PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAFG	1	MED31	0	two hybrid	Stelzl U (2005)	1
MAFG	1	NFE2	0	pull down	Blank V (1997)	1
NFE2L2	1	MAFG	1	imaging technique, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, affinity chromatography technology	Ramani K (2012), Ramani K (2012), Reinke AW (2013), Reinke AW (2013), Wang J (2011), Wu T (2013), Okita Y (2013)	7
BACH2	6	MAFF	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Huttlin EL (2015), Huttlin EL (2017)	4
MAFG	1	GTF2A1L	0	two hybrid	Ravasi T (2010)	1
MAFF	0	BATF3	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DDIT3	1	BACH1	3	fluorescent resonance energy transfe	Reinke AW (2013)	1
NFE2L2	1	NFE2	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAFF	0	NFE2L1	4	pull down, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Johnsen O (1996), Reinke AW (2013), Reinke AW (2013), Huttlin EL (2015), Huttlin EL (2017)	5
HSP90AA1	7	HIF1A	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hogenesch JB (1997), Qian DZ (2006), Kong X (2006), Kubo T (2004), Zhou J (2004), Fu B (2007), Choi YK (2010), Choi YK (2010), Lee JM (2011), Liu YV (2007), Liu YV (2007), Katschinski DM (2004), Katschinski DM (2004), Katschinski DM (2004), Trisciuoglio D (2010), Trisciuoglio D (2010), Ueda K (2008), Sun H (2013), Kawanami D (2009), Prince TL (2015), Prince TL (2015), Isaacs JS (2004), Lee SH (2015)	23
CHD3	19	VIM	0	two hybrid	Goehler H (2004)	1
GTF2A1L	0	MAFF	0	two hybrid	Ravasi T (2010)	1
PARP1	3	MAFG	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu T (2013), Wu T (2013), Wu T (2013)	3
HSP90AA1	7	ATF3	0	affinity chromatography technology	Taipale M (2012)	1
HOXD12	1	MAFF	0	pull down	Kataoka K (2001)	1
MAF	4	HOXD12	1	pull down	Kataoka K (2001)	1
BATF3	0	BACH2	6	fluorescent resonance energy transfe, affinity chromatography technology	Reinke AW (2013), Huttlin EL (2017)	2
MAFF	0	NFIL3	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
PARP1	3	MAFF	0	affinity chromatography technology	Wu T (2013)	1
MAFG	1	NFIL3	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
DDIT3	1	ATF3	0	affinity chromatography technology, pull down, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Chen BP (1996), Chen BP (1996), Reinke AW (2013), Reinke AW (2013)	4
DDIT3	1	BACH2	6	fluorescent resonance energy transfe	Reinke AW (2013)	1
NFATC2	1	MAFG	1	affinity chromatography technology	Gabriel CH (2016)	1
NFE2L3	6	NFE2L1	4	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAF	4	MAFG	1	pull down	Dhakshinamoorthy S (2002)	1
VIM	0	RBM48	1	two hybrid	Goehler H (2004)	1
MAFF	0	NFE2L2	1	pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marini MG (2002), Reinke AW (2013), Okita Y (2013), Huttlin EL (2015), Huttlin EL (2017)	5
MAFF	0	ATF3	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DDIT3	1	MAFF	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
HSP90AA1	7	MAFG	1	affinity chromatography technology	Taipale M (2012)	1
MAF	4	NFE2L2	1	affinity chromatography technology	Liu K (2015)	1
BATF3	0	ATF3	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DEUP1	0	MAFF	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPP1CA	3	MAFG	1	two hybrid	Esteves SL (2012)	1
MAFG	1	BATF3	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
NFE2L3	6	BACH2	6	fluorescent resonance energy transfe	Reinke AW (2013)	1
BATF3	0	BACH1	3	affinity chromatography technology	Huttlin EL (2017)	1
NFE2L3	6	MAFF	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Huttlin EL (2015), Huttlin EL (2017)	4
HOXD12	1	MAFG	1	pull down	Kataoka K (2001)	1
DEUP1	0	MAFG	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BACH2	6	MAFG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
HIF1A	1	MAFG	1	two hybrid, pull down	Ueda K (2008), Ueda K (2008)	2
DDIT3	1	BATF3	0	fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Rolland T (2014)	2
BACH1	3	MAFG	1	affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Dohi Y (2008), Reinke AW (2013), Reinke AW (2013), Hein MY (2015), Huttlin EL (2017)	5
NFATC2	1	PARP1	3	affinity chromatography technology	Gabriel CH (2016)	1
MAFG	1	MAFF	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DDIT3	1	MAFG	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
NFE2L3	6	MAFG	1	fluorescent resonance energy transfe, affinity chromatography technology	Reinke AW (2013), Huttlin EL (2017)	2
NFE2L1	4	BACH2	6	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAFG	1	RBM48	1	two hybrid	Stelzl U (2005)	1
MAFG	1	ATF3	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAFG	1	CHD3	19	two hybrid	Stelzl U (2005)	1
NFATC2	1	VIM	0	two hybrid	Stelzl U (2005)	1
NFE2L3	6	NFE2L2	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
PARP1	3	HIF1A	1	affinity chromatography technology	Elser M (2008)	1
BACH1	3	NFE2L2	1	imaging technique, imaging technique	Dhakshinamoorthy S (2005), Dhakshinamoorthy S (2005)	2
NFATC2	1	MED31	0	two hybrid	Stelzl U (2005)	1
PIDD1	5	MAFG	1	two hybrid	Wang J (2011)	1
DDIT3	1	NFIL3	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAFG	1	SNRPN	0	two hybrid	Wang J (2011)	1
MAFG	1	VIM	0	two hybrid	Stelzl U (2005)	1
NFE2L3	6	NFE2	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
NFATC2	1	PPP1CA	3	affinity chromatography technology	Gabriel CH (2016)	1
MAFG	1	NFE2L1	4	pull down, fluorescent resonance energy transfe	Johnsen O (1996), Reinke AW (2013)	2
MAFG	1	MAFG	1	pull down, fluorescent resonance energy transfe	Blank V (1997), Reinke AW (2013)	2
CYP2E1	0	MAFG	1	two hybrid	Wang J (2011)	1
BACH1	3	MAFF	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	5