PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAP3K4	1	GADD45B	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takekawa M (1998), Takekawa M (1998), Aissouni Y (2005), Huttlin EL (2017)	4
GADD45A	1	GADD45B	1	affinity chromatography technology	Kovalsky O (2001)	1
NEDD1	1	MAP3K4	1	affinity chromatography technology	Hein MY (2015)	1
SORT1	1	MAP3K4	1	affinity chromatography technology	Hein MY (2015)	1
MAP3K4	1	TPR	5	two hybrid	Bandyopadhyay S (2010)	1
MAP3K4	1	RIPK2	0	affinity chromatography technology	Marinis JM (2011)	1
CDC42	3	MAP3K4	1	pull down, imaging technique	Gerwins P (1997), Chen TC (2014)	2
ACTBL2	0	MAP3K4	1	affinity chromatography technology	Huttlin EL (2017)	1
MAP3K4	1	YWHAZ	1	two hybrid	Bandyopadhyay S (2010)	1
BAG6	2	CNTRL	5	affinity chromatography technology	Hein MY (2015)	1
GSK3B	1	BAG6	2	two hybrid	Vinayagam A (2011)	1
TOP2A	2	GSK3B	1	affinity chromatography technology	Chen MC (2011)	1
KIF21A	7	MAP3K4	1	affinity chromatography technology	Hein MY (2015)	1
AP4E1	4	MAP3K4	1	affinity chromatography technology	Hein MY (2015)	1
HNRNPD	3	BAG6	2	affinity chromatography technology	Hein MY (2015)	1
MAP3K4	1	MAP2K6	2	enzymatic study, enzymatic study, two hybrid, pull down, enzymatic study, enzymatic study, imaging technique	Chan-Hui PY (1998), Abell AN (2005), Takekawa M (2005), Takekawa M (2005), Takekawa M (2005), Abell AN (2007), Chen TC (2014)	7
SRPRA	3	INTS14	5	affinity chromatography technology	Hein MY (2015)	1
GSK3B	1	AXIN1	1	two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Mak BC (2003), Hino S (2005), Oosterveen T (2007), Kim MJ (2008), Kitagawa M (1999), Cha B (2011), Cha B (2011), Arnold HK (2009), Kashikar ND (2011), Kashikar ND (2011), Zhou F (2012), Yan D (2012), Zhang YG (2012), Sue Ng S (2010), Kim JW (2003), Tang Y (2008), Luo W (2007), Li VS (2012), Rosano L (2009), Yamamoto H (2006), Fei C (2013), Wang J (2011), Varjosalo M (2013), Gao C (2014), Varjosalo M (2013), Castellone MD (2005), Hein MY (2015), Chen TC (2014), Chen Y (2016), Novellasdemunt L (2017)	36
GSK3B	1	MAP3K4	1	enzymatic study	Abell AN (2007)	1
HNRNPD	3	MAP2K1	8	two hybrid	Lehner B (2004)	1
ALK	8	MAP2K7	5	affinity chromatography technology	Crockett DK (2004)	1
TOP2A	2	TOP1	1	biochemical	Wan C (2015)	1
SGTB	2	MAP3K4	1	affinity chromatography technology	Hein MY (2015)	1
MAPK8	3	YWHAZ	1	enzymatic study	Yoshida K (2005)	1
ZFP36	2	SH3KBP1	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Kedar VP (2010), Kedar VP (2010), Kedar VP (2010)	3
CHUK	5	MAP3K4	1	enzymatic study	Marinis JM (2012)	1
MAP3K4	1	MAP2K3	1	enzymatic study, pull down, pull down, imaging technique	Chan-Hui PY (1998), Takekawa M (2005), Takekawa M (2005), Chen TC (2014)	4
MAP2K4	3	MAPK8	3	pull down, pull down, enzymatic study, genetic interference, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Lee CM (2002), Park HS (2002), Chen Z (2001), Tournier C (1997), Cheng J (2000), Deacon K (1997), Xia Y (1998), Xia Y (1998), Ho DT (2006), Song JJ (2005), Sundarrajan M (2003), Ho DT (2003), Ho DT (2003)	13
MAP2K3	1	MAP2K6	2	genetic interference, affinity chromatography technology, imaging technique, affinity chromatography technology, fluorescent resonance energy transfe	Huber TB (2001), Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017), Ivanov AA (2017)	5
CNTRL	5	KIF7	3	bioid	Gupta GD (2015)	1
BAG3	4	MAP3K4	1	affinity chromatography technology	Hein MY (2015)	1
MAP2K6	2	MAP2K4	3	enzymatic study	Takekawa M (2005)	1
SH3KBP1	1	MAP3K4	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Aissouni Y (2005), Aissouni Y (2005), Aissouni Y (2005), Kedar VP (2010), Kedar VP (2010), Kim J (2013)	6
SORT1	1	SYNCRIP	6	affinity chromatography technology	Hein MY (2015)	1
MAP2K7	5	GSK3B	1	biochemical	Wan C (2015)	1
MAP3K4	1	MAP3K4	1	enzymatic study	Abell AN (2007)	1
SGTB	2	BAG6	2	affinity chromatography technology	Hein MY (2015)	1
CNTRL	5	NEDD1	1	bioid	Gupta GD (2015)	1
KIF7	3	MAP3K4	1	affinity chromatography technology	Hein MY (2015)	1
MAP3K4	1	MAP2K4	3	enzymatic study, pull down	Chan-Hui PY (1998), Takekawa M (2005)	2
SIGLECL1	0	MAP3K4	1	affinity chromatography technology	Huttlin EL (2017)	1
BAG3	4	USF1	0	affinity chromatography technology	Chen Y (2013)	1
MAP3K4	1	GADD45G	0	two hybrid, affinity chromatography technology	Takekawa M (1998), Takekawa M (1998)	2
RAC1	7	BAG6	2	two hybrid	Vinayagam A (2011)	1
RAP1B	0	MAP3K4	1	affinity chromatography technology	Hein MY (2015)	1
MAP2K4	3	MAP2K7	5	genetic interference, affinity chromatography technology, affinity chromatography technology	Fleming Y (2000), Sundarrajan M (2003), Sundarrajan M (2003)	3
MAP2K7	5	MAP3K4	1	pull down	Takekawa M (2005)	1
SH3KBP1	1	KIF23	0	affinity chromatography technology	Havrylov S (2009)	1
MAPK13	1	MAP3K4	1	imaging technique	Chen TC (2014)	1
RAC1	7	MAP3K4	1	pull down	Gerwins P (1997)	1
MAP2K1	8	YWHAZ	1	affinity chromatography technology	Gloeckner CJ (2007)	1
TOP2A	2	MAP3K4	1	genetic interference	Srivas R (2016)	1
ZFP36	2	MAP3K4	1	affinity chromatography technology	Kedar VP (2010)	1
CDC42	3	MAPK8	3	imaging technique	Chen TC (2014)	1
RAC1	7	TOP2A	2	affinity chromatography technology	Sandrock K (2010)	1
TOP1	1	TPR	5	biochemical	Havugimana PC (2012)	1
HNRNPD	3	MAP3K4	1	affinity chromatography technology	Hein MY (2015)	1
ALK	8	MAP3K4	1	affinity chromatography technology	Crockett DK (2004)	1
HNRNPD	3	SYNCRIP	6	two hybrid, pull down, affinity chromatography technology	Moraes KC (2003), Moraes KC (2003), Hein MY (2015)	3
TRAF4	1	RIPK2	0	affinity chromatography technology	Marinis JM (2011)	1
CNTROB	6	NEDD1	1	bioid	Gupta GD (2015)	1
MAP3K4	1	MAPK8	3	enzymatic study, affinity chromatography technology	Sun BK (2011), Hein MY (2015)	2
GADD45B	1	MAP2K7	5	affinity chromatography technology, pull down	Papa S (2004), Papa S (2004)	2
KIF23	0	MAP3K4	1	affinity chromatography technology	Hein MY (2015)	1
BTK	1	MAP3K4	1	affinity chromatography technology	Huttlin EL (2017)	1
CHUK	5	RIPK2	0	enzymatic study	Marinis JM (2012)	1
BAG6	2	MAP3K4	1	affinity chromatography technology	Hein MY (2015)	1
MAP3K4	1	GADD45A	1	two hybrid, affinity chromatography technology	Takekawa M (1998), Takekawa M (1998)	2
MAPK8	3	MAP2K7	5	enzymatic study, enzymatic study, genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study	Tournier C (1997), Tournier C (1997), Tournier C (1997), Cheng J (2000), Ho DT (2006), Ho DT (2006), Ho DT (2006), Ho DT (2006), Enomoto A (2003), Takeda AN (2014), Sundarrajan M (2003), Chen TC (2014), Zhu T (2016), Zhu T (2016)	14
SRPRA	3	MAP3K4	1	affinity chromatography technology	Hein MY (2015)	1
YWHAZ	1	KIF23	0	affinity chromatography technology	Brajenovic M (2004)	1
BAG3	4	YWHAZ	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013), Chen Y (2013)	3
SYNCRIP	6	MAP3K4	1	affinity chromatography technology	Hein MY (2015)	1
MAP3K4	1	AXIN1	1	affinity chromatography technology	Abell AN (2007)	1
USF1	0	MAP3K4	1	affinity chromatography technology	Hein MY (2015)	1
INTS14	5	MAP3K4	1	affinity chromatography technology	Hein MY (2015)	1
RAP1B	0	CDC42	3	biochemical	Wan C (2015)	1
CHUK	5	TRAF4	1	enzymatic study	Marinis JM (2012)	1
POLR2F	1	MAP3K4	1	affinity chromatography technology	Hein MY (2015)	1
MAPK8	3	MAP2K1	8	unspecified method	Ho DT (2006)	1
TOP3A	0	MAP3K4	1	genetic interference	Srivas R (2016)	1
GADD45A	1	GADD45G	0	affinity chromatography technology	Kovalsky O (2001)	1
CNTROB	6	MAP3K4	1	affinity chromatography technology	Hein MY (2015)	1
SPATA1	0	MAP3K4	1	affinity chromatography technology	Huttlin EL (2017)	1
TRAF4	1	MAP3K4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abell AN (2005), Abell AN (2005), Marinis JM (2011), Marinis JM (2011)	4
GOLT1B	0	CDC42	3	affinity chromatography technology	Hein MY (2015)	1
MAP3K4	1	MAP2K1	8	enzymatic study	Chan-Hui PY (1998)	1
MAP2K3	1	CDC42	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TOP1	1	MAP3K4	1	genetic interference	Srivas R (2016)	1
MAP3K4	1	CNTRL	5	two hybrid	Bandyopadhyay S (2010)	1
MAP2K6	2	GADD45A	1	imaging technique	Chen TC (2014)	1
GADD45A	1	BAG6	2	two hybrid	Vinayagam A (2011)	1
GOLT1B	0	MAP3K4	1	affinity chromatography technology	Hein MY (2015)	1