PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2D2	0	LRSAM1	2	two hybrid	Markson G (2009)	1
ABL1	9	CDKN1A	1	enzymatic study	Hukkelhoven E (2012)	1
TP53	0	TP73	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Stindt MH (2015), Puca R (2011), De Laurenzi V (1998), Di Como CJ (1999)	4
YWHAZ	1	APP	1	pull down	Olah J (2011)	1
TP53	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Wang C (2003), Akakura S (2001), Peng Y (2001), Nagata Y (1999), Wang J (2011), Burch L (2004), Taipale M (2012), Fogeron ML (2013), Walerych D (2004)	9
MAP2K5	1	MDM4	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAQ	0	YWHAG	5	affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Kristensen AR (2012)	2
MDM4	0	CDKN1A	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Jin Y (2008), Jin Y (2008), Jin Y (2008), Jin Y (2008), Jin Y (2008), Lee JH (2011), Lee JH (2011)	7
EP300	36	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qiu P (2006), Furumatsu T (2005), Itoh S (2000), Akiyoshi S (1999), Abecassis L (2004), Kaimori A (2010), Janknecht R (1998), Janknecht R (1998), Nishihara A (1999), Nishihara A (1999), Furumatsu T (2005), Ghosh AK (2004), Shen X (1998), Shen X (1998), Ghosh AK (2001), Postigo AA (2003), Postigo AA (2003), Yang WS (2005), Lim JY (2012), Lim JY (2012), Jinnin M (2007), Wang G (2005)	22
EP300	36	MRE11	3	affinity chromatography technology	Jung SY (2005)	1
SFN	1	ABL1	9	affinity chromatography technology	Raina D (2006)	1
MDM2	2	6025	0	affinity chromatography technology	Li M (2011)	1
BCL2	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu C (2011), Xu C (2011), Trisciuoglio D (2010)	3
MDM4	0	ASRGL1	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D3	1	MKRN3	2	two hybrid	Markson G (2009)	1
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
CDKN2A	1	HSP90AA1	7	pull down	Souza-Rodrigues E (2007)	1
CHEK2	2	APP	1	pull down	Olah J (2011)	1
PELI1	1	UBC	7	enzymatic study, enzymatic study	Smith H (2009), Smith H (2011)	2
PPP1CB	9	BCL2	0	affinity chromatography technology	Flores-Delgado G (2007)	1
HNRNPL	3	EP300	36	affinity chromatography technology	Fei T (2017)	1
MAP2K5	1	NF2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAZ	1	HNRNPL	3	affinity chromatography technology	Ewing RM (2007)	1
EP300	36	CDK1	0	affinity chromatography technology, enzymatic study	Wang SA (2014), Wang SA (2014)	2
USP2	0	MNAT1	0	two hybrid	Hayes SD (2012)	1
CHEK2	2	CHEK1	2	genetic interference	Srivas R (2016)	1
CDK1	0	HSP90AA1	7	affinity chromatography technology	Garcia-Morales P (2007)	1
EP300	36	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Kim RH (2000), Luciakova K (2008), Janknecht R (1998), Chung CL (2011), Shen X (1998), Dornan D (2003), Yang Y (2015)	7
MAP2K5	1	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2D1	0	NBN	1	pull down	Lu CS (2012)	1
BECN1	2	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SPATA46	0	APP	1	pull down	Olah J (2011)	1
CD44	1	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NF2	1	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CBLC	1	MDM4	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK4	2	CHEK2	2	genetic interference	Shen JP (2017)	1
USP7	14	RB1	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Bhattacharya S (2014), Bhattacharya S (2014), Bhattacharya S (2014), Bhattacharya S (2014)	4
YWHAG	5	HGF	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAZ	1	MDM4	0	affinity chromatography technology, affinity chromatography technology	Lopez-Pajares V (2008), Huttlin EL (2017)	2
PPP1CC	2	APP	1	pull down	Olah J (2011)	1
USP2	0	CBLC	1	two hybrid	Hayes SD (2012)	1
PELI1	1	UBE2D2	0	pull down	Smith H (2009)	1
BECN1	2	MDM4	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TRIM46	3	MDM4	0	two hybrid	Woodsmith J (2012)	1
SFN	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Yang HY (2007), Yang HY (2007), Yang HY (2007), Wood NT (2009)	4
MDM4	0	PSMC5	4	biochemical	Jin Y (2008)	1
RCHY1	0	UBE2D1	0	pull down, pull down	Abou Zeinab R (2013), McClurg UL (2016)	2
GLIS2	2	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CD44	1	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HSP90AA1	7	CDK4	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsutsumi S (2012), Wang H (2002), Taipale M (2012), Varjosalo M (2013), Huttlin EL (2015), Woodford MR (2016), Huttlin EL (2017)	7
HNRNPL	3	LATS2	1	affinity chromatography technology	Fei T (2017)	1
PRKAA1	2	MDM4	0	enzymatic study	He G (2014)	1
PRKAA1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Al-Hakim AK (2005), Taipale M (2012), Varjosalo M (2013)	3
CHEK2	2	TP53	0	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Louria-Hayon I (2003), Shieh SY (2000), Bjorling-Poulsen M (2005), Hirao A (2000), Adams CJ (2008)	5
CDKN1A	1	YWHAQ	0	affinity chromatography technology, affinity chromatography technology, pull down	Wang B (2010), Wang B (2010), Wang B (2010)	3
PPP1CA	3	PPP1CB	9	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	6
CDKN1A	1	CDK4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Selma Dagtas A (2010), Guidoboni M (2005), Santiago FS (2007), Santiago FS (2007), Hsu SP (2008), Kehn K (2004), Kokontis JM (1998), Orend G (1998), Zheleva DI (2002), Mandal M (1998), Chen J (1996), Chen J (1996), Ramachandran N (2004), Gorospe M (1996), Fogeron ML (2013), Hukkelhoven E (2012), Hukkelhoven E (2012), Hukkelhoven E (2012), Huttlin EL (2017), Roessig L (2001)	20
TP73	2	RCHY1	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Wu H (2011), Wu H (2011), Wu H (2011), Wu H (2011), Wu H (2011)	5
UBE2D1	0	LRSAM1	2	two hybrid, pull down, enzymatic study	Markson G (2009), Chua HH (2016), Hakonen JE (2017)	3
MDM4	0	UBC	7	enzymatic study	Egorova O (2014)	1
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
HGF	1	NF2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RCHY1	0	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Corcoran CA (2009), Wang L (2011), Wang L (2011), Corcoran CA (2009)	4
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
EP300	36	UBC	7	enzymatic study, affinity chromatography technology	Delvecchio M (2013), Kirilyuk A (2012)	2
MAP2K5	1	BECN1	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EP300	36	UBE2D1	0	pull down, pull down	Shi D (2009), Grossman SR (2003)	2
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
YWHAH	0	PPP1CA	3	biochemical	Kristensen AR (2012)	1
MDM4	0	USP7	14	pull down, x-ray crystallography, unspecified method	Sarkari F (2010), Sarkari F (2010), Sarkari F (2010)	3
EP300	36	E2F1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ji W (2014), Ianari A (2004), Aoki I (2012)	3
USP22	1	MDM4	0	affinity chromatography technology, affinity chromatography technology	Ding F (2014), Ding F (2014)	2
CBLC	1	UBE2D2	0	pull down, pull down	Ryan PE (2010), Kim M (2004)	2
TP53	0	RPS15	1	affinity chromatography technology	Fogeron ML (2013)	1
YWHAZ	1	ABL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Raina D (2006), Yoshida K (2005), Yoshida K (2005), Yoshida K (2005), So J (2015)	5
UBC	7	E2F1	0	affinity chromatography technology	Rizos H (2007)	1
RNF115	1	SFN	1	two hybrid, pull down, affinity chromatography technology	Bacopulos S (2012), Bacopulos S (2012), Bacopulos S (2012)	3
UBC	7	USP22	1	pull down	Kwasna D (2018)	1
RFWD2	0	YWHAZ	1	imaging technique, affinity chromatography technology, pull down, affinity chromatography technology	Su CH (2010), Su CH (2010), Su CH (2010), Su CH (2010)	4
CDK4	2	CDKN2A	1	affinity chromatography technology, unspecified method, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ewing RM (2007), Fahraeus R (1996), Li J (2004), Sugimoto M (1999), Serrano M (1993), Serrano M (1993), Serrano M (1993), Coleman KG (1997), Zhang Y (1998), Haddad MM (1999), Li J (2002), Li J (2002), Lal G (2000), Yarbrough WG (1999), Della Torre G (2001), Jones R (2007), Jones R (2007), Ramachandran N (2004), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Hein MY (2015), Fei HJ (2017), Huttlin EL (2017), Ivanov AA (2017)	25
TP53	0	HNRNPL	3	affinity chromatography technology	Horikawa I (2014)	1
MDM4	0	YWHAQ	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lopez-Pajares V (2008), Lopez-Pajares V (2008), Gilkes DM (2006)	3
MDM2	2	SMARCA2	17	pull down	Yasuhara T (2014)	1
CDK1	0	MDM4	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Elias B (2005), Elias B (2005), Elias B (2005)	3
PPARD	4	PSMC5	4	two hybrid	Albers M (2005)	1
CDKN2A	1	E2F1	0	affinity chromatography technology, pull down	Eymin B (2001), Eymin B (2001)	2
EPHA2	3	APP	1	pull down	Olah J (2011)	1
TP63	0	RCHY1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Jung YS (2012), Jung YS (2012), Jung YS (2012)	3
LATS2	1	CDKN1A	1	enzymatic study	Suzuki H (2013)	1
TP53	0	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM4	0	EP300	36	pull down	Kadakia M (2002)	1
HSP90AA1	7	LRSAM1	2	affinity chromatography technology	Taipale M (2012)	1
MDM4	0	RCHY1	0	affinity chromatography technology, affinity chromatography technology	Wang L (2011), Wang L (2011)	2
HGF	1	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PRKAA1	2	RAD54B	3	two hybrid	Rolland T (2014)	1
CDKN2A	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Zhang Y (2003), Zhang Y (2003), Rizos H (2003), Zhang Y (1998), Zhang Y (1998), Li L (2010), Li L (2010), Kamijo T (1998), Stott FJ (1998), Ivanov AA (2017)	10
CHEK1	2	LATS2	1	enzymatic study, enzymatic study	Okada N (2011), Suzuki H (2013)	2
CSNK1A1	1	HSP90AA1	7	enzymatic study, affinity chromatography technology, affinity chromatography technology	Muller P (2012), Gano JJ (2010), Taipale M (2012)	3
CHEK2	2	LATS2	1	enzymatic study	Okada N (2011)	1
FGFR4	6	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EP300	36	TP63	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Liao JM (2013), Liao JM (2013), MacPartlin M (2005), MacPartlin M (2005), MacPartlin M (2005), MacPartlin M (2005), MacPartlin M (2005), Restelli M (2015), Restelli M (2015)	9
BCL2	0	CDK4	2	genetic interference	Shen JP (2017)	1
GLIS2	2	MDM2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBC	7	HNRNPL	3	affinity chromatography technology	Matsumoto M (2005)	1
CD44	1	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CHEK1	2	TP53	0	affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study	Tian H (2002), Sengupta S (2004), Tian H (2002), Goudelock DM (2003), Shieh SY (2000)	5
MDM4	0	HIPK2	0	affinity chromatography technology	Mancini F (2016)	1
YWHAB	1	RFWD2	0	pull down, affinity chromatography technology	Su CH (2011), Su CH (2011)	2
SPATA46	0	MDM4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MDM4	0	MDM2	2	pull down, two hybrid, enzymatic study, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, two hybrid, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, two hybrid, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Kadakia M (2002), Tanimura S (1999), Badciong JC (2002), Tanimura S (1999), Tanimura S (1999), Linke K (2008), Okamoto K (2005), Pan Y (2003), Kashuba E (2011), Kashuba E (2011), Ohtsubo C (2009), Singh RK (2007), Zhu Y (2009), Zhu Y (2009), Allende-Vega N (2010), Okamoto K (2009), Okamoto K (2009), Li X (2011), Nie J (2010), Nie J (2010), Li M (2011), Li M (2011), Singh RK (2007), de Graaf P (2003), Wade M (2012), Uldrijan S (2007), Wade M (2012), Stad R (2000), Dolezelova P (2012), Kulikov R (2005), Kawai H (2007), Kawai H (2007), Miller KR (2010), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Li C (2002), Wu S (2012), Ranaweera RS (2013), Woodsmith J (2012), Wang J (2011), Egorova O (2014), Chang YS (2013), Malbert-Colas L (2014), Yasuhara T (2014), Yasuhara T (2014), Iyappan S (2010), Stad R (2001), Marcar L (2015), Ling X (2014), Leslie PL (2015), Jacob AG (2014), Jacob AG (2014), Tournillon AS (2015), Tournillon AS (2015), Tournillon AS (2015), Zhang H (2015), Chen L (2015), Pellegrino M (2015), Pellegrino M (2015), Pellegrino M (2015), Medina-Medina I (2016), Medina-Medina I (2016), Moscetti I (2016), Liu T (2017), Liu T (2017), Liu T (2017), Huttlin EL (2017), Wu W (2015), Ivanov AA (2017), Mancini F (2016), Mancini F (2016)	74
CDK4	2	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EP300	36	YWHAZ	1	enzymatic study	Mortenson JB (2015)	1
PPP1CA	3	CDK1	0	affinity chromatography technology	Flores-Delgado G (2007)	1
HIPK2	0	EP300	36	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Aikawa Y (2006), Aikawa Y (2006), Aikawa Y (2006), Aikawa Y (2006)	4
E2F1	0	YWHAQ	0	two hybrid, pull down, affinity chromatography technology	Wang B (2004), Wang B (2004), Wang B (2004)	3
MDM4	0	CSNK1A1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen L (2005), Chen L (2005), Li M (2011), Gilkes DM (2006), Wu S (2012), Chen L (2015), Huttlin EL (2017)	7
YWHAB	1	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
PPP1CC	2	EIF2AK4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017)	3
RFWD2	0	UBE2D1	0	pull down, pull down	Choi HH (2011), Lu G (2014)	2
BECN1	2	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SFN	1	CDK1	0	affinity chromatography technology	Chan TA (1999)	1
UBC	7	PSMC5	4	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhu Q (2004), Zhang X (2017)	3
PPP1CA	3	MDM4	0	affinity chromatography technology, affinity chromatography technology	Lu Z (2012), Lu Z (2012)	2
SMARCA2	17	EP300	36	affinity chromatography technology	Zhang Y (2010)	1
PSMD2	2	MDM2	2	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Jin Y (2008), Jin Y (2008), Kulikov R (2010), Kulikov R (2010)	4
MDM4	0	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM2	2	MRE11	3	affinity chromatography technology, affinity chromatography technology	Alt JR (2005), Alt JR (2005)	2
MDM4	0	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN1A	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe, affinity chromatography technology, imaging technique	Zhang Z (2004), Zhang Z (2004), Zhang Z (2004), Jin Y (2003), Jin Y (2003), Wang B (2010), Xu H (2010), Xu H (2010), Frum R (2007), Chen TC (2014)	10
BECN1	2	UBC	7	pull down	Shi CS (2010)	1
PPP1CB	9	CDKN2A	1	affinity chromatography technology	Flores-Delgado G (2007)	1
YWHAB	1	YWHAG	5	affinity chromatography technology, biochemical	Couzens AL (2013), Wan C (2015)	2
HSP90AA1	7	CHEK1	2	affinity chromatography technology, pull down, affinity chromatography technology	Ha K (2011), Arlander SJ (2006), Taipale M (2012)	3
MAP2K5	1	HGF	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K5	1	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PPP1CA	3	EIF2AK4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017)	3
BECN1	2	TP53	0	affinity chromatography technology	Verma N (2017)	1
HNRNPL	3	YWHAE	0	biochemical, affinity chromatography technology	Wan C (2015), Fei T (2017)	2
UBC	7	RPS20	1	affinity chromatography technology	Matsumoto M (2005)	1
PPP1CA	3	RB1	2	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Flores-Delgado G (2007), Dunaief JL (2002), Durfee T (1993), Durfee T (1993), Durfee T (1993), Guo C (2007)	6
MDM2	2	USP2	0	two hybrid, pull down, affinity chromatography technology, pull down	Stevenson LF (2007), Stevenson LF (2007), Stevenson LF (2007), Stevenson LF (2007)	4
CHEK1	2	RB1	2	enzymatic study, pull down	Inoue Y (2007), Inoue Y (2007)	2
CBLC	1	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TP53	0	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Tian H (2002), Yang HY (2007), Yang HY (2003), Yang HY (2003), Choi HH (2011)	5
YWHAZ	1	SFN	1	biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	3
MDM2	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, protein complementation assay, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, unspecified method, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, far western blotting, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, biochemical, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, protein complementation assay, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, imaging technique, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, pull down, unspecified method, fluorescent resonance energy transfe, two hybrid, pull down	Li M (2003), Latonen L (2001), Zhang Y (2003), Zhang Y (2003), Kurki S (2003), Kurki S (2003), Freeman DJ (2003), Ito A (2002), Ito A (2002), Grossman SR (1998), Fang S (2000), Liu G (2000), Zhang Y (1998), Zhang Y (1998), Chen J (1993), Thut CJ (1997), Leung KM (2002), Wawrzynow B (2009), Ochocka AM (2009), Chen D (2009), Hedstroem E (2009), Brenkman AB (2008), Qiu W (2008), Qiu W (2008), Zhang Z (2008), Muller P (2008), Colaluca IN (2008), Colaluca IN (2008), Colaluca IN (2008), Tang Y (2008), Tang Y (2008), Lu X (2007), Lukashchuk N (2007), Lukashchuk N (2007), Lee JH (2007), Carter S (2007), Sasaki M (2007), Brooks CL (2007), Li L (2007), Becker K (2007), Zhao BX (2006), Zhao BX (2006), Abida WM (2007), Yang WH (2006), Ma J (2006), Wallace M (2006), Shimizu H (2006), Andrews P (2006), Yang J (2009), Zhu Z (2009), Wang C (2005), Higashitsuji H (2005), Higashitsuji H (2005), Yan C (2005), Vega FM (2004), Dai MS (2004), Dai MS (2004), Groenroos E (2004), Ohkubo S (2006), Sui G (2004), Di Stefano V (2004), Brignone C (2004), Katayama H (2004), Linares LK (2003), OKeefe K (2003), Wang W (2003), Blattner C (2002), Matt T (2004), Matt T (2004), Eyckerman S (2005), Shimizu H (2002), Shimizu H (2002), Migliorini D (2002), Gu J (2001), Sengupta S (2001), Chernov MV (2001), Cross B (2011), Cross B (2011), Cross B (2011), Buschmann T (2001), Nakamura S (2000), Rodriguez MS (2000), Rodriguez MS (2000), Geyer RK (2000), Zaika A (1999), Maki CG (1999), Chen L (2010), Chen L (2010), Lin RK (2010), Fuchs SY (1998), Xirodimas DP (2001), Fuchs SY (1998), Inoue T (2001), Wu L (2011), Du W (2009), Li DQ (2009), Illuzzi JL (2011), Oliver TG (2011), Kim MM (2007), Marchenko ND (2007), Vaseva AV (2009), Vaseva AV (2009), Lai KP (2010), Naderi EH (2011), Zdzalik M (2010), Singh RK (2007), Meng L (2011), Moore L (2007), Kim S (2010), Inoue Y (2011), Fraser JA (2010), Worrall EG (2009), Wu H (2011), Wang KS (2011), Wang KS (2011), Wang KS (2011), Izumi T (2010), Huang YF (2009), Tang J (2006), Tang J (2006), Fu X (2010), Fu X (2010), Shloush J (2011), Yadavilli S (2009), Stevenson LF (2007), Suzuki T (2010), Cheng Q (2009), Kulikov R (2010), Kulikov R (2010), Li L (2010), Li L (2010), Cheng Q (2011), Li D (2011), Nie J (2010), Demma M (2010), Sun XX (2011), Jung CR (2010), Jung CR (2010), Jung CR (2010), Jung CR (2010), Nishida T (2011), Li M (2011), Li M (2011), Amson R (2011), Amson R (2011), Bhatt P (2011), David Y (2011), Zhang Y (2010), Liu J (2010), Liu J (2010), Song MS (2008), Cummins JM (2004), Kim CK (2010), Kim CK (2010), Yan C (2010), Wang X (2011), Phillips A (2010), Phillips A (2010), Kang HN (2011), Kang HN (2011), Wang X (2004), Sionov RV (2001), Wei S (2012), Camus S (2012), Ding B (2012), Yang Z (2012), Yang Z (2012), Tripathi V (2007), Tripathi V (2007), Dai C (2011), Chen S (2012), Honda R (1997), Kinyamu HK (2003), Zhan C (2012), Zhan C (2012), Lee CW (2010), Zhou X (2012), Bouska A (2008), Wade M (2012), Ferreon JC (2009), Domenici F (2011), Uldrijan S (2007), Uldrijan S (2007), Stad R (2000), Stad R (2000), Banks D (2006), Banks D (2006), Bernal F (2010), Bernal F (2010), Jain AK (2012), Kane SA (2000), Tan Z (2000), Yang Z (2012), Wawrzynow B (2007), Wawrzynow B (2007), Wawrzynow B (2007), Hiramatsu K (2006), Bao-Lei T (2006), Kulikov R (2005), Yang Y (2005), Lindstroem MS (2007), Bech-Otschir D (2001), Li Y (2012), Gillotin S (2010), Burch L (2004), Liu WL (2001), OHagan HM (2004), OHagan HM (2004), Funari G (2009), Candeias MM (2008), Brew CT (2006), Wang J (2011), Calabro V (2002), Burch L (2004), Iyappan S (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Kurki S (2004), Tian LF (2006), Wang J (2006), Bae S (2012), Bae S (2012), Frazier DP (2012), Frazier DP (2012), Lew QJ (2012), Lew QJ (2012), Huart AS (2012), Li Z (2004), Balint E (1999), Balint E (1999), Funston G (2012), Dou X (2012), Sadagopan S (2012), Sadagopan S (2012), Dixit D (2012), Roxburgh P (2012), Xu L (2012), Drago-Ferrante R (2008), Li H (2009), Negorev D (2001), Wang X (2012), Wang X (2012), Wang X (2012), Boettger A (1997), Jung H (2008), Oliner JD (1992), Seemann S (2005), Kawai H (2007), Schuster K (2007), Dawson R (2003), DArcy P (2009), Schon O (2004), Schon O (2004), Hogan C (2008), Lottin-Divoux S (2005), Latini P (2011), Latini P (2011), Latini P (2011), McCoy MA (2003), Kussie PH (1996), Shieh SY (1997), Shieh SY (1997), Naski N (2009), Naski N (2009), Schon O (2002), Tamborini E (2001), Wade M (2006), Wade M (2006), Lohrum MA (2003), Garcia JF (2002), Garcia JF (2002), Kallen J (2009), Kulikov R (2006), Kulikov R (2006), Czarna A (2009), Czarna A (2009), Hu B (2007), Chi SW (2005), Yu GW (2006), Yu GW (2006), Saji S (2001), Chen L (1997), Zhang H (1998), Issaeva N (2004), Wade M (2008), Wade M (2008), Chen HF (2007), Chen HF (2007), Li HH (2004), Wang J (2011), Gu L (2009), Gu L (2009), Meng L (2008), Meng L (2008), Okamoto K (2006), Malaguarnera R (2008), Zhou M (2003), Zhou M (2003), Di Conza G (2012), Xirodimas DP (2004), Auger KR (2005), Li J (2011), Li J (2011), Li J (2011), Lee SJ (2007), Chau JF (2012), Lu X (2005), Mazars A (2010), Mazars A (2010), Mazars A (2010), Olson DC (1993), Picksley SM (1994), Issaeva N (2004), Issaeva N (2004), Zhang J (2012), Wen W (2013), Wen W (2013), Bursac S (2012), Yang Y (2013), Yang Y (2013), Landre V (2013), Pettersson S (2012), Thin TH (2007), Thin TH (2007), Piccinin S (2012), Shan B (2012), Caratozzolo MF (2012), Lui K (2013), Kobet E (2000), Lim KH (2010), Ranaweera RS (2013), Cui D (2013), Ebina M (2013), He Y (2013), He Y (2013), Siepe D (2009), Suh HW (2013), Zhan YA (2013), Wang J (2011), Hjerpe R (2010), Murray MF (2007), Jin L (2013), Jin L (2013), Zhang R (2013), Yan S (2013), Sun XX (2011), Heyne K (2014), Heyne K (2014), Bista M (2013), Jin J (2014), Mikawa T (2014), Qi M (2014), Cheng Q (2014), Zhang HH (2014), Perry ME (2000), Nishizaki M (2004), Sanchez-Aguilera A (2006), Chen YC (2013), Bertamino A (2013), Ding G (2013), Kubo N (2013), Kubo N (2013), Hsueh KW (2013), Kofod-Olsen E (2014), Fogeron ML (2013), Chang YS (2013), Gotoh T (2014), Gotoh T (2014), Oi N (2014), Corcoran CA (2009), Corcoran CA (2009), Ayroldi E (2014), Wu G (2014), Rajendra R (2004), Zhang J (2014), Lee MG (2014), Lee MG (2014), Freedman DA (1997), Freedman DA (1997), Saxena A (2006), Shi D (2009), Lohrum MA (2001), Lohrum MA (2001), Grossman SR (2003), Yan S (2013), Xirodimas DP (2004), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Saville MK (2004), Rodriguez MS (1999), Lui K (2013), Wu PY (2003), Pavithra L (2009), He Y (2013), Tan BX (2014), Huttlin EL (2015), Marcar L (2015), Borcherds W (2014), Borcherds W (2014), Li YC (2014), Ayroldi E (2014), Ling X (2014), Batuello CN (2015), Zhu N (2006), Mo XL (2015), Chen TC (2014), Stindt MH (2015), Caratozzolo MF (2014), Li X (2015), Saxena R (2016), Reed SM (2014), Du C (2016), Du C (2016), Du C (2016), Fraser JA (2015), Fraser JA (2015), Wu B (2015), Qin JJ (2015), Raza S (2015), Raza S (2015), Yamauchi T (2014), Yamauchi T (2014), Yamauchi T (2014), Shi Y (2010), Ahn HJ (2015), Lim KH (2015), Kang JH (2016), Chen J (2015), Liu X (2016), Yang P (2016), Yang P (2016), Liu D (2016), Liu D (2016), Liu D (2016), Datta D (2015), Reddy BA (2014), He X (2016), Shostak K (2014), Liu LJ (2016), Liu LJ (2016), Stegh AH (2010), Liu XH (2005), Medina-Medina I (2016), Medina-Medina I (2016), Kayama K (2017), Singh AK (2016), Liu WT (2016), Yue X (2016), Soares J (2015), Mukhopadhyay R (2016), Mukhopadhyay R (2016), Zhou X (2016), Zhou X (2016), Xie X (2016), Leao M (2015), Luo H (2016), Luo H (2016), Xie N (2016), Maeda R (2017), Maeda R (2017), Maeda R (2017), Sheng W (2017), Sheng W (2017), Liu M (2010), Huttlin EL (2017), Chauhan KM (2016), Goetz C (1999), Zhang J (2017), Unger T (1999), Liu Z (2004), Wu W (2015), Tan G (2017), Nomura K (2017), Lu W (2017), Lu W (2017), Hjerrild M (2001), Landre V (2017), Landre V (2017), Landre V (2017), Landre V (2017), Shangary S (2008), Shangary S (2008), Du WW (2017), Du WW (2017), Bista M (2013), Bista M (2013), Jin M (2017), LaRusch GA (2007), LaRusch GA (2007), Kurokawa M (2013), Ivanov AA (2017), Wong JH (2017), Wong JH (2017)	496
HNRNPL	3	CSNK1A1	1	affinity chromatography technology	Fei T (2017)	1
TP53	0	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Lu D (2013), Ali A (2013)	4
MDM4	0	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Wang L (2011), Wang L (2011)	2
RPL37	0	APP	1	pull down	Olah J (2011)	1
TP53	0	CSNK1A1	1	affinity chromatography technology, affinity chromatography technology	Huart AS (2009), Wei X (2016)	2
MDM4	0	CDKN2A	1	affinity chromatography technology, fluorescent resonance energy transfe	Jackson MW (2001), Ivanov AA (2017)	2
SFN	1	TP63	0	affinity chromatography technology, affinity chromatography technology	Fomenkov A (2004), Fomenkov A (2004)	2
UBE2D3	1	LRSAM1	2	two hybrid	Markson G (2009)	1
YWHAG	5	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Benzinger A (2005), Huttlin EL (2015), Huttlin EL (2017)	4
MNAT1	0	MKRN3	2	two hybrid	Woodsmith J (2012)	1
CDKN1A	1	UBE2D1	0	two hybrid	Vinayagam A (2011)	1
CDKN2A	1	BECN1	2	pull down, fluorescent resonance energy transfe	Pimkina J (2009), Ivanov AA (2017)	2
TP53	0	NF2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K5	1	CD44	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2D1	0	RNF115	1	two hybrid, two hybrid	van Wijk SJ (2009), Rolland T (2014)	2
RPL37	0	MDM2	2	affinity chromatography technology, affinity chromatography technology	Daftuar L (2013), Daftuar L (2013)	2
GLIS2	2	CDKN2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK4	2	CD44	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAZ	1	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
YWHAB	1	ABL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raina D (2006), Yoshida K (2005), Yoshida K (2005), So J (2015)	4
YWHAQ	0	YWHAH	0	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
ABL1	9	TP73	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yuan ZM (1999), Yuan ZM (1999), Agami R (1999), Tompkins JD (2009), Satija YK (2016)	5
SPATA46	0	CSNK1A1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	ABL1	9	affinity chromatography technology, two hybrid	Chen R (2013), Chen R (2013)	2
RPS15	1	MDM2	2	affinity chromatography technology, affinity chromatography technology	Daftuar L (2013), Daftuar L (2013)	2
LATS2	1	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM4	0	UBE2D1	0	pull down, pull down	Badciong JC (2002), Singh RK (2007)	2
TP53	0	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li M (2002), Li M (2002), Li M (2002), Li M (2002), Brooks CL (2007), Brooks CL (2007), Becker K (2007), Hu M (2006), Hu M (2006), Sarkari F (2010), Marchenko ND (2007), Epping MT (2011), Qing P (2011), Tang J (2006), Ma J (2010), Dai C (2011), Holowaty MN (2003), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Yi P (2013), Yi P (2013), Zhang J (2014), Fang Z (2013), Ye M (2015), Lim KH (2015), Lim KH (2015), Reddy BA (2014), Reddy BA (2014)	29
MDM2	2	PSMC5	4	affinity chromatography technology, pull down, biochemical, pull down	Kulikov R (2010), Kulikov R (2010), Kulikov R (2010), Kulikov R (2010)	4
MDM4	0	SMAD4	9	pull down	Kadakia M (2002)	1
YWHAB	1	UBC	7	affinity chromatography technology	Jin J (2004)	1
MDM4	0	APP	1	pull down	Olah J (2011)	1
MDM4	0	FAM193A	4	affinity chromatography technology	Huttlin EL (2017)	1
MDM2	2	YWHAQ	0	affinity chromatography technology, pull down, affinity chromatography technology	Pereg Y (2006), Wang B (2010), Wang B (2010)	3
HIPK2	0	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Di Stefano V (2005), Di Stefano V (2005), Rinaldo C (2007), Rinaldo C (2007), He Y (2013)	5
CBLC	1	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
TP53	0	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SMAD3	1	USP7	14	affinity chromatography technology, two hybrid	Brown KA (2008), Wang J (2011)	2
CHEK2	2	MDM2	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Pereg Y (2006), Kass EM (2009), Kass EM (2009), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005)	7
RPS20	1	APP	1	pull down	Olah J (2011)	1
CDKN1A	1	EP300	36	pull down, affinity chromatography technology	Cazzalini O (2008), Cazzalini O (2008)	2
TP63	0	CHEK2	2	affinity chromatography technology	Huttlin EL (2017)	1
TP63	0	HIPK2	0	two hybrid	Kim EJ (2002)	1
MDM4	0	PSMD2	2	affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Jin Y (2008), Jin Y (2008), Jin Y (2008), Jin Y (2008)	4
MDM4	0	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAQ	0	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pozuelo-Rubio M (2010), Huttlin EL (2015), Huttlin EL (2017)	3
MDM4	0	CD44	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBC	7	MRE11	3	affinity chromatography technology	Matsumoto M (2005)	1
HNRNPL	3	HIPK2	0	affinity chromatography technology	Fei T (2017)	1
MAGEA1	0	MDM4	0	two hybrid	Kozakova L (2015)	1
RB1	2	CDKN1A	1	affinity chromatography technology, pull down	Nakanishi M (1999), Nakanishi M (1999)	2
BECN1	2	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HSP90AA1	7	MDM4	0	affinity chromatography technology	Taipale M (2012)	1
MDM4	0	NBN	1	affinity chromatography technology	Carrillo AM (2015)	1
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
YWHAE	0	YWHAQ	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Bandyopadhyay S (2010), Pozuelo-Rubio M (2010), Gloeckner CJ (2007), Wang J (2011)	4
CDK4	2	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2D2	0	MKRN3	2	two hybrid	Markson G (2009)	1
MAP2K5	1	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN1A	1	TP63	0	genetic interference	McDade SS (2011)	1
NBN	1	CHEK1	2	genetic interference	Pichierri P (2004)	1
MAP2K5	1	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2D1	0	TRIM55	2	two hybrid	Markson G (2009)	1
BCL2	0	CDK1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Pathan N (2002), Pathan N (2001), Ling YH (1998)	3
TP53	0	BCL2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Heo KS (2011), Jung JH (2011), Jung JH (2011), Mancini F (2009), Mancini F (2009)	5
CBLC	1	UBC	7	enzymatic study	Kim M (2004)	1
TRIM55	2	USP7	14	enzymatic study	Loch CM (2012)	1
MDM4	0	UBE2D3	1	pull down	Zhu Y (2009)	1
TP53	0	HIPK2	0	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Hofmann TG (2002), Hofmann TG (2002), Hofmann TG (2002), Hofmann TG (2002), Kim EJ (2002), Sung KS (2005), Li Q (2011), Di Stefano V (2005), Rinaldo C (2007), Rinaldo C (2007), Lee MG (2014), Mancini F (2016)	12
SMAD3	1	APP	1	pull down	Olah J (2011)	1
CHEK2	2	RAD50	3	affinity chromatography technology	Matsuoka S (2007)	1
PRKAA1	2	EP300	36	affinity chromatography technology	Lim JY (2012)	1
UBE2D2	0	TRIM55	2	two hybrid	Markson G (2009)	1
TP53	0	HBB	0	affinity chromatography technology	Kikuchi J (2003)	1
CDK4	2	CDKN2B	0	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Rual JF (2005), Stelzl U (2005), Vinayagam A (2011), Xin X (2009), Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Ivanov AA (2017)	12
GLIS2	2	MDM4	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
USP7	14	UBE2D3	1	enzymatic study	Zhang ZM (2015)	1
MDM4	0	EIF2AK4	3	affinity chromatography technology	Huttlin EL (2017)	1
CHEK1	2	SFN	1	affinity chromatography technology	Tian H (2002)	1
MDM2	2	LATS2	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Aylon Y (2006), Aylon Y (2006), Aylon Y (2006)	3
MAP2K5	1	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAQ	0	ABL1	9	unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu C (2012), Raina D (2006), Yoshida K (2005), Yoshida K (2005), So J (2015)	5
MDM4	0	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
LATS2	1	YWHAH	0	affinity chromatography technology	Couzens AL (2013)	1
CDKN2A	1	TP63	0	affinity chromatography technology, pull down	Calabro V (2004), Calabro V (2004)	2
PSMD2	2	CDKN1A	1	biochemical, affinity chromatography technology	Jin Y (2008), Jin Y (2008)	2
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
UBC	7	PSMD2	2	pull down	Zhang X (2017)	1
CDK4	2	SMAD3	1	enzymatic study, imaging technique	Matsuura I (2004), Chen TC (2014)	2
MDM4	0	CD160	0	two hybrid	Rolland T (2014)	1
BECN1	2	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2D3	1	TRIM55	2	two hybrid, pull down	Markson G (2009), Loch CM (2012)	2
SMAD3	1	HIPK2	0	pull down	Harada J (2003)	1
NBN	1	RAD50	3	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Cerosaletti KM (2003), Trujillo KM (1998), Desai-Mehta A (2001), Goldberg M (2003), Goldberg M (2003), Cho YW (2007), Nakanishi K (2002), Greenberg RA (2006), Falck J (2005), Wu J (2012), Alt JR (2005), Havugimana PC (2012), Wan C (2015), Suhasini AN (2013), Suhasini AN (2013), Lee KY (2015)	17
USP2	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
PPP1CA	3	MDM2	2	affinity chromatography technology	Liu X (2016)	1
HGF	1	GLIS2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PSMC5	4	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Zhu Q (2007), Zhu Q (2007), Kulikov R (2010), Kulikov R (2010)	4
CDK4	2	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Nair JS (2009), Takaki T (2004), Deep G (2006), Kehn K (2004), Scholz A (2003), Gladden AB (2003), Mori S (1999), Higashi H (1996), Musgrove EA (1996), Sarmento LM (2005), Kim KS (2002), Li J (2002), Garcia-Morales P (2006), Tsai CH (2009), Miralem T (2003), Toji S (2004), Halder SK (2005), Dynlacht BD (1997), Mandal M (1998), Voit R (1999), Annicotte JS (2006), Connell-Crowley L (1997), Matsuura I (2004), Chen J (1996), Kitagawa M (1996), Anders L (2011), Gaiddon C (2003), Seo DW (2006), Kabuta T (2013), Lee B (2006), Kossatz U (2006), Zarkowska T (1997), Nakanishi M (1999), Iyer NG (2007), Guidoboni M (2005), Barbash O (2009), Wang C (2001), Denicourt C (2008), Pan W (2001)	39
PPP1CB	9	MDM4	0	affinity chromatography technology	Lu Z (2012)	1
RB1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study	Iyer NG (2007), Iyer NG (2007), Chan HM (2001)	3
YWHAZ	1	UBC	7	affinity chromatography technology	Jin J (2004)	1
CDKN1A	1	PSMC5	4	biochemical	Jin Y (2008)	1
MDM4	0	RAD54B	3	affinity chromatography technology, pull down	Yasuhara T (2014), Yasuhara T (2014)	2
CDKN2B	0	APP	1	pull down	Olah J (2011)	1
CDKN2B	0	CDKN2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TP63	0	MDM2	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zdzalik M (2010), Zdzalik M (2010), Galli F (2010), Calabro V (2002), Calabro V (2002), Stindt MH (2015)	6
MAP2K5	1	TP53	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM2	2	MKRN3	2	two hybrid	Woodsmith J (2012)	1
MDM4	0	RNF115	1	two hybrid	Rolland T (2014)	1
PPP1CC	2	TP53	0	affinity chromatography technology	Flores-Delgado G (2007)	1
E2F1	0	CSNK1A1	1	affinity chromatography technology	Huart AS (2009)	1
HSP90AA1	7	PPARD	4	two hybrid, affinity chromatography technology	Sumanasekera WK (2003), Taipale M (2012)	2
USP7	14	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, unspecified method, biochemical, x-ray crystallography, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lu X (2007), Becker K (2007), Pereg Y (2006), Hu M (2006), Hu M (2006), Hu M (2006), Hu M (2006), Sarkari F (2010), Sarkari F (2010), Tang J (2006), Tang J (2006), Ma J (2010), Song MS (2008), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Ye M (2015), Lim KH (2015), Reddy BA (2014), Rouge L (2016), Nihira NT (2017), Nihira NT (2017), Mungamuri SK (2016), Mungamuri SK (2016), Sun Y (2017)	25
ABL1	9	LATS2	1	affinity chromatography technology, enzymatic study	Reuven N (2013), Reuven N (2013)	2
HSP90AA1	7	BECN1	2	affinity chromatography technology	Xu C (2011)	1
ABL1	9	RB1	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down	Miyamura T (1997), Welch PJ (1993), Knudsen ES (1996), Knudsen ES (1996), Welch PJ (1995), Welch PJ (1995)	6
CBLC	1	TP53	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PPP1CA	3	BCL2	0	affinity chromatography technology	Flores-Delgado G (2007)	1
CDK1	0	E2F1	0	enzymatic study	Dynlacht BD (1997)	1
NF2	1	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM4	0	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
MAP2K5	1	CDKN2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN2A	1	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM4	0	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAE	0	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Couzens AL (2013), Wan C (2015)	4
PPP1CC	2	MDM4	0	affinity chromatography technology	Lu Z (2012)	1
ABL1	9	TP53	0	pull down	Nie Y (2000)	1
CBLC	1	NF2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
APP	1	TRIM46	3	pull down	Virok DP (2011)	1
MDM4	0	TP53	0	enzymatic study, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, protein complementation assay, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, fluorescent resonance energy transfe, pull down	Badciong JC (2002), Shvarts A (1997), Shvarts A (1997), Tang Y (2008), Okamoto K (2005), Chen L (2005), Wang X (2001), Ohtsubo C (2009), Zdzalik M (2010), Singh RK (2007), Kim S (2010), Li M (2011), Li M (2011), David Y (2011), de Graaf P (2003), Wade M (2012), Wade M (2012), Wade M (2012), Stad R (2000), Stad R (2000), Bernal F (2010), Bernal F (2010), Bernal F (2010), Bernal F (2010), Miller KR (2010), Zuckerman V (2009), Kallen J (2009), Czarna A (2009), Czarna A (2009), Popowicz GM (2008), Hu B (2007), Sharp DA (1999), Li C (2002), Di Conza G (2012), Mancini F (2009), Mancini F (2009), Wu S (2012), Shan B (2012), Wu S (2012), Wu S (2012), Ranaweera RS (2013), Bista M (2013), Bista M (2013), Wang CL (2014), Wang CL (2014), Rallapalli R (1999), Chang YS (2013), Chang YS (2013), Tan BX (2014), Huttlin EL (2015), Sanchez MC (2010), Sanchez MC (2010), Li YC (2014), Li X (2015), Chen X (2015), Chen L (2015), Chen L (2015), Chen L (2015), Wei X (2016), Wei X (2016), Xie X (2016), Huttlin EL (2017), Borcherds W (2017), Shangary S (2008), Ivanov AA (2017), Mancini F (2016)	66
RCHY1	0	UBE2D3	1	pull down	Abou Zeinab R (2013)	1
TP53	0	CDKN1A	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Tian H (2002), Vinayagam A (2011), Kinyamu HK (2003), Giono LE (2007), Chen TC (2014)	5
MDM2	2	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Yadavilli S (2009), Nie J (2010), Minsky N (2004), Wang X (2011), Sionov RV (2001), Oh W (2010), Zhu Y (2009), Latini P (2011), Jung CR (2010), David Y (2011), Ye B (2013), Cheng Q (2014), Saville MK (2004), Yamauchi T (2014), Jin M (2017)	15
PELI1	1	UBE2D1	0	pull down	Smith H (2009)	1
PPP1CC	2	CDK1	0	affinity chromatography technology	Flores-Delgado G (2007)	1
YWHAE	0	MDM4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	LeBron C (2006), Okamoto K (2005), Okamoto K (2005), Lopez-Pajares V (2008), Lopez-Pajares V (2008)	5
GLIS2	2	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RB1	2	TP53	0	affinity chromatography technology, pull down	Delston RB (2011), Sommer MH (1994)	2
MRE11	3	RAD50	3	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Chiba N (2001), Chiba N (2001), Chiba N (2001), Dolganov GM (1996), Dolganov GM (1996), Trujillo KM (1998), Goedecke W (1999), Zheng L (2009), Goldberg M (2003), Goldberg M (2003), Goldberg M (2003), Cho YW (2007), Cho YW (2007), Greenberg RA (2006), Alt JR (2005), Alt JR (2005), Havugimana PC (2012), Wan C (2015), Wijnhoven P (2015), Boldt K (2016), Suhasini AN (2013), Suhasini AN (2013), Lee KY (2015), Nicholson J (2017)	25
RNF115	1	APP	1	pull down	Olah J (2011)	1
MNAT1	0	MDM4	0	two hybrid	Woodsmith J (2012)	1
MDM4	0	TP73	2	affinity chromatography technology, pull down, affinity chromatography technology	Wang X (2001), Zdzalik M (2010), Huttlin EL (2017)	3
YWHAZ	1	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology	Waterman MJ (1998), Waterman MJ (1998), Gu YM (2006)	3
CHEK1	2	CDKN1A	1	affinity chromatography technology	Tian H (2002)	1
HGF	1	MDM4	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM2	2	TP73	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Balint E (1999), Zeng X (1999), Zeng X (1999), Chen L (2010), Zdzalik M (2010), Kim JW (2008), Balint E (1999), Balint E (1999), Wang J (2011), Ongkeko WM (1999), Ongkeko WM (1999), Ongkeko WM (1999), Ongkeko WM (1999), Wu H (2015), Stindt MH (2015), Zhou X (2015), Zhou X (2015)	17
LATS2	1	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN2A	1	CCNDBP1	0	two hybrid	Daakour S (2016)	1
YWHAE	0	RCHY1	0	affinity chromatography technology	Choudhary C (2009)	1
MDM4	0	RB1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Uchida C (2006), Uchida C (2006), Zhang H (2015), Zhang H (2015)	4
YWHAB	1	YWHAH	0	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
EP300	36	RAD50	3	affinity chromatography technology, pull down	Jung SY (2005), Karmakar S (2010)	2
CDK1	0	CHEK1	2	affinity chromatography technology	Hein MY (2015)	1
UBE2D1	0	MDM2	2	two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Singh RK (2007), Poyurovsky MV (2007), Li M (2003), Yogosawa S (2003), Honda R (1997), Sun XX (2011), Singh RK (2007), Taira N (2010), Fu X (2010), Wang KS (2011), Wang X (2004), Sehat B (2008), Wawrzynow B (2007), Burch L (2004), Frazier DP (2012), Huart AS (2012), Pettersson S (2009), Gama V (2009), Demma M (2010), Chymkowitch P (2011), Yan C (2010), Yang Y (2013), Ranaweera RS (2013), Siepe D (2009), Shi D (2009), Uchiki T (2009), Grossman SR (2003), Xirodimas DP (2004), Saville MK (2004), Liu T (2015), Batuello CN (2015), Fraser JA (2015), Yamauchi T (2014), Liu D (2016), McClurg UL (2016), Landre V (2017)	36
RPL37	0	MDM4	0	affinity chromatography technology	Daftuar L (2013)	1
TP53	0	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAB	1	APP	1	pull down	Olah J (2011)	1
GLIS2	2	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM2	2	RAD50	3	affinity chromatography technology, affinity chromatography technology	Alt JR (2005), Alt JR (2005)	2
MAP2K5	1	YWHAZ	1	two hybrid	Bandyopadhyay S (2010)	1
RPS20	1	MDM4	0	affinity chromatography technology	Daftuar L (2013)	1
CDK1	0	CDKN1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Amador V (2007), Ando T (2001), Lin ML (2011), Varjosalo M (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	7
RCHY1	0	UBC	7	enzymatic study	Wu G (2010)	1
CDK1	0	ABL1	9	enzymatic study	Kipreos ET (1990)	1
RB1	2	MDM2	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Hsieh JK (1999), Nguyen DX (2004), Zheng Z (2012), Sdek P (2005), Delston RB (2011), Delston RB (2011), Sdek P (2004), Sdek P (2004), Xiao ZX (1995), Xiao ZX (1995), Xiao ZX (1995), Uchida C (2006), Markham D (2006), Chan HM (2001), Chan HM (2001), Zhang H (2015), Zhang H (2015), Jaenicke RU (1996)	18
RNF115	1	UBC	7	two hybrid, pull down, protein complementation assay, pull down	Amemiya Y (2008), Amemiya Y (2008), Amemiya Y (2008), Amemiya Y (2008)	4
YWHAZ	1	YWHAH	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Hein MY (2015)	4
UBC	7	CDKN2A	1	pull down, imaging technique	Zhang X (2017), Zhang X (2017)	2
RPS15	1	RPL37	0	biochemical	Wan C (2015)	1
YWHAG	5	UBC	7	affinity chromatography technology	Jin J (2004)	1
MDM2	2	E2F1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Zhang Z (2005), Zhang Z (2005), Stevens C (2008), Stevens C (2008)	4
RB1	2	MNAT1	0	pull down	Wu L (2001)	1
MDM4	0	MDM4	0	enzymatic study, biochemical, pull down, enzymatic study, affinity chromatography technology	Singh RK (2007), Bista M (2013), Bista M (2013), Egorova O (2014), Liu T (2015)	5
HNRNPL	3	NF2	1	affinity chromatography technology	Fei T (2017)	1
CBLC	1	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAQ	0	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
PPP1CC	2	BCL2	0	affinity chromatography technology	Flores-Delgado G (2007)	1
HGF	1	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
APP	1	YWHAG	5	two hybrid, affinity chromatography technology, unspecified method	Sumioka A (2005), Sumioka A (2005), Sumioka A (2005)	3
YWHAH	0	ABL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raina D (2006), Yoshida K (2005), Yoshida K (2005), So J (2015)	4
CDK4	2	APP	1	pull down	Olah J (2011)	1
NF2	1	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN2A	1	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NBN	1	MRE11	3	biochemical, affinity chromatography technology, biochemical, two hybrid, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Cerosaletti KM (2003), Trujillo KM (1998), Matsuzaki K (2008), Desai-Mehta A (2001), Desai-Mehta A (2001), Desai-Mehta A (2001), Zheng L (2009), Goldberg M (2003), Goldberg M (2003), Goldberg M (2003), Cho YW (2007), Nakanishi K (2002), Shimada M (2009), Shimada M (2009), Yanagihara H (2011), Falck J (2005), Falck J (2005), Falck J (2005), Wu J (2012), Alt JR (2005), Havugimana PC (2012), Wijnhoven P (2015), Suhasini AN (2013), Suhasini AN (2013), Nicholson J (2017)	26
PRKAA1	2	USP2	0	affinity chromatography technology	Al-Hakim AK (2005)	1
MDM2	2	HSP90AA1	7	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, biochemical, unspecified method, affinity chromatography technology	Lu TL (2010), Burch L (2004), Burch L (2004), Burch L (2004), Burch L (2004), Burch LR (2004), Okoro DR (2013)	7
USP2	0	LRSAM1	2	two hybrid	Hayes SD (2012)	1
YWHAE	0	CSNK1A1	1	affinity chromatography technology	Gloeckner CJ (2007)	1
HGF	1	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PRKAA1	2	YWHAE	0	affinity chromatography technology	Al-Hakim AK (2005)	1
NF2	1	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
LATS2	1	YWHAG	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe	Okada N (2011), Okada N (2011), Okada N (2011), Ivanov AA (2017)	4
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
ABL1	9	RPL37	0	affinity chromatography technology	So J (2015)	1
CDKN1A	1	APP	1	pull down	Olah J (2011)	1
MAP2K5	1	GLIS2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TP73	2	EP300	36	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Strano S (2005), Uramoto H (2004), Zeng X (2000), Zeng X (2000), Zeng X (2000), Zeng X (2000), Zeng X (2000), Mantovani F (2004), Burge S (2009), Burge S (2009), Costanzo A (2002), Hoffmann A (2008), Kramer D (2015)	13
CBLC	1	UBE2D1	0	pull down	Kim M (2004)	1
PPP1CC	2	PPP1CA	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017), Yadav L (2017)	8
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
PSMC5	4	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	EPHA2	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012)	2
USP2	0	UBC	7	x-ray crystallography, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, unspecified method, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Renatus M (2006), Matsumoto M (2005), Bremm A (2010), Komander D (2009), Bozza WP (2012), Bozza WP (2012), Ernst A (2013), Durcan TM (2011), Mullen JR (2010), Ernst A (2013), Wauer T (2015), Louis M (2015), Castaneda CA (2016), Kliza K (2017), Kwasna D (2018), Leung I (2016)	16
TP53	0	MNAT1	0	pull down, affinity chromatography technology	Ko LJ (1997), Ko LJ (1997)	2
TP63	0	MDM4	0	pull down, pull down	Zdzalik M (2010), Zdzalik M (2010)	2
HSP90AA1	7	RPS20	1	biochemical	Havugimana PC (2012)	1
PPARD	4	MDM4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPL	3	MDM4	0	affinity chromatography technology	Fei T (2017)	1
TP63	0	PSMD2	2	affinity chromatography technology	Amoresano A (2010)	1
GLIS2	2	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM4	0	USP2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Allende-Vega N (2010), Allende-Vega N (2010), Wang CL (2014), Wang CL (2014), Wang CL (2014)	5
PPARD	4	MDM2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK1	0	TP53	0	enzymatic study, affinity chromatography technology	Luciani MG (2000), Ababneh M (2001)	2
UBE2D2	0	RNF115	1	two hybrid, pull down, pull down	van Wijk SJ (2009), Smith CJ (2013), Amemiya Y (2008)	3
RNF115	1	YWHAB	1	affinity chromatography technology	Bacopulos S (2012)	1
MDM4	0	UBE2D2	0	pull down, enzymatic study	Iyappan S (2010), Bista M (2013)	2
NF2	1	CDK1	0	affinity chromatography technology	Zhou L (2015)	1
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
RPS15	1	MDM4	0	affinity chromatography technology	Daftuar L (2013)	1
CDK4	2	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SMAD3	1	TP63	0	affinity chromatography technology	Lu D (2013)	1
MDM4	0	RAD50	3	affinity chromatography technology	Carrillo AM (2015)	1
NF2	1	SMAD3	1	affinity chromatography technology	Zhou L (2015)	1
USP7	14	CHEK1	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Qing P (2011), Zhang P (2014), Zhang P (2014), Tan X (2015), Alonso-de Vega I (2014)	5
CBLC	1	UBE2D3	1	pull down	Kim M (2004)	1
YWHAG	5	MDM4	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin Y (2006), Jin Y (2006), Jin Y (2006), Lee JH (2011), Lee JH (2011), Lee JH (2012), He G (2014)	7
CDKN1A	1	SMAD4	9	imaging technique	Chen TC (2014)	1
LATS2	1	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM4	0	CCNDBP1	0	affinity chromatography technology	Huttlin EL (2017)	1
SFN	1	MAGEA1	0	two hybrid	Rolland T (2014)	1
CD44	1	EP300	36	affinity chromatography technology	Su YJ (2011)	1
E2F1	0	MDM4	0	two hybrid, pull down	Strachan GD (2003), Strachan GD (2003)	2
YWHAG	5	ABL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raina D (2006), Yoshida K (2005), Yoshida K (2005), So J (2015)	4
BECN1	2	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAE	0	YWHAH	0	two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Bandyopadhyay S (2010), Gloeckner CJ (2007), Kristensen AR (2012), Wan C (2015), Hein MY (2015)	5
HNRNPL	3	PPP1CB	9	affinity chromatography technology	Fei T (2017)	1
HGF	1	CDKN2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EP300	36	NBN	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Jung SY (2005), Jang ER (2011), Jang ER (2011)	3
MDM2	2	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Wang L (2011), Wang L (2011)	2
UBC	7	PPP1CB	9	affinity chromatography technology	Matsumoto M (2005)	1
CDKN2A	1	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ABL1	9	USP7	14	enzymatic study, affinity chromatography technology, affinity chromatography technology	Morotti A (2013), Morotti A (2013), Morotti A (2013)	3
PPP1CC	2	CSNK1A1	1	two hybrid	Fardilha M (2011)	1
YWHAH	0	MDM4	0	affinity chromatography technology	LeBron C (2006)	1
RFWD2	0	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dornan D (2006), Dornan D (2004), Dornan D (2004), Dornan D (2004), Dornan D (2004), Choi HH (2011), Yamada T (2013), Zou S (2016)	8
MDM2	2	RPS20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Frum R (2007), Daftuar L (2013), Daftuar L (2013)	3
GLIS2	2	BECN1	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAB	1	MDM4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	LeBron C (2006), Okamoto K (2005), Li M (2011), Lopez-Pajares V (2008)	4
YWHAQ	0	YWHAB	1	affinity chromatography technology, affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Couzens AL (2013), Kristensen AR (2012)	3
PPARD	4	EP300	36	pull down, two hybrid	Cho MC (2006), Mochizuki K (2008)	2
TP53	0	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CBLC	1	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK1	0	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Horton LE (1997), Lees JA (1991), Knudsen ES (1996), Jiang W (1998), De Luca A (1997), Chen Z (2002), Knudsen ES (1997), Pan W (2001)	8
GLIS2	2	CD44	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM4	0	SMARCA2	17	pull down	Yasuhara T (2014)	1
YWHAE	0	ABL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raina D (2006), Yoshida K (2005), Yoshida K (2005), So J (2015)	4
CDKN2A	1	CD44	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN2B	0	CD44	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TP53	0	TP63	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McDade SS (2011), Lu D (2013), Chae YS (2012), Chae YS (2012), Stindt MH (2015), Wei S (2014)	6
BCL2	0	BECN1	2	two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liang XH (1998), Liang XH (1998), Chen D (2010), Xu C (2011), Chang NC (2010), Strappazzon F (2011), Zhou L (2013), Molejon MI (2013), Yang L (2012), Yang L (2012), Trisciuoglio D (2013), Han J (2012), Wang Y (2013), Wang Y (2013), Luciani A (2010), Luciani A (2010), Ciechomska IA (2009), Noble CG (2008), Noble CG (2008), Sun Q (2008), Rovito D (2013), Pattingre S (2005), Pattingre S (2005), Criollo A (2010), Tang D (2010), Tang D (2010), Chauhan S (2015), Rui YN (2015), Rui YN (2015), Verma N (2017), Yuan G (2014), Li X (2017)	32
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
ABL1	9	MDM4	0	affinity chromatography technology, affinity chromatography technology	Zuckerman V (2009), Zuckerman V (2009)	2
CHEK2	2	MDM4	0	enzymatic study	Chen L (2005)	1
HNRNPL	3	EIF2AK4	3	affinity chromatography technology	Fei T (2017)	1
GLIS2	2	CBLC	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HGF	1	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAB	1	TP53	0	affinity chromatography technology	Lee MK (2007)	1
RFWD2	0	UBE2D2	0	pull down, pull down, pull down	Dornan D (2006), Dornan D (2004), Choi HH (2011)	3
TP63	0	HNRNPL	3	affinity chromatography technology	Amoresano A (2010)	1
NF2	1	MDM4	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PPP1CA	3	TP53	0	two hybrid	Colland F (2004)	1
MDM4	0	MRE11	3	affinity chromatography technology	Carrillo AM (2015)	1
MDM4	0	SMAD3	1	pull down	Kadakia M (2002)	1
CHEK2	2	RCHY1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Bohgaki M (2013), Bohgaki M (2013), Bohgaki M (2013)	3
TRIM55	2	MDM4	0	two hybrid	Woodsmith J (2012)	1
MDM4	0	CAPN7	1	two hybrid	Rolland T (2014)	1
UBE2D1	0	MKRN3	2	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
CHEK1	2	MDM4	0	enzymatic study, enzymatic study	Jin Y (2006), Chen L (2005)	2
HSP90AA1	7	RB1	2	genetic interference	Srivas R (2016)	1
TRIM46	3	CBLC	1	two hybrid	Woodsmith J (2012)	1
MAP2K5	1	ASRGL1	1	two hybrid	Vinayagam A (2011)	1
PPP1CC	2	YWHAB	1	affinity chromatography technology	Yadav L (2017)	1
USP2	0	TRIM46	3	two hybrid	Hayes SD (2012)	1
BECN1	2	NF2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK1	0	USP22	1	affinity chromatography technology	Lin Z (2015)	1
FGFR4	6	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CHEK2	2	RB1	2	enzymatic study, pull down, affinity chromatography technology	Inoue Y (2007), Inoue Y (2007), Inoue Y (2007)	3
TP53	0	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SFN	1	RPS20	1	affinity chromatography technology	Wilker EW (2007)	1
MDM2	2	CSNK1A1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huart AS (2009), Huart AS (2012), Huart AS (2012)	3
LRSAM1	2	MDM4	0	two hybrid	Woodsmith J (2012)	1
BCL2	0	MDM4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mancini F (2009), Mancini F (2009), Wang CL (2014)	3
MDM2	2	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Zhang Y (2003), Zhang Y (2003), Zhang Y (2003), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Clark PA (2002), Clark PA (2002), Clark PA (2002), Pomerantz J (1998), Ivanchuk SM (2008), Wang C (2005), Wang X (2001), Midgley CA (2000), Shen J (2011), Li L (2010), Li L (2010), Li X (2011), Woods YL (2004), Bouska A (2008), Lindstroem MS (2007), Lohrum MA (2000), Wang J (2006), Wang J (2006), Wang J (2006), Drago-Ferrante R (2008), Schuster K (2007), Hogan C (2008), Rizos H (2000), Gargano B (2008), Kamijo T (1998), Wang S (2010), Jones R (2007), Stott FJ (1998), Lo D (2014), Pimkina J (2009), Blattner C (2002), Leslie PL (2015), Bothner B (2003), Ivanov AA (2017)	42
UBE2D3	1	RNF115	1	two hybrid, two hybrid	van Wijk SJ (2009), Rolland T (2014)	2
RCHY1	0	TP53	0	affinity chromatography technology, pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Leng RP (2003), Leng RP (2003), Sheng Y (2008), Sheng Y (2008), Corcoran CA (2009), Duan S (2007), Duan S (2007), Duan S (2007), Duan S (2007), Shloush J (2011), Jung YS (2011), Wu G (2010), Wu G (2010), Wang J (2011), Abou Zeinab R (2013), Corcoran CA (2009), Corcoran CA (2009), Yan W (2014), Yan W (2014), Yan W (2014)	20
PSMC5	4	PSMD2	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Hamazaki J (2007), Lee SH (2012), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	5
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
TP53	0	YWHAE	0	affinity chromatography technology	Fogeron ML (2013)	1
MDM2	2	APP	1	pull down	Miyamoto-Sato E (2010)	1
MDM4	0	PELI1	1	affinity chromatography technology	Huttlin EL (2017)	1
GLIS2	2	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PPP1CB	9	PPP1CC	2	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
HIPK2	0	ABL1	9	affinity chromatography technology, pull down, enzymatic study	Reuven N (2015), Reuven N (2015), Reuven N (2015)	3
ABL1	9	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bali P (2005), Sun H (2011), Tsukahara F (2010), Taipale M (2012), Wu LX (2006)	5
MDM2	2	NBN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alt JR (2005), Alt JR (2005), Bouska A (2008)	3
SFN	1	MDM4	0	affinity chromatography technology	LeBron C (2006)	1
MDM4	0	6025	0	affinity chromatography technology, affinity chromatography technology, unspecified method	Li M (2011), Li M (2011), Li M (2011)	3
MAGEB1	0	MDM4	0	affinity chromatography technology	Kozakova L (2015)	1
LRSAM1	2	MKRN3	2	two hybrid	Woodsmith J (2012)	1
MKRN3	2	MDM4	0	two hybrid	Woodsmith J (2012)	1
MDM2	2	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Iyappan S (2010), Dou H (2012), Brenkman AB (2008), Fang S (2000), Szypowska AA (2011), Okamoto K (2009), Busso CS (2009), Maguire M (2008), Sehat B (2008), Uldrijan S (2007), Yang Y (2005), Jin Y (2004), Roxburgh P (2012), Shloush J (2011), Rinaldo C (2007), Cheng Q (2009), Amson R (2011), Li X (2009), David Y (2011), Sosin AM (2012), Schumacher FR (2013), Bista M (2013), Mikawa T (2014), Lohrum MA (2001), Fang S (2001), Saville MK (2004), Rodriguez MS (1999), Auger KR (2005), Wu PY (2003), Wu H (2015), Yamauchi T (2014), Nomura K (2017), Kurokawa M (2013)	33
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
PPP1CC	2	CDKN2A	1	affinity chromatography technology	Flores-Delgado G (2007)	1
SFN	1	YWHAB	1	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	SMARCA2	17	affinity chromatography technology	Fei T (2017)	1
HSP90AA1	7	CDKN1A	1	affinity chromatography technology	Jascur T (2005)	1
NF2	1	LATS2	1	x-ray crystallography, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Li Y (2015), Yin F (2013), Ivanov AA (2017), Zhu C (2018)	4
RFWD2	0	SFN	1	enzymatic study	Choi HH (2011)	1
EPHA2	3	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PRKAA1	2	YWHAZ	1	affinity chromatography technology	Al-Hakim AK (2005)	1
CD44	1	NF2	1	affinity chromatography technology, unspecified method, fluorescent resonance energy transfe	Tang X (2007), Mori T (2014), Ivanov AA (2017)	3
CHEK1	2	APP	1	pull down	Olah J (2011)	1
HSP90AA1	7	MAP2K5	1	affinity chromatography technology	Taipale M (2012)	1
EP300	36	MDM2	2	pull down, affinity chromatography technology, biochemical, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study	Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Matt T (2004), Wang X (2004), Gillotin S (2010), Kobet E (2000), Nihira NT (2017)	9
ABL1	9	MDM2	2	affinity chromatography technology, pull down, enzymatic study, unspecified method, enzymatic study	Goldberg Z (2002), Goldberg Z (2002), Goldberg Z (2002), Batuello CN (2015), Batuello CN (2015)	5
CDKN1A	1	SMAD3	1	affinity chromatography technology	Dai M (2012)	1
MDM2	2	RAD54B	3	affinity chromatography technology, affinity chromatography technology	Yasuhara T (2014), Yasuhara T (2014)	2
HGF	1	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RB1	2	E2F1	0	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Nicolas E (2001), Pardo PS (2002), Choubey D (1996), Fajas L (2000), Dyson N (1993), Dyson N (1993), Wu CL (1995), Taniura H (1998), Dai Y (2003), Fedele M (2006), Fedele M (2006), Brown VD (2002), De Blasio A (2005), Chau CM (2008), Dasgupta P (2004), Yang L (2011), Kruetzfeldt M (2005), Harbour JW (1999), Lee SJ (1998), Gao D (2009), Delston RB (2011), Gupta K (2000), Sdek P (2004), Flemington EK (1993), Chang YH (2012), Inoue Y (2007), Inoue Y (2007), Inoue Y (2007), Liu X (2006), Moberg K (1996), Knudsen ES (1996), Brown VD (1999), Brown VD (1999), Whitaker LL (1998), Whitaker LL (1998), Hagemeier C (1993), Bhat UG (1999), Xiao B (2003), Xiao B (2003), Vidal M (1996), Markham D (2006), Markham D (2006), Ianari A (2009), Ianari A (2009), Dhillon NK (2002), Knudsen ES (1997), Knudsen ES (1997), Gery S (2004), Gery S (2004), Kashuba E (2008), Kashuba E (2008), Pearson A (1997), Ginsberg D (1994), Welch PJ (1995), Wang J (2009), Aoki I (2012), Trimarchi JM (1998), Kumari A (2015), Gamell C (2017), Chen TT (2000), Chen TT (2000), Chen TT (2000), Chen TT (2000)	63
TP63	0	TP73	2	affinity chromatography technology	Huttlin EL (2017)	1
E2F1	0	CDKN1A	1	imaging technique	Devgan V (2005)	1
SFN	1	MKRN3	2	two hybrid	Rolland T (2014)	1
RCHY1	0	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hattori T (2007), Duan S (2007), Sheng Y (2008), Wu G (2010), Corcoran CA (2009), Abe K (2008), Shloush J (2011), Bohgaki M (2013), Abou Zeinab R (2013)	9
GLIS2	2	NF2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TP73	2	RB1	2	affinity chromatography technology	Ozaki T (2003)	1
YWHAG	5	YWHAH	0	biochemical, biochemical, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015)	3
TP73	2	HIPK2	0	two hybrid	Kim EJ (2002)	1
RFWD2	0	RCHY1	0	affinity chromatography technology, affinity chromatography technology	Wang L (2011), Wang L (2011)	2
PPP1CA	3	CDK4	2	affinity chromatography technology, biochemical	Flores-Delgado G (2007), Havugimana PC (2012)	2
MAGEA1	0	LRSAM1	2	two hybrid	Kozakova L (2015)	1
YWHAZ	1	MDM2	2	affinity chromatography technology	Zhang B (2017)	1