PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NCF1	2	MYBPC3	2	two hybrid	Takeshita F (2005)	1
TTN	102	TRIM63	0	two hybrid, pull down, two hybrid, x-ray crystallography, pull down, two hybrid	Centner T (2001), Centner T (2001), Witt SH (2005), Mrosek M (2007), Bogomolovas J (2014), Witt CC (2008)	6
TRIM55	2	TTN	102	two hybrid	Witt CC (2008)	1
CAPN1	3	MYBPC3	2	two hybrid	Jiang LQ (2002)	1
FBXO32	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Al-Yacoub N (2016), Al-Yacoub N (2016), Reitsma JM (2017)	3
FBXO32	2	MYBPC3	2	affinity chromatography technology	Mearini G (2010)	1
TRIM63	0	TRIM55	2	two hybrid, two hybrid	Centner T (2001), Witt CC (2008)	2
TRIM55	2	MYBPC3	2	two hybrid	Witt CC (2008)	1
BLNK	2	MYBPC3	2	affinity chromatography technology	Oellerich T (2011)	1
TNNI3K	0	MYBPC3	2	two hybrid	Zhao Y (2003)	1
HSPB2	1	TTN	102	two hybrid	Grose JH (2015)	1
MYBPC3	2	TRIM63	0	two hybrid, two hybrid	Mearini G (2010), Witt CC (2008)	2
TTN	102	MYBPC3	2	far western blotting	Freiburg A (1996)	1
CUL1	7	MYBPC3	2	affinity chromatography technology	Bennett EJ (2010)	1
HSPB2	1	MYBPC3	2	two hybrid	Grose JH (2015)	1