PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BRCA1	7	MYC	2	affinity chromatography technology, imaging technique, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Li H (2002), Xiong J (2003), Xiong J (2003), Wang Q (1998), Wang Q (1998), Wang Q (1998), Harte MT (2010), Harte MT (2010), Xiong J (2003), Xiong J (2003), Zhou C (2003)	11
BRCA1	7	EWSR1	2	affinity chromatography technology	Ertych N (2016)	1
HSP90AA1	7	ERBB2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu W (2001), Jeong JH (2008), Mollapour M (2010), Citri A (2002), Jung Y (2007), Suzuki T (2011), Tsutsumi S (2012), Taipale M (2012), Bali P (2005), Woodford MR (2016), Yan YY (2011), Yan YY (2011)	12
MYC	2	MATK	2	genetic interference	Toyoshima M (2012)	1
HSP90AA1	7	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Johnson N (2013), Johnson N (2013), Ertych N (2016)	3
BRCA1	7	MATK	2	affinity chromatography technology	Tian F (2013)	1
HSP90AA1	7	MYC	2	affinity chromatography technology	Carystinos GD (2003)	1
CACNA1A	21	MATK	2	two hybrid	Kahle JJ (2011)	1
SMURF1	4	MATK	2	enzymatic study	Andrews PS (2010)	1
CD36	2	MATK	2	affinity chromatography technology	Hirao A (1997)	1
NTRK1	1	EWSR1	2	affinity chromatography technology	Emdal KB (2015)	1
ERBB2	6	MATK	2	unspecified method	Jones RB (2006)	1
MYC	2	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
FRS3	0	ERBB2	6	affinity chromatography technology	Minegishi Y (2012)	1
MYC	2	NTRK1	1	genetic interference	Toyoshima M (2012)	1
SRC	2	ERBB2	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Ren Z (2002), Li X (2007), Liang K (2010), Liang K (2010), Shen JP (2017)	5
NTRK1	1	SRC	2	affinity chromatography technology	Emdal KB (2015)	1
SRC	2	KIT	4	unspecified method	Wollberg P (2003)	1
MATK	2	SRC	2	enzymatic study	Avraham S (1995)	1
CSK	3	SRC	2	pull down	Sabe H (1994)	1
SRC	2	PXN	1	pull down	Angers-Loustau A (1999)	1
CSK	3	MATK	2	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rao R (2010), Taipale M (2012), Emdal KB (2015)	3
CSK	3	PXN	1	affinity chromatography technology	Bergman M (1995)	1
MATK	2	KIT	4	pull down, pull down	Jhun BH (1995), Price DJ (1997)	2
MATK	2	PXN	1	affinity chromatography technology	Grgurevich S (1999)	1
HSP90AA1	7	SRC	2	affinity chromatography technology, affinity chromatography technology	Hutchison KA (1992), Tsutsumi S (2012)	2
MATK	2	NTRK1	1	affinity chromatography technology, far western blotting	Yamashita H (1999), Yamashita H (1999)	2
FRS3	0	MATK	2	two hybrid	Grossmann A (2015)	1
HSP90AA1	7	MATK	2	affinity chromatography technology	Taipale M (2012)	1
EWSR1	2	MATK	2	two hybrid	Rual JF (2005)	1