PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MSX2	1	GTF2F1	0	pull down	Newberry EP (1997)	1
CEBPA	0	XRCC5	5	affinity chromatography technology, pull down, affinity chromatography technology	Yin H (2006), Yin H (2006), Yin H (2006)	3
MSX2	1	CEBPA	0	pull down	Cheng SL (2003)	1
XRCC6	3	PPARG	0	affinity chromatography technology, affinity chromatography technology	Kim E (2008), Kim E (2008)	2
MSX2	1	ZDHHC2	1	two hybrid	Ravasi T (2010)	1
MSX2	1	MSX2	1	pull down	Zhang H (1997)	1
DLX2	0	MSX2	1	pull down, pull down	Zhang H (1997), Zhang H (1997)	2
MSX2	1	TLE2	4	two hybrid	Ravasi T (2010)	1
XRCC5	5	RUNX2	2	affinity chromatography technology	Willis DM (2002)	1
XRCC6	3	MSX2	1	affinity chromatography technology	Willis DM (2002)	1
GTF2F2	0	GTF2F1	0	pull down, biochemical	Wang BQ (1994), Wan C (2015)	2
XRCC6	3	DLX2	0	pull down	Schild-Poulter C (2001)	1
PIAS2	2	NR3C1	2	pull down	Kotaja N (2000)	1
POLR3D	0	MSX2	1	two hybrid	Ravasi T (2010)	1
MSX2	1	ZNF703	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MSX2	1	GTF2F2	0	pull down	Newberry EP (1997)	1
NR3C1	2	MSX2	1	two hybrid	Ravasi T (2010)	1
XRCC5	5	XRCC6	3	two hybrid, biochemical, two hybrid, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology	Gell D (1999), Barlev NA (1998), Yang CR (1999), Singleton BK (1999), Song K (2000), Gell D (1999), Gell D (1999), Willis DM (2002), Willis DM (2002), Drouet J (2005), Drouet J (2005), Cohen HY (2004), Lan L (2010), Cooper MP (2000), Cooper MP (2000), Velma V (2010), Zheng Y (2011), Sucharov CC (2004), Sucharov CC (2004), Sibani S (2005), Sibani S (2005), Walker JR (2001), Nick McElhinny SA (2000), Nick McElhinny SA (2000), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Pucci S (2009), Trougakos IP (2009), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Rivera-Calzada A (2007), Kelavkar UP (2001), Kelavkar UP (2001), Kristensen AR (2012), Kim E (2008), Wan C (2015), Hein MY (2015), Hein MY (2015), Nolens G (2009), Nolens G (2009), Nolens G (2009), Nolens G (2009), Huttlin EL (2017), Fantini D (2017)	46
MSX2	1	MSX1	0	pull down, pull down, two hybrid	Zhang H (1997), Zhang H (1997), Zhang H (1997)	3
DLX5	0	MSX2	1	pull down, pull down	Zhang H (1997), Zhang H (1997)	2
DLX5	0	DLX2	0	pull down, pull down	Zhang H (1997), Zhang H (1997)	2
ATXN1	2	MSX2	1	two hybrid	Suter B (2013)	1
DLX2	0	MSX1	0	pull down, pull down, two hybrid	Zhang H (1997), Zhang H (1997), Zhang H (1997)	3
TLE1	6	TLE2	4	pull down, pull down, two hybrid	Grbavec D (1998), Grbavec D (1998), Grbavec D (1998)	3
MSX2	1	POU2AF1	1	two hybrid	Ravasi T (2010)	1
PITX2	1	MSX2	1	genetic interference	Green PD (2002)	1
CEBPA	0	NR3C1	2	pull down	Boruk M (1998)	1
CEBPA	0	XRCC6	3	pull down, affinity chromatography technology	Yin H (2006), Yin H (2006)	2
XRCC5	5	MSX2	1	affinity chromatography technology	Willis DM (2002)	1
MSX2	1	TLE1	6	two hybrid	Ravasi T (2010)	1
PPARG	0	XRCC5	5	affinity chromatography technology	Kim E (2008)	1
RUNX2	2	TLE1	6	affinity chromatography technology, imaging technique	Ali SA (2010), Ali SA (2010)	2
MSX2	1	PPARG	0	two hybrid	Ravasi T (2010)	1
MSX2	1	HBS1L	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RUNX2	2	MSX2	1	affinity chromatography technology	Shirakabe K (2001)	1
MSX2	1	PIAS2	2	two hybrid, pull down	Wu L (1997), Wu L (1997)	2
MSX1	0	TLE2	4	two hybrid	Ravasi T (2010)	1
MSX2	1	ANKRD40	1	affinity chromatography technology	Huttlin EL (2017)	1
XRCC6	3	RUNX2	2	affinity chromatography technology	Willis DM (2002)	1
NR3C1	2	PPARG	0	affinity chromatography technology	Nie M (2005)	1
DLX5	0	MSX1	0	pull down, pull down	Zhang H (1997), Zhang H (1997)	2