PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SIN3A	13	MNT	2	two hybrid, pull down	Meroni G (1997), Meroni G (1997)	2
MXD3	1	MAX	0	two hybrid, two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Billin AN (1999), Gupta K (1998), Meroni G (1997), FitzGerald MJ (1999), Meroni G (2000), Huttlin EL (2017), Cheng J (2017), Hauri S (2016)	8
MAD1L1	2	HDAC1	4	affinity chromatography technology, biochemical	Yoon YM (2004), Yoon YM (2004)	2
MXD3	1	MNT	2	affinity chromatography technology	Huttlin EL (2017)	1
MNT	2	MAX	0	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meroni G (1997), Meroni G (1997), Matsuoka Y (2008), Kim J (2010), Li X (2015), Cheng J (2017), Hauri S (2016)	7
MNT	2	MNT	2	pull down, two hybrid	Meroni G (1997), Meroni G (2000)	2
HDAC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Yao YL (2003), Fleischer TC (2003), Fleischer TC (2003), Yang L (2003), Grozinger CM (1999), Zhang J (2002), Zhang J (2002), You A (2001), Zhang Y (1999), Zhang Y (2002), Tong JK (1998), Hassig CA (1998), Yasui D (2002), Huang EY (2000), Huang EY (2000), Kuzmichev A (2002), Kuzmichev A (2002), Martinowich K (2003), Martinowich K (2003), Suzuki M (2003), Suzuki M (2006), Nakamura T (2002), Wei Q (2005), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Skowyra D (2001), Humphrey GW (2001), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Oh YM (2009), Wan C (2015), Hein MY (2015), Hsu DS (2014), Huttlin EL (2017)	45
UBE3A	4	MNT	2	pull down, affinity chromatography technology, affinity chromatography technology	Kapoor I (2015), Kapoor I (2015), Kapoor I (2015)	3
CEBPA	0	UBE3A	4	affinity chromatography technology, pull down, affinity chromatography technology	Pal P (2013), Pal P (2013), Pal P (2013)	3
MNT	2	MLX	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Cairo S (2001), Meroni G (2000), Meroni G (2000), Meroni G (2000), Meroni G (2000)	5
MXD1	2	MLX	0	two hybrid, two hybrid	Cairo S (2001), Meroni G (2000)	2
CEBPA	0	MAX	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Zada AA (2006), Zada AA (2006), Zada AA (2006), Zada AA (2006), Zada AA (2006)	5
MNT	2	MAD1L1	2	affinity chromatography technology	Matsuoka Y (2008)	1
MAX	0	SIN3A	13	affinity chromatography technology, affinity chromatography technology	Li X (2015), Cheng J (2017)	2
SIN3A	13	MXD3	1	two hybrid, affinity chromatography technology	Meroni G (1997), Huttlin EL (2017)	2
MNT	2	MYC	2	affinity chromatography technology, affinity chromatography technology	Matsuoka Y (2008), Matsuoka Y (2008)	2
MXD1	2	MNT	2	affinity chromatography technology	Cheng J (2017)	1
FOXK2	9	MNT	2	affinity chromatography technology	Li X (2015)	1
FOXK2	9	SIN3A	13	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Li X (2015), Ji Z (2014), Ji Z (2014), Shan L (2016), Shan L (2016), Shan L (2016), Shan L (2016)	7
MAD1L1	2	SIN3A	13	pull down	Icardi L (2012)	1
SOX4	5	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SOX4	5	MNT	2	two hybrid	Jang SM (2015)	1
CEBPA	0	HDAC1	4	affinity chromatography technology, biochemical, imaging technique, affinity chromatography technology	Duan H (2005), Matsunaga N (2012), Matsunaga N (2012), Girard N (2013)	4
ELAVL1	0	MYC	2	affinity chromatography technology	Abdelmohsen K (2009)	1
HDAC1	4	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsuoka Y (2008), Matsuoka Y (2008), Liu T (2007), Liu T (2007), Liu T (2007), Koch HB (2007), Hwang IY (2012), Hein MY (2015)	8
MAX	0	MXD1	2	pull down, pull down, two hybrid, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee CM (2002), Ayer DE (1993), Gupta K (1998), Nair SK (2003), Hatakeyama S (2005), Wang Z (2006), Gordan JD (2007), Ayer DE (1993), Naderi S (1999), Huttlin EL (2015), FitzGerald MJ (1999), Huttlin EL (2017), Cheng J (2017), Hauri S (2016)	14
MYC	2	MAX	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, two hybrid, pull down, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), McMahon SB (2000), McMahon SB (1998), Cheng SW (1999), Mac Partlin M (2003), Mac Partlin M (2003), Blackwood EM (1991), Lee CM (2002), Billin AN (1999), Gupta K (1998), Meroni G (1997), Nair SK (2003), Nair SK (2003), FitzGerald MJ (1999), Meroni G (2000), Hatakeyama S (2005), Bandyopadhyay S (2010), Matsuoka Y (2009), Cowling VH (2006), Wang Z (2006), Faiola F (2005), Siegel PM (2003), Veldman T (2003), Patel JH (2004), Liu T (2007), Zhang Y (2007), Gordan JD (2007), Gordan JD (2007), Gargano B (2007), Zippo A (2007), Zippo A (2007), Zhang P (2010), Kim J (2010), Kim J (2010), Kim J (2010), Kim J (2010), Koch HB (2007), Koch HB (2007), Patel JH (2006), Lavigne P (1998), Amente S (2007), Ayer DE (1993), Huang Z (2004), Huang Z (2004), Okano HJ (1999), Agrawal P (2010), Agrawal P (2010), Wong WJ (2013), Wang J (2011), Yu L (2009), Liu X (2003), Hein MY (2015), Li X (2015), Li X (2015), Kalkat M (2014), Hauri S (2016)	56
ELAVL1	0	MNT	2	affinity chromatography technology	Abdelmohsen K (2009)	1
MNT	2	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Matsuoka Y (2008), Matsuoka Y (2008)	2
MXD1	2	MXD3	1	affinity chromatography technology	Cheng J (2017)	1
MYC	2	CEBPA	0	affinity chromatography technology	Tinel M (2003)	1
SIN3A	13	MXD1	2	pull down, x-ray crystallography, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Swanson KA (2004), Swanson KA (2004), Brubaker K (2000), Ayer DE (1995), Farias EF (2010), Huttlin EL (2015), Huttlin EL (2017), Cheng J (2017)	8
MAX	0	FOXK2	9	affinity chromatography technology, affinity chromatography technology	Li X (2015), Li X (2015)	2
CEBPA	0	MNT	2	affinity chromatography technology	Bararia D (2008)	1
ELAVL1	0	CEBPA	0	affinity chromatography technology	Abdelmohsen K (2009)	1
MXD1	2	HDAC1	4	pull down	Spronk CA (2000)	1
FOXK2	9	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Ji Z (2014), Huttlin EL (2017), Shan L (2016), Shan L (2016), Shan L (2016)	5
ELAVL1	0	SOX4	5	affinity chromatography technology	Abdelmohsen K (2009)	1