Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
NCAM1 4684 LORVOTUZUMAB MERTANSINE CHEMBL1743037 ChemblInteractions
NCAM1 4684 ONCOLYSIN S CHEMBL2109634 ChemblInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
NCAM1 rs2303377 TT duloxetine efficacy yes Patients with the TT genotype had a greater % decrease in the Montgomery-Asberg Depression Rating Scale (MADRS) score from baseline as compared to those with the CC or CT genotype. Note that in the initial GWAS analysis, this variant only reached the "suggestive" (p<5E-5) threshold. Genotype TT is associated with increased response to duloxetine in people with Depressive Disorder, Major as compared to genotypes CC + CT. 28696415 1449750794