PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2D2	0	STAM2	0	enzymatic study	Hoeller D (2007)	1
MAP2K7	5	JUN	0	enzymatic study	Sundarrajan M (2003)	1
MAP3K1	4	DYRK1A	36	affinity chromatography technology	Ritterhoff S (2010)	1
TRAF2	1	MAPK9	3	imaging technique	Chen TC (2014)	1
NOP56	0	RPL4	4	affinity chromatography technology, biochemical, affinity chromatography technology	Hayano T (2003), Havugimana PC (2012), Hein MY (2015)	3
TOM1L2	0	CUEDC1	4	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	EPN1	4	affinity chromatography technology	Emdal KB (2015)	1
YWHAQ	0	YWHAG	5	affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Kristensen AR (2012)	2
MAP3K1	4	FKBP6	1	enzymatic study	Charlaftis N (2014)	1
XPO1	8	YWHAG	5	affinity chromatography technology	Kirli K (2015)	1
FAF2	4	RNF126	2	affinity chromatography technology	Alexandru G (2008)	1
MAP3K1	4	CDC37	0	affinity chromatography technology	Bouwmeester T (2004)	1
TP53	0	STAM2	0	genetic interference	Xie L (2013)	1
YWHAE	0	DCAF7	4	affinity chromatography technology, affinity chromatography technology	Gloeckner CJ (2007), Boldt K (2016)	2
NTRK1	1	RPL4	4	affinity chromatography technology	Emdal KB (2015)	1
ARRB1	2	MAPK9	3	two hybrid, two hybrid	Wang J (2011), Rolland T (2014)	2
UBE2V1	0	TRIM5	4	two hybrid	Markson G (2009)	1
UBE2D4	0	DTX1	2	two hybrid	van Wijk SJ (2009)	1
ACTN1	5	STAM2	0	biochemical	Kristensen AR (2012)	1
MAP3K1	4	RPL30	1	affinity chromatography technology	Bouwmeester T (2004)	1
DVL2	5	TRAF2	1	two hybrid	Rual JF (2005)	1
VHL	0	RPL30	1	affinity chromatography technology	Lai Y (2011)	1
NTRK1	1	RABEP2	0	affinity chromatography technology	Emdal KB (2015)	1
MAP3K1	4	UBE2K	0	enzymatic study	Charlaftis N (2014)	1
ARRB1	2	YWHAG	5	affinity chromatography technology	Xiao K (2007)	1
ATXN3	2	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Liu H (2016), Liu H (2016), Liu H (2016), Liu H (2016), Liu H (2016)	5
MCM2	3	MAP3K1	4	affinity chromatography technology	Drissi R (2015)	1
DCUN1D1	0	VHL	0	affinity chromatography technology	Heir P (2013)	1
ARRB2	5	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
MAPK9	3	MAP2K7	5	unspecified method, enzymatic study	Ho DT (2006), Enomoto A (2003)	2
ARRB2	5	YWHAG	5	affinity chromatography technology	Xiao K (2007)	1
UBXN7	3	NPLOC4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015)	3
ALK	8	MAP3K1	4	affinity chromatography technology, affinity chromatography technology	Crockett DK (2004), Crockett DK (2004)	2
MCM2	3	MAPK1	1	affinity chromatography technology	Drissi R (2015)	1
MCM2	3	YWHAQ	0	affinity chromatography technology	Drissi R (2015)	1
MAP3K1	4	FKBP5	0	affinity chromatography technology	Bouwmeester T (2004)	1
MAP3K1	4	RAD23A	1	enzymatic study	Charlaftis N (2014)	1
MAP3K1	4	FRAT1	0	affinity chromatography technology, affinity chromatography technology	Loke J (2014), Loke J (2014)	2
DCUN1D1	0	RHOA	0	pull down	Huang G (2014)	1
TRIM5	4	CUEDC1	4	affinity chromatography technology	Huttlin EL (2017)	1
MAP4K2	1	MAP3K1	4	pull down, affinity chromatography technology, affinity chromatography technology	Yuasa T (1998), Chadee DN (2002), Chadee DN (2002)	3
BRCA1	7	UBE2W	0	two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down	Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Christensen DE (2007), David Y (2011), Vittal V (2015)	6
MAP3K1	4	HIP1	4	enzymatic study	Charlaftis N (2014)	1
EPN1	4	PLEKHB2	4	two hybrid	Rolland T (2014)	1
FAF2	4	UBXN7	3	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015)	2
MAPK1	1	ARRB1	2	enzymatic study	Lin FT (1999)	1
UBE2D4	0	TRIM5	4	two hybrid	Markson G (2009)	1
TAB1	1	TRAF2	1	affinity chromatography technology	Bouwmeester T (2004)	1
MCM2	3	RPL30	1	affinity chromatography technology	Drissi R (2015)	1
TP53	0	6207	0	affinity chromatography technology	Horikawa I (2014)	1
UBE2E1	1	UBASH3B	4	enzymatic study	Hoeller D (2007)	1
MAP3K1	4	NOTCH1	25	enzymatic study, affinity chromatography technology	Ahn JS (2016), Ahn JS (2016)	2
CDC37	0	RAF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Li J (2013)	3
DCAF7	4	DYRK1B	1	affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skurat AV (2004), Ritterhoff S (2010), Ritterhoff S (2010), Miyata Y (2011), Varjosalo M (2013), Glenewinkel F (2016), Glenewinkel F (2016), Huttlin EL (2017), Hauri S (2016)	9
UBE2D2	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
ARRB1	2	MAP3K1	4	affinity chromatography technology	Xiao K (2007)	1
NOP56	0	RPL30	1	affinity chromatography technology, affinity chromatography technology	Hayano T (2003), Hein MY (2015)	2
NTRK1	1	MAP4K4	13	affinity chromatography technology	Emdal KB (2015)	1
ARRB2	5	MAP2K4	3	affinity chromatography technology, unspecified method	McDonald PH (2000), Li X (2009)	2
NTRK1	1	CHUK	5	affinity chromatography technology	Emdal KB (2015)	1
NOTCH1	25	EPN1	4	affinity chromatography technology	Sorensen EB (2010)	1
KDM5C	9	XPO1	8	affinity chromatography technology	Hein MY (2015)	1
BRCA1	7	MAP4K4	13	unspecified method	Rodriguez M (2003)	1
MAPK8	3	TRAF2	1	affinity chromatography technology	Gravestein LA (1998)	1
BRCA1	7	UBE2I	0	fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, affinity chromatography technology	Morris JR (2009), Morris JR (2009), Xu J (2009), Xu J (2009)	4
DCUN1D1	0	HSPA1L	2	affinity chromatography technology	Bennett EJ (2010)	1
UBE2I	0	MAP2K1	8	enzymatic study	Kubota Y (2011)	1
ARRB2	5	HGS	5	affinity chromatography technology, affinity chromatography technology	Han SO (2012), Malik R (2010)	2
HGS	5	STAM2	0	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Rual JF (2005), Bache KG (2003), Bache KG (2003), Mizuno E (2004), Kanazawa C (2003), Kanazawa C (2003), Stuible M (2010), Havugimana PC (2012), Hoeller D (2006), Wan C (2015)	10
MAP3K1	4	DENND6B	5	enzymatic study	Charlaftis N (2014)	1
MAP3K1	4	UBQLN1	1	enzymatic study	Charlaftis N (2014)	1
XPO1	8	DNAJB6	3	affinity chromatography technology	Kirli K (2015)	1
MAP3K1	4	UBAP1	2	enzymatic study	Charlaftis N (2014)	1
MAP3K1	4	PSMD4	1	enzymatic study	Charlaftis N (2014)	1
GSK3B	1	JUN	0	enzymatic study, imaging technique	Chen BK (2007), Chen TC (2014)	2
UBE2I	0	NOP56	0	enzymatic study	Matafora V (2009)	1
MAP3K1	4	MBP	0	enzymatic study	Ninomiya-Tsuji J (2003)	1
ARRB2	5	HSPA1L	2	affinity chromatography technology	Xiao K (2007)	1
BRCA1	7	YWHAE	0	affinity chromatography technology	Ertych N (2016)	1
HGS	5	GGA2	2	pull down	Pridgeon JW (2009)	1
FRAT1	0	RABEP2	0	two hybrid	Wang J (2011)	1
UBE2D4	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
NTRK1	1	YWHAE	0	affinity chromatography technology	Emdal KB (2015)	1
XPO1	8	MAP4K4	13	affinity chromatography technology	Kirli K (2015)	1
UBQLN1	1	DNAJB2	0	pull down	Heir R (2006)	1
UBE2V1	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
IKBKB	1	JUN	0	enzymatic study	Orel L (2010)	1
MAP3K1	4	RNF114	0	enzymatic study	Charlaftis N (2014)	1
MAPK8IP3	9	RAF1	3	affinity chromatography technology, pull down, affinity chromatography technology	Kuboki Y (2000), Kuboki Y (2000), Ito M (1999)	3
BRCA1	7	DCAF7	4	affinity chromatography technology	Ertych N (2016)	1
CDC37	0	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
NTRK1	1	GSTP1	0	affinity chromatography technology	Emdal KB (2015)	1
MAPK3	4	MBP	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Plun-Favreau H (2007), Momose H (2003), Wasserman T (2010), Tresini M (2001)	4
NTRK1	1	HIP1	4	affinity chromatography technology	Emdal KB (2015)	1
AXIN1	1	DVL2	5	affinity chromatography technology	Zhang Y (2000)	1
HGS	5	UBQLN1	1	two hybrid, affinity chromatography technology	Rual JF (2005), Regan-Klapisz E (2005)	2
TP53	0	RPL30	1	affinity chromatography technology	Fogeron ML (2013)	1
UBQLN1	1	ATXN3	2	pull down	Heir R (2006)	1
GSK3B	1	AXIN1	1	two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Mak BC (2003), Hino S (2005), Oosterveen T (2007), Kim MJ (2008), Kitagawa M (1999), Cha B (2011), Cha B (2011), Arnold HK (2009), Kashikar ND (2011), Kashikar ND (2011), Zhou F (2012), Yan D (2012), Zhang YG (2012), Sue Ng S (2010), Kim JW (2003), Tang Y (2008), Luo W (2007), Li VS (2012), Rosano L (2009), Yamamoto H (2006), Fei C (2013), Wang J (2011), Varjosalo M (2013), Gao C (2014), Varjosalo M (2013), Castellone MD (2005), Hein MY (2015), Chen TC (2014), Chen Y (2016), Novellasdemunt L (2017)	36
BRCA1	7	DYRK1A	36	affinity chromatography technology	Ertych N (2016)	1
JUN	0	MAPK1	1	affinity chromatography technology, enzymatic study, pull down	Kumar NV (2001), Zuniga A (1999), Zuniga A (1999)	3
MAPK1	1	RAF1	3	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Lin YL (2000), Dougherty MK (2005), Zhu J (2005), Blaukat A (2000), Wang J (2009), Wang J (2009), Wang J (2009)	7
BRCA1	7	UBE2K	0	two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down	Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Christensen DE (2007), David Y (2011), Shabbeer S (2013)	6
TP53	0	NFKBIA	0	affinity chromatography technology, two hybrid	Chang NS (2002), Chang NS (2002)	2
FKBP5	0	DNAJB6	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
UBE2D1	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
PAK1	2	YWHAG	5	two hybrid	Bandyopadhyay S (2010)	1
MAPK3	4	ARRB1	2	enzymatic study	Lin FT (1999)	1
MAPK9	3	MAPK8	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
TRIM5	4	MAP3K1	4	affinity chromatography technology	Pertel T (2011)	1
MAP3K1	4	NR4A1	4	enzymatic study	Han YH (2006)	1
ALK	8	MAP2K7	5	affinity chromatography technology	Crockett DK (2004)	1
BRCA1	7	UBE2D2	0	two hybrid, two hybrid, x-ray crystallography, pull down	Dynek JN (2010), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009)	4
NFKBIA	0	RHOA	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MCM2	3	HSPA1L	2	affinity chromatography technology	Drissi R (2015)	1
PAK1	2	HGS	5	pull down	Sasaki Y (2001)	1
UBE2D2	0	RNF126	2	two hybrid, pull down, pull down, pull down	Markson G (2009), Hou X (2012), Smith CJ (2013), Delker RK (2013)	4
RAD23A	1	UBQLN1	1	x-ray crystallography, affinity chromatography technology, biochemical	Kang Y (2007), Kang Y (2007), Wan C (2015)	3
XPO1	8	EPN1	4	affinity chromatography technology	Kirli K (2015)	1
UBE2D3	1	RNF114	0	two hybrid, enzymatic study	Markson G (2009), Lin B (2017)	2
DCUN1D1	0	GRB2	2	affinity chromatography technology	Bennett EJ (2010)	1
HGS	5	NOTCH1	25	affinity chromatography technology	Sjoeqvist M (2014)	1
RAF1	3	MAP3K1	4	affinity chromatography technology, affinity chromatography technology, pull down	Karandikar M (2000), Karandikar M (2000), Karandikar M (2000)	3
UBE2D1	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
BRCA1	7	BAP1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Jensen DE (1998), Jensen DE (1998), Jensen DE (1998), Jensen DE (1998)	4
ARRB2	5	MAP3K1	4	affinity chromatography technology, imaging technique	Xiao K (2007), Chen TC (2014)	2
BRCA1	7	XPO1	8	affinity chromatography technology	Ertych N (2016)	1
MAPK1	1	DYRK1B	1	enzymatic study	Lee K (2000)	1
MAP3K1	4	MINDY3	3	enzymatic study	Charlaftis N (2014)	1
FKBP6	1	CDC37	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
MAP3K1	4	TOM1L2	0	enzymatic study	Charlaftis N (2014)	1
XPO1	8	ARRB2	5	affinity chromatography technology	Kirli K (2015)	1
ALK	8	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Crockett DK (2004), Crockett DK (2004), Bai RY (1998), Ambrogio C (2005), Ambrogio C (2005)	5
DCAF7	4	DYRK1A	36	biochemical, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skurat AV (2004), Skurat AV (2004), Ritterhoff S (2010), Ritterhoff S (2010), Miyata Y (2011), Miyata Y (2011), Miyata Y (2011), Miyata Y (2011), Miyata Y (2011), Varjosalo M (2013), Miyata Y (2014), Miyata Y (2014), Glenewinkel F (2016), Glenewinkel F (2016), Glenewinkel F (2016), Huttlin EL (2017), Boldt K (2016), Hauri S (2016)	18
MAP2K4	3	MAPK9	3	two hybrid, affinity chromatography technology, pull down	Vinayagam A (2011), Li Y (2012), Ho DT (2003)	3
ACTN1	5	FAF2	4	biochemical	Havugimana PC (2012)	1
UBE2I	0	UBE2E1	1	biochemical	Wan C (2015)	1
MAPK9	3	ARRB2	5	two hybrid, two hybrid	Venkatesan K (2009), Rolland T (2014)	2
MAP3K1	4	UBASH3B	4	enzymatic study	Charlaftis N (2014)	1
TP53	0	CHUK	5	affinity chromatography technology	Huang WC (2007)	1
FLNB	11	UFD1	1	biochemical	Wan C (2015)	1
XPO1	8	NR4A1	4	affinity chromatography technology	Kirli K (2015)	1
MAPK3	4	RAF1	3	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Lin YL (2000), Wang J (2009), Wang J (2009), Wang J (2009)	4
MAP3K1	4	JUN	0	enzymatic study	Park KJ (2003)	1
NOTCH1	25	DTX1	2	affinity chromatography technology, affinity chromatography technology	Yamamoto N (2001), Zhang P (2010)	2
UBE2D1	0	DTX1	2	two hybrid	van Wijk SJ (2009)	1
NTRK1	1	XPO1	8	affinity chromatography technology	Emdal KB (2015)	1
MAP3K1	4	DVL2	5	affinity chromatography technology	Zhang Y (2000)	1
ARRB2	5	6207	0	affinity chromatography technology	Xiao K (2007)	1
ARRB2	5	TAB1	1	affinity chromatography technology	Xiao K (2007)	1
MAP3K1	4	IKBKB	1	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Deng L (2000), Nemoto S (1998), Nemoto S (1998), Li Q (2006)	4
MAP2K4	3	MAPK8	3	pull down, pull down, enzymatic study, genetic interference, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Lee CM (2002), Park HS (2002), Chen Z (2001), Tournier C (1997), Cheng J (2000), Deacon K (1997), Xia Y (1998), Xia Y (1998), Ho DT (2006), Song JJ (2005), Sundarrajan M (2003), Ho DT (2003), Ho DT (2003)	13
UBE2W	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
NTRK1	1	ASCC2	3	affinity chromatography technology	Emdal KB (2015)	1
MAP3K1	4	MAP3K1	4	enzymatic study, affinity chromatography technology, biochemical, enzymatic study	Chadee DN (2002), Chadee DN (2002), Chadee DN (2002), Ninomiya-Tsuji J (2003)	4
MAP3K1	4	RAD51AP1	1	enzymatic study	Charlaftis N (2014)	1
MAP3K1	4	6207	0	affinity chromatography technology	Bouwmeester T (2004)	1
ARRB1	2	STAM	3	affinity chromatography technology, pull down, imaging technique, pull down	Malik R (2010), Malik R (2010), Malik R (2010), Malik R (2010)	4
NTRK1	1	HGS	5	affinity chromatography technology	Emdal KB (2015)	1
NOTCH1	25	TAB1	1	affinity chromatography technology	Yatim A (2012)	1
LLGL2	4	RAD18	3	affinity chromatography technology, affinity chromatography technology	Hauri S (2013), Huttlin EL (2017)	2
MAPK8	3	JUN	0	enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, two hybrid, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study	Ishitani T (2003), Nishitoh H (1998), Derijard B (1994), Derijard B (1994), Yazgan O (2002), Tada K (2001), Meyer CF (1996), Cano E (1995), Cano E (1995), Trivedi AK (2007), Zhu F (2006), Zuniga A (1999), Zuniga A (1999), Higashimoto T (2008), Garcia-Guzman M (2000), Singhirunnusorn P (2005), Hofmann TG (2005), Lewis J (2004), Jeon YJ (2009), Yamashita M (2008), Ryoo K (2004), Abell AN (2005), Burns K (1998), Hirano T (2002), Gravestein LA (1998), Dadgostar H (2003), Han YH (2006), Kolluri SK (2003), Chen LY (2003), Manna SK (2010), Gallagher ED (2002), Liu HP (2011), Xia Y (1998), Funakoshi-Tago M (2005), Ho DT (2006), Wang J (2000), Choi HK (2011), Chang TS (2003), Yao K (2009), Chang TS (2003), Dai R (2000), Gupta S (1996), Gupta S (1996), Sundarrajan M (2003), Kallunki T (1994), Kallunki T (1994), Wasserman T (2010), Blonska M (2007), Lee KH (2005), Kadoya T (2005), Katagiri C (2006), Yao K (2007), Wu X (2007), Kato T (2008), Cavigelli M (1995), Katagiri C (2006), Choi BY (2005), Choi BY (2005), Yuan ZQ (2003), Phelan DR (2001), Eliopoulos AG (2006), Hayashi T (2007), Zhang J (2013), Li X (2002), Kendrick TS (2004), Holzberg D (2003), Grau R (2004), Hernandez M (2000), Hwang SG (2014), Larsson H (1999), Rausch O (1997), Morley SJ (2000), Ho JM (2002), Shkoda A (2012), Pop M (2004), Chang HY (1999)	76
UBE2D2	0	DTX1	2	two hybrid	van Wijk SJ (2009)	1
NTRK1	1	MCM2	3	affinity chromatography technology	Emdal KB (2015)	1
KAT5	1	MAP3K1	4	affinity chromatography technology	Zhu P (2006)	1
MAPK8	3	GSTP1	0	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, imaging technique	Wang T (2001), Wang T (2001), Wu Y (2006), Chen TC (2014), Okamura T (2015), Okamura T (2015), Okamura T (2015)	7
DCUN1D1	0	YWHAE	0	affinity chromatography technology	Bennett EJ (2010)	1
NOP56	0	6207	0	biochemical	Havugimana PC (2012)	1
APPL1	1	TP53	0	two hybrid	Grossmann A (2015)	1
KDM5C	9	MAP3K1	4	genetic interference	Shen JP (2017)	1
NOP56	0	MAP3K1	4	affinity chromatography technology	Hein MY (2015)	1
BRCA1	7	RAD18	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tian F (2013), Tian F (2013), Hill SJ (2014)	3
MAP3K1	4	KRT36	4	enzymatic study	Charlaftis N (2014)	1
NTRK1	1	UBXN7	3	affinity chromatography technology	Emdal KB (2015)	1
MCM2	3	ACTN1	5	affinity chromatography technology	Drissi R (2015)	1
USP28	3	BAP1	4	enzymatic study	Loch CM (2012)	1
BRCA1	7	UBE2D3	1	two hybrid, affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, pull down	Dynek JN (2010), Polanowska J (2006), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Calvo V (2011), Wu-Baer F (2010), Yu X (2006), Starita LM (2005), Sato K (2012), Starita LM (2004), Wei L (2011), Wu W (2007), David Y (2011), Kentsis A (2002), Kleiman FE (2005), Zhao GY (2007), Wenzel DM (2011), Wenzel DM (2011), McGinty RK (2014), Chen A (2002), Shabbeer S (2013), Ando K (2017)	23
ARRB2	5	RPL4	4	affinity chromatography technology	Xiao K (2007)	1
CHUK	5	CDC37	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen G (2002), Li S (2011), Taipale M (2014), Taipale M (2014), Li J (2013)	5
XPO1	8	TRIM5	4	affinity chromatography technology	Kirli K (2015)	1
MAP3K1	4	RBCK1	0	enzymatic study	Charlaftis N (2014)	1
RPL30	1	6207	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
NOTCH1	25	RHOA	0	two hybrid	Daakour S (2016)	1
MAP3K1	4	ASCC2	3	enzymatic study	Charlaftis N (2014)	1
UBQLN1	1	HSPA1L	2	biochemical	Kristensen AR (2012)	1
BRCA1	7	UBE2E1	1	two hybrid, x-ray crystallography, pull down, two hybrid, pull down	Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Christensen DE (2007), David Y (2011)	5
USP28	3	STAM	3	enzymatic study	Loch CM (2012)	1
MAP3K1	4	FAM184A	2	enzymatic study	Charlaftis N (2014)	1
UBE2I	0	CHUK	5	enzymatic study	Bernier-Villamor V (2002)	1
ARRB2	5	NOP56	0	affinity chromatography technology	Xiao K (2007)	1
UFD1	1	NPLOC4	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology	Botta A (2001), Lass A (2008), Vong QP (2005), Bruderer RM (2004), Havugimana PC (2012), Li JM (2013), Pye VE (2007), Wan C (2015), Raman M (2015), Raman M (2015)	10
XPO1	8	CHUK	5	affinity chromatography technology	Kirli K (2015)	1
UBE2I	0	XPO1	8	biochemical	Havugimana PC (2012)	1
ODF2	1	DVL2	5	bioid	Gupta GD (2015)	1
ARRB2	5	CHUK	5	affinity chromatography technology, imaging technique	Xiao K (2007), Chen TC (2014)	2
MAP2K4	3	MAPK1	1	pull down	Ho DT (2003)	1
MAP2K7	5	GSK3B	1	biochemical	Wan C (2015)	1
TNIP1	1	MAPK1	1	two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Zhang S (2002), Zhang S (2002), Zhang S (2002), Wang J (2011), Chen Y (2015), Chen Y (2015)	6
PAK1	2	MAP3K1	4	enzymatic study	Gallagher ED (2002)	1
XPO1	8	STAM2	0	affinity chromatography technology	Kirli K (2015)	1
NTRK1	1	DNAJB6	3	affinity chromatography technology	Emdal KB (2015)	1
TRAF2	1	APPL1	1	two hybrid, imaging technique	Rual JF (2005), Chen TC (2014)	2
NTRK1	1	UBQLN1	1	affinity chromatography technology	Emdal KB (2015)	1
RNF126	2	MCM2	3	affinity chromatography technology	OConnor HF (2015)	1
MAP2K4	3	JUN	0	enzymatic study	Sundarrajan M (2003)	1
YWHAQ	0	RAF1	3	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Ewing RM (2007), Yeung K (2000), Van Der Hoeven PC (2000), Liu YC (1996), Subramanian RR (2001), ONeill E (2004), Rajalingam K (2005), Zhu J (2005), Bonnefoy-Berard N (1995), So J (2015)	10
MAP3K1	4	RNF141	2	enzymatic study	Charlaftis N (2014)	1
MAPK1	1	MAP3K1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Karandikar M (2000), Karandikar M (2000), Gallagher ED (2004), Tu Z (2003), Loke J (2014)	5
MAP3K1	4	STAM	3	enzymatic study	Charlaftis N (2014)	1
ARRB2	5	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Huttlin EL (2017)	4
MAP2K1	8	MAPK3	4	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, enzymatic study, pull down, affinity chromatography technology	Marti A (1997), Butch ER (1996), Schaeffer HJ (1998), Yung Y (2000), Yung Y (2000), Zheng CF (1993), Zheng CF (1993), Zheng CF (1993), Wang J (2009)	9
UFD1	1	TP53	0	two hybrid	Vinayagam A (2011)	1
NFKBIA	0	UBE2D1	0	two hybrid, enzymatic study	Desterro JM (1997), Kroll M (1997)	2
UBE2E1	1	RNF114	0	two hybrid, enzymatic study	Markson G (2009), Lin B (2017)	2
RPL4	4	6207	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
UBE2D3	1	NFKBIA	0	enzymatic study, enzymatic study	Gonen H (1999), Wu K (2010)	2
MCM2	3	GSTP1	0	affinity chromatography technology	Drissi R (2015)	1
TRAF2	1	HSPA1L	2	imaging technique	Chen TC (2014)	1
RAB3IL1	0	ODF2	1	affinity chromatography technology	Huttlin EL (2015)	1
DCUN1D1	0	RPL4	4	affinity chromatography technology	Bennett EJ (2010)	1
XPO1	8	AXIN1	1	affinity chromatography technology	Kirli K (2015)	1
RHOA	0	MAPK8	3	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
GRB2	2	MAP3K1	4	pull down, affinity chromatography technology, affinity chromatography technology	Pomerance M (1998), Pomerance M (1998), Saito T (2004)	3
ARRB2	5	RPL30	1	affinity chromatography technology	Xiao K (2007)	1
HSPA1L	2	XPO1	8	biochemical	Kristensen AR (2012)	1
UBE2I	0	MAP3K1	4	two hybrid, pull down, affinity chromatography technology	Saltzman A (1998), Saltzman A (1998), Kubota Y (2011)	3
MAP3K1	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Islam MR (2010), Islam MR (2010), Chipps E (2015), Chipps E (2015), Chipps E (2015)	5
MAPK3	4	JUN	0	enzymatic study	Pulverer BJ (1991)	1
GRB2	2	YWHAG	5	affinity chromatography technology	Bisson N (2011)	1
UBE2D3	1	UBASH3B	4	enzymatic study	Hoeller D (2007)	1
XPO1	8	CEP85	5	affinity chromatography technology	Kirli K (2015)	1
ODF2	1	TNIP1	1	bioid	Gupta GD (2015)	1
FGFR2	6	MAP3K1	4	genetic interference	Shen JP (2017)	1
MAPK8	3	MBP	0	enzymatic study	Chen G (2000)	1
KAT5	1	YWHAG	5	two hybrid	Sumioka A (2005)	1
MAP3K1	4	ODF2	1	enzymatic study	Charlaftis N (2014)	1
RAD23A	1	UBAC1	2	affinity chromatography technology	Scanlon TC (2009)	1
MCM2	3	UBE2D2	0	affinity chromatography technology	Drissi R (2015)	1
TP53	0	MAPK9	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Hu MC (1997), Lin Y (2002), Li Y (2012)	3
MAPK1	1	MBP	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Plun-Favreau H (2007), Momose H (2003), Cavigelli M (1995), Tresini M (2001), Blaukat A (2000), Blaukat A (2000), Blaukat A (1999), Blaukat A (2001), Sang N (2003), Raskin A (2012), Egan JE (2002), Chen G (2000), Lammering G (2003), Larsson H (1999), Camps M (1998)	15
MAPK9	3	JUN	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, enzymatic study	Kallunki T (1996), Natoli G (1997), Chin AI (1999), Ho DT (2006), Yao K (2009), Gupta S (1996), Gupta S (1996), Kallunki T (1994), Kallunki T (1994), Wasserman T (2010), Blonska M (2007), Katagiri C (2006), Yao K (2007), Phelan DR (2001), Ho DT (2003), Camps M (1998)	16
UBE2V1	0	YWHAQ	0	biochemical	Kristensen AR (2012)	1
ARRB2	5	YWHAE	0	affinity chromatography technology	Xiao K (2007)	1
UBE2L6	0	RBCK1	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
TRAF2	1	MAP3K1	4	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique	Baud V (1999), Baud V (1999), Wu Y (2006), Charlaftis N (2014), Chen TC (2014)	5
KAT5	1	VHL	0	affinity chromatography technology, affinity chromatography technology	Roe JS (2011), Roe JS (2011)	2
MAP3K1	4	GGA2	2	enzymatic study	Charlaftis N (2014)	1
YWHAE	0	MAP3K1	4	pull down	Fanger GR (1998)	1
UBAC1	2	PSMD4	1	affinity chromatography technology	Hara T (2005)	1
MAP3K1	4	PLEKHB2	4	enzymatic study	Charlaftis N (2014)	1
MAP2K1	8	YWHAE	0	affinity chromatography technology	Gloeckner CJ (2007)	1
ARRB2	5	MAPK3	4	affinity chromatography technology, imaging technique	Tohgo A (2003), Chen TC (2014)	2
YWHAE	0	YWHAQ	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Bandyopadhyay S (2010), Pozuelo-Rubio M (2010), Gloeckner CJ (2007), Wang J (2011)	4
NPLOC4	4	NFKBIA	0	affinity chromatography technology	Li JM (2013)	1
CDC37	0	YWHAQ	0	affinity chromatography technology	Li J (2013)	1
TP53	0	KAT5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legube G (2004), Tyteca S (2006), Tyteca S (2006), Kurash JK (2008), Cheng Z (2008), Cheng Z (2008), Cheng Z (2008), Tang Y (2006), Tang Y (2006), Tang Y (2006), Dai C (2013)	11
GSK3B	1	MAP3K1	4	affinity chromatography technology, pull down	Kim JW (2003), Kim JW (2003)	2
CDC37	0	FKBP5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
ARRB1	2	NFKBIA	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Witherow DS (2004), Witherow DS (2004), Witherow DS (2004), Gao H (2004), Gao H (2004)	5
XPO1	8	TOM1	3	affinity chromatography technology	Kirli K (2015)	1
NTRK1	1	APPL1	1	affinity chromatography technology	Emdal KB (2015)	1
MAP2K4	3	MAP2K7	5	genetic interference, affinity chromatography technology, affinity chromatography technology	Fleming Y (2000), Sundarrajan M (2003), Sundarrajan M (2003)	3
FAM184A	2	BRCA1	7	two hybrid	Hill SJ (2014)	1
FAF2	4	MCM2	3	affinity chromatography technology	Christianson JC (2012)	1
UBE2G1	2	RBCK1	0	two hybrid	Markson G (2009)	1
MAP4K4	13	MAP3K1	4	affinity chromatography technology	Su YC (1997)	1
UBE2L6	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
MAP3K1	4	MAP2K7	5	affinity chromatography technology, pull down	Tu Z (2003), Takekawa M (2005)	2
MAP3K1	4	FAF2	4	enzymatic study	Charlaftis N (2014)	1
GSK3B	1	FRAT1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Hein MY (2015)	3
MAPK3	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Persons DL (2000), How PC (2011), Lin C (2011), Lin C (2011)	4
NTRK1	1	ACTN1	5	affinity chromatography technology	Emdal KB (2015)	1
MAP3K1	4	DCAF7	4	affinity chromatography technology, pull down, imaging technique, affinity chromatography technology	Bouwmeester T (2004), Ritterhoff S (2010), Ritterhoff S (2010), Miyata Y (2014)	4
VHL	0	UBE2D2	0	pull down	Xin H (2011)	1
TP53	0	HIPK2	0	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Hofmann TG (2002), Hofmann TG (2002), Hofmann TG (2002), Hofmann TG (2002), Kim EJ (2002), Sung KS (2005), Li Q (2011), Di Stefano V (2005), Rinaldo C (2007), Rinaldo C (2007), Lee MG (2014), Mancini F (2016)	12
MAP3K1	4	AXIN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2002), Zhang Y (2000), Zhang Y (2000), Sue Ng S (2010), Sue Ng S (2010), Loke J (2014)	6
MAPK1	1	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, imaging technique	Persons DL (2000), How PC (2011), Srivastav RK (2011), Fogeron ML (2013), Chen TC (2014)	5
MAPK8IP3	9	MAP3K1	4	affinity chromatography technology	Ito M (1999)	1
MAP3K1	4	TOM1	3	enzymatic study	Charlaftis N (2014)	1
UBE2D1	0	RNF114	0	two hybrid, pull down, enzymatic study	Markson G (2009), Bijlmakers MJ (2011), Lin B (2017)	3
UBAC1	2	DVL2	5	two hybrid	Yu H (2011)	1
NTRK1	1	UCHL5	1	affinity chromatography technology	Emdal KB (2015)	1
BRCA1	7	JUN	0	affinity chromatography technology, pull down	Hu YF (2002), Hu YF (2002)	2
UBASH3B	4	HSPA1L	2	affinity chromatography technology	Brehme M (2009)	1
MAPK8IP3	9	MAP2K1	8	affinity chromatography technology, pull down, affinity chromatography technology	Kuboki Y (2000), Kuboki Y (2000), Ito M (1999)	3
STAM	3	STAM2	0	imaging technique	Kanazawa C (2003)	1
ARRB1	2	DVL2	5	two hybrid, affinity chromatography technology	Chen W (2001), Chen W (2001)	2
GSK3B	1	UBE2D1	0	two hybrid	Vinayagam A (2011)	1
STK38	0	MAP3K1	4	affinity chromatography technology, affinity chromatography technology	Enomoto A (2008), Enomoto A (2008)	2
VHL	0	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roe JS (2006), Roe JS (2006), Roe JS (2006), Lai Y (2011), Lai Y (2011)	5
AXIN1	1	HIPK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li Q (2011), He Y (2013), He Y (2013)	3
MAP3K1	4	CHUK	5	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Lee FS (1998), Nemoto S (1998), Nemoto S (1998), Li Q (2006)	4
NOTCH1	25	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Yatim A (2012), Yatim A (2012)	2
TRAF2	1	IKBKB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Devin A (2001), Li S (2009), Li S (2009), Li HY (2008), Shen RR (2012), Shen RR (2012), Zhang W (2010), Chen TC (2014), Mei ZZ (2016)	9
MAP3K1	4	DCUN1D1	0	enzymatic study	Charlaftis N (2014)	1
GSK3B	1	ARRB1	2	enzymatic study	Lin FT (1999)	1
MAP3K1	4	RAD18	3	enzymatic study	Charlaftis N (2014)	1
BRCA1	7	6207	0	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
BRCA1	7	MCM2	3	affinity chromatography technology	Ertych N (2016)	1
MAP3K1	4	EPN1	4	enzymatic study	Charlaftis N (2014)	1
YWHAE	0	CDC37	0	affinity chromatography technology	Zuo S (2010)	1
UBE2D4	0	RBCK1	0	two hybrid	Markson G (2009)	1
MCM2	3	MAPK3	4	affinity chromatography technology	Drissi R (2015)	1
UBXN7	3	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015)	3
RPL30	1	RPL4	4	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
BRCA1	7	UCHL5	1	affinity chromatography technology	Ertych N (2016)	1
XPO1	8	MAP2K7	5	affinity chromatography technology	Kirli K (2015)	1
MAP3K1	4	CUEDC1	4	enzymatic study	Charlaftis N (2014)	1
UBE2V1	0	UBQLN1	1	two hybrid	Rolland T (2014)	1
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
UBE2K	0	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay	Bae Y (2013), Bae Y (2013), Bae Y (2013)	3
FAF2	4	NPLOC4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015), Raman M (2015)	4
ARRB1	2	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
MAPK1	1	MAP2K7	5	unspecified method, enzymatic study, enzymatic study	Ho DT (2006), Mori S (1995), Saito T (2004)	3
UBQLN1	1	STAM2	0	affinity chromatography technology	Regan-Klapisz E (2005)	1
UBE2D1	0	RNF126	2	two hybrid, two hybrid, two hybrid	Rual JF (2005), Markson G (2009), Rolland T (2014)	3
NFKBIA	0	CUEDC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2E1	1	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
BRCA1	7	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Yan Y (2008), Yan Y (2008)	2
NTRK1	1	MAP3K1	4	affinity chromatography technology	Emdal KB (2015)	1
TOM1	3	UBE2D1	0	pull down	Singh RK (2009)	1
NTRK1	1	DVL2	5	affinity chromatography technology	Emdal KB (2015)	1
TP53	0	DNAJB6	3	affinity chromatography technology	Lunardi A (2010)	1
MAP3K1	4	NPLOC4	4	enzymatic study	Charlaftis N (2014)	1
MAPK3	4	RNF114	0	two hybrid	Vinayagam A (2011)	1
MAP3K1	4	MAPK8	3	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique	Xu S (1997), Xu S (1997), Xu S (1997), Xu S (1997), Ryoo K (2004), Tu Z (2003), Sun BK (2011), Gallagher ED (2002), Chen TC (2014)	9
MAP3K1	4	ARHGAP4	2	two hybrid	Gallagher ED (2004)	1
GSK3B	1	NOTCH1	25	enzymatic study, pull down	Foltz DR (2002), Foltz DR (2002)	2
MAPK1	1	MAP2K1	8	affinity chromatography technology, enzymatic study, two hybrid, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, enzymatic study, protein complementation assay, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sanz-Moreno V (2003), Sanz-Moreno V (2003), Robinson FL (2002), Yeung K (2000), Yeung K (2000), Wunderlich W (2001), Xu Be (2001), Xu Be (2001), Chen Z (2001), Srivastav RK (2011), Kubota Y (2011), Ho DT (2003), Wang J (2009), Jahrling JB (2014)	14
MAP3K1	4	BAP1	4	enzymatic study	Charlaftis N (2014)	1
UBE2W	0	RNF114	0	two hybrid	Markson G (2009)	1
UBE2I	0	HGS	5	two hybrid	Rual JF (2005)	1
CHUK	5	NFKBIA	0	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	DiDonato JA (1997), Cohen L (1998), Woronicz JD (1997), Ninomiya-Tsuji J (1999), Burke JR (2002), Wu ZH (2010), Tong KM (2008), Singhirunnusorn P (2005), Heilker R (1999), Huang TT (2002), Lee FS (1998), Kim KS (2002), Cappello C (2007), Hong S (2007), Morrison BH (2007), Zandi E (1998), Li Q (2006), Manna SK (2010), Li XH (2001), Poyet JL (2001), Zhang W (2010), Bauer JA (2007), Chan H (2005), Munzert G (2002), Stehlik C (2002), Shambharkar PB (2007), Cui J (2010), Li Q (2006), Bernier M (2006), Mitsuhashi S (2008), Hayashi T (2007), Niu J (2013), Dan HC (2008), Criollo A (2010), Kim Y (2002), Huttlin EL (2015), Liu D (2014), Zhang H (2004), Aggarwal S (2006), Ninomiya-Tsuji J (2003), Huttlin EL (2017)	41
HSPA1L	2	TAB1	1	imaging technique	Chen TC (2014)	1
DNAJB2	0	ATXN3	2	affinity chromatography technology	Gao XC (2011)	1
UBE2D4	0	RNF114	0	two hybrid	Markson G (2009)	1
MAP3K1	4	MAPK3	4	enzymatic study, imaging technique	Loke J (2014), Chen TC (2014)	2
NR4A1	4	TP53	0	affinity chromatography technology, pull down, pull down	Zhao BX (2006), Zhao BX (2006), Zhao BX (2006)	3
NTRK1	1	HBS1L	3	affinity chromatography technology	Emdal KB (2015)	1
UBE2I	0	UBE2K	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, biochemical	Knipscheer P (2008), Gruenwald M (2011), Pichler A (2005), Galisson F (2011), Wan C (2015)	5
MAP3K1	4	DCUN1D2	0	enzymatic study	Charlaftis N (2014)	1
BRCA1	7	CDC37	0	affinity chromatography technology	Ertych N (2016)	1
TRAF2	1	APEX2	2	two hybrid	Rual JF (2005)	1
TAB1	1	IKBKB	1	affinity chromatography technology	Neil JR (2008)	1
IKBKB	1	FKBP5	0	affinity chromatography technology	Li S (2011)	1
UBE2D3	1	STAM2	0	enzymatic study	Hoeller D (2007)	1
HIPK2	0	DYRK1A	36	affinity chromatography technology	Ritterhoff S (2010)	1
UBE2D2	0	RAF1	3	enzymatic study	Demand J (2001)	1
RBCK1	0	UBE2D3	1	pull down, pull down, pull down, pull down	Zenke-Kawasaki Y (2007), Yamanaka K (2003), Inn KS (2011), Kirisako T (2006)	4
ALK	8	EPHA1	5	affinity chromatography technology, affinity chromatography technology	Crockett DK (2004), Crockett DK (2004)	2
FKBP5	0	CHUK	5	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
RAF1	3	NPLOC4	4	two hybrid	Johnson SE (2006)	1
CRELD1	0	KAT5	1	two hybrid	Stelzl U (2005)	1
MAP4K2	1	TRAF2	1	pull down, affinity chromatography technology	Yuasa T (1998), Yuasa T (1998)	2
GRB2	2	YWHAE	0	affinity chromatography technology	Bisson N (2011)	1
RAD23A	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Brignone C (2004), Hsieh HC (2005)	2
UBE2D2	0	NFKBIA	0	enzymatic study	Gonen H (1999)	1
YWHAE	0	CRTC1	4	affinity chromatography technology	Gloeckner CJ (2007)	1
NTRK1	1	TOM1	3	affinity chromatography technology	Emdal KB (2015)	1
NOTCH1	25	STK38	0	affinity chromatography technology	Yatim A (2012)	1
MAP3K1	4	3324	0	affinity chromatography technology	Bouwmeester T (2004)	1
DTX1	2	GRB2	2	two hybrid	Matsuno K (1998)	1
TP53	0	RPL4	4	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), He X (2016)	2
XPO1	8	UBAP1	2	affinity chromatography technology	Kirli K (2015)	1
BRCA1	7	RPL30	1	affinity chromatography technology	Ertych N (2016)	1
UBE2D3	1	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
MAP3K1	4	ZFAND5	1	enzymatic study	Charlaftis N (2014)	1
MCM2	3	UBE2D3	1	affinity chromatography technology	Drissi R (2015)	1
MAPK8IP3	9	MAPK8	3	pull down, pull down, enzymatic study	Ito M (1999), Kelkar N (2000), Kelkar N (2000)	3
XPO1	8	NFKBIA	0	affinity chromatography technology	Kirli K (2015)	1
KAT5	1	RPL30	1	biochemical	Havugimana PC (2012)	1
RAF1	3	YWHAE	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vincenz C (1996), Conklin DS (1995), Subramanian RR (2001), Gloeckner CJ (2007), Rajalingam K (2005), Zhu J (2005), Choudhary C (2009), Choudhary C (2009), So J (2015)	9
UBE2I	0	UBE2D2	0	biochemical	Wan C (2015)	1
RAD23A	1	PSMD4	1	two hybrid, pull down, x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Hiyama H (1999), Mueller TD (2003), Kang Y (2007), Kang Y (2007), Wang Q (2003), Walters KJ (2003), Walters KJ (2002), Scanlon TC (2009), Hsieh HC (2005)	9
GSK3B	1	TP53	0	affinity chromatography technology, two hybrid	Watcharasit P (2002), Vinayagam A (2011)	2
RAD23A	1	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Fang DF (2013), Fang DF (2013), Rolland T (2014), Akhtar N (2016)	5
FAF2	4	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015), Raman M (2015)	4
MAP3K1	4	ZFAND3	0	enzymatic study	Charlaftis N (2014)	1
UCHL5	1	PSMD4	1	affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Qiu XB (2006), Yao T (2008), Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	6
MAP3K1	4	C6orf106	1	enzymatic study	Charlaftis N (2014)	1
MAP3K1	4	FLNB	11	affinity chromatography technology	Jeon YJ (2009)	1
NTRK1	1	DYRK1A	36	affinity chromatography technology	Emdal KB (2015)	1
UBE2D2	0	UBQLN1	1	biochemical	Havugimana PC (2012)	1
MCM2	3	TAB1	1	affinity chromatography technology	Drissi R (2015)	1
XPO1	8	RAD18	3	affinity chromatography technology	Kirli K (2015)	1
NR4A1	4	VHL	0	affinity chromatography technology, affinity chromatography technology, pull down	Kim BY (2008), Kim BY (2008), Kim BY (2008)	3
UBE2D3	1	DTX1	2	two hybrid	van Wijk SJ (2009)	1
AXIN1	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, pull down	Li Q (2011), Li Q (2011), He Y (2013), He Y (2013), He Y (2013), He Y (2013)	6
MAPK8IP3	9	MAPK9	3	pull down, pull down	Ito M (1999), Kelkar N (2000)	2
FGFR2	6	HGS	5	affinity chromatography technology, imaging technique	Belleudi F (2009), Belleudi F (2009)	2
BRCA1	7	FLNB	11	affinity chromatography technology	Ertych N (2016)	1
NTRK1	1	YWHAG	5	affinity chromatography technology	Emdal KB (2015)	1
MAP4K2	1	MAP2K4	3	pull down	Yuasa T (1998)	1
ARRB1	2	YWHAE	0	affinity chromatography technology	Xiao K (2007)	1
LLGL2	4	MAP3K1	4	affinity chromatography technology	Hein MY (2015)	1
GRB2	2	TAB1	1	affinity chromatography technology	Bisson N (2011)	1
BRCA1	7	PSMD4	1	affinity chromatography technology	Ertych N (2016)	1
YWHAG	5	RAF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ewing RM (2007), Autieri MV (1999), Van Der Hoeven PC (2000), Rajalingam K (2005), Zhu J (2005), So J (2015), Ivanov AA (2017)	7
IKBKB	1	NFKBIA	0	pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Mercurio F (1999), Cohen L (1998), Woronicz JD (1997), Burke JR (2002), Tsuchiya Y (2010), Tsuchiya Y (2010), Da Silva-Ferrada E (2011), Ducut Sigala JL (2004), Heilker R (1999), Edinger RS (2009), Lee FS (1998), Hai T (2006), Zandi E (1998), Henkler F (2003), Li XH (2001), Byun MS (2006), Mauro C (2003), Zhang W (2010), Munzert G (2002), Shibata Y (2012), Shambharkar PB (2007), Cui J (2010), Li Q (2006), Bernier M (2006), Gao H (2004), Hauenstein AV (2014), Fujita H (2014), Zhang J (2013), Chong RA (2014), Dan HC (2008), Sun L (2004), Criollo A (2010), Liu D (2014), Vincendeau M (2016), Zhang L (2015), Zilberman-Rudenko J (2016), Minassian A (2015), Lindstroem TM (2008), Kim BH (2008), Pandey MK (2008), Joo M (2005), Ninomiya-Tsuji J (2003), Chang YJ (2004), Huang WC (2004), Kim EK (2017), Mei ZZ (2016), Shinohara H (2016), Shkoda A (2012)	48
UBE2I	0	HIPK2	0	two hybrid, two hybrid, two hybrid, pull down, two hybrid, enzymatic study	Lee BH (2003), Bandyopadhyay S (2010), Sung KS (2005), Sung KS (2005), Hofmann TG (2005), Sung KS (2005)	6
MAPK8	3	RAD18	3	enzymatic study	Barkley LR (2012)	1
UBE2V1	0	UBE2K	0	biochemical	Wan C (2015)	1
MAP3K1	4	NFKBIA	0	enzymatic study	Tu Z (2003)	1
XPO1	8	DCAF7	4	affinity chromatography technology	Kirli K (2015)	1
YWHAQ	0	MAP3K1	4	affinity chromatography technology	Sun BK (2011)	1
STAM	3	HGS	5	two hybrid, affinity chromatography technology, biochemical, pull down, imaging technique, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Asao H (1997), Bache KG (2003), Malik R (2010), Kanazawa C (2003), Kanazawa C (2003), Havugimana PC (2012), Sirisaengtaksin N (2014), Sirisaengtaksin N (2014), Holleman J (2014), Holleman J (2014), Wan C (2015), Berlin I (2010), Huttlin EL (2017)	14
ALK	8	MAPK1	1	affinity chromatography technology	Crockett DK (2004)	1
ACTN1	5	KDM5C	9	biochemical	Wan C (2015)	1
MCM2	3	YWHAG	5	affinity chromatography technology	Drissi R (2015)	1
MCM2	3	6207	0	affinity chromatography technology	Drissi R (2015)	1
UBE2D1	0	TRIM5	4	two hybrid	Markson G (2009)	1
ALK	8	MAPK8IP3	9	affinity chromatography technology	Crockett DK (2004)	1
XPO1	8	6207	0	affinity chromatography technology	Kirli K (2015)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
UBE2K	0	TRIM5	4	two hybrid	Markson G (2009)	1
DCUN1D1	0	MAPK3	4	biochemical	Wan C (2015)	1
MAPK8	3	NR4A1	4	enzymatic study, enzymatic study	Liu B (2007), Kolluri SK (2003)	2
TP53	0	HSPA1L	2	affinity chromatography technology, imaging technique	Fogeron ML (2013), Chen TC (2014)	2
DVL2	5	TP53	0	two hybrid, two hybrid	Rual JF (2005), Lim J (2006)	2
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
NTRK1	1	STAM	3	affinity chromatography technology	Emdal KB (2015)	1
KAT5	1	UBE2I	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheng Z (2008), Cheng Z (2008), Cheng Z (2008)	3
UBE2I	0	CDC37	0	enzymatic study	Jakobs A (2007)	1
UBE2D1	0	UBASH3B	4	enzymatic study	Hoeller D (2007)	1
MAP3K1	4	RNF126	2	enzymatic study	Charlaftis N (2014)	1
IKBKB	1	TP53	0	enzymatic study	Xia Y (2009)	1
YWHAE	0	RPL4	4	affinity chromatography technology	Zuo S (2010)	1
IKBKB	1	CDC37	0	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen G (2002), Chen G (2002), Li S (2011), Taipale M (2014), Taipale M (2014), Hein MY (2015)	6
UBE2E1	1	DTX1	2	two hybrid	van Wijk SJ (2009)	1
VHL	0	UBE2D1	0	pull down	Gao C (2010)	1
RAD23A	1	MINDY3	3	two hybrid	Rolland T (2014)	1
MAPK8	3	MAP2K7	5	enzymatic study, enzymatic study, genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study	Tournier C (1997), Tournier C (1997), Tournier C (1997), Cheng J (2000), Ho DT (2006), Ho DT (2006), Ho DT (2006), Ho DT (2006), Enomoto A (2003), Takeda AN (2014), Sundarrajan M (2003), Chen TC (2014), Zhu T (2016), Zhu T (2016)	14
XPO1	8	GSK3B	1	affinity chromatography technology	Kirli K (2015)	1
MAP3K1	4	DNAJB6	3	enzymatic study	Charlaftis N (2014)	1
XPO1	8	DVL2	5	affinity chromatography technology	Kirli K (2015)	1
UBE2D2	0	RNF114	0	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study	Markson G (2009), Huttlin EL (2015), Huttlin EL (2017), Lin B (2017)	4
RBCK1	0	UBE2D1	0	pull down	Kirisako T (2006)	1
MCM2	3	XPO1	8	affinity chromatography technology	Drissi R (2015)	1
UBE2V1	0	YWHAG	5	biochemical	Kristensen AR (2012)	1
MAPK1	1	GSTP1	0	affinity chromatography technology	Wu Y (2006)	1
MAP3K1	4	RABEP2	0	enzymatic study	Charlaftis N (2014)	1
BRCA1	7	MAPK3	4	affinity chromatography technology, affinity chromatography technology	Yan Y (2008), Yan Y (2008)	2
MAP3K1	4	APEX2	2	enzymatic study	Charlaftis N (2014)	1
MAP3K1	4	APPL1	1	enzymatic study	Charlaftis N (2014)	1
UBQLN1	1	PSMD4	1	pull down, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Fallon L (2006), Heir R (2006), Ko HS (2004), Walters KJ (2002), Fatimababy AS (2010), Fatimababy AS (2010), Ko HS (2004), Ko HS (2004), Kurlawala Z (2017), Kurlawala Z (2017)	10
UBXN7	3	VHL	0	affinity chromatography technology	Alexandru G (2008)	1
ARRB2	5	NFKBIA	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Witherow DS (2004), Witherow DS (2004), Gao H (2004), Gao H (2004), Gao H (2004)	5
TRAF2	1	UBE2D1	0	pull down	Alvarez SE (2010)	1
MAP3K1	4	CRELD1	0	enzymatic study	Charlaftis N (2014)	1
NTRK1	1	MAPK8IP3	9	affinity chromatography technology	Emdal KB (2015)	1
JUN	0	UBE2I	0	two hybrid, enzymatic study	Goettlicher M (1996), Muller S (2000)	2
ARRB2	5	STK38	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
MAP2K4	3	FLNB	11	affinity chromatography technology	Jeon YJ (2009)	1
UBE2D2	0	UBASH3B	4	enzymatic study	Hoeller D (2007)	1
NTRK1	1	FKBP5	0	affinity chromatography technology	Emdal KB (2015)	1
DCUN1D1	0	DCUN1D2	0	affinity chromatography technology	Bennett EJ (2010)	1
YWHAG	5	DYRK1A	36	affinity chromatography technology	Jin J (2004)	1
MCM2	3	NPLOC4	4	affinity chromatography technology	Drissi R (2015)	1
XPO1	8	DYRK1A	36	affinity chromatography technology	Kirli K (2015)	1
FAF2	4	UBE2D1	0	pull down	Phan VT (2010)	1
ARRB2	5	FLNB	11	affinity chromatography technology	Huttlin EL (2017)	1
MAP3K1	4	SPART	0	enzymatic study	Charlaftis N (2014)	1
TRAF2	1	GSK3B	1	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Huttlin EL (2017)	2
MCM2	3	UBE2D4	0	affinity chromatography technology	Drissi R (2015)	1
FAF2	4	DCAF7	4	affinity chromatography technology	Alexandru G (2008)	1
MAP3K1	4	GSTP1	0	affinity chromatography technology	Wu Y (2006)	1
ARRB1	2	MAP2K4	3	unspecified method	Li X (2009)	1
ARRB1	2	HGS	5	affinity chromatography technology, affinity chromatography technology	Malik R (2010), Han SO (2012)	2
DCAF7	4	HIPK2	0	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, imaging technique, imaging technique, affinity chromatography technology	Ritterhoff S (2010), Ritterhoff S (2010), Ritterhoff S (2010), Ritterhoff S (2010), Ritterhoff S (2010), Ritterhoff S (2010), Glenewinkel F (2016)	7
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
MAPK8	3	RAF1	3	two hybrid	Wang J (2011)	1
DTX1	2	MAP3K1	4	affinity chromatography technology, pull down	Liu WH (2005), Liu WH (2005)	2
ARRB1	2	STK38	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
PSMD4	1	RBCK1	0	affinity chromatography technology, pull down	Yoshimoto N (2009), Beasley SA (2012)	2
XPO1	8	RPL4	4	affinity chromatography technology	Kirli K (2015)	1
UBE2I	0	NFKBIA	0	enzymatic study, two hybrid	Desterro JM (1998), Desterro JM (1997)	2
UBXN7	3	JUN	0	affinity chromatography technology	Raman M (2015)	1
NTRK1	1	YWHAQ	0	affinity chromatography technology	Emdal KB (2015)	1
DCUN1D1	0	MAPK1	1	biochemical	Wan C (2015)	1
MAP3K1	4	UFD1	1	enzymatic study	Charlaftis N (2014)	1
TRAF2	1	UBE2V1	0	pull down	Deng L (2000)	1
XPO1	8	C6orf106	1	affinity chromatography technology	Kirli K (2015)	1
NTRK1	1	6207	0	affinity chromatography technology	Emdal KB (2015)	1
MAP2K7	5	RPL30	1	two hybrid	Wang J (2011)	1
UBE2D3	1	RNF126	2	two hybrid, two hybrid, pull down	Rual JF (2005), Markson G (2009), Delker RK (2013)	3
MAPK8	3	TP53	0	affinity chromatography technology, pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Hu MC (1997), Yin ZM (2004), Yin ZM (2004), Fuchs SY (1998), Topisirovic I (2009), Drago-Ferrante R (2008), Wang J (2000), Chang NS (2003), Fuchs SY (1998)	9
NTRK1	1	NPLOC4	4	affinity chromatography technology	Emdal KB (2015)	1
GRB2	2	MAPK9	3	pull down, pull down	Saleem A (1995), Kharbanda S (1995)	2
KAT5	1	NOTCH1	25	affinity chromatography technology, genetic interference, affinity chromatography technology	Kim MY (2007), Kim SY (2007), Kim SY (2007)	3
UBE2D2	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
BRCA1	7	NOP56	0	affinity chromatography technology	Ertych N (2016)	1
UBE2D3	1	TRIM5	4	two hybrid, pull down, pull down	Markson G (2009), Langelier CR (2008), Yudina Z (2015)	3
MAP3K1	4	GRIPAP1	0	enzymatic study	Charlaftis N (2014)	1
ARRB2	5	MAP2K1	8	affinity chromatography technology	Luttrell LM (2001)	1
MCM2	3	GRB2	2	affinity chromatography technology	Drissi R (2015)	1
MAPK8IP3	9	MAP2K4	3	affinity chromatography technology, affinity chromatography technology	Ito M (1999), Matsuura H (2002)	2
BAP1	4	PSMD4	1	affinity chromatography technology	Hauri S (2016)	1
MAP3K1	4	DYRK1B	1	affinity chromatography technology	Ritterhoff S (2010)	1
TRAF2	1	JUN	0	enzymatic study	Park KJ (2003)	1
UBE2K	0	RBCK1	0	two hybrid	Markson G (2009)	1
XPO1	8	TAB1	1	affinity chromatography technology	Kirli K (2015)	1
MAP3K1	4	CCDC69	1	enzymatic study	Charlaftis N (2014)	1
XPO1	8	TOM1L2	0	affinity chromatography technology	Kirli K (2015)	1
UFD1	1	NFKBIA	0	affinity chromatography technology	Li JM (2013)	1
MAP3K1	4	MAP2K4	3	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study	Cheng J (2000), Gallagher ED (2004), Ryoo K (2004), Ryoo K (2004), Tu Z (2003), Takekawa M (2005), Xia Y (1998), Xia Y (1998), Gallagher ED (2002), Xia Y (1998), Chen Z (2006), Ahn JS (2016)	12
RBCK1	0	UBE2D2	0	pull down	Kirisako T (2006)	1
XPO1	8	HBS1L	3	affinity chromatography technology	Kirli K (2015)	1
MAP3K1	4	UBE2V1	0	enzymatic study	Charlaftis N (2014)	1
MCM2	3	UBE2L6	0	affinity chromatography technology	Drissi R (2015)	1
UBE2D4	0	RNF126	2	two hybrid, two hybrid	Rual JF (2005), Markson G (2009)	2
TP53	0	PSMD4	1	affinity chromatography technology, pull down	Kulikov R (2010), Sparks A (2014)	2
XPO1	8	GGA2	2	affinity chromatography technology	Kirli K (2015)	1
UBE2D2	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
MAP3K1	4	RAB3IL1	0	enzymatic study	Charlaftis N (2014)	1
YWHAG	5	DCAF7	4	affinity chromatography technology	Jin J (2004)	1
HIPK2	0	DYRK1B	1	affinity chromatography technology	Ritterhoff S (2010)	1
XPO1	8	MAP3K1	4	affinity chromatography technology	Kirli K (2015)	1
MAPK8	3	MAP2K1	8	unspecified method	Ho DT (2006)	1
KDM5C	9	VHL	0	genetic interference	Shen JP (2017)	1
MAP3K1	4	USP28	3	enzymatic study	Charlaftis N (2014)	1
XPO1	8	CRTC1	4	affinity chromatography technology	Kirli K (2015)	1
MAP3K1	4	HGS	5	enzymatic study	Charlaftis N (2014)	1
VHL	0	STK38	0	affinity chromatography technology	Lai Y (2011)	1
MAPK1	1	GSK3B	1	affinity chromatography technology, pull down, enzymatic study	Ding Q (2005), Ding Q (2005), Ding Q (2005)	3
ATXN3	2	RAD23A	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wang G (2000), Wang G (2000), Wang G (2000), Scanlon TC (2009), Lim J (2006), Laco MN (2012), Laco MN (2012), Ferro A (2007), Chen L (2006)	9
BRCA1	7	RPL4	4	affinity chromatography technology	Ertych N (2016)	1
JUN	0	ARRB1	2	two hybrid	Bandyopadhyay S (2010)	1
BRCA1	7	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down, pull down, pull down	Mallery DL (2002), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Wu-Baer F (2003), Hashizume R (2001), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Morris JR (2006), Vandenberg CJ (2003), Morris JR (2006), Nhukeaw T (2014), Thakar A (2010)	14
MAP3K1	4	RHOA	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gallagher ED (2004), Gallagher ED (2004), Pearlman A (2010), Loke J (2014)	4
MCM2	3	FLNB	11	affinity chromatography technology	Drissi R (2015)	1
ARRB2	5	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Shenoy SK (2005), Luttrell LM (2001), Xiao K (2007), Chen TC (2014)	4
MAP3K1	4	RPL4	4	affinity chromatography technology	Bouwmeester T (2004)	1
MAP3K1	4	ACTN1	5	two hybrid	Gallagher ED (2004)	1
DNAJB2	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	YWHAQ	0	affinity chromatography technology	Ertych N (2016)	1
GRB2	2	KRT36	4	affinity chromatography technology	Brehme M (2009)	1
GRB2	2	YWHAQ	0	affinity chromatography technology	Bisson N (2011)	1
YWHAE	0	XPO1	8	biochemical	Kristensen AR (2012)	1
GRB2	2	NTRK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Song C (2002), MacDonald JI (2000), Emdal KB (2015), Emdal KB (2015)	4
USP28	3	UCHL5	1	enzymatic study	Loch CM (2012)	1
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
GSTP1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, imaging technique	Wu Y (2006), Wu Y (2006), De Luca A (2014), De Luca A (2014), Chen TC (2014)	5
GSK3B	1	ATXN3	2	two hybrid, pull down, affinity chromatography technology, enzymatic study	Vinayagam A (2011), Fei E (2007), Fei E (2007), Fei E (2007)	4
MAP3K1	4	TAB1	1	enzymatic study	Charlaftis N (2014)	1
ARRB1	2	NOTCH1	25	affinity chromatography technology	Puca L (2013)	1
IKBKB	1	CHUK	5	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Zandi E (1997), Chen G (2002), Otsuki T (2002), May MJ (2000), May MJ (2000), Woronicz JD (1997), Woronicz JD (1997), Deng L (2000), Yeung KC (2001), Mercurio F (1997), Mercurio F (1997), Rothwarf DM (1998), Wu ZH (2010), Li S (2011), Li S (2011), May MJ (2002), Heilker R (1999), Leotoing L (2011), McKenzie FR (2000), Zandi E (1998), Lee DF (2007), Li XH (2001), Yeh PY (2011), Yeh PY (2011), Stehlik C (2002), Li Q (2006), So J (2015), Chen TC (2014), Karim ZA (2015), Huttlin EL (2017)	30
XPO1	8	RAF1	3	affinity chromatography technology	Kirli K (2015)	1
DCUN1D1	0	UFD1	1	biochemical	Wan C (2015)	1
MAP3K1	4	MAPK9	3	two hybrid, pull down	Gallagher ED (2004), Gallagher ED (2002)	2
CRTC1	4	MAP3K1	4	affinity chromatography technology, enzymatic study	Siu YT (2008), Siu YT (2008)	2
MCM2	3	UBE2D1	0	affinity chromatography technology	Drissi R (2015)	1
PAK1	2	RAF1	3	affinity chromatography technology, pull down, enzymatic study	Zang M (2002), Zang M (2002), Zang M (2002)	3
LLGL2	4	IMPACT	1	affinity chromatography technology	Hein MY (2015)	1
DNAJB6	3	DNAJB2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D1	0	UBQLN1	1	biochemical	Havugimana PC (2012)	1
EPN1	4	DVL2	5	affinity chromatography technology, affinity chromatography technology	Chang B (2015), Chang B (2015)	2
MAP3K1	4	STAM2	0	enzymatic study	Charlaftis N (2014)	1
NFKBIA	0	ATXN3	2	affinity chromatography technology	Hein MY (2015)	1
TP53	0	YWHAE	0	affinity chromatography technology	Fogeron ML (2013)	1
GRB2	2	HSPA1L	2	affinity chromatography technology	Brehme M (2009)	1
YWHAG	5	MAP3K1	4	affinity chromatography technology	Sun BK (2011)	1
MAP3K1	4	HIPK2	0	affinity chromatography technology, imaging technique	Ritterhoff S (2010), Ritterhoff S (2010)	2
STAM2	0	PLEKHB2	4	two hybrid	Rolland T (2014)	1
NTRK1	1	CDC37	0	affinity chromatography technology, affinity chromatography technology	Rao R (2010), Emdal KB (2015)	2
MAP3K1	4	ATXN3	2	enzymatic study	Charlaftis N (2014)	1
MAP3K1	4	CEP85	5	enzymatic study	Charlaftis N (2014)	1
NTRK1	1	MAPK1	1	affinity chromatography technology	Emdal KB (2015)	1
MAP3K1	4	UCHL5	1	enzymatic study	Charlaftis N (2014)	1
CHUK	5	TRAF2	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Regnier CH (1997), Devin A (2001), Li S (2009), Shen RR (2012), Zhang W (2010), Chen TC (2014)	6
XPO1	8	TNIP1	1	affinity chromatography technology	Kirli K (2015)	1
MAPK8	3	FLNB	11	affinity chromatography technology	Jeon YJ (2009)	1
RAD23A	1	UCHL5	1	affinity chromatography technology	Scanlon TC (2009)	1
ARRB2	5	RAF1	3	affinity chromatography technology	Luttrell LM (2001)	1
ARRB1	2	AXIN1	1	affinity chromatography technology, affinity chromatography technology	Rosano L (2009), Rosano L (2009)	2
UBE2I	0	RAD18	3	two hybrid	Markson G (2009)	1
MCM2	3	YWHAE	0	affinity chromatography technology	Drissi R (2015)	1
UBE2D1	0	STAM2	0	enzymatic study	Hoeller D (2007)	1
NTRK1	1	PSMD4	1	affinity chromatography technology	Emdal KB (2015)	1
TP53	0	DCAF7	4	affinity chromatography technology	Fogeron ML (2013)	1
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
HIPK2	0	MBP	0	enzymatic study	Hofmann TG (2000)	1
BRCA1	7	HSPA1L	2	affinity chromatography technology	Ertych N (2016)	1
MAP3K1	4	TNIP1	1	enzymatic study	Charlaftis N (2014)	1
PAK1	2	DYRK1B	1	two hybrid	Bandyopadhyay S (2010)	1
KAT5	1	BRCA1	7	two hybrid	Hill SJ (2014)	1
MAP3K1	4	UBXN7	3	enzymatic study	Charlaftis N (2014)	1
MAP2K1	8	RAF1	3	pull down, pull down, pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Yeung K (2000), Yeung K (2000), Dasgupta P (2004), Dasgupta P (2004), Dasgupta P (2004), Boussiotis VA (1997), Kilili GK (2010), Kubota Y (2011), Madonna S (2008), Takekawa M (2005), Gloeckner CJ (2007), Zhu J (2005), Zhu J (2005), Blaukat A (2000), Wang J (2009), Hein MY (2015), Mitra S (2016)	17
ODF2	1	BRCA1	7	imaging technique	Tarapore P (2012)	1
MAP3K1	4	CD74	0	enzymatic study	Charlaftis N (2014)	1
MAP3K1	4	UBAC1	2	enzymatic study	Charlaftis N (2014)	1
MAP3K1	4	EPHA1	5	enzymatic study	Charlaftis N (2014)	1
MAPK8IP3	9	MAP2K7	5	pull down, affinity chromatography technology	Kelkar N (2000), Matsuura H (2002)	2
MAP3K1	4	CARD14	6	enzymatic study	Charlaftis N (2014)	1
GRB2	2	HGS	5	affinity chromatography technology	Bisson N (2011)	1
MAP3K1	4	HBS1L	3	enzymatic study	Charlaftis N (2014)	1
UBE2K	0	RNF114	0	two hybrid	Markson G (2009)	1
HSPA1L	2	MAP3K1	4	imaging technique	Chen TC (2014)	1
MAP3K1	4	NEK10	4	enzymatic study	Charlaftis N (2014)	1
UBASH3B	4	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), Li J (2013), Li J (2013)	3
MAP2K1	8	MAP3K1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Karandikar M (2000), Karandikar M (2000), Tu Z (2003)	3
VHL	0	DVL2	5	enzymatic study, affinity chromatography technology	Gao C (2010), Ma B (2015)	2
UBE2D2	0	TRIM5	4	two hybrid, pull down, pull down	Markson G (2009), Yamauchi K (2008), Xu L (2003)	3
MAP3K1	4	VHL	0	genetic interference	Shen JP (2017)	1
ARRB2	5	RAD18	3	affinity chromatography technology	Huttlin EL (2017)	1
MAP3K1	4	DNAJB2	0	enzymatic study	Charlaftis N (2014)	1
BAALC	0	MAP3K1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Morita K (2015), Morita K (2015), Morita K (2015), Morita K (2015)	4
MAP3K1	4	UBE2G1	2	enzymatic study	Charlaftis N (2014)	1
MAP3K1	4	IMPACT	1	enzymatic study	Charlaftis N (2014)	1
MAP2K1	8	VHL	0	genetic interference	Shen JP (2017)	1
ODF2	1	CEP85	5	bioid	Gupta GD (2015)	1
BRCA1	7	MAP3K1	4	two hybrid	Woods NT (2012)	1
UCHL5	1	RBCK1	0	two hybrid	Hayes SD (2012)	1