PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ATXN1L	0	MBD1	1	two hybrid	Lim J (2006)	1
EP300	36	MBD1	1	genetic interference	Wong AS (2016)	1
PRMT5	3	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Pal S (2003), Amente S (2005), Pal S (2004), Migliori V (2012)	4
SP1	0	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, two hybrid, imaging technique, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Gao J (2009), Goto T (2006), Hung JJ (2006), Hung JJ (2006), Hung JJ (2006), Choi HS (2002), Walker GE (2001), Kundu TK (2000), Suzuki T (2000), Suzuki T (2000), Wang X (2008), Wang X (2008), Wang X (2008), Chen YJ (2007), Chen YJ (2007), Azahri NS (2012), Azahri NS (2012), Li J (2013), Li J (2013), Wang SA (2014)	20
PRMT5	3	MBD1	1	genetic interference	Wong AS (2016)	1
MYC	2	RBPJ	1	affinity chromatography technology	Agrawal P (2010)	1
MCM2	3	HIST1H3A	3	affinity chromatography technology, affinity chromatography technology	Drissi R (2015), Huttlin EL (2017)	2
EP300	36	PIAS1	4	pull down, affinity chromatography technology	Ledsaak M (2016), Ledsaak M (2016)	2
MCM2	3	MBD1	1	affinity chromatography technology	Drissi R (2015)	1
MBD1	1	PIAS2	2	two hybrid, pull down	Lyst MJ (2006), Lyst MJ (2006)	2
PCNA	0	MBD1	1	affinity chromatography technology	Sarraf SA (2004)	1
MBD1	1	MYC	2	affinity chromatography technology	Zhang B (2016)	1
PRAM1	4	MBD1	1	affinity chromatography technology	Villa R (2006)	1
MBD1	1	CBX5	3	affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Fujita N (2003), Fujita N (2003), Fujita N (2003), Reese BE (2003)	4
MBD1	1	SP1	0	pull down	Schwarzenbach H (2014)	1
MBD1	1	PIAS1	4	affinity chromatography technology, two hybrid, pull down	McGough JM (2008), Lyst MJ (2006), Lyst MJ (2006)	3
ATF7IP2	2	SETDB1	3	pull down, affinity chromatography technology	Ichimura T (2005), Ichimura T (2005)	2
MYC	2	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Faiola F (2005), Faiola F (2005), Faiola F (2005), Faiola F (2005), Faiola F (2005), Zhang K (2005), Covic M (2005), Fujii M (2006)	8
HTT	14	MBD1	1	two hybrid	Suter B (2013)	1
SP1	0	CBX5	3	pull down	Marban C (2005)	1
CHAF1A	1	SETDB1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loyola A (2009), Sarraf SA (2004), Sarraf SA (2004)	3
HTT	14	PIAS1	4	two hybrid	Suter B (2013)	1
SUV39H1	0	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study	Carbone R (2006), Kamoi K (2006), Mal AK (2006)	3
NXF1	0	SP1	0	affinity chromatography technology	Castello A (2012)	1
MBD1	1	SETDB1	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Lyst MJ (2006), Sarraf SA (2004), Sarraf SA (2004), Sarraf SA (2004)	4
PRMT5	3	EP300	36	genetic interference	Wong AS (2016)	1
HDAC3	5	SP1	0	affinity chromatography technology	Huang W (2006)	1
SUV39H1	0	CBX4	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Sewalt RG (2002), Sewalt RG (2002), Sewalt RG (2002), Sewalt RG (2002), Yang L (2011)	5
CHAF1A	1	PCNA	0	pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Moggs JG (2000), Rolef Ben-Shahar T (2009), Gerard A (2006), Gerard A (2006), Gerard A (2006), Naryzhny SN (2005), Sarraf SA (2004), Hoek M (2011), Hoek M (2011), Takami Y (2007), Hein MY (2015)	11
PIAS2	2	PIAS1	4	imaging technique	Chen TC (2014)	1
ATF7IP2	2	MBD1	1	pull down, pull down	Ichimura T (2005), Ichimura T (2005)	2
EP300	36	MCM2	3	pull down	Karmakar S (2010)	1
KIF2C	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
MYC	2	HDAC3	5	affinity chromatography technology, affinity chromatography technology	Kurland JF (2008), Zhang X (2011)	2
MBD1	1	RNF2	1	pull down, affinity chromatography technology	Sakamoto Y (2007), Sakamoto Y (2007)	2
MOV10	6	MBD1	1	affinity chromatography technology	Castello A (2012)	1
RNF2	1	CBX4	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Gao Z (2012), Gao Z (2012), Vandamme J (2011), Cao Q (2014), Hein MY (2015), Hein MY (2015), Hauri S (2016), Hauri S (2016)	9
NXF1	0	KIF2C	1	affinity chromatography technology	Castello A (2012)	1
HDAC3	5	MBD1	1	affinity chromatography technology	Villa R (2006)	1
SP1	0	HTT	14	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down	Li SH (2002), Li SH (2002), Dunah AW (2002), Dunah AW (2002), Dunah AW (2002)	5
CBX5	3	CHAF1A	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Reese BE (2003), Lechner MS (2000), Lechner MS (2005), Lechner MS (2005), Quivy JP (2004), Quivy JP (2004), Quivy JP (2004), Hoek M (2011), Hoek M (2011), Nozawa RS (2010), Hauri S (2016)	11
KIF2C	1	MBD1	1	affinity chromatography technology	Hein MY (2015)	1
MBD1	1	APP	1	pull down	Olah J (2011)	1
SHMT2	3	APP	1	pull down	Olah J (2011)	1
MOV10	6	KIF2C	1	affinity chromatography technology	Castello A (2012)	1
CHAF1A	1	HIST1H3A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Sarraf SA (2004), Tagami H (2004), Zhang H (2012), Groth A (2005), Lambert JP (2015), Huttlin EL (2017), Elsaesser SJ (2010)	7
MBD1	1	HIST1H3A	3	affinity chromatography technology	Sarraf SA (2004)	1
APP	1	MYC	2	pull down	Virok DP (2011)	1
MBD1	1	TENM1	4	two hybrid	Nunes SM (2005)	1
ATF7IP	5	SETDB1	3	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Ichimura T (2005), Ichimura T (2005), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
MBD1	1	ZNF512B	2	two hybrid	Ravasi T (2010)	1
EP300	36	PCNA	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Hasan S (2001), Hasan S (2001), Hasan S (2001), Hong R (2003), Hong R (2003), Cazzalini O (2008), Cazzalini O (2008), Naryzhny SN (2004), Cazzalini O (2014), Cazzalini O (2014)	10
SUV39H1	0	ATF7IP	5	affinity chromatography technology	Huttlin EL (2017)	1
SHMT2	3	MBD1	1	affinity chromatography technology	Castello A (2012)	1
EP300	36	HDAC3	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Kadeppagari RK (2009), Gregoire S (2007), Gregoire S (2007), Sankar N (2008), Sankar N (2008)	5
EP300	36	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Liu B (2009), Brackertz M (2006), Faiola F (2005), Daujat S (2002), Kalkhoven E (2002), Seo SB (2002), Kim JH (2005), Bordoli L (2001), Kim MY (2001), Kutney SN (2004), Wang F (2010), Loven MA (2004), Kiernan RE (1999), Wong K (2005), Ogryzko VV (1996), Yamaguchi Y (2004), Furumatsu T (2005), An W (2002), Delvecchio M (2013), Delvecchio M (2013), Tropberger P (2013), Das C (2009), Shimura M (2011), Ji A (2003), Fu M (2005), Suganuma T (2002), Tang Z (2013), Kim JH (2006), Lopes da Rosa J (2013), Li X (2014), Wang YL (2008), Du C (2017), Yi P (2017), Wan W (2017)	34
PCNA	0	SETDB1	3	affinity chromatography technology	Sarraf SA (2004)	1
SUV39H1	0	SETDB1	3	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H3A	3	ZNF512B	2	bioid	Lambert JP (2015)	1
CHAF1A	1	MBD1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Reese BE (2003), Reese BE (2003), Reese BE (2003), Lyst MJ (2006), Sarraf SA (2004), Sarraf SA (2004), Sarraf SA (2004)	7
RBPJ	1	MBD1	1	affinity chromatography technology	Li X (2015)	1
PRAM1	4	SUV39H1	0	affinity chromatography technology, imaging technique	Carbone R (2006), Carbone R (2006)	2
MYC	2	PIAS2	2	affinity chromatography technology	Zhang Y (2007)	1
MBD1	1	CBX4	1	pull down, affinity chromatography technology	Sakamoto Y (2007), Sakamoto Y (2007)	2
MCM2	3	APP	1	pull down	Olah J (2011)	1
RBPJ	1	APP	1	pull down	Olah J (2011)	1
APP	1	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
RNF2	1	MOV10	6	affinity chromatography technology	Cao Q (2014)	1
EP300	36	STAT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Paulson M (1999), Hiroi M (2003), Ray S (2002), Strassheim D (2009), Liu X (2008), Ghosh AK (2001), Yang WS (2005), Zhang Y (2015), Kotla S (2015), Kotla S (2015)	10
SP1	0	ATF7IP	5	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down	Liu L (2009), Liu L (2009), Chang LK (2005), Chang LK (2005), Ichimura T (2005), Ichimura T (2005)	6
NXF1	0	MBD1	1	affinity chromatography technology	Castello A (2012)	1
RNF2	1	APP	1	affinity chromatography technology	Cao Q (2014)	1
PIAS1	4	STAT1	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Liao J (2000), Liao J (2000), Reardon C (2007), Reardon C (2007), Mowen KA (2001), Liu X (2008), Zhu W (2002), Liu B (1998), Chen TC (2014)	9
RNF2	1	KIF20A	3	affinity chromatography technology	Cao Q (2014)	1
KIF20A	3	MBD1	1	affinity chromatography technology	Hein MY (2015)	1
NXF1	0	SETDB1	3	affinity chromatography technology	Castello A (2012)	1
MOV10	6	SETDB1	3	affinity chromatography technology	Castello A (2012)	1
CBX5	3	SUV39H1	0	two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Fujita N (2003), Rual JF (2005), Nozawa RS (2010), Rolland T (2014), Huttlin EL (2017), Hauri S (2016)	6
STAT1	1	SHMT2	3	biochemical	Kristensen AR (2012)	1
ATF7IP2	2	SP1	0	affinity chromatography technology, pull down	Ichimura T (2005), Ichimura T (2005)	2
MBD1	1	SUV39H1	0	affinity chromatography technology, pull down, imaging technique	Fujita N (2003), Fujita N (2003), Fujita N (2003)	3
CBX5	3	HIST1H3A	3	affinity chromatography technology, pull down, pull down, unspecified method, imaging technique, bioid, affinity chromatography technology	Terada Y (2006), Lavigne M (2009), Lavigne M (2009), Dawson MA (2009), Dawson MA (2009), Lambert JP (2015), Huttlin EL (2017)	7
MBD1	1	STAT1	1	affinity chromatography technology	McGough JM (2008)	1
CBX5	3	SETDB1	3	affinity chromatography technology	Loyola A (2009)	1
ECT2	2	MBD1	1	two hybrid	Woods NT (2012)	1
RBPJ	1	KIF2C	1	affinity chromatography technology	Li X (2015)	1
ATF7IP	5	MBD1	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Fujita N (2003), Fujita N (2003), Fujita N (2003), Uchimura Y (2006), Ichimura T (2005), Ichimura T (2005)	6
SETDB1	3	HIST1H3A	3	enzymatic study, pull down	Vandel L (2001), Binda O (2011)	2
SP1	0	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Gartel AL (2001), Liu T (2007), Gordan JD (2007), Gordan JD (2007), Koshiji M (2005), Koshiji M (2005)	6
HDAC3	5	STAT1	1	affinity chromatography technology	Kraemer OH (2006)	1
PRAM1	4	HDAC3	5	affinity chromatography technology, affinity chromatography technology	Atsumi A (2006), Villa R (2006)	2
SUV39H1	0	HDAC3	5	affinity chromatography technology, pull down	Vaute O (2002), Vaute O (2002)	2
MYC	2	SUV39H1	0	genetic interference, affinity chromatography technology	Toyoshima M (2012), Hauri S (2016)	2
HIST1H3A	3	HDAC3	5	pull down	Li X (2014)	1