Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
ASS1 445 ASPARTIC ACID CHEMBL274323 DrugBank 2791302, 17139284, 17016423, 15588718, 17869551
ASS1 445 ADENOSINE TRIPHOSPHATE CHEMBL14249 DrugBank 17139284, 17016423
ASS1 445 SODIUM BENZOATE CHEMBL1356 PharmGKB
ASS1 445 L-CITRULLINE CHEMBL444814 DrugBank 10944418, 10407171, 11072090, 10353334, 11067741, 9879717, 12709047, 16449956, 17427379, 12445581
ASS1 445 ARGININE CHEMBL1485 DrugBank 17354225, 17210712, 16787144, 16809898

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
ASS1 rs10793902 T hydroxyurea efficacy yes Patients with plateau fetal hemoglobin (HbF) levels below 20% were considered ‘HU nonresponders’, while patients with plateau HbF levels rising over 20% were considered ‘HU responders’. Allele T is associated with increased response to hydroxyurea in people with Anemia, Sickle Cell and beta-Thalassemia as compared to allele C. 26895070 1447949328
ASS1 rs10901080 T hydroxyurea efficacy yes Patients with plateau fetal hemoglobin (HbF) levels below 20% were considered ‘HU nonresponders’, while patients with plateau HbF levels rising over 20% were considered ‘HU responders’. Allele T is associated with increased response to hydroxyurea in people with Anemia, Sickle Cell and beta-Thalassemia as compared to allele G. 26895070 1447949320