PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PAX1	0	MEOX2	2	two hybrid, pull down	Stamataki D (2001), Stamataki D (2001)	2
MEOX1	0	TCEANC	0	two hybrid	Rolland T (2014)	1
MID1	1	TCEANC	0	two hybrid	Rolland T (2014)	1
MEOX1	0	MORF4L1	1	two hybrid	Rolland T (2014)	1
NXF1	0	QRICH1	8	affinity chromatography technology	Castello A (2012)	1
MORF4L1	1	APP	1	pull down	Olah J (2011)	1
MEOX1	0	SYT17	0	two hybrid	Rolland T (2014)	1
MEOX1	0	QRICH1	8	two hybrid	Rolland T (2014)	1
MEOX1	0	TP53RK	0	affinity chromatography technology	Huttlin EL (2015)	1
UBXN2B	2	NIF3L1	0	affinity chromatography technology	Huttlin EL (2015)	1
FMR1	1	MEOX1	0	two hybrid	Corominas R (2014)	1
NXF1	0	TXLNA	3	affinity chromatography technology	Castello A (2012)	1
MEOX1	0	CIAO1	3	two hybrid	Rolland T (2014)	1
DCX	5	MEOX1	0	two hybrid	Rolland T (2014)	1
ALOX5	1	APP	1	pull down	Olah J (2011)	1
TCEANC	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
ALOX5	1	MEOX1	0	two hybrid	Rolland T (2014)	1
CWF19L2	2	APP	1	pull down	Olah J (2011)	1
MEOX1	0	NEIL2	2	two hybrid	Rolland T (2014)	1
PRKN	1	UBE2R2	2	pull down	Kazlauskaite A (2014)	1
MEOX1	0	NAGK	4	two hybrid	Rolland T (2014)	1
PAX3	6	MEOX2	2	two hybrid, pull down	Stamataki D (2001), Stamataki D (2001)	2
NXF1	0	CHMP1A	3	affinity chromatography technology	Castello A (2012)	1
MEOX1	0	CIB3	0	two hybrid	Rolland T (2014)	1
MVP	1	MEOX2	2	two hybrid	Corominas R (2014)	1
MEOX2	2	TXLNA	3	two hybrid	Rolland T (2014)	1
MEOX1	0	MID1	1	two hybrid	Rolland T (2014)	1
MEOX1	0	TXLNA	3	two hybrid	Rolland T (2014)	1
SYT17	0	APP	1	pull down	Olah J (2011)	1
MEOX1	0	MEOX2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKN	1	APP	1	affinity chromatography technology, imaging technique	Rosen KM (2010), Lonskaya I (2012)	2
MVP	1	MEOX1	0	two hybrid	Corominas R (2014)	1
MEOX1	0	UBE2R2	2	two hybrid	Rolland T (2014)	1
MEOX1	0	NIF3L1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NXF1	0	LMNA	2	affinity chromatography technology	Castello A (2012)	1
MEOX1	0	APP	1	pull down	Olah J (2011)	1
MEOX1	0	APPL1	1	two hybrid	Rolland T (2014)	1
PAX1	0	MEOX1	0	two hybrid, pull down	Stamataki D (2001), Stamataki D (2001)	2
MORF4L1	1	LMNA	2	affinity chromatography technology, two hybrid	Hayakawa T (2007), Dittmer TA (2014)	2
PAX3	6	MEOX1	0	two hybrid, pull down	Stamataki D (2001), Stamataki D (2001)	2
LMNA	2	TCEANC	0	two hybrid	Dittmer TA (2014)	1
FMR1	1	CYFIP1	2	pull down, affinity chromatography technology, two hybrid	Schenck A (2001), Schenck A (2001), Schenck A (2001)	3
CYFIP1	2	MEOX1	0	two hybrid	Corominas R (2014)	1
PRKN	1	LMNA	2	affinity chromatography technology	Zanon A (2013)	1
CIAO1	3	APP	1	pull down	Olah J (2011)	1
MEOX1	0	UBXN2B	2	two hybrid	Rolland T (2014)	1
CKS1B	0	MEOX1	0	two hybrid	Rolland T (2014)	1
MEOX2	2	CIB3	0	two hybrid	Rolland T (2014)	1
SYT17	0	NIF3L1	0	two hybrid	Rolland T (2014)	1
NXF1	0	RANBP3	0	affinity chromatography technology	Castello A (2012)	1
LMNA	2	MEOX1	0	two hybrid	Dittmer TA (2014)	1
PRKN	1	MEOX2	2	two hybrid	Corominas R (2014)	1
MEOX1	0	RANBP3	0	two hybrid	Rolland T (2014)	1
LMNA	2	CWF19L2	2	two hybrid	Dittmer TA (2014)	1
MEOX1	0	CWF19L2	2	two hybrid	Rolland T (2014)	1
APP	1	QRICH1	8	two hybrid, affinity chromatography technology, affinity chromatography technology	Lakshmana MK (2005), Lakshmana MK (2005), Lakshmana MK (2005)	3
MEOX1	0	PAGE3	0	two hybrid	Rolland T (2014)	1
MEOX1	0	MAPK9	3	two hybrid	Rolland T (2014)	1
NXF1	0	MEOX1	0	affinity chromatography technology	Castello A (2012)	1
DCX	5	APP	1	pull down	Olah J (2011)	1
PRKN	1	MEOX1	0	two hybrid	Corominas R (2014)	1
MEOX1	0	CHMP1A	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP53RK	0	NIF3L1	0	biochemical	Kristensen AR (2012)	1
MEOX2	2	SYT17	0	two hybrid	Rolland T (2014)	1