology	Xie Y (2013)	1
SMAD3	1	EPAS1	6	imaging technique, two hybrid, imaging technique	Chae KS (2011), Colland F (2004), Chen TC (2014)	3
SMAD3	1	TSC2	17	affinity chromatography technology, affinity chromatography technology, pull down	Birchenall-Roberts MC (2004), Birchenall-Roberts MC (2004), Birchenall-Roberts MC (2004)	3
TP53	0	SMARCA4	19	pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee D (2002), Lee D (2002), Lee D (2002), Napolitano MA (2007), Guan B (2011), Oh J (2008)	6
E2F4	0	AR	3	affinity chromatography technology, affinity chromatography technology	Li Y (2012), Li Y (2012)	2
CREBBP	29	JUNB	0	affinity chromatography technology	Tran NQ (2004)	1
EP300	36	CEBPD	0	enzymatic study	Wang JM (2006)	1
PIAS4	5	LEF1	3	two hybrid, pull down, affinity chromatography technology	Sachdev S (2001), Sachdev S (2001), Sachdev S (2001)	3
HDAC5	4	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Backs J (2008), Backs J (2008), Rui J (2012), Rui J (2012)	4
ZMIZ1	7	AR	3	affinity chromatography technology, two hybrid	Sharma M (2003), Sharma M (2003)	2
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
SNW1	0	SMAD4	9	genetic interference, two hybrid	Leong GM (2001), Leong GM (2001)	2
LEF1	3	EP300	36	enzymatic study, affinity chromatography technology, pull down	Hecht A (2003), Hecht A (2003), Hecht A (2003)	3
CSNK1D	3	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique	Kulikov R (2006), Alsheich-Bartok O (2008), Alsheich-Bartok O (2008), Wolff S (2006), Chen TC (2014)	5
RUNX3	1	HDAC5	4	affinity chromatography technology	Jin YH (2004)	1
SMAD3	1	SMARCC2	9	affinity chromatography technology, affinity chromatography technology	Xi Q (2008), Xi Q (2008)	2
S100A4	0	TP53	0	pull down, affinity chromatography technology	Chen H (2001), Matsuura I (2010)	2
SMARCA4	19	CREBBP	29	genetic interference	DiRenzo J (2000)	1
SNW1	0	RBL1	1	pull down	Prathapam T (2002)	1
SREBF2	5	FHL3	0	two hybrid	Bandyopadhyay S (2010)	1
SMAD1	0	AR	3	affinity chromatography technology, affinity chromatography technology, protein complementation assay, imaging technique, affinity chromatography technology	Qiu T (2007), Qiu T (2007), Qiu T (2007), Qiu T (2007), Li Y (2013)	5
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
ATF3	0	JUN	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Pearson AG (2003), Chen BP (1996), Hai T (1991), Filen S (2010), Reinke AW (2013), Reinke AW (2013), Hein MY (2015), Li X (2015)	8
TP53	0	KPNB1	3	affinity chromatography technology, pull down	Akakura S (2001), Akakura S (2001)	2
RBL1	1	SMARCA4	19	two hybrid	Dunaief JL (2002)	1
EP300	36	SREBF2	5	far western blotting	Oliner JD (1996)	1
SMAD2	5	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wotton D (1999), Wotton D (1999), Takeda M (2004), Lo RS (2001)	4
YY1	7	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Bennett MK (1999), Li H (2008), Li H (2008), Santiago FS (2007), Qiao H (2011), Lee JS (1993), Lee JS (1993)	7
SMAD1	0	ERBIN	5	pull down	Warner DR (2003)	1
CREBBP	29	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Pao GM (2000), Pao GM (2000), Benezra M (2003), Fan S (2002), Fan S (2002), Neish AS (1998), Nakuci E (2006), Crowe DL (2006), Chai YL (1999)	9
LDLRAD4	1	WWP2	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EID2	0	SMAD4	9	affinity chromatography technology, affinity chromatography technology	Lee HJ (2004), Lee HJ (2004)	2
SMAD2	5	ERBIN	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Warner DR (2003), Xi Q (2008), Brown KA (2008), Dai F (2007), Dai F (2007), Dai F (2007)	6
HIF1A	1	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Chen D (2003), Ravi R (2000), Hansson LO (2002), An WG (1998), An WG (1998), Chowdhury AR (2017), Chowdhury AR (2017), Suzuki H (2001), Sanchez-Puig N (2005)	9
BRCA1	7	USP7	14	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
MAPK1	1	SREBF2	5	enzymatic study, enzymatic study	Kotzka J (2000), Kotzka J (2004)	2
OTUB1	0	PIN1	0	affinity chromatography technology	Scholz CC (2016)	1
EPAS1	6	CTNNB1	30	affinity chromatography technology	Steunou AL (2012)	1
LDLRAD4	1	WWOX	3	affinity chromatography technology	Huttlin EL (2015)	1
KPNB1	3	SMAD4	9	affinity chromatography technology	Xiao Z (2000)	1
EPAS1	6	JUN	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
SMAD3	1	CSNK1G2	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Guo X (2008), Guo X (2008), Guo X (2008)	3
CTNNB1	30	USP15	4	affinity chromatography technology, affinity chromatography technology	Greenblatt MB (2016), Greenblatt MB (2016)	2
PIAS3	2	SMURF2	3	affinity chromatography technology, affinity chromatography technology	Chandhoke AS (2015), Chandhoke AS (2015)	2
SNW1	0	UCHL5	1	affinity chromatography technology	Lleres D (2010)	1
ZMIZ1	7	SMAD3	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Li X (2006), Li X (2006), Li X (2006), Li X (2006)	4
VDR	2	TP53	0	affinity chromatography technology, affinity chromatography technology	Stambolsky P (2010), Stambolsky P (2010)	2
SMAD4	9	IRF7	2	pull down, affinity chromatography technology	Qing J (2004), Qing J (2004)	2
WWP1	3	NOTCH1	25	pull down, imaging technique	Flasza M (2006), Flasza M (2006)	2
CREBBP	29	HNF4A	2	two hybrid, affinity chromatography technology, pull down, genetic interference, pull down, pull down, enzymatic study, pull down, affinity chromatography technology	Yoshida E (1997), Yoshida E (1997), Yoshida E (1997), Yoshida E (1997), Dell H (1999), Surapureddi S (2008), Soutoglou E (2000), Soutoglou E (2000), Green VJ (1998)	9
HDAC1	4	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsuoka Y (2008), Matsuoka Y (2008), Liu T (2007), Liu T (2007), Liu T (2007), Koch HB (2007), Hwang IY (2012), Hein MY (2015)	8
LDLRAD4	1	WWP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
OTUB1	0	FOXM1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Karunarathna U (2016), Karunarathna U (2016), Wang Y (2016), Wang Y (2016), Wang Y (2016), Wang Y (2016), Wang Y (2016)	7
SMAD3	1	TFE3	4	pull down, pull down	Grinberg AV (2003), Hua X (1999)	2
SNW1	0	MYC	2	affinity chromatography technology, affinity chromatography technology	Bres V (2009), Bres V (2009)	2
RUNX2	2	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shimizu E (2010), Shimizu E (2010), Jeon EJ (2006), Vega RB (2004)	4
HDAC1	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mayanil CS (2006), Chuang HC (2006), Chuang HC (2006)	3
FHL2	0	FHL1	1	pull down	Lange S (2002)	1
SMAD2	5	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tian YC (2002), Dahle O (2010), Xi Y (2013)	3
AR	3	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Chen ST (2015), Chen ST (2015), Chen ST (2015), Chen ST (2015)	4
RUNX2	2	SMURF1	4	imaging technique	Wang Q (2007)	1
SKI	3	TGFBR1	2	affinity chromatography technology, pull down	Ferrand N (2010), Ferrand N (2010)	2
MYC	2	MAX	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, two hybrid, pull down, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), McMahon SB (2000), McMahon SB (1998), Cheng SW (1999), Mac Partlin M (2003), Mac Partlin M (2003), Blackwood EM (1991), Lee CM (2002), Billin AN (1999), Gupta K (1998), Meroni G (1997), Nair SK (2003), Nair SK (2003), FitzGerald MJ (1999), Meroni G (2000), Hatakeyama S (2005), Bandyopadhyay S (2010), Matsuoka Y (2009), Cowling VH (2006), Wang Z (2006), Faiola F (2005), Siegel PM (2003), Veldman T (2003), Patel JH (2004), Liu T (2007), Zhang Y (2007), Gordan JD (2007), Gordan JD (2007), Gargano B (2007), Zippo A (2007), Zippo A (2007), Zhang P (2010), Kim J (2010), Kim J (2010), Kim J (2010), Kim J (2010), Koch HB (2007), Koch HB (2007), Patel JH (2006), Lavigne P (1998), Amente S (2007), Ayer DE (1993), Huang Z (2004), Huang Z (2004), Okano HJ (1999), Agrawal P (2010), Agrawal P (2010), Wong WJ (2013), Wang J (2011), Yu L (2009), Liu X (2003), Hein MY (2015), Li X (2015), Li X (2015), Kalkat M (2014), Hauri S (2016)	56
SMAD4	9	CTNNB1	30	affinity chromatography technology	Tian YC (2002)	1
FHL1	1	AKT1	1	affinity chromatography technology	Zhang F (2012)	1
SMURF1	4	MYD88	1	affinity chromatography technology, affinity chromatography technology	Lee YS (2011), Lee YS (2011)	2
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
JUNB	0	BRCA1	7	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hu YF (2002), Hu YF (2002), Hu YF (2002), Kang HJ (2008), Hill SJ (2014), Huttlin EL (2017)	6
CTNNB1	30	EP300	36	genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, genetic interference, affinity chromatography technology	Kennell JA (2003), Sun Y (2000), Sun Y (2000), Sun Y (2000), Saegusa M (2005), Daniels DL (2002), Levy L (2004), Labalette C (2004), Lee YH (2006), Zhao Y (2016)	10
HDAC5	4	HDAC1	4	affinity chromatography technology	Greco TM (2011)	1
SMARCA4	19	JUNB	0	biochemical, affinity chromatography technology	Reyes JC (1997), Henderson A (2004)	2
LEF1	3	SMAD2	5	pull down, affinity chromatography technology, affinity chromatography technology	Labbe E (2000), Labbe E (2000), Cui Q (2005)	3
SMAD3	1	SQSTM1	0	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
OTUB1	0	MAPK1	1	affinity chromatography technology	Scholz CC (2016)	1
TSC2	17	GSK3B	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Mak BC (2003), Inoki K (2006), Mak BC (2003)	3
SMAD4	9	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
TGFBR1	2	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Eichhorn PJ (2012), Zhang L (2013), Herhaus L (2014)	3
SKIL	3	TGFBR1	2	affinity chromatography technology	Ferrand N (2010)	1
USP15	4	OTUB1	0	enzymatic study	Loch CM (2012)	1
MYC	2	FHL2	0	affinity chromatography technology	Agrawal P (2010)	1
SMAD4	9	CREBBP	29	affinity chromatography technology	Yang Y (2015)	1
MAPK1	1	VDR	2	enzymatic study	Han S (2010)	1
WWOX	3	BRCA1	7	pull down, affinity chromatography technology, affinity chromatography technology	Schrock MS (2017), Schrock MS (2017), Schrock MS (2017)	3
SQSTM1	0	MAPK1	1	affinity chromatography technology	Linares JF (2011)	1
ZFYVE9	5	CTNNB1	30	two hybrid	Colland F (2004)	1
MYC	2	TP53	0	affinity chromatography technology, fluorescent resonance energy transfe	Agrawal P (2010), Ivanov AA (2017)	2
TRIM33	4	RUNX1	0	affinity chromatography technology	Bai X (2010)	1
NOTCH1	25	SNW1	0	pull down, two hybrid, affinity chromatography technology, pull down	Beatus P (2001), Beatus P (2001), Zhou S (2000), Fryer CJ (2004)	4
EP300	36	ZEB2	7	affinity chromatography technology	Weng Q (2012)	1
CREBBP	29	FHL2	0	affinity chromatography technology	Labalette C (2004)	1
CREBBP	29	AR	3	two hybrid, pull down, pull down, genetic interference, affinity chromatography technology, pull down	Kim J (2005), Fronsdal K (1998), Ishitani K (2003), Aarnisalo P (1998), Andersen RJ (2010), Fronsdal K (1998)	6
BRCA1	7	HIVEP1	13	two hybrid	Wang J (2011)	1
PIAS4	5	SMAD2	5	affinity chromatography technology, two hybrid, affinity chromatography technology	Imoto S (2003), Long J (2003), Long J (2003)	3
NOTCH1	25	SMAD9	0	affinity chromatography technology	Yatim A (2012)	1
MYC	2	HIF1A	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Koshiji M (2004), Koshiji M (2004), Ivanov AA (2017)	3
YY1	7	CREBBP	29	affinity chromatography technology, affinity chromatography technology	de Nigris F (2007), de Nigris F (2007)	2
SMAD3	1	NOTCH4	7	affinity chromatography technology, affinity chromatography technology	Sun Y (2005), Sun Y (2005)	2
SMAD2	5	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inui M (2011), Eichhorn PJ (2012), Wijnhoven P (2015)	3
WWP2	7	STRAP	2	affinity chromatography technology	Chaudhary N (2014)	1
VDR	2	SMAD3	1	two hybrid, pull down, two hybrid, pull down	Yanagisawa J (1999), Yanagisawa J (1999), Yanagisawa J (1999), Yanagisawa J (1999)	4
FHL2	0	SMAD2	5	pull down, affinity chromatography technology	Ding L (2009), Ding L (2009)	2
TP53	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015)	26
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
TP53	0	FOXO3	1	imaging technique, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), Du WW (2017), Du WW (2017)	3
SMAD3	1	RBX1	2	affinity chromatography technology, affinity chromatography technology, two hybrid	Fukuchi M (2001), Fukuchi M (2001), Fukuchi M (2001)	3
PCK2	3	LACRT	1	affinity chromatography technology	Huttlin EL (2017)	1
FOXH1	1	TGIF1	1	affinity chromatography technology	Wotton D (1999)	1
SMAD1	0	YY1	7	pull down	Kurisaki K (2003)	1
AR	3	TP53	0	genetic interference	Shenk JL (2001)	1
EPAS1	6	HIF1A	1	affinity chromatography technology	Steunou AL (2012)	1
VDR	2	JUN	0	pull down	Towers TL (1999)	1
BRCA1	7	HIF1A	1	affinity chromatography technology, affinity chromatography technology	Kang HJ (2006), Kang HJ (2006)	2
SKI	3	AKT1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Band AM (2009), Band AM (2009), Band AM (2009)	3
NEDD4	2	BRCA2	6	unspecified method	Burch LR (2004)	1
WWP2	7	MYC	2	affinity chromatography technology, affinity chromatography technology	Yu Z (2016), Yu Z (2016)	2
MYC	2	VDR	2	affinity chromatography technology	Salehi-Tabar R (2012)	1
FHL2	0	RUNX2	2	affinity chromatography technology, pull down	Guenther T (2005), Guenther T (2005)	2
CREBBP	29	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Pearson KL (1999), Sun Y (2001)	2
KAT2B	2	SMAD2	5	pull down, affinity chromatography technology, affinity chromatography technology	Itoh S (2000), Kahata K (2004), Dai M (2012)	3
CTNNB1	30	CBL	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Chitalia V (2013), Chitalia V (2013), Chitalia V (2013), Shivanna S (2015)	4
EP300	36	PCK2	3	two hybrid	Wang J (2011)	1
NEDD4L	3	NOTCH1	25	affinity chromatography technology	Puca L (2013)	1
TP53	0	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Chau JF (2012), Chau JF (2012)	2
SMAD3	1	CITED2	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Chou YT (2006), Chou YT (2006), Chou YT (2006), Chou YT (2006)	4
CDK2	0	SMAD3	1	enzymatic study, imaging technique	Matsuura I (2004), Chen TC (2014)	2
HDAC1	4	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Qiu Z (2008), Battaglioli E (2002), Hang CT (2010), DiRenzo J (2000)	4
CBL	7	SMAD3	1	affinity chromatography technology, affinity chromatography technology	Kang JM (2012), Kang JM (2012)	2
LDLRAD4	1	CSNK1D	3	affinity chromatography technology	Huttlin EL (2015)	1
NEDD4L	3	TGFB1I1	2	pull down	Persaud A (2009)	1
CREBBP	29	FOXM1	3	affinity chromatography technology	Major ML (2004)	1
MYC	2	SMAD3	1	affinity chromatography technology, pull down, two hybrid	Feng XH (2002), Feng XH (2002), Feng XH (2002)	3
ZMIZ1	7	TP53	0	two hybrid, pull down, affinity chromatography technology	Lee J (2007), Lee J (2007), Lee J (2007)	3
SMAD7	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Kuratomi G (2005), Al-Salihi MA (2012)	3
SKIL	3	TRIM33	4	affinity chromatography technology, affinity chromatography technology	Ikeuchi Y (2014), Ikeuchi Y (2014)	2
EPAS1	6	SMARCC2	9	affinity chromatography technology	Steunou AL (2012)	1
CTNNB1	30	USP7	14	affinity chromatography technology, affinity chromatography technology, enzymatic study, unspecified method	Novellasdemunt L (2017), Novellasdemunt L (2017), Novellasdemunt L (2017), Novellasdemunt L (2017)	4
ZEB2	7	HDAC4	10	affinity chromatography technology	Long J (2005)	1
SKIL	3	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Stroschein SL (2001), Stroschein SL (1999), Tan R (2006), Mizuide M (2003), Brown KA (2008), Colland F (2004), Colland F (2004), He J (2003), Ikeuchi Y (2014)	9
NEDD4	2	SKIL	3	affinity chromatography technology	Kuratomi G (2005)	1
MAPK1	1	CITED2	0	enzymatic study	Chen CM (2012)	1
SPTBN1	6	SMAD3	1	affinity chromatography technology, affinity chromatography technology	Tang Y (2003), Tang Y (2003)	2
BRCA1	7	E2F4	0	pull down	Wang H (1997)	1
SKIL	3	PIAS4	5	two hybrid	Colland F (2004)	1
SMAD3	1	SREBF2	5	affinity chromatography technology, affinity chromatography technology	Grimsby S (2004), Grimsby S (2004)	2
EP300	36	NOTCH1	25	affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid	Hao L (2010), Popko-Scibor AE (2011), Popko-Scibor AE (2011), Popko-Scibor AE (2011)	4
EP300	36	SMAD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pearson KL (1999), Nakashima K (1999), Nakashima K (1999), Jeon EJ (2006), Jun JH (2010), Weng Q (2012)	6
SP1	0	JUN	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kardassis D (1999), Hung JJ (2006), Chen BK (2007), Chen BK (2007), Chen BK (2007)	5
SMAD2	5	IRF7	2	pull down, affinity chromatography technology	Qing J (2004), Qing J (2004)	2
PPP1R12C	1	SMAD3	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
HIF1A	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PIN1	0	DAB2	1	affinity chromatography technology, pull down	He J (2003), He J (2003)	2
HNF4A	2	HIF1A	1	affinity chromatography technology, pull down, two hybrid	Tsuchiya T (2002), Tsuchiya T (2002), Tsuchiya T (2002)	3
SMAD1	0	RUNX1	0	affinity chromatography technology	Hanai J (1999)	1
SMAD3	1	SKIL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stroschein SL (2001), Stroschein SL (2001), Stroschein SL (1999), Liberati NT (2001), Tan R (2006), Mizuide M (2003), Colland F (2004), He J (2003), Jinnin M (2007), Jinnin M (2007)	10
YY1	7	UCHL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cai Y (2007), Yao T (2008), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	5
SMAD3	1	YY1	7	pull down, affinity chromatography technology	Kurisaki K (2003), Brown KA (2008)	2
SMAD3	1	SMARCA4	19	affinity chromatography technology, affinity chromatography technology	Xi Q (2008), Xi Q (2008)	2
TP53	0	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SMAD2	5	NOTCH4	7	affinity chromatography technology	Sun Y (2005)	1
HDAC4	10	ATF3	0	pull down	Darlyuk-Saadon I (2012)	1
CREBBP	29	KAT2B	2	pull down, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Tini M (2002), Cho H (1998), Cho H (1998), Cho H (1998), Korzus E (1998), Korzus E (1998), Korzus E (1998), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996)	10
SP1	0	CDK4	2	affinity chromatography technology	Tapias A (2008)	1
YY1	7	HDAC5	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sucharov CC (2006), Sucharov CC (2006), Sucharov CC (2008)	3
NEDD4	2	CSNK1D	3	affinity chromatography technology	Liu J (2014)	1
ZC3H12A	1	HIF1A	1	enzymatic study	Roy A (2013)	1
NOTCH1	25	SMARCC2	9	affinity chromatography technology	Yatim A (2012)	1
RUNX2	2	CREBBP	29	affinity chromatography technology	Makita N (2008)	1
SMAD1	0	NEDD4	2	affinity chromatography technology, two hybrid	Kim BG (2011), Colland F (2004)	2
CBL	7	SPTBN1	6	affinity chromatography technology	Brehme M (2009)	1
MYD88	1	SMAD3	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
SMAD3	1	SMAD9	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CREBBP	29	ATF2	1	pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sano Y (1998), Sano Y (1998), Sano Y (1998), Sano Y (1998), Deb S (2006), Merika M (1998), Johnson J (2007), Venza I (2001)	8
SMAD3	1	ERBIN	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Warner DR (2003), Xi Q (2008), Brown KA (2008), Dai F (2007), Dai F (2007), Dai F (2007)	6
NOTCH1	25	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, pull down	Jin YH (2009), Jin YH (2009), Jin YH (2009)	3
TGFBR1	2	SMAD4	9	biochemical, affinity chromatography technology	Razani B (2001), Barrios-Rodiles M (2005)	2
SMURF1	4	SMAD1	0	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, pull down, unspecified method, two hybrid, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Sangadala S (2006), Komuro A (2004), Tian M (2011), Tian M (2011), Tian M (2011), Sapkota G (2007), Sapkota G (2007), Li L (2004), Alarcon C (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011), Aragon E (2011), Gao S (2009), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Colland F (2004), Cao Y (2014), Cao Y (2014), Sangadala S (2007), Gao S (2009), Wan L (2011), Wan L (2011), Zhang Y (2017), Zhang Y (2017)	28
SKIL	3	TRIM62	4	two hybrid	Colland F (2004)	1
FHL1	1	EP300	36	affinity chromatography technology	Hubbi ME (2012)	1
TP53	0	OTUB1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Sun XX (2011), Sun XX (2011), Sun XX (2011), Li Y (2014), Fernandez-Majada V (2016)	5
CDK2	0	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Ruffner H (1999), Ruffner H (1999), Ruffner H (1999), Wang H (1997), Chen Y (1996)	5
SMAD1	0	ZEB2	7	two hybrid, affinity chromatography technology	Colland F (2004), Weng Q (2012)	2
HIF1A	1	HDAC4	10	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Seo HW (2009), Seo HW (2009), Qian DZ (2006), Bodily JM (2011), Kato H (2004)	5
GSK3B	1	CEBPD	0	enzymatic study	Balamurugan K (2013)	1
EP300	36	YY1	7	enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Yao YL (2001), Lee JS (1995), Lee JS (1995), Lee JS (1995), Lee JS (1995), Kadeppagari RK (2009), Kadeppagari RK (2009), Kadeppagari RK (2009), Sankar N (2008), Sankar N (2008), Sankar N (2008), Wang CC (2007), Wang CC (2007), Galvin KM (1997)	14
IRF7	2	EP300	36	pull down	Yang H (2003)	1
AR	3	PIAS4	5	pull down, pull down	Gross M (2001), Gross M (2004)	2
EP300	36	MAPK1	1	affinity chromatography technology, enzymatic study, enzymatic study	Chen YJ (2007), Chen YJ (2007), Sang N (2003)	3
E2F4	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ferreira R (1998), Iavarone A (1999), Chen L (2012)	3
MAPK1	1	GSK3B	1	affinity chromatography technology, pull down, enzymatic study	Ding Q (2005), Ding Q (2005), Ding Q (2005)	3
FHL1	1	SMAD2	5	pull down, affinity chromatography technology, affinity chromatography technology	Ding L (2009), Ding L (2009), Ding L (2009)	3
SMAD9	0	OTUB1	0	two hybrid	Colland F (2004)	1
RBX1	2	ERBIN	5	enzymatic study	Kuang P (2016)	1
SNW1	0	SPTBN1	6	affinity chromatography technology	Lleres D (2010)	1
TP53	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
FOXH1	1	SMAD4	9	pull down, two hybrid	Chen X (1997), Chen X (1997)	2
PIAS4	5	HDAC1	4	pull down	Gross M (2004)	1
VDR	2	FOS	0	pull down	Towers TL (1999)	1
SMAD9	0	LEMD3	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Colland F (2004), Huttlin EL (2015), Huttlin EL (2017)	3
SNW1	0	SMAD3	1	genetic interference, two hybrid, pull down, affinity chromatography technology	Leong GM (2001), Leong GM (2001), Leong GM (2001), Brown KA (2008)	4
SMAD1	0	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Li L (2004), Chong PA (2010), Colland F (2004), Huttlin EL (2017), Zhou F (2017)	10
EP300	36	HIF1A	1	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down	Lando D (2002), Freedman SJ (2002), Lewis MD (2004), Matt T (2004), Sang N (2002), Luo W (2010), Freedman SJ (2003), Bodily JM (2011), Lee YM (2009), Lee YM (2009), Lee YM (2009), Kung AL (2004), Kung AL (2004), Kung AL (2004), Land SC (2007), Zhang Y (2010), Zhang Y (2010), Fath DM (2006), Fath DM (2006), Lee SJ (2013), Wang D (2014), Kaluz S (2006), Kaluz S (2006), Kaluz S (2006), Shin DH (2008), Shin DH (2008), Wang Y (2012), Huang C (2009), Hewitson KS (2002), Cook KM (2009), Cook KM (2009), Hubbi ME (2012), Kim SY (2014), Sang N (2003), Sang N (2003), Sang N (2003), Yasinska IM (2003), Na YR (2013), Na YR (2013), Mendonca DB (2011), Arany Z (1996), Arany Z (1996), Chen R (2012), Li SH (2008), Galbraith MD (2013), Chen Z (2014), Li Q (2012), Geng H (2012), Geng H (2012), Kato H (2004), Lim JH (2010), Kyle HF (2015), Kyle HF (2015), Rath S (2016), Kimura M (2008), Dubey R (2013)	56
ATF3	0	SMAD2	5	affinity chromatography technology, affinity chromatography technology	Yin X (2010), Yin X (2010)	2
GSK3B	1	SMURF2	3	affinity chromatography technology	Wu Q (2009)	1
STRAP	2	SP1	0	affinity chromatography technology, affinity chromatography technology	Jin L (2014), Jin L (2014)	2
NEDD4	2	AKT1	1	enzymatic study, enzymatic study, affinity chromatography technology	Persaud A (2009), Fan CD (2013), Fan CD (2013)	3
MYC	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NEDD4L	3	NR3C1	2	pull down	Almloef T (1998)	1
TP53	0	IRF7	2	two hybrid	Chen J (2008)	1
HDAC1	4	RBL1	1	affinity chromatography technology, affinity chromatography technology, pull down	Lai A (1999), Ferreira R (1998), Ferreira R (1998)	3
WWOX	3	SMARCA4	19	affinity chromatography technology	Abu-Odeh M (2014)	1
AR	3	KAT2B	2	pull down, enzymatic study	Fu M (2000), Fu M (2000)	2
NR3C1	2	HDAC1	4	affinity chromatography technology, affinity chromatography technology, biochemical, fluorescent resonance energy transfe, pull down	Qiu Y (2006), Jee YK (2005), Kristensen AR (2012), Qiu Y (2011), Qiu Y (2011)	5
SMAD4	9	FOXO3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Seoane J (2004), Fu G (2011), Fu G (2011)	4
RUNX2	2	HDAC1	4	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, genetic interference	Lee HW (2006), Zhang Z (2012), Ali SA (2012), Ali SA (2012), Ali SA (2012)	5
CTNNB1	30	HDAC4	10	affinity chromatography technology	Vietor I (2005)	1
TP53	0	SNW1	0	affinity chromatography technology	Fogeron ML (2013)	1
NOTCH1	25	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Yatim A (2012), Yatim A (2012)	2
GSK3B	1	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology	Guo X (2008), Guo X (2008), Choi SI (2011)	3
JUN	0	AR	3	affinity chromatography technology, affinity chromatography technology	Sato N (1997), Sato N (1997)	2
USP15	4	FHL1	1	affinity chromatography technology, pull down	Isumi Y (2011), Isumi Y (2011)	2
HDAC5	4	STRAP	2	affinity chromatography technology	Greco TM (2011)	1
CHRD	5	SMAD3	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
MAPK1	1	SMAD3	1	enzymatic study, affinity chromatography technology	Alarcon C (2009), Brown KA (2008)	2
SMAD3	1	RUNX2	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang YW (2000), Zhang YW (2000), Hanai J (1999), Ohyama Y (2011)	4
PIAS4	5	SMAD4	9	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Imoto S (2003), Long J (2003), Long J (2003), Long J (2003), Lee PS (2003)	5
SMAD4	9	RBL1	1	affinity chromatography technology	Chen CR (2002)	1
SKI	3	SQSTM1	0	affinity chromatography technology	Rashidian J (2015)	1
RUNX2	2	FOS	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Hess J (2001), Hess J (2001), DAlonzo RC (2002), DAlonzo RC (2002), DAlonzo RC (2002)	5
SP1	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Di Padova M (2003), Singh J (2002), Zhang Y (2002), Sun JM (2002), Gao J (2009), Shon JK (2009), Mottet D (2009), Goto T (2006), Hung JJ (2006), Lagger G (2003), Choi HS (2002), Choi HS (2002), Kang JE (2005), Kang JE (2005), Kang JE (2005), Gan Y (2005), Gan Y (2005), Duan H (2005), Varshochi R (2005), Varshochi R (2005), Plaisance V (2005), Walker GE (2001), Walker GE (2001), Ammanamanchi S (2004), Doetzlhofer A (1999), Sekhavat A (2007), Liu T (2007), Enya K (2008), Liu S (2010), Leclerc GJ (2010), Leclerc GJ (2010), Wong CY (2011), Schnur N (2007)	33
EID2	0	SMAD2	5	affinity chromatography technology, affinity chromatography technology	Lee HJ (2004), Lee HJ (2004)	2
LDLRAD4	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NOTCH1	25	YY1	7	affinity chromatography technology, affinity chromatography technology, pull down	Yeh TS (2003), Yeh TS (2003), Yeh TS (2003)	3
SMAD3	1	FOXO3	1	affinity chromatography technology, affinity chromatography technology, imaging technique	Seoane J (2004), Fu G (2011), Bollinger LM (2014)	3
SMAD3	1	SKI	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Ueki N (2003), Ueki N (2003), Tabata T (2009), Prunier C (2003), Liberati NT (2001), Akiyoshi S (1999), Akiyoshi S (1999), Takeda M (2004), Mizuide M (2003), Wu K (2003), Chen W (2007), Band AM (2009), Qin BY (2002), He J (2003), He J (2003), Jinnin M (2007), Jinnin M (2007), Rashidian J (2015)	19
EP300	36	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Felzien LK (1999), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
CEBPD	0	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lai PH (2008), Turgeon N (2008), Turgeon N (2008), Turgeon N (2008)	4
HDAC5	4	SMAD7	1	affinity chromatography technology, affinity chromatography technology	Simonsson M (2005), Laganiere J (2005)	2
SMAD7	1	TGFB1I1	2	affinity chromatography technology, pull down	Wang H (2008), Wang H (2008)	2
SMAD2	5	JUN	0	affinity chromatography technology, pull down	Pessah M (2001), Miyamoto-Sato E (2010)	2
OTUB1	0	SMAD2	5	affinity chromatography technology, affinity chromatography technology, pull down	Herhaus L (2013), Herhaus L (2013), Herhaus L (2013)	3
EP300	36	JUN	0	pull down, biochemical, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Campbell KM (2002), Campbell KM (2002), Campbell KM (2002), Subbaramaiah K (2002), Duyndam MC (1999), Wang WM (2011), Deng WG (2004), Deng WG (2004), Cheng SE (2011), Cheng SE (2011), Kim BK (2014), Vries RG (2001), Deng WG (2003), Liu L (2017), Liu L (2017)	15
SMAD2	5	NEDD4L	3	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Gao S (2009), Colland F (2004), Gao S (2009), Yan X (2016)	4
SMAD4	9	SMURF1	4	affinity chromatography technology, affinity chromatography technology	Moren A (2005), Zhang L (2013)	2
SP1	0	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Gartel AL (2001), Liu T (2007), Gordan JD (2007), Gordan JD (2007), Koshiji M (2005), Koshiji M (2005)	6
S100A4	0	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down	Matsuura I (2010), Matsuura I (2010), Matsuura I (2010)	3
E2F4	0	CDK4	2	affinity chromatography technology	Boldt K (2016)	1
RUNX1	0	EP300	36	affinity chromatography technology, enzymatic study	Aikawa Y (2006), Yamaguchi Y (2004)	2
BRCA1	7	AKT1	1	pull down, affinity chromatography technology, pull down, enzymatic study, pull down	Altiok S (1999), Xiang T (2008), Xiang T (2008), Xiang T (2008), Xiang T (2011)	5
SMAD3	1	TRIB3	0	affinity chromatography technology, affinity chromatography technology	Hua F (2011), Hua F (2011)	2
FHL3	0	SMAD4	9	pull down, affinity chromatography technology	Ding L (2009), Ding L (2009)	2
SP1	0	SREBF2	5	pull down, two hybrid	Gunther M (2000), Bandyopadhyay S (2010)	2
SMARCA4	19	SMARCC2	9	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Wang W (1996), Otsuki T (2001), Zhao K (1998), Kaeser MD (2008), Kaeser MD (2008), Pal S (2003), Trotter KW (2008), Tando T (2010), Mak AB (2010), Nishimoto N (2012), Nishimoto N (2012), Havugimana PC (2012), Wan C (2015), Dallas PB (1998), Huttlin EL (2017)	15
PIAS3	2	SMAD3	1	affinity chromatography technology, pull down	Long J (2004), Long J (2004)	2
PIAS4	5	HNF4A	2	enzymatic study	Yamamoto H (2003)	1
SMAD3	1	CSNK1D	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Brown KA (2008), Ding L (2009), Ding L (2009)	3
CREBBP	29	JUN	0	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, far western blotting	Sano Y (1998), Sano Y (1998), Merika M (1998), Duyndam MC (1999), Johnson J (2007), Yamaguchi K (2005), Tsai LN (2008), Arias J (1994)	8
FOXO3	1	CREBBP	29	affinity chromatography technology, unspecified method, x-ray crystallography, affinity chromatography technology	van der Horst A (2004), Wang F (2012), Wang F (2012), Li X (2015)	4
PIN1	0	TSC2	17	two hybrid	Vinayagam A (2011)	1
SMAD3	1	ZEB2	7	affinity chromatography technology, affinity chromatography technology, two hybrid	Long J (2005), Long J (2005), Colland F (2004)	3
SKIL	3	HDAC1	4	affinity chromatography technology	Nomura T (1999)	1
EP300	36	ATF2	1	biochemical	Duyndam MC (1999)	1
CDK2	0	E2F4	0	affinity chromatography technology	So J (2015)	1
NR3C1	2	SMARCA4	19	affinity chromatography technology, pull down, biochemical, affinity chromatography technology, bioid	Hsiao PW (2003), Wallberg AE (2000), Reyes JC (1997), Xu R (2007), Lempiaeinen JK (2017)	5
SMAD3	1	RBL1	1	pull down, affinity chromatography technology	Chen CR (2002), Chen CR (2002)	2
CREBBP	29	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, enzymatic study	de Nigris F (2007), de Nigris F (2007), Vervoorts J (2003), Vervoorts J (2003), Vervoorts J (2003), Vervoorts J (2003), Vervoorts J (2003)	7
FOXM1	3	SP1	0	imaging technique, pull down, affinity chromatography technology	Xu K (2013), Xu K (2013), Xu K (2013)	3
AR	3	HNF4A	2	imaging technique	Mulholland DJ (2003)	1
ATF2	1	YY1	7	two hybrid, pull down	Ravasi T (2010), Zhou Q (1995)	2
KAT2B	2	HIF1A	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Bodily JM (2011), Geng H (2012), Geng H (2012), Lim JH (2010)	4
SMAD3	1	AKT1	1	affinity chromatography technology, imaging technique	Song K (2006), Chen TC (2014)	2
SKI	3	TP53	0	affinity chromatography technology	Inoue Y (2011)	1
TGIF1	1	SMAD3	1	affinity chromatography technology, pull down	Melhuish TA (2001), Liberati NT (2001)	2
SMAD4	9	ERBIN	5	pull down	Warner DR (2003)	1
PIN1	0	JUN	0	pull down, affinity chromatography technology	Wulf GM (2001), Wulf GM (2001)	2
SMAD2	5	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe	Brown KA (2008), Wu RY (1997), Wu RY (1997), Ivanov AA (2017)	4
PIAS3	2	SMAD2	5	affinity chromatography technology, pull down	Long J (2004), Long J (2004)	2
SMAD7	1	MYC	2	affinity chromatography technology, affinity chromatography technology	Kim TA (2013), Kim TA (2013)	2
SMAD4	9	AR	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Kang HY (2002), Kang HY (2002), Kang HY (2002), Kang HY (2002)	4
SQSTM1	0	MYD88	1	affinity chromatography technology	Into T (2010)	1
NEDD4L	3	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology	Gao S (2009), Gao S (2009), Aragon E (2012), Herhaus L (2013), Gao S (2009), Gao S (2009), Yan X (2016)	7
WWP2	7	USP15	4	affinity chromatography technology	Chaudhary N (2014)	1
SMAD3	1	NEDD4	2	affinity chromatography technology, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down	Kuratomi G (2005), Persaud A (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011), Aragon E (2011)	6
KAT2B	2	CDK2	0	pull down, affinity chromatography technology, enzymatic study	Mateo F (2009), Mateo F (2009), Mateo F (2009)	3
LDLRAD4	1	RNF31	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SP1	0	HIF1A	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	To KK (2006), To KK (2006), Sanchez-Elsner T (2002), Sanchez-Elsner T (2002), Koshiji M (2005), Koshiji M (2005)	6
BRCA1	7	SMARCA4	19	affinity chromatography technology, pull down, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Hill DA (2004), Bochar DA (2000), Bochar DA (2000), Bochar DA (2000), Tu Z (2013), Ertych N (2016)	6
AKT1	1	NOTCH1	25	enzymatic study, two hybrid	Song J (2008), Daakour S (2016)	2
SPTBN1	6	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Tang Y (2003), Tang Y (2003)	2
CTNNB1	30	FHL2	0	two hybrid, pull down, pull down, affinity chromatography technology	Wei Y (2003), Wei Y (2003), Wei Y (2003), Wei Y (2003)	4