PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EP300	36	MAF	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Chen Q (2002), Chen Q (2002), Chen Q (2002)	3
UBE2I	0	EP300	36	enzymatic study, affinity chromatography technology	Girdwood D (2003), Bian XL (2017)	2
HNRNPL	3	EP300	36	affinity chromatography technology	Fei T (2017)	1
EP300	36	SOX9	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Furumatsu T (2010), Furumatsu T (2010), Tsuda M (2003), Furumatsu T (2005)	4
CREBBP	29	NFE2L2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Katoh Y (2001), Katoh Y (2001), Katoh Y (2001), Liu GH (2008), Liu GH (2008), Sun Z (2009), Sun Z (2009), Sun Z (2009)	8
KDM5B	27	HDAC2	1	affinity chromatography technology	Li Q (2011)	1
NFE2L2	1	MAFG	1	imaging technique, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, affinity chromatography technology	Ramani K (2012), Ramani K (2012), Reinke AW (2013), Reinke AW (2013), Wang J (2011), Wu T (2013), Okita Y (2013)	7
FOS	0	MAF	4	affinity chromatography technology, fluorescent resonance energy transfe	Annunziata CM (2011), Reinke AW (2013)	2
SOX9	2	MAF	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Huang W (2002), Huang W (2002), Huang W (2002), Huang W (2002), Huang W (2002)	5
CREBBP	29	MYB	3	x-ray crystallography, pull down, genetic interference, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, x-ray crystallography, pull down	Zor T (2002), Zor T (2002), Bessa M (2001), Kurahashi T (2005), Kurahashi T (2005), Sano Y (2001), Sano Y (2001), Nomura T (2004), Yang F (2006), Giri R (2013)	10
CREBBP	29	FOS	0	pull down, affinity chromatography technology, two hybrid	Fan S (2002), Bossis G (2005), Patel D (1999)	3
CEBPA	0	MAF	4	affinity chromatography technology	Zada AA (2006)	1
MAFB	1	MAF	4	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
PML	7	CREBBP	29	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsuzaki K (2003), Matsuzaki K (2003), Matsuzaki K (2003), Doucas V (1999), Doucas V (1999), Zhong S (1999), Chen Y (2015)	7
HNRNPL	3	MAF	4	affinity chromatography technology	Fei T (2017)	1
FOSL1	0	EP300	36	affinity chromatography technology, enzymatic study	Crish JF (2008), Wang WM (2011)	2
PML	7	FOS	0	pull down	Vallian S (1998)	1
MAF	4	PML	7	imaging technique	Leavenworth JW (2009)	1
FOS	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
MAF	4	HDAC2	1	affinity chromatography technology	Hu HM (2007)	1
ATF4	2	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
PML	7	MYB	3	affinity chromatography technology, pull down	Dahle O (2004), Dahle O (2004)	2
NFE2L2	1	HDAC2	1	affinity chromatography technology	Lee DY (2012)	1
MYB	3	EP300	36	pull down, imaging technique, affinity chromatography technology, enzymatic study, pull down	Nicot C (2001), Jin W (2011), Sandberg ML (2005), Tomita A (2000), Uttarkar S (2015)	5
UBE2I	0	CREBBP	29	affinity chromatography technology, pull down, enzymatic study, two hybrid	Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Liu ST (2012)	4
MYB	3	SIN3A	13	pull down, affinity chromatography technology, pull down	Nomura T (2004), Nomura T (2004), Nomura T (2004)	3
CREBBP	29	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Ito K (2000), Adenuga D (2010)	2
MAF	4	UBE2O	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Xu Y (2017), Xu Y (2017), Xu Y (2017), Xu Y (2017)	4
KDM5B	27	MAF	4	affinity chromatography technology	Zhou W (2009)	1
UBE2I	0	PML	7	enzymatic study, pull down, enzymatic study, two hybrid, two hybrid, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down	Knipscheer P (2008), Kim YE (2005), Satow R (2012), Duprez E (1999), Wang J (2011), Tatham MH (2003), Duprez E (1999), Gocke CB (2005), Lin DY (2006), Jo S (2016), Schilling EM (2017)	11
MAF	4	HOXD12	1	pull down	Kataoka K (2001)	1
CREBBP	29	HOXD12	1	pull down	Shen WF (2001)	1
MAF	4	MAFG	1	pull down	Dhakshinamoorthy S (2002)	1
EP300	36	FOS	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Wang WM (2011), Pekarsky Y (2008), Wang C (2001)	3
MAF	4	NFE2L2	1	affinity chromatography technology	Liu K (2015)	1
MAF	4	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
UBE2I	0	FOS	0	enzymatic study, enzymatic study, enzymatic study	Jakobs A (2007), Bossis G (2005), Guo D (2005)	3
FOS	0	USF2	3	two hybrid	Rolland T (2014)	1
NFE2L2	1	AHR	3	imaging technique	Xu S (2010)	1
MYB	3	MAF	4	pull down, two hybrid	Hedge SP (1998), Hedge SP (1998)	2
UBE2I	0	SOX9	2	enzymatic study	Ogawa H (2009)	1
ATF4	2	FOS	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, imaging technique	Reinke AW (2013), Reinke AW (2013), Chen TC (2014)	3
EP300	36	AHR	3	affinity chromatography technology, two hybrid, biochemical	Tohkin M (2000), Wang J (2011), Ohtake F (2007)	3
MAF	4	UBE2I	0	affinity chromatography technology	Leavenworth JW (2009)	1
HDAC2	1	PML	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu WS (2001), Morey L (2008), Kraemer OH (2008), Kim YE (2015)	4
SMARCA5	4	MAF	4	affinity chromatography technology, affinity chromatography technology	Yang Y (2006), Yang Y (2006)	2
HOXD12	1	MAFG	1	pull down	Kataoka K (2001)	1
CREBBP	29	FOSL1	0	affinity chromatography technology	Tran NQ (2004)	1
ETS1	4	MAF	4	pull down	Hedge SP (1998)	1
CEBPA	0	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
EP300	36	ETS1	4	genetic interference, unspecified method, pull down, pull down	Pastorcic M (2000), Foulds CE (2004), Jayaraman G (1999), Jayaraman G (1999)	4
MAFB	1	ATF4	2	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAF	4	ATF4	2	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
MAFB	1	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAF	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Chen Q (2002), Chen Q (2002)	2
ATF4	2	EP300	36	affinity chromatography technology, pull down, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology	Lassot I (2005), Lassot I (2005), Lassot I (2005), Deng WG (2004), Deng WG (2004), Ohoka N (2007), Deng WG (2003)	7
NFE2L2	1	ATF4	2	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
PML	7	SIN3A	13	pull down, affinity chromatography technology	Khan MM (2001), Khan MM (2001)	2
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
ATF4	2	FOSL1	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
MAFB	1	FOS	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
HOXD12	1	MAFB	1	pull down	Kataoka K (2001)	1
SMARCA5	4	HDAC2	1	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, biochemical, biochemical	Hakimi MA (2002), Hakimi MA (2002), Zhou J (2005), Zhou J (2005), Zhou J (2005), Havugimana PC (2012), Wan C (2015)	7
MAF	4	USF2	3	pull down	Kurschner C (1997)	1
ATF4	2	CREBBP	29	pull down, affinity chromatography technology, imaging technique	Liang G (1997), Venza I (2001), Chen TC (2014)	3
SMARCA5	4	SIN3A	13	affinity chromatography technology	Burgio G (2008)	1
ETS1	4	UBE2I	0	two hybrid, pull down	Hahn SL (1997), Hahn SL (1997)	2
AHR	3	MAF	4	affinity chromatography technology	Gandhi R (2010)	1
MYB	3	UBE2I	0	two hybrid, enzymatic study	Bies J (2002), Kanei-Ishii C (2012)	2
HNRNPL	3	CREBBP	29	affinity chromatography technology	Fei T (2017)	1
EP300	36	USF2	3	two hybrid	Breen GA (1999)	1
MAF	4	MAF	4	pull down, fluorescent resonance energy transfe	Dhakshinamoorthy S (2002), Reinke AW (2013)	2
MAF	4	SIN3A	13	affinity chromatography technology	Hu HM (2007)	1
ETS1	4	CREBBP	29	unspecified method, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Foulds CE (2004), Foulds CE (2004), Yang C (1998), Yang C (1998), Giese K (1995), Tsai LN (2008)	6
HDAC2	1	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang Y (2003), Fleischer TC (2003), Fleischer TC (2003), Hakimi MA (2003), Yang L (2003), Laherty CD (1997), Zhang Y (2002), Tong JK (1998), Zhang Y (2005), Nakamura T (2002), Sekhavat A (2007), Zou J (2004), Sun JM (2007), Xue Y (1998), Tsai SC (2002), Brandl A (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hsu DS (2014)	20
CEBPA	0	HDAC2	1	affinity chromatography technology	Duan H (2005)	1