PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MT2A	0	ARF6	0	pull down	Venkateswarlu K (2005)	1
MCPH1	4	MT2A	0	two hybrid	Liu X (2017)	1
ASS1	0	MT2A	0	two hybrid	Wang J (2011)	1
NEDD4L	3	MT2A	0	two hybrid, affinity chromatography technology	Araki N (2009), Araki N (2009)	2
BARD1	4	MT2A	0	two hybrid, affinity chromatography technology	Woods NT (2012), Woods NT (2012)	2
DHODH	1	MT2A	0	two hybrid	Wang J (2011)	1
SHBG	0	MT2A	0	two hybrid	Pope SN (2005)	1
SPINK7	0	MT2A	0	two hybrid, two hybrid, pull down, affinity chromatography technology	Cui YP (2003), Cui Y (2003), Cui Y (2003), Cui Y (2003)	4
MT2A	0	RCHY1	0	two hybrid	Wang J (2011)	1
MT2A	0	PRKD1	7	two hybrid, affinity chromatography technology	Rao PS (2003), Rao PS (2003)	2
USP25	0	MT2A	0	two hybrid	Bosch-Comas A (2006)	1
PAXIP1	1	MT2A	0	two hybrid	Woods NT (2012)	1
TNS2	3	MT2A	0	two hybrid	Grossmann A (2015)	1
LAMTOR5	1	MT2A	0	two hybrid	Fan W (2013)	1
RIN3	2	MT2A	0	two hybrid	Grossmann A (2015)	1
MT2A	0	JMJD1C	10	two hybrid	Weimann M (2013)	1
ECT2	2	MT2A	0	two hybrid, affinity chromatography technology	Woods NT (2012), Woods NT (2012)	2
MCPH1	4	LAMTOR5	1	two hybrid	Liu X (2017)	1