Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
MTHFD1	4522	CHEMBL1161866	CHEMBL1161866		DrugBank	17139284, 17016423
MTHFD1	4522	TETRAHYDROFOLATE	CHEMBL2074655	cofactor	DrugBank	12937168, 12949177, 17533396, 16171773, 11323021
MTHFD1	4522	CHEMBL1161862	CHEMBL1161862		DrugBank	17139284, 17016423

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
MTHFD1	rs2236225	A	methotrexate	efficacy	no		Allele A is not associated with response to methotrexate in people with Arthritis, Rheumatoid as compared to allele G.	29743634	1449557951
MTHFD1	rs2236225	A	methotrexate	efficacy	no	This was considered a proxy SNP to compare with rs17850560 (MTHFD1:1958G>A) that has previously been shown to be involved in methotrexate efficacy.	Allele A is not associated with response to methotrexate in people with Arthritis, Rheumatoid.	22450926	827863330
MTHFD1	rs2236225	G	methotrexate	toxicity	no	Discontinuation due to adverse effects.	Allele G is not associated with discontinuation of methotrexate in people with Arthritis, Rheumatoid as compared to allele A.	27217051	1449164998
MTHFD1	rs2236225	AG + GG	methotrexate	efficacy	no	No significant difference in frequency of genotypes was seen between non-responders (DAS28>=3.2) and those with low disease activity (LDA; DAS28<3.2) when treated with methotrexate for 6 months.	Genotypes AG + GG is not associated with response to methotrexate in people with Arthritis, Rheumatoid as compared to genotype AA.	29520081	1449752214