PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SIAH1	2	GAPDH	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee SY (2012), Lee SB (2012), Tristan CA (2015), Suarez S (2015)	4
TRAF6	0	MAP2K6	2	affinity chromatography technology	Lin J (2015)	1
YWHAZ	1	APP	1	pull down	Olah J (2011)	1
TRAF1	0	RB1CC1	9	affinity chromatography technology	Huttlin EL (2017)	1
YWHAQ	0	YWHAG	5	affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Kristensen AR (2012)	2
CCND2	2	MAP3K5	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGLN3	0	PSMC1	2	affinity chromatography technology	Rodriguez J (2016)	1
FGFR4	6	PTPN11	20	two hybrid	Yao Z (2017)	1
AKT1	1	TERT	7	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Kawauchi K (2005), Kim MO (2008), Ivanov AA (2017)	3
PPP5C	2	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Zeke T (2005), Silverstein AM (1997), Schuelke JP (2010), Gano JJ (2010), Cliff MJ (2006), Skarra DV (2011), Skarra DV (2011), Horibe T (2011), Taipale M (2014), Taipale M (2014), Hein MY (2015), Woo SH (2009), Woo SH (2009), Woodford MR (2016), St-Denis N (2016), Yadav L (2017), Yadav L (2017)	17
PSMC4	6	PSMC1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Um JW (2010), Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	9
CDKN2A	1	HSP90AA1	7	pull down	Souza-Rodrigues E (2007)	1
NEDD4	2	LATS2	1	affinity chromatography technology	Bae SJ (2015)	1
FZR1	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RAF1	3	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ARRB2	5	GAPDH	0	affinity chromatography technology	Xiao K (2007)	1
AURKA	1	LATS2	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, fluorescent resonance energy transfe	Yabuta N (2011), Toji S (2004), Toji S (2004), Toji S (2004), Toji S (2004), Ivanov AA (2017)	6
EGLN3	0	CIB1	2	affinity chromatography technology	Rodriguez J (2016)	1
TRAF6	0	HSPA4	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Chen H (2006), Pridgeon JW (2004), Chen H (2006)	3
EGLN3	0	PSMC5	4	affinity chromatography technology	Rodriguez J (2016)	1
NEDD4	2	MAP3K5	1	enzymatic study	Persaud A (2009)	1
ARRB1	2	YWHAG	5	affinity chromatography technology	Xiao K (2007)	1
ARRB2	5	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
ARRB2	5	YWHAG	5	affinity chromatography technology	Xiao K (2007)	1
TRAF2	1	RB1CC1	9	affinity chromatography technology	Gan B (2006)	1
EGLN3	0	CDKN2A	1	affinity chromatography technology	Rodriguez J (2016)	1
CDK4	2	CDK6	0	affinity chromatography technology, fluorescent resonance energy transfe	Varjosalo M (2013), Ivanov AA (2017)	2
MAP3K5	1	EP300	36	two hybrid	Bandyopadhyay S (2010)	1
CDK4	2	CCND2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Lin J (2001), Kehn K (2004), Kehn K (2004), Sweeney KJ (1997), Huttlin EL (2015), Huttlin EL (2017), Denicourt C (2008), Ivanov AA (2017)	8
PIK3R1	6	DAB2IP	3	pull down, affinity chromatography technology, affinity chromatography technology	Xie D (2009), Xie D (2009), Xie D (2009)	3
FZR1	1	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAZ	1	NEDD4L	3	two hybrid	Bandyopadhyay S (2010)	1
MAPK8IP3	9	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Matsuura H (2002), Matsuura H (2002), Matsuura H (2002), Matsuura H (2002), Song JJ (2004)	5
MAP3K5	1	TXN2	0	affinity chromatography technology, biochemical	Yu Y (2013), Yu Y (2013)	2
GAPDH	0	MAP3K5	1	affinity chromatography technology	Tristan CA (2015)	1
SMN1	0	MAP3K5	1	affinity chromatography technology, affinity chromatography technology	Kwon JE (2011), Kwon JE (2011)	2
CDK6	0	MAP3K5	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GLIS2	2	RAF1	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TEAD2	2	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CREBBP	29	DAXX	5	two hybrid, affinity chromatography technology	Kuo HY (2005), Kuo HY (2005)	2
ARRB2	5	MAP2K4	3	affinity chromatography technology, unspecified method	McDonald PH (2000), Li X (2009)	2
FZR1	1	CDC25A	2	affinity chromatography technology, pull down, enzymatic study	Gao D (2009), Donzelli M (2002), Donzelli M (2002)	3
MAP2K6	2	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PTPN11	20	SOCS3	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lehmann U (2003), Lehmann U (2003), Schmitz J (2000), Orr SJ (2007)	4
STK11	2	PRKAA2	1	imaging technique	Chen TC (2014)	1
MAP3K5	1	CREBBP	29	two hybrid	Bandyopadhyay S (2010)	1
STK11	2	STUB1	4	affinity chromatography technology	Gaude H (2012)	1
TNFAIP3	3	TRAF1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Song HY (1996), Song HY (1996), Heyninck K (1999), Greenfeld H (2015), Greenfeld H (2015)	5
YWHAG	5	PIK3R1	6	affinity chromatography technology	Jin J (2004)	1
ERN1	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Qiu Q (2013), Qiu Q (2013)	2
PSMC4	6	PSMC2	2	affinity chromatography technology, pull down, biochemical, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Ewing RM (2007), Hartmann-Petersen R (2001), Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	8
MAP3K7	2	MAP2K4	3	enzymatic study, affinity chromatography technology	Ge B (2003), Li MG (2003)	2
GLIS2	2	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
DMD	6	NEDD4	2	biochemical	Havugimana PC (2012)	1
AKT1	1	CREBBP	29	pull down, enzymatic study	Drendall CI (2010), Drendall CI (2010)	2
NF2	1	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PSMC1	2	APP	1	pull down	Olah J (2011)	1
JAK2	1	MAP3K5	1	affinity chromatography technology, enzymatic study	Yu L (2009), Yu L (2009)	2
HSP90AA1	7	CDK4	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsutsumi S (2012), Wang H (2002), Taipale M (2012), Varjosalo M (2013), Huttlin EL (2015), Woodford MR (2016), Huttlin EL (2017)	7
LATS2	1	DYRK1A	36	enzymatic study	Tschoep K (2011)	1
JAK2	1	SOCS3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Sasaki A (2000), Sasaki A (2000), Sasaki A (1999), Sasaki A (1999), Sasaki A (1999), Masuhara M (1997), Masuhara M (1997), Monni R (2001), Haan S (2009), Babon JJ (2012), Calegari VC (2005), Calegari VC (2005), Varghese LN (2014), Kershaw NJ (2014)	14
STUB1	4	TRAF2	1	affinity chromatography technology	Jang KW (2011)	1
MAP3K5	1	PSMC5	4	affinity chromatography technology	Um JW (2010)	1
CDKN1A	1	YWHAQ	0	affinity chromatography technology, affinity chromatography technology, pull down	Wang B (2010), Wang B (2010), Wang B (2010)	3
GAPDH	0	EP300	36	affinity chromatography technology, affinity chromatography technology	Sen N (2008), Sen N (2008)	2
AURKA	1	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAQ	0	PDCD6	2	pull down	Meek SE (2004)	1
FAS	2	TRAF3	1	pull down	Mosialos G (1995)	1
CDKN1A	1	CDK4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Selma Dagtas A (2010), Guidoboni M (2005), Santiago FS (2007), Santiago FS (2007), Hsu SP (2008), Kehn K (2004), Kokontis JM (1998), Orend G (1998), Zheleva DI (2002), Mandal M (1998), Chen J (1996), Chen J (1996), Ramachandran N (2004), Gorospe M (1996), Fogeron ML (2013), Hukkelhoven E (2012), Hukkelhoven E (2012), Hukkelhoven E (2012), Huttlin EL (2017), Roessig L (2001)	20
MAP3K5	1	PSMC2	2	affinity chromatography technology	Um JW (2010)	1
GADD45B	1	MAP3K5	1	affinity chromatography technology, pull down	Papa S (2004), Papa S (2004)	2
CDKN2A	1	GAPDH	0	pull down	Souza-Rodrigues E (2007)	1
YWHAQ	0	GAPDH	0	pull down	Meek SE (2004)	1
SIAH1	2	PSMC5	4	affinity chromatography technology	Kulikov R (2010)	1
MAP3K5	1	PSMC4	6	affinity chromatography technology	Um JW (2010)	1
STUB1	4	MAP3K7	2	affinity chromatography technology	Wang S (2013)	1
KMT2A	58	MAP3K5	1	affinity chromatography technology	Jeong W (2004)	1
TNFSF13B	0	MAP3K5	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FAS	2	DAXX	5	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, pull down	Ko YG (2001), Kim YY (2003), Cermak L (2002), Yang X (1997), Yang X (1997), Yang X (1997), Charette SJ (2000), Chen TC (2014), Chang HY (1999)	9
ARRB2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2006), Wang Y (2006), Xiao N (2015)	3
CCND2	2	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
ARRB1	2	HSP90AA1	7	affinity chromatography technology	Xiao K (2007)	1
STUB1	4	TERT	7	pull down, affinity chromatography technology, affinity chromatography technology	Lee JH (2010), Lee JH (2010), Lee JH (2010)	3
ALK	8	MAP3K5	1	affinity chromatography technology	Crockett DK (2004)	1
MAPK8IP3	9	RAF1	3	affinity chromatography technology, pull down, affinity chromatography technology	Kuboki Y (2000), Kuboki Y (2000), Ito M (1999)	3
AKT1	1	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Xiong Y (2009), Xiong Y (2009), Ivanov AA (2017)	3
FGFR4	6	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HSPA1A	0	MAP3K5	1	pull down, affinity chromatography technology	Park HS (2002), Park HS (2002)	2
TERT	7	TEAD2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
APP	1	TPD52L2	0	two hybrid	Wang J (2011)	1
HSP90AA1	7	FZR1	1	genetic interference	Srivas R (2016)	1
HSPA4	3	PARK7	0	affinity chromatography technology, affinity chromatography technology	Moore DJ (2005), Deeg S (2010)	2
TERT	7	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NEDD4	2	RAF1	3	pull down	Persaud A (2009)	1
PARK7	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Zucchelli S (2010), Zucchelli S (2010)	2
AURKA	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K7	5	MAP3K5	1	affinity chromatography technology	Zama T (2002)	1
MAP3K5	1	QARS	1	affinity chromatography technology	Ko YG (2001)	1
MAP2K3	1	MAPK8IP3	9	affinity chromatography technology	Hsu CH (2010)	1
STK11	2	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK4	2	CDKN2A	1	affinity chromatography technology, unspecified method, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ewing RM (2007), Fahraeus R (1996), Li J (2004), Sugimoto M (1999), Serrano M (1993), Serrano M (1993), Serrano M (1993), Coleman KG (1997), Zhang Y (1998), Haddad MM (1999), Li J (2002), Li J (2002), Lal G (2000), Yarbrough WG (1999), Della Torre G (2001), Jones R (2007), Jones R (2007), Ramachandran N (2004), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Hein MY (2015), Fei HJ (2017), Huttlin EL (2017), Ivanov AA (2017)	25
YWHAQ	0	CDC25A	2	pull down, affinity chromatography technology, bioid	Meek SE (2004), Yadav L (2017), Yadav L (2017)	3
PSMC3	0	PSMC5	4	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Ishizuka T (2001), Ishizuka T (2001), Um JW (2010), Lee SH (2012), Lee SH (2012), Divald A (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	10
FZR1	1	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SMN1	0	QARS	1	two hybrid	Vinayagam A (2011)	1
EGLN3	0	CDK4	2	affinity chromatography technology	Rodriguez J (2016)	1
TRAF6	0	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nishitoh H (1998), Hoeflich KP (1999), Mochida Y (2000), Fujino G (2007), Fujino G (2007)	5
CDK6	0	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TXN2	0	TXN	1	biochemical	Wan C (2015)	1
ALK	8	MAP2K7	5	affinity chromatography technology	Crockett DK (2004)	1
MAP3K7	2	HSP90AA1	7	affinity chromatography technology	Liu XY (2008)	1
AURKA	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
HSP90AA1	7	MAP3K6	6	affinity chromatography technology	Taipale M (2012)	1
LATS2	1	CDKN1A	1	enzymatic study	Suzuki H (2013)	1
MAP3K5	1	TPD52L2	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Cho S (2004), Cho S (2004), Cho S (2004), Cho S (2004)	4
DAXX	5	TRAF3	1	two hybrid	Wang J (2011)	1
MCRS1	1	TERT	7	affinity chromatography technology, pull down	Song H (2004), Song H (2004)	2
TERT	7	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
STK11	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K3	1	MAP3K5	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	McLaughlin NJ (2006), McLaughlin NJ (2006), Yoon KW (2009), Yoon KW (2009), Ivanov AA (2017)	5
MAP3K5	1	PTPN11	20	affinity chromatography technology, enzymatic study	Yu L (2009), Yu L (2009)	2
TEAD2	2	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TRAF2	1	ERN1	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kaneko M (2003), Zhu X (2014), Chen TC (2014), Zeng T (2015)	4
FZR1	1	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
FZR1	1	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PRKAA2	1	MAP3K5	1	affinity chromatography technology	Behrends C (2010)	1
DYRK1A	36	APP	1	pull down	Olah J (2011)	1
CDKN2A	1	PDCD6	2	pull down	Souza-Rodrigues E (2007)	1
FAS	2	PIK3R1	6	affinity chromatography technology, affinity chromatography technology	Kleber S (2008), Kleber S (2008)	2
STUB1	4	TRAF6	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Yang M (2011), Yang M (2011), Wang S (2013), Li S (2014), Li S (2014), Li S (2014), Li S (2014)	7
MAP2K6	2	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GLRX	0	MAP3K5	1	affinity chromatography technology	Song JJ (2002)	1
MAP3K5	1	MAP2K6	2	pull down, enzymatic study, two hybrid, enzymatic study, enzymatic study	Huang S (2003), Morita K (2001), Takekawa M (2005), Mo JS (2010), Hwang SG (2014)	5
RAF1	3	JAK2	1	pull down	Xia K (1996)	1
PIK3R1	6	JAK2	1	pull down, genetic interference	Ren SY (2005), Shen JP (2017)	2
YWHAQ	0	TPD52L2	0	affinity chromatography technology	Ichimura T (2013)	1
MAP3K5	1	PSMC1	2	affinity chromatography technology, biochemical	Um JW (2010), Um JW (2010)	2
GNA12	2	HSP90AA1	7	affinity chromatography technology, two hybrid	Vaiskunaite R (2001), Vaiskunaite R (2001)	2
MAP3K7	2	TRAF5	1	affinity chromatography technology	Hong S (2007)	1
YWHAG	5	TNFAIP3	3	two hybrid	Bandyopadhyay S (2010)	1
MAP3K5	1	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GLIS2	2	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TNFAIP3	3	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Song HY (1996), Song HY (1996), Fries KL (1999), Yamaguchi N (2013), Rolland T (2014)	5
ARRB1	2	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, unspecified method	Zhang Z (2009), Li X (2009), Li X (2009)	3
NEDD4L	3	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Chandran S (2011), Ichimura T (2013)	2
STK11	2	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
NF2	1	PDCD6	2	affinity chromatography technology	Zhou L (2015)	1
CDK4	2	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EP300	36	YWHAZ	1	enzymatic study	Mortenson JB (2015)	1
LATS2	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ARRB2	5	CDK4	2	affinity chromatography technology	Xiao K (2007)	1
EGLN3	0	ATAD3A	0	affinity chromatography technology	Rodriguez J (2016)	1
NEDD4	2	TEAD2	2	pull down	Persaud A (2009)	1
QARS	1	APP	1	pull down	Olah J (2011)	1
PARK7	0	STUB1	4	affinity chromatography technology	Moore DJ (2005)	1
RAF1	3	NF2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TRAF2	1	DAB2IP	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang H (2007), Zhang H (2004), Dai X (2014)	3
MAP3K5	1	PPP5C	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference	Morita K (2001), Morita K (2001), Morita K (2001), Morita K (2001)	4
TRAF2	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Hong S (2007), Tan B (2015)	4
GLIS2	2	FZR1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TRAF6	0	PSMC3	0	affinity chromatography technology	Bouwmeester T (2004)	1
TRAF5	1	MAP3K5	1	affinity chromatography technology, affinity chromatography technology	Nishitoh H (1998), Hoeflich KP (1999)	2
MAP3K5	1	RAF1	3	affinity chromatography technology, pull down, fluorescent resonance energy transfe	Chen J (2001), Chen J (2001), Ivanov AA (2017)	3
MAP2K3	1	MAP2K6	2	genetic interference, affinity chromatography technology, imaging technique, affinity chromatography technology, fluorescent resonance energy transfe	Huber TB (2001), Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017), Ivanov AA (2017)	5
PPP5C	2	YWHAQ	0	affinity chromatography technology	Yadav L (2017)	1
MAP2K4	3	MAP3K5	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Ryoo K (2004), Song JJ (2004), Kim EK (2007), Zhang H (2004)	4
APOBEC3G	1	APP	1	pull down	Olah J (2011)	1
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
PPP5C	2	HSPA4	3	affinity chromatography technology	Zeke T (2005)	1
CREBBP	29	CDKN1A	1	affinity chromatography technology, imaging technique	Fritah A (2005), Chen TC (2014)	2
PRKAA2	1	PRKAB2	0	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Moreno D (2009), Moreno D (2009), Corominas R (2014), Rolland T (2014), Wong KA (2006), Huttlin EL (2017)	8
SMN1	0	GEMIN5	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gubitz AK (2002), Gubitz AK (2002), Gubitz AK (2002), Piazzon N (2012), Mirabella F (2014), Hein MY (2015), Han KJ (2016)	7
PIK3R1	6	MAP3K5	1	affinity chromatography technology, affinity chromatography technology	Xie D (2009), Xie D (2009)	2
NF2	1	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN2A	1	TEAD2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GNA12	2	APP	1	pull down	Olah J (2011)	1
CCND2	2	PSMC5	4	affinity chromatography technology	Russo LC (2017)	1
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
EGLN3	0	PPP5C	2	affinity chromatography technology	Rodriguez J (2016)	1
HSP90AA1	7	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Haendeler J (2003), Kawauchi K (2005), Sato S (2000), Basso AD (2002), Su CH (2011), Klein JB (2005), Sun L (2012)	7
AKT1	1	AKT2	1	affinity chromatography technology	Huttlin EL (2017)	1
RAF1	3	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SIAH1	2	MAP3K5	1	affinity chromatography technology, pull down, enzymatic study	Tristan CA (2015), Tristan CA (2015), Tristan CA (2015)	3
MAP2K3	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K6	2	MAP2K4	3	enzymatic study	Takekawa M (2005)	1
MAP3K5	1	DMD	6	two hybrid	Bandyopadhyay S (2010)	1
EGLN3	0	YWHAZ	1	affinity chromatography technology	Rodriguez J (2016)	1
PIK3R1	6	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang S (1999), Takahashi Y (1999), Craddock BL (1997), Wu CJ (2000), Wu CJ (2001), Yu WM (2006)	6
PARK7	0	YWHAQ	0	affinity chromatography technology	Malty RH (2017)	1
GLIS2	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RAF1	3	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HSP90AA1	7	EIF2AK2	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Donze O (2001)	2
STUB1	4	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kutuzov MA (2007), Hwang JR (2005), Gao Y (2010), Gao Y (2010)	4
TRAF6	0	SMN1	0	affinity chromatography technology	Kim EK (2017)	1
TRAF5	1	TRAF2	1	affinity chromatography technology, pull down, pull down	Li S (2011), Li S (2011), Pullen SS (1998)	3
ARRB2	5	STUB1	4	affinity chromatography technology	Zhang Z (2009)	1
MAP3K5	1	NACC1	9	affinity chromatography technology	So J (2015)	1
MAP3K5	1	MAP3K7	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mochida Y (2000), Mochida Y (2000), Mochida Y (2000), Kim SY (2012), Kim SY (2012)	5
GLIS2	2	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN2A	1	CCND2	2	pull down, pull down, fluorescent resonance energy transfe	Li J (2004), Li J (2002), Ivanov AA (2017)	3
DYRK1A	36	MAP3K5	1	affinity chromatography technology, affinity chromatography technology	Choi HK (2011), Choi HK (2011)	2
YWHAQ	0	RAF1	3	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Ewing RM (2007), Yeung K (2000), Van Der Hoeven PC (2000), Liu YC (1996), Subramanian RR (2001), ONeill E (2004), Rajalingam K (2005), Zhu J (2005), Bonnefoy-Berard N (1995), So J (2015)	10
GLIS2	2	CDKN2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAZ	1	RAF1	3	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Clark GJ (1997), Tzivion G (2000), Tzivion G (2000), Koyama S (1995), Koyama S (1995), Van Der Hoeven PC (2000), Chow CW (2000), Andersen SD (2012), Subramanian RR (2001), Wang H (1998), Wang H (1998), Wang H (1998), Dougherty MK (2005), Rajalingam K (2005), Zhu J (2005), So J (2015), Powell DW (2003), Ivanov AA (2017)	18
RB1CC1	9	MAP3K5	1	affinity chromatography technology, affinity chromatography technology	Gan B (2006), Gan B (2006)	2
TXN	1	PDCD6	2	biochemical	Wan C (2015)	1
YWHAZ	1	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ARRB2	5	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Huttlin EL (2017)	4
MAP3K5	1	MBP	0	enzymatic study	Waak J (2009)	1
MAP2K3	1	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
FZR1	1	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP3K6	6	MAP3K5	1	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology	Wang XS (1998), Wang XS (1998), Morita K (2001), So J (2015)	4
RAF1	3	CDKN2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TERT	7	YWHAZ	1	two hybrid	Seimiya H (2000)	1
AKT2	1	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Yuan ZQ (2003), Yuan ZQ (2003), Yuan ZQ (2003)	3
CDK4	2	MAP3K5	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PARK7	0	TXN	1	affinity chromatography technology	Malty RH (2017)	1
APP	1	STUB1	4	affinity chromatography technology, affinity chromatography technology	Kumar P (2007), Kumar P (2007)	2
EGLN3	0	SMN1	0	affinity chromatography technology	Rodriguez J (2016)	1
YWHAG	5	HSPA1A	0	affinity chromatography technology	Jin J (2004)	1
AKT1	1	ARRB2	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Beaulieu JM (2008), Beaulieu JM (2008), Lodeiro M (2009), Luan B (2009)	4
MAP3K5	1	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Zou X (2001), Morita K (2001), Tobiume K (2002), Fujino G (2007), Mo JS (2010), Kim EK (2007), Ninomiya-Tsuji J (2003), Hwang SG (2014), Yoon KW (2009), Ivanov AA (2017)	10
YWHAG	5	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PDCD6	2	MAP3K5	1	affinity chromatography technology, pull down, imaging technique	Hwang IS (2002), Hwang IS (2002), Hwang IS (2002)	3
AKT1	1	CDKN1A	1	pull down, enzymatic study, imaging technique, enzymatic study	Heron-Milhavet L (2006), Heron-Milhavet L (2006), Chen TC (2014), Roessig L (2001)	4
FZR1	1	MAP3K5	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SIAH1	2	TXN	1	two hybrid	Wang J (2011)	1
CDK6	0	TEAD2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K3	1	APP	1	pull down	Olah J (2011)	1
MCRS1	1	MAP3K5	1	affinity chromatography technology	Xu M (2012)	1
EGLN3	0	AURKA	1	affinity chromatography technology	Rodriguez J (2016)	1
MAP2K3	1	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ALK	8	DUSP19	0	two hybrid	Yao Z (2017)	1
NF2	1	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGLN3	0	PSMC3	0	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	HSPA4	3	affinity chromatography technology	Rodriguez J (2016)	1
CDC25A	2	DMD	6	two hybrid	Wang J (2011)	1
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
EGLN3	0	USP9X	15	affinity chromatography technology	Rodriguez J (2016)	1
AKT2	1	APP	1	pull down	Olah J (2011)	1
ARRB1	2	DMD	6	affinity chromatography technology	Xiao K (2007)	1
PTPN11	20	JAK2	1	pull down, enzymatic study, enzymatic study, affinity chromatography technology	Yin T (1997), Yin T (1997), Tauchi T (1996), Maegawa H (1996)	4
SOCS1	1	PIK3R1	6	two hybrid	Grossmann A (2015)	1
CDKN1A	1	EP300	36	pull down, affinity chromatography technology	Cazzalini O (2008), Cazzalini O (2008)	2
LATS2	1	USP9X	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Toloczko A (2017), Toloczko A (2017), Toloczko A (2017), Zhu C (2018), Zhu C (2018), Zhu C (2018)	7
MAP3K5	1	DAXX	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Chang HY (1998), Chang HY (1998), Fukuyo Y (2009), Ko YG (2001), Ko YG (2001), Junn E (2005), Song JJ (2004), Charette SJ (2000), Chen TC (2014), Donath S (2016)	10
PSMC2	2	PSMC5	4	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Tipler CP (1997), Kim YC (2011), Lee SH (2012), Lee SH (2012), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	7
FAS	2	MAP3K5	1	affinity chromatography technology, imaging technique	Ko YG (2001), Chen TC (2014)	2
TRAF6	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid, two hybrid	Heyninck K (1999), Evans PC (2001), Lin SC (2008), Xiong Y (2011), Bremm A (2010), Kelly C (2012), Hayes SD (2012), Lin SC (2008), Garg AV (2013), Boone DL (2004), Schimmack G (2017), Schimmack G (2017)	12
YWHAG	5	MAP3K5	1	affinity chromatography technology	Wang H (2015)	1
CDKN2A	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP3K5	1	YWHAZ	1	affinity chromatography technology, affinity chromatography technology	Zhang L (1999), So J (2015)	2
ARRB2	5	MAP3K7	2	affinity chromatography technology	Xiao K (2007)	1
PPP5C	2	GNA13	0	pull down	Yamaguchi Y (2002)	1
ARRB2	5	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Shenoy SK (2008), Han SO (2012)	2
FZR1	1	CDKN2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDC25A	2	MAP3K5	1	two hybrid, affinity chromatography technology, pull down	Zou X (2001), Zou X (2001), Zou X (2001)	3
DMD	6	APP	1	pull down	Olah J (2011)	1
EGLN3	0	CDC25A	2	affinity chromatography technology	Rodriguez J (2016)	1
MAP2K4	3	MAP2K7	5	genetic interference, affinity chromatography technology, affinity chromatography technology	Fleming Y (2000), Sundarrajan M (2003), Sundarrajan M (2003)	3
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
ARRB1	2	MAP2K3	1	affinity chromatography technology, fluorescent resonance energy transfe	McLaughlin NJ (2006), McLaughlin NJ (2006)	2
STUB1	4	HSPA4	3	pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Dai Q (2005), Tateishi Y (2004), Tateishi Y (2004), Ko HS (2009), Qian SB (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Wang L (2011), Wang L (2011), Graf C (2010), Kundrat L (2010), Matsumoto K (2011), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Luo W (2010), Soss SE (2011), Zhou P (2003), Kalia LV (2011), Gao Y (2010), Gao Y (2010), Grelle G (2006), Rao SN (2010), Tetzlaff JE (2008), Kim SA (2005), Dai Q (2003), Zhang X (2011), Zhang X (2011), Muller P (2012), Jang KW (2011), Schuelke JP (2010), Jinwal UK (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Mao RF (2013), Lee JS (2013), Lee JS (2013)	42
DAXX	5	MCRS1	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin DY (2002), Lin DY (2002), Lin DY (2002), Lin DY (2002), Xu M (2012)	5
NEDD4L	3	MAP3K5	1	enzymatic study	Persaud A (2009)	1
CDKN2A	1	MAP3K5	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
DAXX	5	FZR1	1	affinity chromatography technology	Kwan PS (2013)	1
AKT1	1	RAF1	3	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Zimmermann S (1999), Zimmermann S (1999), Wang J (2009), Wang J (2009), Ivanov AA (2017)	5
ARRB1	2	NEDD4	2	affinity chromatography technology	Shenoy SK (2008)	1
GAPDH	0	PPP5C	2	biochemical	Kristensen AR (2012)	1
CDK4	2	CIB1	2	two hybrid	Wang J (2011)	1
PSMC2	2	HSPA4	3	affinity chromatography technology	Grune T (2011)	1
GAPDH	0	TXN	1	affinity chromatography technology	Ewing RM (2007)	1
GLIS2	2	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HSP90AA1	7	TNFAIP3	3	affinity chromatography technology	Taipale M (2012)	1
EIF2AK2	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Gil J (2004), Gao L (2015)	2
AKT1	1	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Lin WN (2008), Lee IT (2010), Sundaresan NR (2011), Howie HL (2011), Chen J (2004), Chen J (2004)	6
DYRK1A	36	CREBBP	29	affinity chromatography technology	Varjosalo M (2013)	1
AURKA	1	HSPA1A	0	affinity chromatography technology	Fogeron ML (2013)	1
ARRB1	2	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Wang Y (2006), Wang Y (2006)	2
FZR1	1	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ERN1	1	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Zhu X (2014), Zhu X (2014), Zhu X (2014), Zhu X (2014)	4
TRAF2	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Li S (2011), He L (2004), He L (2004), Pullen SS (1998)	4
PPP5C	2	APP	1	pull down	Olah J (2011)	1
CDK4	2	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HSP90AA1	7	CDK6	0	affinity chromatography technology	Taipale M (2012)	1
MAP3K5	1	TEAD2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP3K5	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Gao Y (2010), Gao Y (2010)	2
AKT1	1	STUB1	4	affinity chromatography technology, affinity chromatography technology	Dickey CA (2008), Su CH (2011)	2
RAF1	3	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK4	2	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ARRB1	2	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
PIK3R1	6	ALK	8	pull down	Ren SY (2005)	1
TRAF6	0	APP	1	pull down	Olah J (2011)	1
CDKN2A	1	DAXX	5	pull down, affinity chromatography technology, affinity chromatography technology	Ivanchuk SM (2008), Ivanchuk SM (2008), Ivanchuk SM (2008)	3
CCND2	2	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN1A	1	PSMC5	4	biochemical	Jin Y (2008)	1
AKT1	1	YWHAG	5	affinity chromatography technology	Klein JB (2005)	1
SOCS1	1	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	He Y (2006), He Y (2006), He Y (2006), Kolliputi N (2009), Kolliputi N (2009)	5
MAP3K7	2	PPP5C	2	two hybrid	Vinayagam A (2011)	1
AKT1	1	GAPDH	0	affinity chromatography technology	Klein JB (2005)	1
MAP3K5	1	DAB2IP	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang H (2007), Xie D (2009), Xie D (2009), Zhang H (2004), Zhang H (2004), Wang H (2015)	6
SMN1	0	GAPDH	0	two hybrid	Vinayagam A (2011)	1
DUSP19	0	PARK7	0	affinity chromatography technology	Li X (2016)	1
LATS2	1	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN2A	1	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NF2	1	HSPA4	3	affinity chromatography technology	Hauri S (2013)	1
FZR1	1	NF2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN1A	1	QARS	1	two hybrid	Vinayagam A (2011)	1
TRAF3	1	MAP3K5	1	affinity chromatography technology	Nishitoh H (1998)	1
MAP3K5	1	USP9X	15	affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study	Nagai H (2009), Nagai H (2009), Nagai H (2009), Nagai H (2009)	4
USP9X	15	GEMIN5	1	affinity chromatography technology	Han KJ (2012)	1
CDKN2A	1	HSPA4	3	pull down	Souza-Rodrigues E (2007)	1
MAP3K5	1	SOCS3	0	affinity chromatography technology	He Y (2006)	1
MAP3K5	1	ATAD3A	0	affinity chromatography technology	So J (2015)	1
MAP3K5	1	PARK7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Waak J (2009), Mo JS (2010), Mo JS (2010)	3
HSP90AA1	7	GAPDH	0	affinity chromatography technology, biochemical	Falsone SF (2005), Wan C (2015)	2
NF2	1	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EP300	36	TRAF2	1	two hybrid	Wang J (2011)	1
TRAF5	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Li S (2011), He L (2004), Chen TC (2014)	3
CDKN1A	1	TRAF1	0	two hybrid	Rolland T (2014)	1
CDKN2A	1	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TRAF3	1	DYRK1A	36	affinity chromatography technology	van Zuylen WJ (2012)	1
JAK2	1	HSP90AA1	7	affinity chromatography technology	Cheng MB (2010)	1
HSPA4	3	APP	1	affinity chromatography technology	Kumar P (2007)	1
SOCS3	0	MAP3K7	2	affinity chromatography technology	Frobose H (2006)	1
EGLN3	0	MAP3K5	1	affinity chromatography technology	Rodriguez J (2016)	1
HSP90AA1	7	PRKAA2	1	affinity chromatography technology	Taipale M (2012)	1
MAP3K7	2	EIF2AK2	1	affinity chromatography technology	Jiang Z (2003)	1
MAP3K5	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Won M (2010), Won M (2010)	2
DYRK1A	36	EP300	36	affinity chromatography technology	Varjosalo M (2013)	1
TERT	7	YWHAQ	0	two hybrid, pull down, pull down	Seimiya H (2000), Seimiya H (2000), Seimiya H (2000)	3
CDK4	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
QARS	1	TRAF2	1	two hybrid	Rual JF (2005)	1
CDK6	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAQ	0	MAP3K5	1	pull down	Zhang H (2007)	1
ALK	8	SOCS1	1	affinity chromatography technology	Crockett DK (2004)	1
GLIS2	2	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
DUSP19	0	MAP3K5	1	affinity chromatography technology, genetic interference	Zama T (2002), Zama T (2002)	2
ALK	8	JAK2	1	affinity chromatography technology	Crockett DK (2004)	1
TEAD2	2	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGLN3	0	MAP3K7	2	affinity chromatography technology	Rodriguez J (2016)	1
MAP3K5	1	APP	1	imaging technique	Chen TC (2014)	1
SOCS3	0	YWHAQ	0	two hybrid	Grossmann A (2015)	1
PSMC5	4	PSMC1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Hartmann-Petersen R (2001), Kim YC (2011), Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	9
ARRB1	2	STUB1	4	affinity chromatography technology	Zhang Z (2009)	1
AURKA	1	USP9X	15	affinity chromatography technology	Fogeron ML (2013)	1
ARRB1	2	YWHAZ	1	affinity chromatography technology	Xiao K (2007)	1
CDK6	0	CCND2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Lin J (2001), Sweeney KJ (1997), Varjosalo M (2013), Ivanov AA (2017)	4
CCND2	2	PSMC4	6	affinity chromatography technology	Russo LC (2017)	1
RAF1	3	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhu J (2005), Zhu J (2005), Zhu J (2005), da Rocha Dias S (2005)	4
NF2	1	MAP3K5	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP3K5	1	GEMIN5	1	affinity chromatography technology, affinity chromatography technology, pull down	Kim EK (2007), Kim EK (2007), Kim EK (2007)	3
MAP3K7	2	MAP2K7	5	imaging technique	Chen TC (2014)	1
YWHAQ	0	DAB2IP	3	pull down, affinity chromatography technology	Zhang H (2007), Zhang H (2007)	2
DAXX	5	TERT	7	affinity chromatography technology	Tang M (2015)	1
DAB2IP	3	AKT1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Xie D (2009), Xie D (2009), Dai X (2014)	3
EGLN3	0	STUB1	4	affinity chromatography technology	Rodriguez J (2016)	1
JAK2	1	SOCS1	1	two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Yasukawa H (1999), Dif F (2001), Endo TA (1997), Endo TA (1997), Endo TA (1997), Yasukawa H (1999), Yasukawa H (1999), Pezet A (1999), Ungureanu D (2002), Masuhara M (1997), Ali S (2003), Monni R (2001), Monni R (2001), Piessevaux J (2008), Yu L (2009), Maruoka M (2017)	16
GAPDH	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
PRKAB2	0	RB1CC1	9	affinity chromatography technology	Behrends C (2010)	1
TNFAIP3	3	YWHAQ	0	two hybrid	Rodriguez MS (2014)	1
MAP3K7	2	MAP2K6	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Ishitani T (2003), Wang C (2001), Ninomiya-Tsuji J (1999), Sakurai H (2000), Wu ZH (2010), Xia ZP (2009), Jiang Z (2003), Singhirunnusorn P (2005), Jiang Z (2002), Hong S (2007), Kojima H (2005), Huangfu WC (2006), Kajino T (2006), Li MG (2003), Wu X (2007), Shambharkar PB (2007), Kishimoto K (2000), Lamb A (2013), Lin J (2015), Liu X (2013), Ninomiya-Tsuji J (2003)	21
PSMC3	0	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Pollice A (2007), Pollice A (2007), Pollice A (2004), Pollice A (2004), Pollice A (2004)	5
TRAF6	0	TRAF5	1	two hybrid, two hybrid, two hybrid, pull down	Woodsmith J (2012), Rolland T (2014), Yu H (2011), Middleton AJ (2017)	4
STK11	2	APP	1	pull down	Olah J (2011)	1
GADD45B	1	MAP2K7	5	affinity chromatography technology, pull down	Papa S (2004), Papa S (2004)	2
PRKAB2	0	MAP3K5	1	affinity chromatography technology	Behrends C (2010)	1
STK11	2	HSPA1A	0	affinity chromatography technology	Brajenovic M (2004)	1
PRKAB2	0	MAP3K6	6	affinity chromatography technology	Behrends C (2010)	1
RAF1	3	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GNA12	2	MAP3K5	1	affinity chromatography technology	Kutuzov MA (2007)	1
PRKAA2	1	MAP3K6	6	affinity chromatography technology	Behrends C (2010)	1
EGLN3	0	YWHAQ	0	affinity chromatography technology	Rodriguez J (2016)	1
YWHAG	5	RAF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ewing RM (2007), Autieri MV (1999), Van Der Hoeven PC (2000), Rajalingam K (2005), Zhu J (2005), So J (2015), Ivanov AA (2017)	7
AKT1	1	HSPA4	3	affinity chromatography technology	Doong H (2003)	1
TNFSF13B	0	MAP3K6	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
HSP90AA1	7	TERT	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Haendeler J (2003), Kawauchi K (2005), Holt SE (1999), Lee JH (2010), Lee JH (2010), Forsythe HL (2001)	6
SOCS3	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Frobose H (2006), Zhou X (2015)	2
YWHAQ	0	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
TRAF1	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Pullen SS (1998), Greenfeld H (2015)	2
GLIS2	2	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDC25A	2	YWHAG	5	affinity chromatography technology, affinity chromatography technology, bioid	Li X (2016), Yadav L (2017), Yadav L (2017)	3
GAPDH	0	YWHAG	5	biochemical	Kristensen AR (2012)	1
APP	1	YWHAG	5	two hybrid, affinity chromatography technology, unspecified method	Sumioka A (2005), Sumioka A (2005), Sumioka A (2005)	3
CDK4	2	APP	1	pull down	Olah J (2011)	1
NF2	1	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TRAF6	0	SOCS1	1	affinity chromatography technology	Zhou X (2015)	1
MAP2K6	2	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK4	2	TEAD2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CREBBP	29	PSMC5	4	affinity chromatography technology	Koues OI (2008)	1
ALK	8	MAPK8IP3	9	affinity chromatography technology	Crockett DK (2004)	1
LATS2	1	YWHAG	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe	Okada N (2011), Okada N (2011), Okada N (2011), Ivanov AA (2017)	4
EIF2AK2	1	TRAF5	1	affinity chromatography technology, affinity chromatography technology	Gil J (2004), Gil J (2004)	2
CDKN1A	1	GAPDH	0	affinity chromatography technology, pull down	Carujo S (2006), Carujo S (2006)	2
AKT1	1	NF2	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Tang X (2007), Tang X (2007), Tang X (2007), Tang X (2007), Laulajainen M (2011), Laulajainen M (2011), Laulajainen M (2011), Laulajainen M (2011), Ivanov AA (2017)	9
CDKN1A	1	HSPA1A	0	affinity chromatography technology	Fogeron ML (2013)	1
CDKN1A	1	APP	1	pull down	Olah J (2011)	1
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
AKT1	1	APP	1	pull down	Olah J (2011)	1
RAF1	3	CDC25A	2	affinity chromatography technology, pull down, affinity chromatography technology	Galaktionov K (1995), Galaktionov K (1995), Huang TS (1997)	3
CDKN2A	1	CDK6	0	unspecified method, x-ray crystallography, pull down, pull down, pull down, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Fahraeus R (1996), Russo AA (1998), Kaldis P (2001), Yarbrough WG (1999), Della Torre G (2001), Ezhevsky SA (1997), Ezhevsky SA (1997), Jones R (2007), Jones R (2007), Ramachandran N (2004), Varjosalo M (2013), Souza-Rodrigues E (2007), Huttlin EL (2015), Huttlin EL (2017), Ivanov AA (2017)	15
AKT1	1	PSMC5	4	two hybrid	Arroyo R (2015)	1
CDKN2A	1	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAZ	1	CDC25A	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Wang Z (2002), Li X (2016), Huttlin EL (2017)	3
STUB1	4	CDKN1A	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Biswas K (2017), Biswas K (2017), Biswas K (2017)	3
HSP90AA1	7	MAP2K7	5	affinity chromatography technology	Taipale M (2012)	1
PSMC1	2	PSMC2	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Gorbea C (2000), Hartmann-Petersen R (2001), Kaneko T (2009), Kaneko T (2009), Kim YC (2011), Kim YC (2011), Shim SM (2012), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	13
NF2	1	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GLIS2	2	TEAD2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TRAF6	0	AKT1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Yang WL (2009), Mitra S (2011), Mitra S (2011)	3
RAF1	3	TEAD2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K3	1	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PARK7	0	DAXX	5	two hybrid, affinity chromatography technology	Junn E (2005), Junn E (2005)	2
GEMIN5	1	TXN	1	affinity chromatography technology	Hein MY (2015)	1
TERT	7	HSPA1A	0	affinity chromatography technology	Lee JH (2010)	1
GLIS2	2	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TNFAIP3	3	YWHAZ	1	two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid	De Valck D (1997), Vincenz C (1996), Vincenz C (1996), Vincenz C (1996), Bandyopadhyay S (2010), Wang J (2011)	6
JAK2	1	TRAF6	0	two hybrid	Wang J (2011)	1
DUSP19	0	MAP2K7	5	affinity chromatography technology, pull down	Zama T (2002), Zama T (2002)	2
ARRB1	2	AKT1	1	affinity chromatography technology	Lodeiro M (2009)	1
CDK4	2	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HSP90AA1	7	ALK	8	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012)	2
PSMC2	2	PSMC3	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Tipler CP (1997), Kim YC (2011), Lee SH (2012), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	8
RAF1	3	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAG	5	DYRK1A	36	affinity chromatography technology	Jin J (2004)	1
STK11	2	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
AURKA	1	MAP3K5	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CCND2	2	PSMC2	2	affinity chromatography technology	Russo LC (2017)	1
GNA13	0	MAP3K5	1	affinity chromatography technology, affinity chromatography technology	Kutuzov MA (2007), Kutuzov MA (2007)	2
FZR1	1	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
AKT1	1	MAP2K4	3	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Park HS (2002), Park HS (2002), Park HS (2002), Song JJ (2005), Song JJ (2005)	5
LATS2	1	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K6	2	RAF1	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ARRB1	2	MAP2K4	3	unspecified method	Li X (2009)	1
HSP90AA1	7	AKT2	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012)	2
TXN	1	MAP3K5	1	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu Y (2002), Liu Y (2002), Morita K (2001), Saitoh M (1998), Saitoh M (1998), Saitoh M (1998), Fujino G (2007), Fujino G (2007), Goerner K (2007), Im JY (2010), Im JY (2010), Junn E (2000), Yu Y (2013), Yamawaki H (2005), Matsuoka S (2008), Hwang SG (2014), Yoon KW (2009)	17
MAP2K3	1	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
STUB1	4	HSPA1A	0	pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Imai Y (2002), Havugimana PC (2012), Jinwal UK (2012), Yang SW (2013), Choi JR (2016), Schoenbuehler B (2016)	8
TRAF6	0	PSMC1	2	affinity chromatography technology	Bouwmeester T (2004)	1
NF2	1	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TERT	7	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN2A	1	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PSMC4	6	PSMC3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Ewing RM (2007), Lee SH (2012), Lee SH (2012), Ohana B (1993), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	9
YWHAG	5	NEDD4L	3	two hybrid	Bandyopadhyay S (2010)	1
FGFR4	6	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGLN3	0	PSMC4	6	affinity chromatography technology	Rodriguez J (2016)	1
ARRB2	5	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, unspecified method	McDonald PH (2000), Zhang Z (2009), Li X (2009)	3
PSMC3	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ERN1	1	MAP3K5	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Nishitoh H (2002), Chen TC (2014), Zeng T (2015)	3
MAPK8IP3	9	MAP2K4	3	affinity chromatography technology, affinity chromatography technology	Ito M (1999), Matsuura H (2002)	2
TRAF3	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Wang PX (2016), Wang PX (2016), Wang PX (2016)	3
CCND2	2	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GLIS2	2	MAP3K5	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PSMC5	4	TRAF6	0	affinity chromatography technology	Huttlin EL (2017)	1
SOCS3	0	APP	1	pull down	Olah J (2011)	1
MAP2K4	3	APP	1	pull down	Olah J (2011)	1
NF2	1	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CIB1	2	MAP3K5	1	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Yoon KW (2009), Yoon KW (2009), Yoon KW (2009), Yoon KW (2009)	4
RAF1	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stancato LF (1993), Dogan T (2008), Mollapour M (2010), Du J (2006), Maloney A (2007), Fiskus W (2007), Giommarelli C (2010), Arlander SJ (2006), ONeill E (2004), Taipale M (2012), Zhu J (2005), Schneider C (1996), Mollapour M (2014), Atabakhsh E (2012), Mitra S (2016)	15
TERT	7	HSPA4	3	pull down	Forsythe HL (2001)	1
HSP90AA1	7	HSPA1A	0	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kanelakis KC (2002), Gano JJ (2010), Falsone SF (2005), Brychzy A (2003), Scholz GM (2001), Scholz GM (2001)	6
CCND2	2	PSMC3	0	affinity chromatography technology	Russo LC (2017)	1
GSTM1	0	MAP3K5	1	affinity chromatography technology	Dorion S (2002)	1
EIF2AK2	1	MAP3K5	1	affinity chromatography technology, affinity chromatography technology	Takizawa T (2002), Takizawa T (2002)	2
EGLN3	0	PSMC2	2	affinity chromatography technology	Rodriguez J (2016)	1
RAF1	3	STUB1	4	affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study	Dogan T (2008), Dogan T (2008), Alberti S (2004), Westhoff B (2005), Dreiseidler M (2012)	5
MAP2K6	2	GLIS2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK6	0	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK4	2	QARS	1	two hybrid	Vinayagam A (2011)	1
PPP5C	2	GNA12	2	pull down, affinity chromatography technology	Yamaguchi Y (2002), Yamaguchi Y (2002)	2
PARK7	0	YWHAZ	1	affinity chromatography technology	Malty RH (2017)	1
EGLN3	0	PARK7	0	affinity chromatography technology	Rodriguez J (2016)	1
AURKA	1	CDKN2A	1	affinity chromatography technology	Ewing RM (2007)	1
LATS2	1	SIAH1	2	affinity chromatography technology, affinity chromatography technology	Xiang L (2014), Xiang L (2014)	2
PSMC3	0	PSMC1	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
AURKA	1	HSP90AA1	7	affinity chromatography technology	Fogeron ML (2013)	1
MAP3K5	1	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NF2	1	ATAD3A	0	affinity chromatography technology	Zhou L (2015)	1
TEAD2	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CCND2	2	CDKN1A	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Kehn K (2004), Bao GC (2006), Chen J (1996), Fogeron ML (2013), Rolland T (2014), Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017), Welcker M (1998)	10
STUB1	4	TXN2	0	two hybrid	Rolland T (2014)	1
CDK6	0	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TRAF1	0	MAP3K5	1	affinity chromatography technology	Nishitoh H (1998)	1
AKT1	1	YWHAZ	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Powell DW (2002), Powell DW (2002), Powell DW (2002), Klein JB (2005)	4
NEDD4	2	AKT1	1	enzymatic study, enzymatic study, affinity chromatography technology	Persaud A (2009), Fan CD (2013), Fan CD (2013)	3
PRKAB2	0	TRAF2	1	two hybrid, two hybrid, two hybrid	Corominas R (2014), Rolland T (2014), Yu H (2011)	3
CCND2	2	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN1A	1	CDK6	0	affinity chromatography technology, pull down, affinity chromatography technology	Selma Dagtas A (2010), Ramachandran N (2004), Huttlin EL (2017)	3
STK11	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nony P (2003), Brajenovic M (2004), Gaude H (2012), Taipale M (2012), Huttlin EL (2017)	5
PIK3R1	6	EP300	36	affinity chromatography technology	Song L (2011)	1
TRAF2	1	EIF2AK2	1	affinity chromatography technology, affinity chromatography technology	Gil J (2004), Gao L (2015)	2
HSPA4	3	APOBEC3G	1	affinity chromatography technology	Sugiyama R (2011)	1
TNFSF13B	0	APP	1	pull down	Olah J (2011)	1
TNFAIP3	3	NEDD4L	3	affinity chromatography technology	Huttlin EL (2017)	1
PSMC4	6	PSMC5	4	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Hendil KB (2009), Kaneko T (2009), Kaneko T (2009), Lee SH (2012), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Albers M (2005), Albers M (2005), Huttlin EL (2017)	13
CCND2	2	PSMC1	2	affinity chromatography technology	Russo LC (2017)	1
FZR1	1	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HSP90AA1	7	MAP3K5	1	affinity chromatography technology	Taipale M (2012)	1
CCND2	2	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGLN3	0	DYRK1A	36	affinity chromatography technology	Rodriguez J (2016)	1
GLIS2	2	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP3K5	1	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HSPA1A	0	PSMC5	4	pull down	Hjerpe R (2016)	1
CREBBP	29	KMT2A	58	pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, two hybrid, x-ray crystallography, pull down	Goto NK (2002), Goto NK (2002), Ernst P (2001), Ernst P (2001), Ernst P (2001), Ernst P (2001), Yang F (2006), Ramirez JA (2007)	8
MAP3K5	1	PSMC3	0	affinity chromatography technology	Um JW (2010)	1
CDKN1A	1	TXN	1	two hybrid	Wang J (2011)	1
EGLN3	0	TXN	1	affinity chromatography technology	Rodriguez J (2016)	1
ARRB2	5	RAF1	3	affinity chromatography technology	Luttrell LM (2001)	1
DAXX	5	STUB1	4	affinity chromatography technology, pull down	McDonough H (2009), McDonough H (2009)	2
PRKAA2	1	RB1CC1	9	affinity chromatography technology	Behrends C (2010)	1
FZR1	1	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ERN1	1	HSP90AA1	7	affinity chromatography technology, pull down	Marcu MG (2002), Marcu MG (2002)	2
HSP90AA1	7	CDKN1A	1	affinity chromatography technology	Jascur T (2005)	1
CDKN1A	1	MAP3K5	1	affinity chromatography technology	Huang S (2003)	1
TEAD2	2	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
FZR1	1	TEAD2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP3K5	1	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NF2	1	LATS2	1	x-ray crystallography, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Li Y (2015), Yin F (2013), Ivanov AA (2017), Zhu C (2018)	4
CIB1	2	TERT	7	pull down, two hybrid, pull down, affinity chromatography technology	Lee JH (2010), Lee GE (2004), Lee GE (2004), Lee GE (2004)	4
AKT1	1	MAP3K5	1	affinity chromatography technology, enzymatic study	Kim AH (2001), Kim AH (2001)	2
CDC25A	2	APP	1	pull down	Olah J (2011)	1
CDK6	0	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K4	3	GEMIN5	1	affinity chromatography technology, pull down	Kim EK (2007), Kim EK (2007)	2
AURKA	1	TEAD2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAPK8IP3	9	MAP2K7	5	pull down, affinity chromatography technology	Kelkar N (2000), Matsuura H (2002)	2
TRAF1	0	TRAF6	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Wang J (2011), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	4
NEDD4L	3	RAF1	3	affinity chromatography technology, affinity chromatography technology	Soundararajan R (2009), Soundararajan R (2009)	2
SOCS1	1	PTPN11	20	affinity chromatography technology	Ali S (2003)	1
CDKN1A	1	AKT2	1	affinity chromatography technology, pull down	Heron-Milhavet L (2006), Heron-Milhavet L (2006)	2
TRAF2	1	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Nishitoh H (1998), Hoeflich KP (1999), Gan B (2006), Kolliputi N (2009), Fujino G (2007), Fujino G (2007), Wu Y (2006), Zhang H (2004), Hwang SG (2014), Yoon KW (2009), Yoon KW (2009)	11
TRAF6	0	PSMC2	2	affinity chromatography technology	Bouwmeester T (2004)	1
EGLN3	0	CREBBP	29	affinity chromatography technology	Rodriguez J (2016)	1
AURKA	1	PDCD6	2	affinity chromatography technology	Fogeron ML (2013)	1
APOBEC3G	1	MAP3K5	1	affinity chromatography technology	Miyakawa K (2015)	1
EGLN3	0	RAF1	3	affinity chromatography technology	Rodriguez J (2016)	1
RAF1	3	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K6	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CCND2	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HSP90AA1	7	TEAD2	2	affinity chromatography technology	Taipale M (2012)	1
GLIS2	2	NF2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
FAS	2	PDCD6	2	two hybrid, affinity chromatography technology, pull down	Jung YS (2001), Jung YS (2001), Jung YS (2001)	3
CCND2	2	TEAD2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1