PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MCMBP	3	MCM5	1	affinity chromatography technology, affinity chromatography technology, biochemical	Taipale M (2014), Taipale M (2014), Wan C (2015)	3
MCM7	5	ORC6	0	pull down	Ramachandran N (2004)	1
CDC7	2	MCM2	3	two hybrid, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Kneissl M (2003), Kneissl M (2003), Gerard A (2006), Martin L (2007), Martin L (2007), Montagnoli A (2006), Suzuki T (2012), Masai H (2000)	8
CDC7	2	MCM6	5	enzymatic study	Masai H (2000)	1
ILF2	3	MCM7	5	affinity chromatography technology	Karmakar S (2010)	1
CDC5L	2	SF3B1	12	affinity chromatography technology, biochemical, affinity chromatography technology	Ajuh P (2000), Ajuh P (2000), Lleres D (2010)	3
CDC5L	2	ILF3	5	affinity chromatography technology	Lleres D (2010)	1
HSP90AB1	2	MCM5	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Drissi R (2015)	3
MCM5	1	STAT1	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Zhang JJ (1998), Zhang JJ (1998), DaFonseca CJ (2001), DaFonseca CJ (2001)	4
MCM5	1	SF3B1	12	biochemical, affinity chromatography technology	Wan C (2015), Drissi R (2015)	2
L3MBTL1	1	MCM5	1	affinity chromatography technology, affinity chromatography technology	Gurvich N (2010), Gurvich N (2010)	2
MCM2	3	MCM7	5	pull down, pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Drissi R (2015), Boldt K (2016)	14
MCM2	3	HNRNPU	12	affinity chromatography technology	Drissi R (2015)	1
HIST1H4A	0	MCM4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saade E (2009), Saade E (2009), Huttlin EL (2017)	3
CDC5L	2	HNRNPU	12	affinity chromatography technology	Lleres D (2010)	1
MCM4	3	MCM7	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology	Yabuta N (2003), Fujita M (1997), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Wan C (2015), Boldt K (2016)	9
LMNA	2	ILF2	3	affinity chromatography technology	Depreux FF (2015)	1
FANCD2	3	MCM5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lossaint G (2013), Lossaint G (2013), Lossaint G (2013)	3
MCM3	2	MCM2	3	two hybrid, two hybrid, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004), Wan C (2015), Drissi R (2015), Huttlin EL (2017), Lossaint G (2013), Mulvaney KM (2016)	8
FANCD2	3	MCM6	5	affinity chromatography technology	Lossaint G (2013)	1
ORC6	0	ORC2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Vashee S (2001), Vashee S (2001), Sibani S (2005), Sibani S (2005), Keller C (2002), Huttlin EL (2015), Huttlin EL (2017)	8
MCM5	1	CDC7	2	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM4	3	CDC7	2	two hybrid, two hybrid, enzymatic study	Kneissl M (2003), Kneissl M (2003), Masai H (2000)	3
ILF2	3	MCM6	5	affinity chromatography technology	Karmakar S (2010)	1
MCM5	1	CDC5L	2	pull down, affinity chromatography technology	Ramachandran N (2004), Lleres D (2010)	2
ILF2	3	ORC2	0	affinity chromatography technology	Karmakar S (2010)	1
MCM6	5	ORC6	0	pull down	Ramachandran N (2004)	1
MCM4	3	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM3	2	MCM4	3	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Mulvaney KM (2016)	4
MCM4	3	SF3B1	12	biochemical	Wan C (2015)	1
MCM3	2	HSP90AA1	7	biochemical	Kristensen AR (2012)	1
CDC5L	2	HSP90AB1	2	affinity chromatography technology	Lleres D (2010)	1
MCM5	1	MCM6	5	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	DaFonseca CJ (2001), Havugimana PC (2012), Wan C (2015), Drissi R (2015)	4
SSRP1	1	MCM6	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tan BC (2006), OConnell BC (2010), Huttlin EL (2017)	3
L3MBTL1	1	FANCI	1	affinity chromatography technology	Hauri S (2016)	1
FANCD2	3	MCM4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Panneerselvam J (2014), Lossaint G (2013), Lossaint G (2013)	3
CDC5L	2	FANCD2	3	affinity chromatography technology	Lleres D (2010)	1
FANCD2	3	MCM3	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Panneerselvam J (2014), Panneerselvam J (2014), Panneerselvam J (2014), Panneerselvam J (2014), Lossaint G (2013), Lossaint G (2013), Lossaint G (2013)	7
MCM5	1	HSP90AA1	7	biochemical, affinity chromatography technology	Kristensen AR (2012), Drissi R (2015)	2
MCMBP	3	MCM7	5	affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical	Taipale M (2014), Taipale M (2014), Rolland T (2014), Wan C (2015)	4
C1QTNF2	1	MCM5	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST1H4A	0	MCM7	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saade E (2009), Saade E (2009), Huttlin EL (2017)	3
CDC7	2	MCM3	2	enzymatic study, pull down	Sato N (1997), Ramachandran N (2004)	2
MCM2	3	ILF3	5	affinity chromatography technology	Drissi R (2015)	1
ILF3	5	HSP90AA1	7	affinity chromatography technology	Chu L (2012)	1
ILF2	3	MCM5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Karmakar S (2010), Karmakar S (2010), Karmakar S (2010), Drissi R (2015)	4
MCM4	3	ORC6	0	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
ILF2	3	HNRNPU	12	biochemical, affinity chromatography technology	Kristensen AR (2012), Hein MY (2015)	2
L3MBTL1	1	MCM7	5	affinity chromatography technology, affinity chromatography technology	Gurvich N (2010), Hauri S (2016)	2
CDC5L	2	RAD50	3	affinity chromatography technology	Lleres D (2010)	1
HSP90AB1	2	MCM2	3	biochemical, affinity chromatography technology	Kristensen AR (2012), Drissi R (2015)	2
FANCI	1	MCM2	3	affinity chromatography technology	Chen YH (2015)	1
MCM5	1	MCM4	3	affinity chromatography technology, biochemical, biochemical	DaFonseca CJ (2001), Havugimana PC (2012), Wan C (2015)	3
CDC5L	2	ORC2	0	pull down, affinity chromatography technology	Ramachandran N (2004), Lleres D (2010)	2
MCM5	1	ORC6	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC5L	2	HSP90AA1	7	affinity chromatography technology	Lleres D (2010)	1
MCM7	5	SF3B1	12	biochemical	Wan C (2015)	1
MCM6	5	HSP90AB1	2	biochemical	Kristensen AR (2012)	1
SSRP1	1	MCM7	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tan BC (2006), OConnell BC (2010), Huttlin EL (2017)	3
MCM3	2	MCM5	1	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Wan C (2015), Drissi R (2015), Huttlin EL (2017), Chen YH (2015), Lossaint G (2013), Lossaint G (2013), Mulvaney KM (2016)	13
MCM7	5	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM4	3	MCM2	3	pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Ishimi Y (1996), Tan BC (2006), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Drissi R (2015), Boldt K (2016)	11
MCM2	3	MCM6	5	two hybrid, pull down, pull down, two hybrid, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Yabuta N (2003), Yabuta N (2003), Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Rolland T (2014), Wan C (2015), Hein MY (2015), Drissi R (2015), Boldt K (2016)	15
L3MBTL1	1	MCM6	5	affinity chromatography technology	Gurvich N (2010)	1
LMNA	2	HNRNPU	12	affinity chromatography technology	Depreux FF (2015)	1
CDC5L	2	ORC6	0	affinity chromatography technology	Lleres D (2010)	1
L3MBTL1	1	MCM3	2	affinity chromatography technology	Gurvich N (2010)	1
SSRP1	1	MCM3	2	affinity chromatography technology, affinity chromatography technology	Tan BC (2006), OConnell BC (2010)	2
MCM3	2	MCM6	5	biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Mulvaney KM (2016)	6
ILF2	3	RAD50	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Karmakar S (2010), Karmakar S (2010), Karmakar S (2010)	3
FANCI	1	FANCD2	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, imaging technique, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, two hybrid	Yuan F (2009), Ishiai M (2008), Sims AE (2007), Rego MA (2012), Longerich S (2014), Polito D (2014), Wang D (2016), Oka Y (2015), Oka Y (2015), Oka Y (2015), Oka Y (2015), Unno J (2014), Long DT (2011), Sato K (2014), Sato K (2014), Takahashi D (2014), Gwon GH (2014), Lossaint G (2013), Siddiqui MQ (2017), Inano S (2017)	20
ORC2	0	MCM2	3	two hybrid, two hybrid, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	4
MCM7	5	HSP90AB1	2	biochemical	Kristensen AR (2012)	1
LMNA	2	SSRP1	1	affinity chromatography technology	Depreux FF (2015)	1
ILF2	3	SF3B1	12	biochemical	Havugimana PC (2012)	1
ILF2	3	MCM4	3	affinity chromatography technology	Karmakar S (2010)	1
HIST1H4A	0	FANCD2	3	pull down, enzymatic study, pull down	Sato K (2012), Sato K (2012), Sato K (2012)	3
CDC5L	2	LMNA	2	affinity chromatography technology, affinity chromatography technology	Lleres D (2010), Depreux FF (2015)	2
FANCD2	3	MCM7	5	affinity chromatography technology, affinity chromatography technology	Lossaint G (2013), Lossaint G (2013)	2
HIST1H4A	0	MCM6	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saade E (2009), Saade E (2009), Huttlin EL (2017)	3
MCMBP	3	MCM2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Drissi R (2015)	3
MCMBP	3	MCM6	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Jagannathan M (2014), Taipale M (2014), Taipale M (2014), Wan C (2015), Hein MY (2015)	5
MCM6	5	MCM7	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ryu MJ (2006), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
L3MBTL1	1	MCM2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gurvich N (2010), Gurvich N (2010), Huttlin EL (2017)	3
SF3B1	12	SSRP1	1	biochemical	Havugimana PC (2012)	1
SSRP1	1	HIST1H4A	0	pull down, affinity chromatography technology	Winkler DD (2011), Huttlin EL (2017)	2
MCM6	5	SF3B1	12	biochemical	Havugimana PC (2012)	1
CDC5L	2	MCM4	3	pull down	Ramachandran N (2004)	1
LMNA	2	ILF3	5	affinity chromatography technology	Depreux FF (2015)	1
MCM5	1	MCM7	5	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology	Kneissl M (2003), Fujita M (1997), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Wan C (2015), Lossaint G (2013)	7
C1QTNF2	1	MCMBP	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MCM6	5	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
SSRP1	1	MCM5	1	affinity chromatography technology, affinity chromatography technology	Tan BC (2006), OConnell BC (2010)	2
ILF3	5	ILF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reichman TW (2002), Shi L (2007), Shamanna RA (2011), Havugimana PC (2012), Karmakar S (2010), Karmakar S (2010), Karmakar S (2010), Huttlin EL (2015), Huttlin EL (2017), Zhu X (2016), Zhu X (2016)	11
L3MBTL1	1	MCM4	3	affinity chromatography technology, affinity chromatography technology	Gurvich N (2010), Huttlin EL (2017)	2
HNRNPU	12	ILF3	5	affinity chromatography technology	Hein MY (2015)	1
MCMBP	3	MCM4	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HSP90AB1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Cheng MB (2010), Gano JJ (2010), Skarra DV (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Wan C (2015), Hein MY (2015)	8
ILF2	3	MCM3	2	affinity chromatography technology	Karmakar S (2010)	1
SSRP1	1	MCM2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tan BC (2006), OConnell BC (2010), Huttlin EL (2017)	3
LMNA	2	ORC2	0	bioid	Roux KJ (2012)	1
ILF3	5	SF3B1	12	biochemical	Havugimana PC (2012)	1
MCM4	3	MCM6	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
MCM5	1	ORC2	0	two hybrid, two hybrid, biochemical	Kneissl M (2003), Kneissl M (2003), Wan C (2015)	3
STAT1	1	HSP90AB1	2	two hybrid	Bandyopadhyay S (2010)	1
ILF3	5	RAD50	3	affinity chromatography technology, affinity chromatography technology	Karmakar S (2010), Karmakar S (2010)	2
ORC6	0	MCM2	3	pull down	Ramachandran N (2004)	1
MCM7	5	CDC7	2	two hybrid, two hybrid, enzymatic study	Kneissl M (2003), Kneissl M (2003), Masai H (2000)	3
ORC6	0	CDC7	2	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
HNRNPU	12	MCM5	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Drissi R (2015)	2
ORC2	0	MCM3	2	biochemical	Mendez J (2000)	1
FANCI	1	MCM3	2	affinity chromatography technology	Chen YH (2015)	1
MCM2	3	SF3B1	12	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
ILF3	5	MCM5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Karmakar S (2010), Karmakar S (2010), Drissi R (2015)	3
HIST1H4A	0	MCM5	1	affinity chromatography technology, affinity chromatography technology	Saade E (2009), Drissi R (2015)	2
MCM2	3	HSP90AA1	7	affinity chromatography technology	Drissi R (2015)	1
LMNA	2	SF3B1	12	affinity chromatography technology	Depreux FF (2015)	1
FANCD2	3	MCM2	3	imaging technique, affinity chromatography technology, affinity chromatography technology	Panneerselvam J (2014), Lossaint G (2013), Lossaint G (2013)	3
MCM3	2	MCM7	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Fujita M (1999), Fujita M (1997), Fujita M (2002), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Lossaint G (2013), Mulvaney KM (2016)	10
HIST1H4A	0	MCM3	2	affinity chromatography technology	Saade E (2009)	1
MCM5	1	MCM2	3	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Wan C (2015), Drissi R (2015), Drissi R (2015), Huang J (2013), Lossaint G (2013)	10
ILF2	3	MCM2	3	affinity chromatography technology, affinity chromatography technology	Karmakar S (2010), Drissi R (2015)	2
FANCI	1	MCM5	1	affinity chromatography technology, affinity chromatography technology	Chen YH (2015), Chen YH (2015)	2
MCM5	1	RAD50	3	affinity chromatography technology, affinity chromatography technology	Karmakar S (2010), Karmakar S (2010)	2
CDC5L	2	ILF2	3	affinity chromatography technology, biochemical, affinity chromatography technology	Ajuh P (2000), Ajuh P (2000), Huttlin EL (2015)	3
MCMBP	3	MCM3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Jagannathan M (2014), Taipale M (2014), Taipale M (2014), Wan C (2015), Huttlin EL (2017), Mulvaney KM (2016)	6
MCM2	3	HIST1H4A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saade E (2009), Saade E (2009), Saade E (2009), Drissi R (2015), Huttlin EL (2017)	5
CDC5L	2	MCM3	2	pull down	Ramachandran N (2004)	1
MCM2	3	LMNA	2	affinity chromatography technology	Drissi R (2015)	1
MCM5	1	LMNA	2	affinity chromatography technology, two hybrid	Drissi R (2015), Dittmer TA (2014)	2
CDC5L	2	FANCI	1	affinity chromatography technology	Lleres D (2010)	1
SSRP1	1	MCM4	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tan BC (2006), Tan BC (2006), Tan BC (2006), OConnell BC (2010), Huttlin EL (2017)	5