PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CAND1	2	UBC	7	affinity chromatography technology	Bennett EJ (2010)	1
BRCA1	7	CAND1	2	affinity chromatography technology	Ertych N (2016)	1
ESR1	0	MKI67	7	affinity chromatography technology	Tarallo R (2011)	1
SIRT7	1	G3BP1	4	affinity chromatography technology	Tsai YC (2012)	1
CDK1	0	MKI67	7	enzymatic study	MacCallum DE (1999)	1
MCM2	3	CBX3	1	affinity chromatography technology	Drissi R (2015)	1
SIRT7	1	PPP1CA	3	affinity chromatography technology	Tsai YC (2012)	1
CAND1	2	G3BP1	4	affinity chromatography technology	Bennett EJ (2010)	1
OBSL1	9	MCM2	3	affinity chromatography technology	Hanson D (2014)	1
OBSL1	9	SYNCRIP	6	affinity chromatography technology	Hanson D (2014)	1
MKI67	7	KIAA0368	0	two hybrid	Gorbea C (2010)	1
MCM2	3	RACK1	2	affinity chromatography technology	Drissi R (2015)	1
IFI16	1	CDK1	0	affinity chromatography technology	Diner BA (2015)	1
CUL7	4	CBX3	1	affinity chromatography technology	Hanson D (2014)	1
MRPL35	1	MKI67	7	affinity chromatography technology	Huttlin EL (2017)	1
CUL7	4	NPM1	0	affinity chromatography technology	Hanson D (2014)	1
RACK1	2	MKI67	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	RPL10	3	affinity chromatography technology	Ertych N (2016)	1
CUL7	4	PPIB	1	affinity chromatography technology	Hanson D (2014)	1
MCM2	3	NPM1	0	affinity chromatography technology	Drissi R (2015)	1
NPM1	0	MKI67	7	affinity chromatography technology	Hein MY (2015)	1
CAND1	2	RPL10	3	affinity chromatography technology	Bennett EJ (2010)	1
RPL10	3	G3BP1	4	affinity chromatography technology	Hein MY (2015)	1
MDC1	8	MKI67	7	affinity chromatography technology	Woods NT (2012)	1
CUL7	4	TOP1	1	affinity chromatography technology	Hanson D (2014)	1
LMNA	2	NOP56	0	affinity chromatography technology	Depreux FF (2015)	1
TSSK1B	0	MKI67	7	affinity chromatography technology	Huttlin EL (2017)	1
CCDC8	1	LMNA	2	affinity chromatography technology	Hanson D (2014)	1
BRCA1	7	LMNA	2	affinity chromatography technology	Ertych N (2016)	1
RNF168	0	KIAA0368	0	two hybrid	Gorbea C (2010)	1
SUMO2	0	MKI67	7	pull down	Ouyang J (2009)	1
PPP1CC	2	ESR1	0	affinity chromatography technology	Flores-Delgado G (2007)	1
PPP1CC	2	MKI67	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017), Yadav L (2017)	5
BRCA1	7	CDK1	0	pull down	Wang H (1997)	1
TK1	0	MKI67	7	two hybrid	Vinayagam A (2011)	1
UBC	7	NPM1	0	affinity chromatography technology, pull down	Matsumoto M (2005), Koike A (2010)	2
G3BP1	4	CDK1	0	affinity chromatography technology	Jain S (2016)	1
CBR3	4	MKI67	7	affinity chromatography technology	Hein MY (2015)	1
CAND1	2	SYNCRIP	6	affinity chromatography technology	Bennett EJ (2010)	1
BRCA1	7	MKI67	7	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
CCDC8	1	NOP56	0	affinity chromatography technology	Hanson D (2014)	1
PPP1CA	3	CDK1	0	affinity chromatography technology	Flores-Delgado G (2007)	1
TOP1	1	NPM1	0	affinity chromatography technology	Czubaty A (2005)	1
PPP1R3A	2	MKI67	7	affinity chromatography technology	Hauri S (2013)	1
SMN1	0	MKI67	7	two hybrid	Vinayagam A (2011)	1
G3BP1	4	LMNA	2	affinity chromatography technology	Jain S (2016)	1
OBSL1	9	PPP1CA	3	affinity chromatography technology	Hanson D (2014)	1
ESR1	0	TOP1	1	affinity chromatography technology	Tarallo R (2011)	1
OBSL1	9	TOP1	1	affinity chromatography technology	Hanson D (2014)	1
SIRT7	1	TOP1	1	affinity chromatography technology	Tsai YC (2012)	1
NPM1	0	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Sato K (2004), Ertych N (2016)	2
ABI1	1	MKI67	7	affinity chromatography technology	Hein MY (2015)	1
RACK1	2	SYNCRIP	6	biochemical	Kristensen AR (2012)	1
OBSL1	9	CDK1	0	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Hanson D (2014)	2
HDAC9	7	TOP1	1	affinity chromatography technology	Joshi P (2013)	1
OBSL1	9	CBX3	1	affinity chromatography technology	Hanson D (2014)	1
OBSL1	9	UBC	7	affinity chromatography technology	Hanson D (2014)	1
CUL7	4	RACK1	2	affinity chromatography technology	Hanson D (2014)	1
UBC	7	MKI67	7	affinity chromatography technology	Matsumoto M (2005)	1
DAXX	5	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
TOP1	1	MKI67	7	affinity chromatography technology	Czubaty A (2005)	1
SMN1	0	EZH2	4	two hybrid	Vinayagam A (2011)	1
EZH2	4	RACK1	2	affinity chromatography technology	Cao Q (2014)	1
CUL7	4	NOP56	0	affinity chromatography technology	Hanson D (2014)	1
CUL7	4	SYNCRIP	6	affinity chromatography technology	Hanson D (2014)	1
PASK	7	MKI67	7	affinity chromatography technology	Li S (2014)	1
CCDC8	1	UBC	7	affinity chromatography technology	Hanson D (2014)	1
TK1	0	EZH2	4	two hybrid	Vinayagam A (2011)	1
UBC	7	G3BP1	4	affinity chromatography technology	Matsumoto M (2005)	1
LMNA	2	TOP1	1	affinity chromatography technology	Depreux FF (2015)	1
DAXX	5	MKI67	7	affinity chromatography technology	Hein MY (2015)	1
MKI67	7	KIF15	4	two hybrid, affinity chromatography technology	Sueishi M (2000), Sueishi M (2000)	2
SIRT7	1	CBX3	1	affinity chromatography technology	Tsai YC (2012)	1
CDK1	0	EZH2	4	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Chen S (2010), Avdic V (2011), Avdic V (2011), Avdic V (2011), Wei Y (2011), Wei Y (2011), Kaneko S (2010), Wan J (2015), Li Z (2017)	9
SIRT7	1	MKI67	7	affinity chromatography technology	Tsai YC (2012)	1
UBC	7	NOP56	0	affinity chromatography technology	Matsumoto M (2005)	1
SIRT7	1	KIAA0368	0	affinity chromatography technology	Tsai YC (2012)	1
ESR1	0	EZH2	4	pull down, affinity chromatography technology, affinity chromatography technology	Shi B (2007), Shi B (2007), Shi B (2007)	3
SIRT7	1	CUL7	4	affinity chromatography technology	Tsai YC (2012)	1
SLC33A1	1	KIAA0368	0	affinity chromatography technology	Hein MY (2015)	1
MCM2	3	G3BP1	4	affinity chromatography technology	Drissi R (2015)	1
MDC1	8	CBX3	1	affinity chromatography technology	Woods NT (2012)	1
CCDC8	1	CDK1	0	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Hanson D (2014)	2
OBSL1	9	MDC1	8	affinity chromatography technology	Hanson D (2014)	1
SYNCRIP	6	RPL10	3	biochemical	Havugimana PC (2012)	1
OBSL1	9	NPM1	0	affinity chromatography technology	Hanson D (2014)	1
NPM1	0	PPP1CC	2	affinity chromatography technology	Chen R (2013)	1
HINFP	0	MKI67	7	two hybrid, pull down	Miele A (2007), Miele A (2007)	2
ESR1	0	PPIB	1	pull down	Nalvarte I (2010)	1
HBP1	1	MKI67	7	affinity chromatography technology	Lampert F (2018)	1
PPP1CA	3	MKI67	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017)	3
NOP56	0	RPL10	3	affinity chromatography technology	Hayano T (2003)	1
RPL10	3	PPP1CC	2	affinity chromatography technology	Hein MY (2015)	1
DAXX	5	SUMO2	0	x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, two hybrid	Escobar-Cabrera E (2011), Escobar-Cabrera E (2011), Chen A (2006), Chen A (2006), Ullmann R (2012), Ullmann R (2012), Lin DY (2006), Ouyang J (2009), Li C (2017)	9
CUL7	4	UBC	7	affinity chromatography technology	Hanson D (2014)	1
CUL7	4	PPP1CA	3	affinity chromatography technology	Hanson D (2014)	1
NPM1	0	G3BP1	4	affinity chromatography technology	Hein MY (2015)	1
SYNCRIP	6	MKI67	7	affinity chromatography technology	Hein MY (2015)	1
UBC	7	CBR3	4	pull down	Nathan JA (2013)	1
NOP56	0	NPM1	0	affinity chromatography technology, affinity chromatography technology	Hayano T (2003), Hein MY (2015)	2
ESR1	0	G3BP1	4	affinity chromatography technology	Tarallo R (2011)	1
BRCA1	7	MCM2	3	affinity chromatography technology	Ertych N (2016)	1
SLC33A1	1	MKI67	7	affinity chromatography technology	Hein MY (2015)	1
CUL7	4	MDC1	8	affinity chromatography technology	Hanson D (2014)	1
MDC1	8	PPP1CA	3	affinity chromatography technology	Woods NT (2012)	1
SMN1	0	NOP56	0	affinity chromatography technology	Fuller HR (2010)	1
ESR1	0	HDAC9	7	pull down	van Rooij E (2010)	1
BRCA1	7	CBX3	1	affinity chromatography technology, pull down	Hill SJ (2014), Wu W (2015)	2
RPL10	3	RACK1	2	affinity chromatography technology	Hein MY (2015)	1
NOP56	0	TOP1	1	affinity chromatography technology	Hayano T (2003)	1
MDC1	8	SMN1	0	affinity chromatography technology	Woods NT (2012)	1
PPP1R3A	2	BRCA1	7	affinity chromatography technology	Winter SL (2007)	1
NOP56	0	MKI67	7	affinity chromatography technology	Hein MY (2015)	1
PPP1CA	3	BRCA1	7	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Winter SL (2007), Liu Y (2002), Liu Y (2002), Liu Y (2002), Liu Y (2002), Woods NT (2012), Chen BY (2014)	7
OBSL1	9	MKI67	7	affinity chromatography technology	Hanson D (2014)	1
UBC	7	SYNCRIP	6	affinity chromatography technology	Matsumoto M (2005)	1
CAND1	2	NOP56	0	affinity chromatography technology	Bennett EJ (2010)	1
MCM2	3	SYNCRIP	6	affinity chromatography technology	Drissi R (2015)	1
PPP1R3A	2	PPP1CA	3	affinity chromatography technology	Hauri S (2013)	1
LMNA	2	NPM1	0	affinity chromatography technology	Depreux FF (2015)	1
FOXP4	3	MKI67	7	biochemical	Havugimana PC (2012)	1
SYNCRIP	6	PPP1CA	3	biochemical	Havugimana PC (2012)	1
LMNA	2	MKI67	7	bioid	Roux KJ (2012)	1
SIRT7	1	NPM1	0	affinity chromatography technology	Tsai YC (2012)	1
ESR1	0	NPM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Ambrosino C (2010), Ambrosino C (2010), Tarallo R (2011), Nalvarte I (2010)	4
IFI16	1	CBX3	1	affinity chromatography technology	Diner BA (2015)	1
NPM1	0	RPL10	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen R (2013), Hein MY (2015), Hein MY (2015)	3
SIRT7	1	LMNA	2	affinity chromatography technology	Tsai YC (2012)	1
HDAC9	7	MKI67	7	affinity chromatography technology	Joshi P (2013)	1
OBSL1	9	NOP56	0	affinity chromatography technology	Hanson D (2014)	1
CAND1	2	MKI67	7	affinity chromatography technology	Bennett EJ (2010)	1
PPP1CC	2	CDK1	0	affinity chromatography technology	Flores-Delgado G (2007)	1
PPP1CC	2	LMNA	2	affinity chromatography technology, affinity chromatography technology	Cid C (2007), Depreux FF (2015)	2
RNF168	0	MKI67	7	affinity chromatography technology	Guturi KK (2016)	1
RPL10	3	MKI67	7	affinity chromatography technology	Hein MY (2015)	1
RPL10	3	IFI16	1	affinity chromatography technology	Hein MY (2015)	1
SIRT7	1	RPL10	3	affinity chromatography technology	Tsai YC (2012)	1
MKI67	7	PPIB	1	biochemical	Wan C (2015)	1
MCM2	3	UBC	7	affinity chromatography technology	Drissi R (2015)	1
G3BP1	4	SYNCRIP	6	affinity chromatography technology	Jain S (2016)	1
CUL7	4	MKI67	7	affinity chromatography technology	Hanson D (2014)	1
BRCA1	7	KIAA0368	0	affinity chromatography technology	Ertych N (2016)	1
ESR1	0	NOP56	0	affinity chromatography technology	Tarallo R (2011)	1
CAND1	2	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
SMN1	0	RPL10	3	affinity chromatography technology	Fuller HR (2010)	1
SIRT7	1	SYNCRIP	6	affinity chromatography technology	Tsai YC (2012)	1
MCM2	3	RPL10	3	affinity chromatography technology	Drissi R (2015)	1
MKI67	7	CBX3	1	two hybrid, pull down	Kametaka A (2002), Kametaka A (2002)	2
SUMO2	0	MDC1	8	pull down	Ouyang J (2009)	1
CCDC8	1	NPM1	0	affinity chromatography technology	Hanson D (2014)	1
CUL7	4	RPL10	3	affinity chromatography technology	Hanson D (2014)	1
MECP2	36	MKI67	7	affinity chromatography technology	Huttlin EL (2017)	1
CCDC8	1	MKI67	7	affinity chromatography technology	Hanson D (2014)	1
BRCA1	7	TOP1	1	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Shen JP (2017), Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017)	7
G3BP1	4	MKI67	7	affinity chromatography technology	Jain S (2016)	1
ESR1	0	PPP1CA	3	affinity chromatography technology, pull down	Tarallo R (2011), Nalvarte I (2010)	2
PPP1CC	2	PPP1CA	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017), Yadav L (2017)	8
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
CCDC8	1	SYNCRIP	6	affinity chromatography technology	Hanson D (2014)	1
PASK	7	OBSL1	9	affinity chromatography technology	Li S (2014)	1
MCM2	3	PPIB	1	affinity chromatography technology	Drissi R (2015)	1
SMN1	0	NPM1	0	affinity chromatography technology	Fuller HR (2010)	1
ESR1	0	RPL10	3	affinity chromatography technology	Tarallo R (2011)	1
UBC	7	SUMO2	0	affinity chromatography technology	Sahin U (2014)	1
SIRT7	1	RACK1	2	affinity chromatography technology	Tsai YC (2012)	1
MECP2	36	CBX3	1	affinity chromatography technology	Gonzales ML (2012)	1
HBP1	1	SMN1	0	affinity chromatography technology	Lampert F (2018)	1
EZH2	4	MKI67	7	affinity chromatography technology	Hein MY (2015)	1
CCDC8	1	CAND1	2	affinity chromatography technology	Hanson D (2014)	1
OBSL1	9	CCDC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hanson D (2011), Hanson D (2011), Hanson D (2014), Nie J (2015)	4
HINFP	0	MDC1	8	two hybrid	Miele A (2007)	1
RNF168	0	SUMO2	0	affinity chromatography technology, pull down	Shire K (2016), Shire K (2016)	2
BRCA1	7	NOP56	0	affinity chromatography technology	Ertych N (2016)	1
CAND1	2	RACK1	2	affinity chromatography technology	Bennett EJ (2010)	1
BRCA1	7	IFI16	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Aglipay JA (2003), Dutta D (2015), Dutta D (2015), Dutta D (2015)	4
MDC1	8	RACK1	2	affinity chromatography technology	Woods NT (2012)	1
CCDC8	1	G3BP1	4	affinity chromatography technology	Hanson D (2014)	1
BRCA1	7	ESR1	0	imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Zheng L (2001), Fan S (2001), Fan S (2001), Kawai H (2002), Fan S (2002), Fan S (2002), Nakuci E (2006), Wang C (2005), Wang C (2005), Dizin E (2010), Dizin E (2010), Ma Y (2010), Ma Y (2010), Fan S (2001), Ma YX (2005), Ma YX (2005), Ma YX (2005), Ma Y (2007), Ma Y (2007), Kawai H (2002), Jung YS (2014), Kawai H (2002), Kawai H (2002)	23
BRCA1	7	SYNCRIP	6	affinity chromatography technology	Ertych N (2016)	1
SUMO2	0	BRCA1	7	affinity chromatography technology	Hu X (2012)	1
MCM2	3	MKI67	7	affinity chromatography technology	Drissi R (2015)	1
NPM1	0	RACK1	2	affinity chromatography technology	Hein MY (2015)	1
CAND1	2	MCM2	3	affinity chromatography technology	Bennett EJ (2010)	1
OBSL1	9	LMNA	2	affinity chromatography technology	Hanson D (2014)	1
SIRT7	1	PPP1CC	2	affinity chromatography technology	Tsai YC (2012)	1
HBP1	1	SYNCRIP	6	affinity chromatography technology	Lampert F (2018)	1
ESR1	0	RACK1	2	pull down	Nalvarte I (2010)	1
IFI16	1	MKI67	7	affinity chromatography technology	Diner BA (2015)	1
BRCA1	7	RACK1	2	affinity chromatography technology, affinity chromatography technology	Woods NT (2012), Ertych N (2016)	2
SIRT7	1	MDC1	8	affinity chromatography technology	Tsai YC (2012)	1
CAND1	2	TOP1	1	affinity chromatography technology	Bennett EJ (2010)	1
LTBR	0	MKI67	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL7	4	LMNA	2	affinity chromatography technology	Hanson D (2014)	1
CCDC8	1	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Nie J (2015), Nie J (2015)	3
CCDC8	1	MCM2	3	affinity chromatography technology	Hanson D (2014)	1
OBSL1	9	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litterman N (2011), Litterman N (2011), Hanson D (2011), Hanson D (2011), Nie J (2015)	5
EZH2	4	BRCA1	7	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Wang L (2013), Wang L (2013), Wang L (2013), Wang L (2013), Gong C (2015)	5
CUL7	4	CDK1	0	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Hanson D (2014)	2
LMNA	2	MDC1	8	bioid	Roux KJ (2012)	1
SMC6	3	MKI67	7	affinity chromatography technology	Hein MY (2015)	1
OBSL1	9	RACK1	2	affinity chromatography technology	Hanson D (2014)	1
MCM2	3	LMNA	2	affinity chromatography technology	Drissi R (2015)	1
MDC1	8	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, imaging technique, imaging technique	Matsuoka S (2007), Strauss C (2011), Strauss C (2011), Stewart GS (2003), Lou Z (2003), Mok MT (2010), Au WW (2005)	7
ESR1	0	HBP1	1	two hybrid	Arroyo R (2015)	1
RNF168	0	UBC	7	pull down, pull down, pull down, pull down, pull down	Panier S (2012), Feng L (2012), Thorslund T (2015), Luijsterburg MS (2017), Luijsterburg MS (2017)	5
ESR1	0	SYNCRIP	6	affinity chromatography technology, pull down, affinity chromatography technology	Tarallo R (2011), Nalvarte I (2010), Han SJ (2016)	3
OBSL1	9	PPIB	1	affinity chromatography technology	Hanson D (2014)	1