PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GABARAP	0	WDFY3	17	affinity chromatography technology, pull down, pull down, x-ray crystallography, imaging technique	Lystad AH (2014), Lystad AH (2014), Lystad AH (2014), Lystad AH (2014), Lystad AH (2014)	5
WDR81	5	MAP1LC3C	0	affinity chromatography technology, affinity chromatography technology, pull down	Liu X (2017), Liu X (2017), Liu X (2017)	3
NBR1	0	MAP1LC3C	0	affinity chromatography technology	Kirkin V (2009)	1
WDFY3	17	ATG16L1	1	affinity chromatography technology	Filimonenko M (2010)	1
USP11	3	UBC	7	enzymatic study, pull down, pull down	Faesen AC (2011), Zhang X (2017), Kwasna D (2018)	3
MAP1LC3C	0	ATG16L1	1	affinity chromatography technology	Behrends C (2010)	1
GABARAP	0	ATG13	0	affinity chromatography technology, unspecified method, two hybrid	Alemu EA (2012), Alemu EA (2012), Fujita N (2013)	3
MAP1LC3C	0	USP11	3	affinity chromatography technology	Behrends C (2010)	1
GABARAPL2	0	CUL3	17	affinity chromatography technology, pull down	Behrends C (2010), Genau HM (2015)	2
CUL3	17	SF3A1	1	affinity chromatography technology	Bennett EJ (2010)	1
GABARAPL2	0	ATG3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Ewing RM (2007), Behrends C (2010), Behrends C (2010), Sou YS (2006), Sou YS (2006)	5
MAP1LC3C	0	UBC	7	imaging technique	Liu X (2017)	1
ATG5	0	WDFY3	17	affinity chromatography technology, pull down	Filimonenko M (2010), Filimonenko M (2010)	2
MEFV	3	GABARAP	0	pull down, unspecified method, pull down	Kimura T (2015), Kimura T (2015), Kimura T (2015)	3
RB1CC1	9	ATG5	0	affinity chromatography technology	Gammoh N (2013)	1
OPTN	1	GABARAP	0	pull down	Wild P (2011)	1
ATG5	0	CALCOCO2	0	pull down	Fracchiolla D (2016)	1
ATG3	4	ATG5	0	affinity chromatography technology, pull down, affinity chromatography technology	Behrends C (2010), Qiu Y (2013), Huttlin EL (2017)	3
CALCOCO2	0	RB1CC1	9	two hybrid	Wang J (2011)	1
SQSTM1	0	TAX1BP1	3	affinity chromatography technology	Mildenberger J (2017)	1
SQSTM1	0	NBR1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	DAgostino C (2011), Lange S (2005), Lamark T (2003), Lamark T (2003), Yang JQ (2010), Erdogan E (2006), Yamashita SI (2014), Nicot AS (2014)	8
SQSTM1	0	UBC	7	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, affinity chromatography technology, unspecified method, pull down, pull down, pull down, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, imaging technique, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Vinayagam A (2011), Vadlamudi RK (1996), Tanji K (2012), Matsumoto G (2011), Long J (2008), Long J (2008), Najat D (2009), Najat D (2009), Hocking LJ (2004), Boh BK (2011), Long J (2010), Seibenhener ML (2004), Seibenhener ML (2004), Seibenhener ML (2004), Fenner BJ (2009), Nathan JA (2013), Ciani B (2003), Shi J (2013), Goode A (2014), Bish RA (2007), Lu K (2014), Zhou L (2014), Zhou L (2014), Vadlamudi RK (1996), Long J (2008), Cavey JR (2006), Cavey JR (2006), Kirkin V (2009), Nakayasu ES (2013), Nakayasu ES (2013), Lim J (2015), Milan E (2015), Milan E (2015), Ordureau A (2015), Wurzer B (2015), Zhang X (2017), Wang L (2017), Liu X (2017), Peng H (2017), Donohue E (2014), Nibe Y (2017), Nibe Y (2017), Govindaraju VK (2017)	43
CALCOCO2	0	SQSTM1	0	affinity chromatography technology	Cemma M (2011)	1
ATG16L1	1	ULK1	8	affinity chromatography technology	Gammoh N (2013)	1
ATG3	4	ATG16L1	1	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Huttlin EL (2017)	2
CUL3	17	KBTBD6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Genau HM (2015), Genau HM (2015), Huttlin EL (2017)	5
MAP1LC3C	0	ATG13	0	affinity chromatography technology	Alemu EA (2012)	1
MEFV	3	ULK1	8	affinity chromatography technology, pull down	Kimura T (2015), Kimura T (2015)	2
TRIM21	0	UBC	7	enzymatic study	McEwan WA (2013)	1
NBR1	0	UBC	7	pull down, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down	Waters S (2009), Kirkin V (2009), Walinda E (2014), Walinda E (2014), Nicot AS (2014), Nakayasu ES (2013), Nakayasu ES (2013), Zhang X (2017)	8
GABARAPL2	0	KBTBD7	3	two hybrid, affinity chromatography technology, pull down	Vinayagam A (2011), Genau HM (2015), Genau HM (2015)	3
GABARAP	0	TRIM21	0	pull down	Kimura T (2015)	1
UBC	7	ATG16L1	1	affinity chromatography technology, pull down, pull down	Fujita N (2013), Fujita N (2013), Ver Heul AM (2013)	3
GABARAP	0	TAX1BP1	3	pull down	Newman AC (2012)	1
UBC	7	CALCOCO2	0	pull down, affinity chromatography technology, two hybrid, pull down, x-ray crystallography, pull down, affinity chromatography technology, imaging technique, pull down, imaging technique	Fenner BJ (2009), Fenner BJ (2009), Rolland T (2014), Tumbarello DA (2015), Xie X (2015), Xie X (2015), Xie X (2015), Xie X (2015), Ordureau A (2015), Minowa-Nozawa A (2017)	10
CUL3	17	WDR81	5	affinity chromatography technology	Bennett EJ (2010)	1
KBTBD7	3	KBTBD6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Genau HM (2015), Genau HM (2015), Hein MY (2015), Huttlin EL (2017)	5
PIK3C3	1	USP11	3	affinity chromatography technology	Behrends C (2010)	1
ULK1	8	GABARAPL2	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method	Okazaki N (2000), Okazaki N (2000), Behrends C (2010), Alemu EA (2012), Alemu EA (2012)	5
ATG16L1	1	ATG5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, x-ray crystallography, biochemical, x-ray crystallography, two hybrid, pull down, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Chen D (2012), Chen D (2012), Ravikumar B (2010), Itoh T (2008), Kristensen AR (2012), Gammoh N (2013), Otomo C (2013), Wan C (2015), Kim JH (2014), Kim JH (2014), Kim JH (2014), Zheng Y (2017)	14
MAP1LC3C	0	ATG3	4	affinity chromatography technology	Behrends C (2010)	1
ATG7	2	GABARAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Tanida I (2001), Sou YS (2006), Sou YS (2006), Dunlop EA (2014)	6
CALCOCO2	0	GABARAPL2	0	two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Verlhac P (2015)	3
CUL3	17	ACTA2	1	affinity chromatography technology	Bennett EJ (2010)	1
OPTN	1	MAP1LC3C	0	two hybrid	Tumbarello DA (2015)	1
ATG13	0	RB1CC1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Hosokawa N (2009)	3
ATG16L1	1	ATG13	0	affinity chromatography technology	Gammoh N (2013)	1
ATG3	4	ATG7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Tanida I (2002), Tanida I (2002), Behrends C (2010), Behrends C (2010), Qiu Y (2013), Huttlin EL (2017)	6
UBC	7	LMNB1	1	affinity chromatography technology	Matsumoto M (2005)	1
MAP1LC3C	0	ACTA2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
MAP1LC3C	0	GABARAP	0	affinity chromatography technology	Behrends C (2010)	1
GABARAPL2	0	NBR1	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Behrends C (2010), Kirkin V (2009), Kirkin V (2009)	3
GABARAP	0	GABARAPL2	0	affinity chromatography technology	Behrends C (2010)	1
TRIM21	0	ULK1	8	affinity chromatography technology	Kimura T (2015)	1
UBC	7	ATG13	0	affinity chromatography technology	Matsumoto M (2005)	1
MAP1LC3C	0	PIK3R4	3	affinity chromatography technology	Behrends C (2010)	1
MAP1LC3C	0	KBTBD7	3	pull down	Genau HM (2015)	1
SQSTM1	0	MAP1LC3C	0	affinity chromatography technology	Kirkin V (2009)	1
SQSTM1	0	ULK1	8	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Ro SH (2014), Ro SH (2014), Lim J (2015), Lim J (2015)	4
GABARAP	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Behrends C (2010), Kirkin V (2009), Maruyama Y (2014), Dunlop EA (2014), Wurzer B (2015), Wurzer B (2015)	6
SQSTM1	0	GABARAPL2	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Rual JF (2005), Behrends C (2010), Vinayagam A (2011), Shvets E (2011), Kirkin V (2009), Kirkin V (2009), Maruyama Y (2014), Rolland T (2014), Yu H (2011)	9
GABARAP	0	NBR1	0	affinity chromatography technology, affinity chromatography technology, pull down	Behrends C (2010), Kirkin V (2009), Nicot AS (2014)	3
MAP1LC3C	0	ULK1	8	affinity chromatography technology	Alemu EA (2012)	1
KBTBD6	0	GABARAPL2	0	affinity chromatography technology, pull down	Genau HM (2015), Genau HM (2015)	2
GABARAP	0	LMNB1	1	pull down	Dou Z (2015)	1
ATG7	2	MAP1LC3C	0	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010)	2
UBC	7	TAX1BP1	3	pull down, x-ray crystallography, pull down, pull down	Fenner BJ (2009), Tumbarello DA (2015), Tumbarello DA (2015), Zhang X (2017)	4
ULK1	8	RB1CC1	9	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Rui YN (2015)	2
GABARAPL2	0	WDFY3	17	affinity chromatography technology, pull down	Lystad AH (2014), Lystad AH (2014)	2
SQSTM1	0	CUL3	17	imaging technique, affinity chromatography technology	Lau A (2010), Mori Y (2015)	2
ATG5	0	OPTN	1	pull down, affinity chromatography technology, pull down	Fracchiolla D (2016), Bansal M (2018), Bansal M (2018)	3
PIK3C3	1	PIK3R4	3	affinity chromatography technology, biochemical, pull down	Behrends C (2010), Wan C (2015), Stjepanovic G (2017)	3
ULK1	8	ATG13	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Dunlop EA (2011), Nazio F (2013), Nazio F (2013), Hosokawa N (2009), Li J (2015), Dunlop EA (2014), Rui YN (2015)	7
MAP1LC3C	0	TAX1BP1	3	pull down, two hybrid	Newman AC (2012), Tumbarello DA (2015)	2
MAP1LC3C	0	GABARAPL2	0	affinity chromatography technology	Behrends C (2010)	1
MEFV	3	ATG16L1	1	affinity chromatography technology	Kimura T (2015)	1
ATG3	4	GABARAP	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Sou YS (2006), Sou YS (2006), Huttlin EL (2017)	5
MAP1LC3C	0	CUL3	17	pull down	Genau HM (2015)	1
GABARAPL2	0	TRIM21	0	pull down	Kimura T (2015)	1
OPTN	1	GABARAPL2	0	pull down	Wild P (2011)	1
MAP1LC3C	0	CALCOCO2	0	affinity chromatography technology, pull down, x-ray crystallography, two hybrid, affinity chromatography technology	von Muhlinen N (2012), von Muhlinen N (2012), von Muhlinen N (2012), Tumbarello DA (2015), Verlhac P (2015)	5
MAP1LC3C	0	SF3A1	1	affinity chromatography technology	Behrends C (2010)	1
MAP1LC3C	0	WDFY3	17	affinity chromatography technology, pull down	Lystad AH (2014), Lystad AH (2014)	2
TAX1BP1	3	OPTN	1	affinity chromatography technology, affinity chromatography technology	Journo C (2009), Journo C (2009)	2
GABARAP	0	CUL3	17	pull down	Genau HM (2015)	1
MAP1LC3C	0	RB1CC1	9	affinity chromatography technology	Behrends C (2010)	1
MAP1LC3C	0	TFCP2	1	affinity chromatography technology	Behrends C (2010)	1
ULK1	8	GABARAP	0	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology	Ewing RM (2007), Okazaki N (2000), Okazaki N (2000), Alemu EA (2012), Alemu EA (2012), Dunlop EA (2014)	6
MAP1LC3C	0	TRIM21	0	pull down	Kimura T (2015)	1
OPTN	1	UBC	7	affinity chromatography technology, pull down, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down	Wild P (2011), Fenner BJ (2009), Zhu G (2007), Zhu G (2007), Wagner S (2008), Gleason CE (2011), Nagabhushana A (2011), Korac J (2012), Wild P (2011), Tumbarello DA (2015), Heo JM (2015), Ordureau A (2015), Richter B (2016), Richter B (2016), Nakazawa S (2016), Zhang X (2017), Kliza K (2017), Bansal M (2018)	18
MEFV	3	MAP1LC3C	0	pull down	Kimura T (2015)	1
OPTN	1	SQSTM1	0	affinity chromatography technology, pull down	Liu Z (2014), Liu Z (2014)	2
WDR81	5	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Liu X (2017), Liu X (2017), Liu X (2017), Liu X (2017)	4
MAP1LC3C	0	LMNB1	1	pull down	Dou Z (2015)	1
ATG7	2	GABARAPL2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Behrends C (2010), Behrends C (2010), Tanida I (2001), Sou YS (2006), Sou YS (2006)	5
MAP1LC3C	0	PIK3C3	1	affinity chromatography technology	Behrends C (2010)	1
GABARAP	0	RB1CC1	9	affinity chromatography technology, unspecified method	Alemu EA (2012), Alemu EA (2012)	2
MAP1LC3C	0	ATG5	0	affinity chromatography technology	Behrends C (2010)	1
MAP1LC3C	0	KBTBD6	0	pull down	Genau HM (2015)	1
TAX1BP1	3	GABARAPL2	0	two hybrid	Tumbarello DA (2015)	1
KBTBD6	0	GABARAP	0	affinity chromatography technology, pull down, x-ray crystallography	Genau HM (2015), Genau HM (2015), Genau HM (2015)	3
RB1CC1	9	UBC	7	pull down	Choi JD (2012)	1
KBTBD7	3	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Bennett EJ (2010), Genau HM (2015), Genau HM (2015), Huttlin EL (2017)	5
CALCOCO2	0	TAX1BP1	3	affinity chromatography technology, two hybrid	Morriswood B (2007), Morriswood B (2007)	2
SQSTM1	0	WDFY3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hocking LJ (2010), Clausen TH (2010), Clausen TH (2010), Isakson P (2013)	4
ATG5	0	SQSTM1	0	pull down, affinity chromatography technology	Fracchiolla D (2016), Fracchiolla D (2016)	2
GABARAP	0	CALCOCO2	0	affinity chromatography technology	Verlhac P (2015)	1
SQSTM1	0	ATG7	2	affinity chromatography technology	Tanji K (2012)	1
SQSTM1	0	TRIM21	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kim JY (2009), Kim JY (2009), Kimura T (2015), Milan E (2015), Pan JA (2016), Pan JA (2016)	6
RB1CC1	9	ATG16L1	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Fujita N (2013), Fujita N (2013), Gammoh N (2013), Gammoh N (2013), Gammoh N (2013), Gammoh N (2013), Dooley HC (2014)	7
KBTBD7	3	GABARAP	0	affinity chromatography technology, pull down	Genau HM (2015), Genau HM (2015)	2
OPTN	1	ATG16L1	1	affinity chromatography technology, pull down	Bansal M (2018), Bansal M (2018)	2
MEFV	3	GABARAPL2	0	pull down	Kimura T (2015)	1
GABARAPL2	0	ATG13	0	two hybrid, affinity chromatography technology, unspecified method	Vinayagam A (2011), Alemu EA (2012), Alemu EA (2012)	3
WDR81	5	UBC	7	imaging technique	Liu X (2017)	1