Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
MECP2 4204 FLUOROURACIL CHEMBL185 PharmGKB
MECP2 4204 CARBOQUONE CHEMBL443014 PharmGKB

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
MECP2 rs17435 A cisplatin efficacy yes The study described this variant within the MECP2 gene which is on the minus chromosomal strand, the allele associated with increased response is therefore not clear. [stat_test: chi squared allele test] Allele A is associated with response to cisplatin, fluorouracil and mitoxantrone in people with Carcinoma, Hepatocellular as compared to allele T. 21635146 827812222
MECP2 rs1734787 A cisplatin efficacy yes The study described this variant within the MECP2 gene which is on the minus chromosomal strand, and reported the association between complementary alleles T and G. [stat_test: chi squared allele test] Allele A is associated with response to cisplatin, fluorouracil and mitoxantrone in people with Carcinoma, Hepatocellular as compared to allele C. 21635146 827812230
MECP2 rs1734791 A cisplatin efficacy yes The study described this variant within the MECP2 gene which is on the minus chromosomal strand, the allele associated with increased response is therefore not clear. [stat_test: chi squared allele test] Allele A is associated with response to cisplatin, fluorouracil and mitoxantrone in people with Carcinoma, Hepatocellular as compared to allele T. 21635146 827812238