PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
VDR	2	CREBBP	29	imaging technique, pull down	Saramaeki A (2006), Jimenez-Lara AM (1999)	2
NLK	1	MDM2	2	affinity chromatography technology	Zhang HH (2014)	1
FOXO1	2	FOXO4	0	affinity chromatography technology	Li X (2015)	1
AKT1	1	FOXO1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Matsuzaki H (2005), Brent MM (2008), Rena G (1999), Tang ED (1999), Chen TC (2014)	5
ESR1	0	FOXO1	2	two hybrid, pull down, two hybrid, pull down, affinity chromatography technology	Schuur ER (2001), Schuur ER (2001), Zhao HH (2001), Zhao HH (2001), Castoria G (2012)	5
100132074	0	FOXO1	2	affinity chromatography technology	Li X (2015)	1
PIN1	0	SMAD3	1	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, two hybrid	Nakano A (2009), Nakano A (2009), Nakano A (2009), Aragon E (2011), Matsuura I (2010), Matsuura I (2010), Wang J (2011)	7
SFN	1	FOXO4	0	two hybrid	Rolland T (2014)	1
MDM2	2	SIRT1	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Nihira NT (2017), Nihira NT (2017), Nihira NT (2017)	3
ESR1	0	SFN	1	affinity chromatography technology	Tarallo R (2011)	1
SFN	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Yang HY (2007), Yang HY (2007), Yang HY (2007), Wood NT (2009)	4
AKT1	1	CREBBP	29	pull down, enzymatic study	Drendall CI (2010), Drendall CI (2010)	2
CTNNB1	30	SIRT1	3	affinity chromatography technology	Holloway KR (2010)	1
CTNNB1	30	CREBBP	29	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ma H (2005), Sustmann C (2008), Taurin S (2006), Zhao Y (2016), Benoit YD (2017)	5
AKT1	1	SFN	1	affinity chromatography technology, affinity chromatography technology	Calvo N (2010), Calvo N (2010)	2
XPO1	8	FOXO1	2	affinity chromatography technology	Kirli K (2015)	1
CREBBP	29	NLK	1	affinity chromatography technology, enzymatic study	Kurahashi T (2005), Yasuda J (2004)	2
AKT1	1	ESR1	0	enzymatic study	Campbell RA (2001)	1
REL	5	CREBBP	29	pull down, affinity chromatography technology	Garbati MR (2010), Garbati MR (2010)	2
SMAD4	9	FOXO1	2	affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Seoane J (2004)	2
OGT	4	USP7	14	affinity chromatography technology, affinity chromatography technology	Ding X (2015), Ding X (2015)	2
SMAD4	9	AKT1	1	affinity chromatography technology	Song K (2006)	1
CREBBP	29	MDM2	2	affinity chromatography technology, enzymatic study, affinity chromatography technology	Inoue Y (2011), Wang X (2004), Sanchez M (2012)	3
ESR1	0	CREBBP	29	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Sheppard HM (2001), Fan S (2002), Fan S (2002), Fan S (2002), Jin W (2008), Jaber BM (2004), Jaber BM (2004), Heery DM (1997), Ku TK (2007), Crowe DL (2006)	10
NLK	1	SMAD4	9	two hybrid, affinity chromatography technology	Wang J (2011), Varjosalo M (2013)	2
AKT1	1	CTNNB1	30	enzymatic study, enzymatic study	Tian Q (2004), Fang D (2007)	2
XPO1	8	CTNNB1	30	affinity chromatography technology	Kirli K (2015)	1
SMAD3	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tian YC (2002), Dahle O (2010), Charbonney E (2011), Zhou B (2012)	4
SMAD3	1	USP7	14	affinity chromatography technology, two hybrid	Brown KA (2008), Wang J (2011)	2
FOXO4	0	AKT1	1	affinity chromatography technology, pull down, enzymatic study	Yang H (2005), Yang H (2005), Matsuzaki H (2005)	3
SFN	1	CTNNB1	30	affinity chromatography technology	Mancini M (2015)	1
NLK	1	CTNNB1	30	affinity chromatography technology	Ishitani T (2003)	1
VDR	2	MDM2	2	affinity chromatography technology, affinity chromatography technology	Heyne K (2015), Heyne K (2015)	2
FOXO4	0	USP7	14	affinity chromatography technology, affinity chromatography technology	van der Horst A (2006), Szypowska AA (2011)	2
CTNNB1	30	ESR1	0	affinity chromatography technology	Kouzmenko AP (2004)	1
ESR1	0	FOXO4	0	pull down	Schuur ER (2001)	1
PIN1	0	FOXO4	0	pull down, affinity chromatography technology	Brenkman AB (2008), Brenkman AB (2008)	2
FOXO1	2	SIRT1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kitamura YI (2005), Bastien-Dionne PO (2011), Yang Y (2005), Yang Y (2005)	4
VDR	2	FOXO4	0	affinity chromatography technology	An BS (2010)	1
XPO1	8	ESR1	0	affinity chromatography technology	Castoria G (2012)	1
NLK	1	FOXO4	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Szypowska AA (2011), Szypowska AA (2011), Szypowska AA (2011)	3
SMAD3	1	FOXO1	2	affinity chromatography technology	Seoane J (2004)	1
SFN	1	FOXO1	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
USP7	14	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, unspecified method, biochemical, x-ray crystallography, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lu X (2007), Becker K (2007), Pereg Y (2006), Hu M (2006), Hu M (2006), Hu M (2006), Hu M (2006), Sarkari F (2010), Sarkari F (2010), Tang J (2006), Tang J (2006), Ma J (2010), Song MS (2008), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Ye M (2015), Lim KH (2015), Reddy BA (2014), Rouge L (2016), Nihira NT (2017), Nihira NT (2017), Mungamuri SK (2016), Mungamuri SK (2016), Sun Y (2017)	25
OGT	4	FOXO4	0	affinity chromatography technology	Ho SR (2010)	1
FOXO4	0	XPO1	8	pull down	Brownawell AM (2001)	1
SMAD3	1	FOXO4	0	affinity chromatography technology	Seoane J (2004)	1
CREBBP	29	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kang JS (2005), Alliston T (2005), Xi Q (2008), Cui Q (2005), Cui Q (2005), Chen W (2007), Nishihara A (1999), Tomita M (2004), Oussaief L (2009), Oussaief L (2009), Cui Q (2005)	11
VDR	2	SIRT1	3	affinity chromatography technology, pull down	An BS (2010), An BS (2010)	2
MDM2	2	AKT1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique	Lin HK (2002), Ogawara Y (2002), Zhou BP (2001), Zhou BP (2001), Kim CK (2011), Kim CK (2011), Zhu QS (2011), Milne D (2004), Deep G (2008), Deep G (2008), Chen TC (2014)	11
CTNNB1	30	PIN1	0	pull down	Ryo A (2001)	1
MDM2	2	FOXO4	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Brenkman AB (2008), Brenkman AB (2008), Brenkman AB (2008), Szypowska AA (2011), Szypowska AA (2011), Oteiza A (2011)	6
SMAD4	9	CTNNB1	30	affinity chromatography technology	Tian YC (2002)	1
NLK	1	FOXO1	2	affinity chromatography technology	Szypowska AA (2011)	1
FOXO4	0	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Essers MA (2005), Szypowska AA (2011)	2
SMAD4	9	CREBBP	29	affinity chromatography technology	Yang Y (2015)	1
MDM2	2	XPO1	8	affinity chromatography technology	Jacob AG (2014)	1
FOXO1	2	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Fu W (2009), Fu W (2009), Fu W (2009), Fu W (2009), Jang H (2016)	5
VDR	2	SMAD3	1	two hybrid, pull down, two hybrid, pull down	Yanagisawa J (1999), Yanagisawa J (1999), Yanagisawa J (1999), Yanagisawa J (1999)	4
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
CREBBP	29	FOXO4	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nasrin N (2000), van der Horst A (2004), van der Horst A (2004), Szypowska AA (2011)	4
FOXO4	0	SIRT1	3	affinity chromatography technology	van der Horst A (2004)	1
SIRT1	3	ESR1	0	affinity chromatography technology	Elangovan S (2011)	1
XPO1	8	REL	5	affinity chromatography technology	Kirli K (2015)	1
FOXO4	0	FEN1	1	affinity chromatography technology	Li X (2015)	1
CTNNB1	30	USP7	14	affinity chromatography technology, affinity chromatography technology, enzymatic study, unspecified method	Novellasdemunt L (2017), Novellasdemunt L (2017), Novellasdemunt L (2017), Novellasdemunt L (2017)	4
FOXO4	0	ATXN3	2	affinity chromatography technology, affinity chromatography technology, imaging technique	Araujo J (2011), Araujo J (2011), Araujo J (2011)	3
ESR1	0	MDM2	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down	Liu G (2000), Kinyamu HK (2003), Duong V (2007), Duong V (2007), Duong V (2007), Duong V (2007), Saji S (2001), Saji S (2001)	8
SMAD4	9	FOXO4	0	affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Seoane J (2004)	2
ATXN3	2	CREBBP	29	pull down, affinity chromatography technology, affinity chromatography technology	Li F (2002), Li F (2002), Li Y (2007)	3
100132074	0	FOXO4	0	affinity chromatography technology	Li X (2015)	1
SIRT1	3	AKT1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Sundaresan NR (2011), Sundaresan NR (2011), Sundaresan NR (2011)	3
XPO1	8	SMAD4	9	affinity chromatography technology	Kirli K (2015)	1
SMAD3	1	AKT1	1	affinity chromatography technology, imaging technique	Song K (2006), Chen TC (2014)	2
SMAD3	1	ESR1	0	affinity chromatography technology	Ito I (2010)	1
FOXO1	2	CREBBP	29	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nasrin N (2000), Nasrin N (2000), Kitamura YI (2005), Daitoku H (2004), Daitoku H (2004), Daitoku H (2004), Daitoku H (2004), Pramanik KC (2014), Pramanik KC (2014), Li X (2015)	10
FOXO4	0	REL	5	two hybrid	Rolland T (2014)	1