PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RNF111	2	SMAD6	9	affinity chromatography technology	Koinuma D (2003)	1
ELAVL1	0	MAPK6	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TGFBR1	2	BAMBI	3	pull down, affinity chromatography technology	Yan X (2009), Yan X (2009)	2
MAP3K7	2	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Kimura N (2000), Yanagisawa M (2001)	2
SMAD1	0	PIAS4	5	two hybrid, affinity chromatography technology, two hybrid	Long J (2003), Long J (2003), Colland F (2004)	3
PIAS4	5	SMAD7	1	two hybrid, affinity chromatography technology, two hybrid	Imoto S (2003), Imoto S (2003), Colland F (2004)	3
USP15	4	BMPR1B	3	affinity chromatography technology	Herhaus L (2014)	1
SMAD6	9	ACTR1B	1	affinity chromatography technology	Hata A (1998)	1
SMAD6	9	SMAD7	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Topper JN (1997), Topper JN (1997), Topper JN (1997), Yan X (2016)	4
SMAD5	2	YAP1	0	affinity chromatography technology, affinity chromatography technology	Alarcon C (2009), Alarcon C (2009)	2
WWP2	7	WWP1	3	affinity chromatography technology, affinity chromatography technology	Chaudhary N (2014), Chaudhary N (2014)	2
ACVR1B	1	ACVR1	4	affinity chromatography technology, affinity chromatography technology	De Winter JP (1996), Huttlin EL (2015)	2
USP15	4	BMPR1A	5	affinity chromatography technology, imaging technique, enzymatic study	Herhaus L (2014), Herhaus L (2014), Herhaus L (2014)	3
SMAD7	1	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mochizuki T (2004), Asano Y (2004), Koinuma D (2003), Kavsak P (2000), Hayashi H (1997), Hayashi H (1997), Datta PK (2000), Wicks SJ (2005), Lallemand F (2005), Seong HA (2007), Yan X (2011), Cai Y (2012), Cai Y (2012), Seo SR (2004), Zhu L (2012), Zhu L (2012), Nakao A (1997), Yan X (2009), Kamiya Y (2010), Suzuki C (2002), Hsu HY (2014)	21
MAP3K7	2	ITCH	1	affinity chromatography technology	Kathania M (2015)	1
ACVR1	4	SMURF1	4	affinity chromatography technology	Murakami G (2003)	1
ACVR2B	0	ACVR1B	1	biochemical, affinity chromatography technology	Attisano L (1996), De Winter JP (1996)	2
STRAP	2	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Datta PK (1998), Datta PK (2000)	2
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
SMAD7	1	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lallemand F (2005), Lallemand F (2005), Al-Salihi MA (2012), Gen Y (2017), Gen Y (2017)	5
BMPR1B	3	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
RNF111	2	SMAD7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Koinuma D (2003), Koinuma D (2003), Erker Y (2013), Elkouris M (2016)	4
BMPR1A	5	SMURF1	4	affinity chromatography technology	Murakami G (2003)	1
SMAD5	2	SMAD6	9	affinity chromatography technology	Murakami G (2003)	1
ACVR2B	0	SMAD2	5	affinity chromatography technology	Miura S (2000)	1
SMAD7	1	SMURF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Asano Y (2004), Kavsak P (2000), Lee YS (2008), Komuro A (2004), Chong PA (2010), Chong PA (2010), Chong PA (2010), Cai Y (2012), Cai Y (2012), Chong PA (2006), Al-Salihi MA (2012), Ogunjimi AA (2005), Aragon E (2012), Aragon E (2012), Colland F (2004), Zhang L (2013), Chandhoke AS (2015), Iyengar PV (2015), Elkouris M (2016)	19
SMAD6	9	WWP2	7	affinity chromatography technology	Herhaus L (2014)	1
NEDD4	2	SMURF2	3	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Huttlin EL (2017)	2
YAP1	0	SMAD2	5	affinity chromatography technology	Pefani DE (2016)	1
SMAD4	9	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moren A (2003), Wotton D (1999), Mori N (2001), Wu JW (2002), Wu JW (2002), Nakao A (1997), Wicks SJ (2000), Wu JW (2001), Chen X (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Razani B (2001), Razani B (2001), Wang B (2008), Moren A (2005), Kurisaki K (2003), Prunier C (2003), Kato Y (2002), Xu J (2000), Wang L (2011), He W (2006), He W (2006), Dupont S (2009), Brown JD (1999), Pardali K (2000), Fu G (2011), Chen W (2007), Gao S (2009), Lin X (2003), Seo SR (2006), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Barrios-Rodiles M (2005), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Ali A (2013), Yamakawa N (2002), Yamakawa N (2002), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Zhou F (2017)	56
ZEB1	3	SMAD1	0	affinity chromatography technology	Postigo AA (2003)	1
PELI1	1	MYD88	1	affinity chromatography technology	Choi KC (2006)	1
STRAP	2	SMAD2	5	affinity chromatography technology, affinity chromatography technology, genetic interference	Datta PK (2000), Datta PK (2000), Datta PK (2000)	3
SMAD6	9	ACVR2B	0	affinity chromatography technology	Kamiya Y (2010)	1
SMAD6	9	ACVR1B	1	affinity chromatography technology	Kamiya Y (2010)	1
ELAVL1	0	ACVR1B	1	affinity chromatography technology	Abdelmohsen K (2009)	1
YAP1	0	SMAD6	9	affinity chromatography technology	Ferrigno O (2002)	1
MAPK6	1	UBE2O	5	affinity chromatography technology	Rodriguez J (2016)	1
ACVR1B	1	SMAD2	5	affinity chromatography technology	Lebrun JJ (1999)	1
PIAS4	5	SMAD6	9	two hybrid, affinity chromatography technology	Imoto S (2003), Imoto S (2003)	2
SMAD2	5	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Kuratomi G (2005)	2
HOXC8	0	SMAD4	9	affinity chromatography technology	Shi X (1999)	1
CTBP2	7	ZEB1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Postigo AA (1999), Zhao LJ (2009), Furusawa T (1999), Furusawa T (1999), Zhang P (2014)	5
SMAD5	2	WWP1	3	affinity chromatography technology, two hybrid	Komuro A (2004), Colland F (2004)	2
BMPR1B	3	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Itoh F (2001), Hata A (1998)	2
SMURF2	3	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang L (2013), Zhou F (2017), Zhou F (2017)	3
SMAD2	5	SMAD6	9	affinity chromatography technology	Topper JN (1997)	1
SMAD4	9	SMAD5	2	affinity chromatography technology, two hybrid, two hybrid	Hanai J (1999), Haag J (2006), Colland F (2004)	3
SMAD7	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Asano Y (2004), Yamaguchi T (2006), Komuro A (2004), Ebisawa T (2001), Ebisawa T (2001), Al-Salihi MA (2012), Suzuki C (2002), Aragon E (2012), Aragon E (2012), Tajima Y (2003), Fei C (2013), Fei C (2014), Wan L (2011), Elkouris M (2016)	14
BMPR1A	5	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
SMAD1	0	SMAD7	1	affinity chromatography technology	Yan X (2016)	1
SMAD7	1	WWP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004), Seo SR (2004), Al-Salihi MA (2012)	4
SMAD2	5	SMAD7	1	genetic interference, pull down, affinity chromatography technology	Lebrun JJ (1999), Zhang S (2007), Yan X (2016)	3
SMAD6	9	PIGR	4	affinity chromatography technology	Herhaus L (2014)	1
ELAVL1	0	YAP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD2	5	WWP1	3	affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004)	2
ITCH	1	WWP1	3	affinity chromatography technology	OConnor HF (2015)	1
ELAVL1	0	CTBP1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD6	9	BPIFA1	3	affinity chromatography technology	Herhaus L (2014)	1
SMAD6	9	KPNA2	0	affinity chromatography technology	Herhaus L (2014)	1
BMPR1B	3	SMURF1	4	affinity chromatography technology	Murakami G (2003)	1
SMAD2	5	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Runyan CE (2009), Runyan CE (2009), Chong PA (2010), Brown KA (2008), Colland F (2004), Colland F (2004), Zhang Y (2017), Zhou F (2017), Zhou F (2017)	16
SMAD2	5	SMAD5	2	affinity chromatography technology	Brown KA (2008)	1
ACVR1	4	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Pardali E (2000), Macias-Silva M (1998)	2
USP15	4	SMURF2	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Eichhorn PJ (2012), Iyengar PV (2015), Iyengar PV (2015)	3
CTBP1	2	ZEB1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Postigo AA (1999), Kuppuswamy M (2008), Furusawa T (1999), Furusawa T (1999), Zhang P (2014), Huttlin EL (2015), Huttlin EL (2017)	7
YAP1	0	USP15	4	affinity chromatography technology	Enzo E (2015)	1
TGFBR1	2	SMAD2	5	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Razani B (2001), Faresse N (2008), Bai Y (2004), Tang Y (2003), Tang Y (2003), Ding L (2009), Lu D (2013), Herhaus L (2015)	8
RNF111	2	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Levy L (2007), Erker Y (2013), Le Scolan E (2008)	3
ACVR1B	1	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
NEDD4	2	BMPR1A	5	pull down	Persaud A (2009)	1
TGFBR1	2	TSC22D1	1	two hybrid, affinity chromatography technology, pull down	Yan X (2011), Yan X (2011), Yan X (2011)	3
SMAD4	9	SMAD7	1	genetic interference, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Lebrun JJ (1999), Moren A (2005), Moren A (2005), Moren A (2005), Zhang S (2007), Yan X (2016)	6
NEDD4L	3	BMPR1A	5	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
CTBP1	2	RNF111	2	two hybrid	Corominas R (2014)	1
SMAD4	9	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Topper JN (1997), Moren A (2005)	2
SMAD6	9	CTBP1	2	affinity chromatography technology, affinity chromatography technology	Lin X (2003), Herhaus L (2014)	2
CTBP2	7	CTBP1	2	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sewalt RG (1999), Wang J (2011), Corominas R (2014), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
BMPR2	1	BMPR1B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Liu F (1995), Liu F (1995), Gilboa L (2000), Gilboa L (2000)	4
SMAD6	9	BMPR2	1	affinity chromatography technology	Kamiya Y (2010)	1
BMPR1A	5	BMPR1B	3	affinity chromatography technology, imaging technique	Gilboa L (2000), Gilboa L (2000)	2
SMAD6	9	CTBP2	7	affinity chromatography technology	Herhaus L (2014)	1
SMAD7	1	MAP3K7	2	affinity chromatography technology	Edlund S (2003)	1
USP15	4	ACVR1	4	affinity chromatography technology	Herhaus L (2014)	1
NEDD4L	3	ACVR1B	1	enzymatic study, affinity chromatography technology	Persaud A (2009), Persaud A (2009)	2
SMAD7	1	UBE2O	5	affinity chromatography technology, affinity chromatography technology	Zhang X (2013), Zhang X (2013)	2
SMAD2	5	SMURF1	4	affinity chromatography technology, affinity chromatography technology, two hybrid	Komuro A (2004), Ito I (2010), Colland F (2004)	3
SMAD7	1	TSC22D1	1	affinity chromatography technology, affinity chromatography technology	Yan X (2011), Yan X (2011)	2
ELAVL1	0	SMAD5	2	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD1	0	SMAD4	9	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Hanai J (1999), Lopez-Rovira T (2002), Kato Y (2002), Wang L (2011), Li L (2004), Hata A (1998), Barrios-Rodiles M (2005), Wu RY (1997), Wu RY (1997), Colland F (2004), Qiu T (2007), Yan X (2016), Zhou F (2017)	14
SMURF2	3	RNF111	2	two hybrid	Colland F (2004)	1
SMAD1	0	WWP1	3	affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004)	2
SMAD5	2	NEDD4	2	two hybrid	Colland F (2004)	1
ELAVL1	0	NEDD4L	3	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD6	9	ZEB1	3	affinity chromatography technology, affinity chromatography technology	Nakahata S (2010), Nakahata S (2010)	2
SMAD6	9	MYD88	1	affinity chromatography technology, affinity chromatography technology	Lee YS (2011), Lee YS (2011)	2
WWP2	7	SMAD7	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Soond SM (2011), Soond SM (2011), Soond SM (2011), Al-Salihi MA (2012)	4
ELAVL1	0	ITCH	1	affinity chromatography technology	Abdelmohsen K (2009)	1
STRAP	2	SMAD7	1	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Datta PK (2000), Datta PK (2000), Datta PK (2000), Seong HA (2007)	4
SMAD6	9	USP11	3	affinity chromatography technology, affinity chromatography technology	Herhaus L (2014), Herhaus L (2014)	2
ACVR1B	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology	Yamaguchi T (2006), Murakami G (2003)	2
SMAD6	9	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Hata A (1998), Kamiya Y (2010)	2
WWP2	7	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Soond SM (2011), Soond SM (2011), Brown KA (2008)	3
TGFBR1	2	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koinuma D (2003), Ebisawa T (2001), Murakami G (2003)	3
ELAVL1	0	SMAD2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
ACVR1	4	BMPR1A	5	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Lavery K (2008), Lavery K (2008), Huttlin EL (2015), Huttlin EL (2017)	4
SMAD6	9	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
SMURF1	4	USP15	4	affinity chromatography technology	Xie Y (2013)	1
ACVR1B	1	SMAD7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu X (2002), Yamaguchi T (2006), Yamaguchi T (2006), Kamiya Y (2010)	4
SMAD6	9	STRAP	2	affinity chromatography technology, affinity chromatography technology	Datta PK (2000), Datta PK (2000)	2
SMAD6	9	BMPR1A	5	affinity chromatography technology	Kamiya Y (2010)	1
SMURF2	3	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kavsak P (2000), Yan X (2011), Cai Y (2012), Cai Y (2012), Zhang L (2013), Chandhoke AS (2015), Hsu HY (2014)	7
MAPK6	1	ACTR1B	1	two hybrid	Vinayagam A (2011)	1
SMAD6	9	LYZ	0	affinity chromatography technology	Herhaus L (2014)	1
YAP1	0	ITCH	1	affinity chromatography technology	Levy D (2007)	1
SMAD5	2	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, two hybrid, two hybrid, enzymatic study	Lu K (2008), Komuro A (2004), Ebisawa T (2001), Nie J (2010), Alarcon C (2009), Murakami G (2003), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Haag J (2006), Colland F (2004), Lu K (2008)	12
BMPR2	1	TGFBR1	2	two hybrid, two hybrid	Liu F (1995), Kawabata M (1995)	2
SMAD7	1	NEDD4L	3	affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology	Al-Salihi MA (2012), Aragon E (2012), Aragon E (2012), Aragon E (2012)	4
SMAD4	9	USP15	4	affinity chromatography technology, affinity chromatography technology	Inui M (2011), Eichhorn PJ (2012)	2
SMAD7	1	ACVR2B	0	affinity chromatography technology	Kamiya Y (2010)	1
STAMBP	2	SMAD6	9	affinity chromatography technology, two hybrid, two hybrid	Itoh F (2001), Itoh F (2001), Itoh F (2001)	3
MAPK6	1	MAP3K7	2	two hybrid	Vinayagam A (2011)	1
ACVR1	4	SMAD5	2	affinity chromatography technology, affinity chromatography technology	Pardali E (2000), Macias-Silva M (1998)	2
SMAD7	1	USP15	4	affinity chromatography technology	Eichhorn PJ (2012)	1
TGFBR1	2	USP11	3	affinity chromatography technology	Al-Salihi MA (2012)	1
SMURF2	3	STAMBP	2	affinity chromatography technology, affinity chromatography technology	Li H (2004), Li H (2004)	2
SMAD6	9	SMURF1	4	affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Ebisawa T (2001), Sangadala S (2007), Lee YS (2011), Lee YS (2011)	5
SMAD1	0	USP15	4	affinity chromatography technology, affinity chromatography technology	Inui M (2011), Eichhorn PJ (2012)	2
WWP1	3	SMAD4	9	affinity chromatography technology	Seo SR (2004)	1
SMAD1	0	HOXC8	0	two hybrid, pull down, affinity chromatography technology	Shi X (1999), Shi X (1999), Shi X (1999)	3
ACVR1	4	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
MYD88	1	MAP3K7	2	genetic interference	Fitzgerald KA (2001)	1
CUL2	3	SMAD6	9	affinity chromatography technology	Bennett EJ (2010)	1
SMURF1	4	TAB1	1	enzymatic study	Andrews PS (2010)	1
SMAD6	9	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Herhaus L (2014), Herhaus L (2014), Herhaus L (2014)	3
BMPR2	1	ACVR1	4	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Liu F (1995), Liu F (1995), Liu F (1995), Liu F (1995), Kawabata M (1995), Huttlin EL (2017)	6
YAP1	0	KPNA2	0	affinity chromatography technology	Enzo E (2015)	1
SMAD7	1	BMPR1A	5	affinity chromatography technology, affinity chromatography technology	Mochizuki T (2004), Kamiya Y (2010)	2
SMAD6	9	ITCH	1	affinity chromatography technology	Herhaus L (2014)	1
SMAD6	9	WWP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004), Herhaus L (2014)	3
PELI1	1	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Choi KC (2006), Choi KC (2006)	2
SMAD6	9	NEDD4	2	affinity chromatography technology	Kuratomi G (2005)	1
ELAVL1	0	TGFBR1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
STAMBP	2	SMAD7	1	affinity chromatography technology, two hybrid	Itoh F (2001), Itoh F (2001)	2
ITCH	1	KPNA2	0	affinity chromatography technology	OConnor HF (2015)	1
SMURF1	4	MYD88	1	affinity chromatography technology, affinity chromatography technology	Lee YS (2011), Lee YS (2011)	2
TGFBR1	2	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Eichhorn PJ (2012), Zhang L (2013), Herhaus L (2014)	3
HOXC8	0	SMAD6	9	two hybrid, affinity chromatography technology, pull down	Bai S (2000), Bai S (2000), Bai S (2000)	3
BMPR2	1	BMPR1A	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Liu F (1995), Liu F (1995), Gilboa L (2000), Gilboa L (2000)	4
PIAS4	5	SMAD2	5	affinity chromatography technology, two hybrid, affinity chromatography technology	Imoto S (2003), Long J (2003), Long J (2003)	3
SMAD2	5	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inui M (2011), Eichhorn PJ (2012), Wijnhoven P (2015)	3
WWP2	7	STRAP	2	affinity chromatography technology	Chaudhary N (2014)	1
SMAD7	1	BMPR2	1	affinity chromatography technology	Kamiya Y (2010)	1
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
CUL2	3	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
ITCH	1	TAB1	1	affinity chromatography technology, affinity chromatography technology, pull down	Theivanthiran B (2015), Theivanthiran B (2015), Theivanthiran B (2015)	3
ELAVL1	0	PIAS4	5	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD6	9	ACVR1	4	affinity chromatography technology, affinity chromatography technology	Kamiya Y (2010), Zhang X (2013)	2
SMAD1	0	YAP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Alarcon C (2009), Alarcon C (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011)	5
SMAD7	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Kuratomi G (2005), Al-Salihi MA (2012)	3
MAP3K7	2	TAB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Channavajhala PL (2003), Ninomiya-Tsuji J (1999), Sakurai H (2000), Liu XY (2008), Li S (2011), Li S (2011), Ear T (2010), Singhirunnusorn P (2005), Prickett TD (2008), Kim SY (2012), Jiang Z (2002), Shibuya H (1996), Shibuya H (1996), Minoda Y (2009), Minoda Y (2009), Scholz R (2010), Scholz R (2010), Scholz R (2010), Kim SI (2009), Ge B (2003), Blonska M (2005), Kishimoto K (2000), Kishimoto K (2000), Zhu Y (2013), Liu R (2014), Chen TC (2014), Moon G (2015), Ninomiya-Tsuji J (2003), Min Y (2016), St-Denis N (2016), Zhang J (2017)	33
ITCH	1	SMAD2	5	enzymatic study, affinity chromatography technology	Bai Y (2004), Bai Y (2004)	2
SMAD1	0	SMAD6	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Topper JN (1997), Murakami G (2003), Itoh F (2001), Hata A (1998), Hata A (1998)	5
MAPK6	1	SMAD6	9	two hybrid	Vinayagam A (2011)	1
RPS6KA5	2	SMAD6	9	two hybrid	Vinayagam A (2011)	1
SMAD1	0	NEDD4	2	affinity chromatography technology, two hybrid	Kim BG (2011), Colland F (2004)	2
ELAVL1	0	SMAD6	9	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD7	1	TAB1	1	affinity chromatography technology, affinity chromatography technology	Edlund S (2003), Yanagisawa M (2001)	2
BMPR1A	5	SMAD1	0	enzymatic study	Kretzschmar M (1997)	1
SMAD6	9	NEDD4L	3	affinity chromatography technology	Herhaus L (2014)	1
USP15	4	USP11	3	affinity chromatography technology	Sowa ME (2009)	1
TGFBR1	2	SMAD4	9	biochemical, affinity chromatography technology	Razani B (2001), Barrios-Rodiles M (2005)	2
SMURF1	4	SMAD1	0	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, pull down, unspecified method, two hybrid, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Sangadala S (2006), Komuro A (2004), Tian M (2011), Tian M (2011), Tian M (2011), Sapkota G (2007), Sapkota G (2007), Li L (2004), Alarcon C (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011), Aragon E (2011), Gao S (2009), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Colland F (2004), Cao Y (2014), Cao Y (2014), Sangadala S (2007), Gao S (2009), Wan L (2011), Wan L (2011), Zhang Y (2017), Zhang Y (2017)	28
ACVR1	4	BAMBI	3	pull down	Yan X (2009)	1
SMAD7	1	ZEB1	3	affinity chromatography technology, affinity chromatography technology, pull down	Nakahata S (2010), Nakahata S (2010), Nakahata S (2010)	3
ACVR1B	1	BAMBI	3	pull down	Yan X (2009)	1
BMPR2	1	ACVR1B	1	two hybrid	Liu F (1995)	1
SMAD7	1	BAMBI	3	affinity chromatography technology, affinity chromatography technology	Yan X (2009), Yan X (2009)	2
ZEB1	3	SMAD2	5	affinity chromatography technology	Postigo AA (2003)	1
BMPR1B	3	BAMBI	3	pull down	Yan X (2009)	1
SMAD1	0	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Li L (2004), Chong PA (2010), Colland F (2004), Huttlin EL (2017), Zhou F (2017)	10
SMAD6	9	BAMBI	3	affinity chromatography technology	Yan X (2009)	1
SMAD7	1	ACVR1	4	affinity chromatography technology	Kamiya Y (2010)	1
BMPR1A	5	BAMBI	3	pull down	Yan X (2009)	1
SMAD6	9	SMURF2	3	affinity chromatography technology, two hybrid, affinity chromatography technology	Komuro A (2004), Colland F (2004), Herhaus L (2014)	3
PIAS4	5	SMAD4	9	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Imoto S (2003), Long J (2003), Long J (2003), Long J (2003), Lee PS (2003)	5
TGFBR1	2	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sorrentino A (2008), Kim SI (2009), Kim SI (2009), Zhang L (2013)	4
UBE2O	5	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Zhang X (2013), Zhang X (2013)	2
SMAD2	5	NEDD4L	3	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Gao S (2009), Colland F (2004), Gao S (2009), Yan X (2016)	4
SMAD4	9	SMURF1	4	affinity chromatography technology, affinity chromatography technology	Moren A (2005), Zhang L (2013)	2
TGFBR1	2	ITCH	1	affinity chromatography technology	Bai Y (2004)	1
MAPK6	1	USP11	3	affinity chromatography technology	Rodriguez J (2016)	1
SMAD7	1	USP11	3	affinity chromatography technology, biochemical, affinity chromatography technology	Al-Salihi MA (2012), Al-Salihi MA (2012), Herhaus L (2014)	3
SMAD6	9	TAB1	1	affinity chromatography technology	Yanagisawa M (2001)	1
SMAD7	1	YAP1	0	two hybrid, genetic interference, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down	Ferrigno O (2002), Ferrigno O (2002), Ferrigno O (2002), Aragon E (2012), Aragon E (2012), Aragon E (2012), Schuchardt BJ (2014)	7
SMAD5	2	SMURF2	3	affinity chromatography technology, enzymatic study, two hybrid, affinity chromatography technology	Komuro A (2004), Nie J (2010), Colland F (2004), Huttlin EL (2017)	4
SMAD6	9	NASP	3	affinity chromatography technology	Herhaus L (2014)	1
SMAD2	5	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe	Brown KA (2008), Wu RY (1997), Wu RY (1997), Ivanov AA (2017)	4
WWP2	7	USP15	4	affinity chromatography technology	Chaudhary N (2014)	1
SMAD1	0	SMAD5	2	two hybrid	Colland F (2004)	1