PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2I	0	EP300	36	enzymatic study, affinity chromatography technology	Girdwood D (2003), Bian XL (2017)	2
MITF	3	RBM6	1	affinity chromatography technology	Huttlin EL (2017)	1
EP300	36	PIAS1	4	pull down, affinity chromatography technology	Ledsaak M (2016), Ledsaak M (2016)	2
XPO1	8	TFEB	6	affinity chromatography technology	Kirli K (2015)	1
FBXO7	1	MITF	3	enzymatic study	Teixeira FR (2016)	1
ELAVL1	0	MITF	3	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM25	5	MITF	3	affinity chromatography technology	Choudhury NR (2017)	1
EBP	1	MITF	3	two hybrid	Wang J (2011)	1
XPO1	8	FBXO7	1	pull down	Nelson DE (2011)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
MITF	3	MARK3	2	two hybrid	Schwarz T (2010)	1
UBE2I	0	APP	1	enzymatic study	Gocke CB (2005)	1
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
PAX6	3	EP300	36	pull down, affinity chromatography technology, affinity chromatography technology	Hussain MA (1999), Hussain MA (1999), Hussain MA (1999)	3
ELAVL1	0	EBP	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM25	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
SUMO1	0	PIAS2	2	two hybrid, two hybrid, two hybrid, two hybrid, pull down, two hybrid	Lee BH (2003), Stehmeier P (2009), Wang J (2011), Hecker CM (2006), Hecker CM (2006), Rolland T (2014)	6
SPI1	1	MITF	3	pull down	Sato M (1999)	1
PSMD14	3	STUB1	4	biochemical	Havugimana PC (2012)	1
EPAS1	6	MITF	3	affinity chromatography technology, affinity chromatography technology	Steunou AL (2012), Steunou AL (2012)	2
TRIM25	5	FBXO7	1	affinity chromatography technology	Choudhury NR (2017)	1
XPO1	8	KLHL20	2	affinity chromatography technology	Kirli K (2015)	1
MITF	3	PATZ1	1	two hybrid, affinity chromatography technology, pull down	Morii E (2002), Morii E (2002), Morii E (2002)	3
PIAS2	2	PIAS1	4	imaging technique	Chen TC (2014)	1
APP	1	UCHL1	1	affinity chromatography technology	Zhang M (2014)	1
FOS	0	APP	1	pull down	Miyamoto-Sato E (2010)	1
TRIM25	5	MARK3	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	HINT1	0	affinity chromatography technology	Choudhury NR (2017)	1
XPO1	8	MITF	3	affinity chromatography technology	Kirli K (2015)	1
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2I	0	XPO1	8	biochemical	Havugimana PC (2012)	1
ELAVL1	0	PIAS3	2	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM25	5	RBM6	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	STUB1	4	affinity chromatography technology	Choudhury NR (2017)	1
TFE3	4	MITF	3	genetic interference, affinity chromatography technology, affinity chromatography technology	Steingrimsson E (2002), Mansky KC (2002), Huttlin EL (2017)	3
UBE2I	0	PIAS3	2	two hybrid, two hybrid	Bandyopadhyay S (2010), Wang J (2011)	2
PAX6	3	MITF	3	pull down	Planque N (2001)	1
APP	1	STUB1	4	affinity chromatography technology, affinity chromatography technology	Kumar P (2007), Kumar P (2007)	2
EP300	36	FOS	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Wang WM (2011), Pekarsky Y (2008), Wang C (2001)	3
XPO1	8	TFE3	4	affinity chromatography technology	Kirli K (2015)	1
MITF	3	PIAS3	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Levy C (2002), Levy C (2002), Levy C (2002), Levy C (2002), Murakami H (2005)	5
UBE2I	0	FOS	0	enzymatic study, enzymatic study, enzymatic study	Jakobs A (2007), Bossis G (2005), Guo D (2005)	3
MITF	3	STUB1	4	two hybrid	Wang J (2011)	1
MITF	3	TFEC	0	affinity chromatography technology	Mansky KC (2002)	1
MITF	3	PIAS2	2	pull down, pull down	Murakami H (2005), Murakami H (2005)	2
EP300	36	EPAS1	6	pull down, affinity chromatography technology, affinity chromatography technology	Kung AL (2004), Steunou AL (2012), Chen R (2012)	3
TFEC	0	TFE3	4	pull down	Chung MC (2001)	1
CDK2	0	UBE2I	0	affinity chromatography technology	Neganova I (2011)	1
CDK2	0	MITF	3	genetic interference	Du J (2004)	1
TRIM25	5	XPO1	8	affinity chromatography technology	Choudhury NR (2017)	1
MITF	3	FOS	0	affinity chromatography technology	Sato M (1999)	1
SUMO1	0	PIAS1	4	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, pull down	Lee BH (2003), Kahyo T (2001), Stehmeier P (2009), Stehmeier P (2009), Stehmeier P (2009), Ullmann R (2012), Ullmann R (2012), Hecker CM (2006), Hecker CM (2006), Gocke CB (2008), Ullmann R (2012), Ledsaak M (2016)	12
EP300	36	PIAS3	2	affinity chromatography technology	Long J (2004)	1
MITF	3	APP	1	pull down	Olah J (2011)	1
SUMO1	0	PIAS3	2	two hybrid, two hybrid, pull down	Stehmeier P (2009), Hecker CM (2006), Hecker CM (2006)	3
PAX6	3	SUMO1	0	pull down	Yan Q (2010)	1
UCHL1	1	MITF	3	affinity chromatography technology	Seo EY (2017)	1
SUMO1	0	MITF	3	affinity chromatography technology	Murakami H (2005)	1
LEF1	3	EP300	36	enzymatic study, affinity chromatography technology, pull down	Hecht A (2003), Hecht A (2003), Hecht A (2003)	3
TFEB	6	TFE3	4	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
EP300	36	MITF	3	affinity chromatography technology	Price ER (1998)	1
MITF	3	PIAS1	4	pull down	Murakami H (2005)	1
TFEB	6	TFEC	0	affinity chromatography technology	Huttlin EL (2017)	1
FBXO7	1	MARK3	2	enzymatic study	Teixeira FR (2016)	1
MITF	3	HINT1	0	two hybrid, affinity chromatography technology	Genovese G (2012), Genovese G (2012)	2
UBE2I	0	PIAS2	2	two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down	Rual JF (2005), Lee BH (2003), Bandyopadhyay S (2010), Schmidt D (2002), Wang J (2011), Rolland T (2014), Saul VV (2014), van den Akker E (2005), Schmidt D (2002)	9
EPAS1	6	STUB1	4	affinity chromatography technology	Luo W (2010)	1
SPI1	1	FOS	0	pull down	Carrere S (1998)	1
UCHL1	1	UBE2I	0	two hybrid	Caballero OL (2002)	1
EBP	1	APP	1	pull down	Olah J (2011)	1
LEF1	3	HINT1	0	affinity chromatography technology	Weiske J (2005)	1
HK3	3	MITF	3	two hybrid	Wang J (2011)	1
MITF	3	KLHL20	2	affinity chromatography technology	Huttlin EL (2017)	1
CDK2	0	UCHL1	1	affinity chromatography technology	Neganova I (2011)	1
ELAVL1	0	EPAS1	6	affinity chromatography technology	Abdelmohsen K (2009)	1
MITF	3	PSMD14	3	two hybrid, affinity chromatography technology	Schwarz T (2010), Schwarz T (2010)	2
TFEB	6	MITF	3	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
MITF	3	LEF1	3	two hybrid, affinity chromatography technology, pull down, pull down	Yasumoto K (2002), Yasumoto K (2002), Yasumoto K (2002), Saito H (2002)	4
EP300	36	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Felzien LK (1999), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
MITF	3	UBE2I	0	two hybrid, pull down, pull down	Xu W (2000), Xu W (2000), Murakami H (2005)	3
EPAS1	6	XPO1	8	affinity chromatography technology	Steunou AL (2012)	1
TRIM25	5	EPAS1	6	affinity chromatography technology	Choudhury NR (2017)	1
EPAS1	6	KLHL20	2	two hybrid, two hybrid, affinity chromatography technology	Higashimura Y (2011), Higashimura Y (2011), Higashimura Y (2011)	3
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
UBE2I	0	PIAS1	4	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Lee BH (2003), Sapetschnig A (2002), Kahyo T (2001), Bandyopadhyay S (2010), Driscoll JJ (2010), Kahyo T (2001), Yin Y (2012), Gocke CB (2005), van den Akker E (2005), Ogawa H (2009), Schmidt D (2002), Gibbs-Seymour I (2015)	12