PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MX1	0	CHD3	19	two hybrid	Brantis-de-Carvalho CE (2015)	1
MX1	0	UBE2I	0	two hybrid, affinity chromatography technology	Brantis-de-Carvalho CE (2015), Brantis-de-Carvalho CE (2015)	2
BLM	2	UBE2I	0	two hybrid, affinity chromatography technology	Eladad S (2005), Eladad S (2005)	2
DAXX	5	SUMO1	0	two hybrid, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, two hybrid, x-ray crystallography, two hybrid	Lin DY (2002), Ryu SW (2000), Ryu SW (2000), Ryu SW (2000), Escobar-Cabrera E (2011), Escobar-Cabrera E (2011), Naik MT (2011), Chang CC (2011), Chang CC (2011), Chen A (2006), Chen A (2006), Saul VV (2014), Ullmann R (2012), Lin DY (2006), Lin DY (2006), Ullmann R (2012), Ullmann R (2012), Lin DY (2006), Naik MT (2011), Li C (2017)	20
TDG	0	FANCA	5	affinity chromatography technology	Karras GI (2017)	1
SUMO1	0	ZCCHC12	1	affinity chromatography technology, two hybrid, two hybrid	Cho G (2009), Hecker CM (2006), Rolland T (2014)	3
TUBA1A	13	BLM	2	genetic interference	Srivas R (2016)	1
UBE2I	0	HNRNPA1	1	biochemical	Wan C (2015)	1
UBE2I	0	APP	1	enzymatic study	Gocke CB (2005)	1
MX1	0	EPM2AIP1	1	two hybrid	Brantis-de-Carvalho CE (2015)	1
CFTR	5	MX1	0	affinity chromatography technology	Pankow S (2015)	1
FANCA	5	BLM	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meetei AR (2003), Meetei AR (2003), Meetei AR (2003), Meetei AR (2003), Meetei AR (2003), Yan Z (2012), Ali AM (2012)	7
MX1	0	SP100	4	two hybrid	Engelhardt OG (2001)	1
MX1	0	KIF26B	11	two hybrid	Brantis-de-Carvalho CE (2015)	1
CHD3	19	SUMO1	0	two hybrid, pull down	Minty A (2000), Goodarzi AA (2011)	2
MX1	0	KLHL35	0	two hybrid	Brantis-de-Carvalho CE (2015)	1
FANCA	5	DAXX	5	two hybrid	Reuter TY (2003)	1
ZBTB16	4	UBE2I	0	two hybrid, enzymatic study	Chao TT (2007), Kang SI (2003)	2
MX1	0	MX1	0	two hybrid, two hybrid, biochemical	Rolland T (2014), Brantis-de-Carvalho CE (2015), Brantis-de-Carvalho CE (2015)	3
SP100	4	SUMO1	0	two hybrid, two hybrid, pull down, two hybrid	Rual JF (2005), Hecker CM (2006), Hecker CM (2006), Rolland T (2014)	4
SIAH1	2	PIAS1	4	two hybrid, pull down, affinity chromatography technology	Depaux A (2007), Depaux A (2007), Lee JH (2016)	3
CASP8AP2	3	PIAS1	4	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Alm-Kristiansen AH (2011), Alm-Kristiansen AH (2011), Alm-Kristiansen AH (2011), Alm-Kristiansen AH (2011)	4
HNRNPA1	1	APP	1	pull down	Olah J (2011)	1
ISG15	0	MX1	0	affinity chromatography technology, affinity chromatography technology	Zhao C (2005), Zhao C (2005)	2
PLRG1	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
MX1	0	APP	1	pull down	Olah J (2011)	1
MX1	0	TUBA1A	13	two hybrid	Brantis-de-Carvalho CE (2015)	1
MX1	0	SUMO1	0	two hybrid, two hybrid, affinity chromatography technology	Engelhardt OG (2001), Brantis-de-Carvalho CE (2015), Brantis-de-Carvalho CE (2015)	3
CASP8AP2	3	SUMO1	0	affinity chromatography technology	Sun H (2012)	1
MX1	0	CASP8AP2	3	two hybrid	Brantis-de-Carvalho CE (2015)	1
MX1	0	SLC25A3	1	two hybrid	Brantis-de-Carvalho CE (2015)	1
MX1	0	RELA	1	two hybrid	Brantis-de-Carvalho CE (2015)	1
MX1	0	C7orf25	0	two hybrid	Brantis-de-Carvalho CE (2015)	1
SIAH1	2	UBE2I	0	two hybrid, two hybrid	Depaux A (2007), Hu G (1997)	2
ADRM1	4	APP	1	pull down	Olah J (2011)	1
UBE2I	0	TDG	0	enzymatic study, enzymatic study, enzymatic study	Knipscheer P (2008), Mohan RD (2007), Coey CT (2014)	3
MX1	0	TDG	0	two hybrid	Brantis-de-Carvalho CE (2015)	1
MX1	0	BCS1L	0	affinity chromatography technology	Huttlin EL (2017)	1
MX1	0	ZBTB16	4	two hybrid	Brantis-de-Carvalho CE (2015)	1
UBE2I	0	SP100	4	enzymatic study, pull down, two hybrid, enzymatic study, enzymatic study, enzymatic study	Knipscheer P (2008), Knipscheer P (2008), Bandyopadhyay S (2010), Pelisch F (2010), Meulmeester E (2008), Knipscheer P (2007)	6
TDG	0	SUMO1	0	two hybrid, pull down, two hybrid, x-ray crystallography, pull down, two hybrid, pull down, two hybrid	Minty A (2000), Hardeland U (2002), Hardeland U (2002), Smet-Nocca C (2011), Smet-Nocca C (2011), Plosky BS (2006), Mohan RD (2007), Hecker CM (2006)	8
ZBTB16	4	SUMO1	0	two hybrid, pull down	Chao TT (2007), Kang SI (2003)	2
SUMO1	0	PIAS1	4	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, pull down	Lee BH (2003), Kahyo T (2001), Stehmeier P (2009), Stehmeier P (2009), Stehmeier P (2009), Ullmann R (2012), Ullmann R (2012), Hecker CM (2006), Hecker CM (2006), Gocke CB (2008), Ullmann R (2012), Ledsaak M (2016)	12
MX1	0	CBX4	1	two hybrid	Brantis-de-Carvalho CE (2015)	1
UBE2I	0	CASP8AP2	3	two hybrid, enzymatic study	Bandyopadhyay S (2010), Gocke CB (2005)	2
MX1	0	ZNF251	1	two hybrid	Brantis-de-Carvalho CE (2015)	1
MX1	0	HMGXB4	0	two hybrid	Brantis-de-Carvalho CE (2015)	1
MX1	0	GMEB1	4	two hybrid	Brantis-de-Carvalho CE (2015)	1
HNRNPA1	1	MX1	0	affinity chromatography technology	Roy R (2014)	1
MX1	0	CAB39L	0	two hybrid	Rolland T (2014)	1
UBE2I	0	CFTR	5	enzymatic study, enzymatic study	Ahner A (2013), Gong X (2016)	2
FANCA	5	MX1	0	two hybrid	Reuter TY (2003)	1
MX1	0	PLRG1	1	two hybrid	Brantis-de-Carvalho CE (2015)	1
CFTR	5	SLC25A3	1	affinity chromatography technology	Pankow S (2015)	1
MX1	0	PIAS1	4	two hybrid, two hybrid	Engelhardt OG (2001), Brantis-de-Carvalho CE (2015)	2
MX1	0	PSD3	4	two hybrid	Brantis-de-Carvalho CE (2015)	1
UBE2I	0	DAXX	5	two hybrid, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, two hybrid	Ryu SW (2000), Knipscheer P (2008), Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Chang CC (2011), Lin DY (2006), Lin DY (2006)	8
MX1	0	SIAH1	2	two hybrid	Rolland T (2014)	1
MX1	0	DAXX	5	two hybrid, two hybrid	Engelhardt OG (2001), Brantis-de-Carvalho CE (2015)	2
MX1	0	BRD7	2	two hybrid	Brantis-de-Carvalho CE (2015)	1
MX1	0	ADRM1	4	two hybrid	Brantis-de-Carvalho CE (2015)	1
MX1	0	ZNF623	5	two hybrid	Brantis-de-Carvalho CE (2015)	1
SUMO1	0	BLM	2	two hybrid	Hecker CM (2006)	1
ZCCHC12	1	APP	1	pull down	Olah J (2011)	1
ISG15	0	CBX4	1	affinity chromatography technology	Zhao C (2005)	1
MX1	0	LRRC4B	2	two hybrid	Brantis-de-Carvalho CE (2015)	1
MX1	0	BLM	2	two hybrid	Engelhardt OG (2001)	1
CFTR	5	ISG15	0	affinity chromatography technology	Pankow S (2015)	1
CFTR	5	ADRM1	4	affinity chromatography technology	Pankow S (2015)	1
UBE2I	0	CHD3	19	two hybrid	Lee BH (2003)	1
MX1	0	ZCCHC12	1	two hybrid	Brantis-de-Carvalho CE (2015)	1
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
UBE2I	0	PIAS1	4	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Lee BH (2003), Sapetschnig A (2002), Kahyo T (2001), Bandyopadhyay S (2010), Driscoll JJ (2010), Kahyo T (2001), Yin Y (2012), Gocke CB (2005), van den Akker E (2005), Ogawa H (2009), Schmidt D (2002), Gibbs-Seymour I (2015)	12