PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NDN	0	LPXN	4	two hybrid	Corominas R (2014)	1
NDN	0	GKAP1	0	two hybrid	Corominas R (2014)	1
HNRNPU	12	U2AF1	0	biochemical	Havugimana PC (2012)	1
EGFR	5	PPARGC1A	3	affinity chromatography technology	Foerster S (2013)	1
NDN	0	EID3	1	affinity chromatography technology	Hudson JJ (2011)	1
IRS4	2	MAGEL2	6	two hybrid	Wijesuriya TM (2017)	1
NDN	0	RPS11	0	affinity chromatography technology	Ewing RM (2007)	1
NDN	0	TFIP11	5	two hybrid	Corominas R (2014)	1
NDN	0	MPP6	3	pull down	Miyamoto-Sato E (2010)	1
NDN	0	TNPO1	1	affinity chromatography technology	Lavi-Itzkovitz A (2012)	1
NDN	0	FSD2	4	two hybrid	Corominas R (2014)	1
P4HA3	3	FXR2	2	affinity chromatography technology	Huttlin EL (2017)	1
TP53	0	PPARGC1A	3	affinity chromatography technology, affinity chromatography technology, pull down	Sen N (2011), Sen N (2011), Sen N (2011)	3
LEPR	3	NDN	0	two hybrid, bioid	Wijesuriya TM (2017), Wijesuriya TM (2017)	2
PPARGC1A	3	SIRT1	3	imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study	Amat R (2009), Nemoto S (2005), Nemoto S (2005), Nemoto S (2005)	4
TFIP11	5	SSX2IP	0	two hybrid	Rolland T (2014)	1
SIRT1	3	HIF1A	1	affinity chromatography technology, pull down, affinity chromatography technology	Lim JH (2010), Lim JH (2010), Lim JH (2010)	3
NDN	0	EID2	0	affinity chromatography technology	Hudson JJ (2011)	1
EGFR	5	KPNB1	3	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
NDN	0	SERTAD3	2	two hybrid	Corominas R (2014)	1
NDN	0	TMEM33	0	affinity chromatography technology	Ewing RM (2007)	1
NDN	0	LAX1	2	two hybrid	Corominas R (2014)	1
SSX2IP	0	TP53	0	bioid	Gupta GD (2015)	1
HNRNPU	12	RPS11	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
NDN	0	NGFR	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuwako K (2004), Kuwako K (2004), Bronfman FC (2003), Tcherpakov M (2002), Tcherpakov M (2002)	5
TFIP11	5	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down	Ye M (2015), Ye M (2015), Ye M (2015)	3
NDN	0	TP53	0	two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Taniura H (1999), Taniura H (1999), Huang Z (2013), Corominas R (2014), Hasegawa K (2008), Hasegawa K (2008)	6
NDN	0	EID2B	1	affinity chromatography technology	Hudson JJ (2011)	1
EGFR	5	TRIM28	1	affinity chromatography technology	Liccardi G (2014)	1
PPARGC1A	3	NDN	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Hasegawa K (2016), Hasegawa K (2016), Hasegawa K (2016), Hasegawa K (2016)	4
NDN	0	ZBTB7B	6	two hybrid	Corominas R (2014)	1
NDN	0	MIER2	0	two hybrid	Corominas R (2014)	1
NDN	0	KPNB1	3	affinity chromatography technology	Lavi-Itzkovitz A (2012)	1
IL32	1	NDN	0	two hybrid	Park YS (2014)	1
HIF1A	1	TRIM28	1	affinity chromatography technology	Cai Q (2013)	1
SIRT1	3	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Zhao W (2008), Liu X (2011), Inoue Y (2011), Jain AK (2012), Langley E (2002), Langley E (2002), Langley E (2002), Kim JE (2008), Kim JE (2008), Kim EJ (2007), Kim EJ (2007), Busch F (2012), Busch F (2012), Hasegawa K (2008), Hasegawa K (2008), Hasegawa K (2008), Zannini L (2012)	17
NDN	0	E2F1	0	two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Taniura H (1998), Kuwako K (2004), Kuwako K (2004), Kuwako K (2004), Taniura H (1998), Taniura H (1998)	6
TP53	0	IRS4	2	affinity chromatography technology	Fogeron ML (2013)	1
NDN	0	NUCB2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Taniguchi N (2000), Taniguchi N (2000), Taniguchi N (2000), Taniguchi N (2000)	4
SIRT1	3	EPAS1	6	enzymatic study, affinity chromatography technology	Chen R (2012), Chen R (2012)	2
EGFR	5	SEC61A1	1	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Wang YN (2010)	2
NDN	0	SIRT1	3	affinity chromatography technology, pull down	Hasegawa K (2008), Hasegawa K (2008)	2
EPAS1	6	NDN	0	affinity chromatography technology, affinity chromatography technology, pull down	Huang Z (2013), Huang Z (2013), Huang Z (2013)	3
EID3	1	EID2	0	affinity chromatography technology, affinity chromatography technology	Sasajima Y (2005), Sasajima Y (2005)	2
NDN	0	DTNBP1	1	two hybrid, two hybrid	Corominas R (2014), Ma X (2011)	2
NDN	0	CCDC136	1	two hybrid	Corominas R (2014)	1
IRS4	2	NDN	0	two hybrid	Wijesuriya TM (2017)	1
SIRT1	3	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Lin Z (2012), Lin YH (2015), Lin YH (2015), Lin YH (2015)	4
IRS4	2	EGFR	5	unspecified method, affinity chromatography technology	Jones RB (2006), Tong J (2014)	2
HIF1A	1	GKAP1	0	affinity chromatography technology	Hein MY (2015)	1
NDN	0	NEFL	1	two hybrid	Corominas R (2014)	1
NDN	0	CALCOCO2	0	two hybrid	Corominas R (2014)	1
NDN	0	APBB1IP	1	two hybrid	Corominas R (2014)	1
NDN	0	NDN	0	two hybrid	Taniguchi N (2000)	1
EGFR	5	TNPO1	1	affinity chromatography technology	Foerster S (2013)	1
NDN	0	SRPRB	0	affinity chromatography technology	Ewing RM (2007)	1
EGFR	5	NDN	0	protein complementation assay	Deribe YL (2009)	1
NDN	0	EEF1AKMT1	0	two hybrid	Corominas R (2014)	1
TP53	0	HNRNPU	12	affinity chromatography technology	Fogeron ML (2013)	1
NDN	0	P4HA3	3	two hybrid	Corominas R (2014)	1
NDN	0	U2AF1	0	two hybrid	Corominas R (2014)	1
BLOC1S6	0	CCDC136	1	two hybrid	Rolland T (2014)	1
NDN	0	FAM131C	0	two hybrid	Corominas R (2014)	1
NDN	0	HNRNPU	12	biochemical, affinity chromatography technology, affinity chromatography technology	Taniura H (2002), Taniura H (2002), Taniura H (2002)	3
TP53	0	KPNB1	3	affinity chromatography technology, pull down	Akakura S (2001), Akakura S (2001)	2
BLOC1S6	0	DTNBP1	1	biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Starcevic M (2004), Starcevic M (2004), Starcevic M (2004), Huttlin EL (2015), Huttlin EL (2017)	5
NDN	0	NSMCE4A	0	affinity chromatography technology	Hudson JJ (2011)	1
ZBTB1	4	RPS11	0	affinity chromatography technology	Kim H (2014)	1
HIF1A	1	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Chen D (2003), Ravi R (2000), Hansson LO (2002), An WG (1998), An WG (1998), Chowdhury AR (2017), Chowdhury AR (2017), Suzuki H (2001), Sanchez-Puig N (2005)	9
ZBTB1	4	TRIM28	1	affinity chromatography technology, affinity chromatography technology	Kim H (2014), Kim H (2014)	2
NDN	0	GOLGA2	2	two hybrid	Corominas R (2014)	1
NDN	0	DHCR7	4	affinity chromatography technology	Ewing RM (2007)	1
DTNBP1	1	P4HA3	3	two hybrid	Rolland T (2014)	1
TRIM28	1	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Doyle JM (2010), Gilmore-Hebert M (2010), Okamoto K (2006)	3
NDN	0	AUP1	0	affinity chromatography technology	Ewing RM (2007)	1
EPAS1	6	HIF1A	1	affinity chromatography technology	Steunou AL (2012)	1
EGFR	5	SRPRB	0	affinity chromatography technology	Tong J (2014)	1
NDN	0	TRIM28	1	affinity chromatography technology	Doyle JM (2010)	1
NDN	0	MKRN2	2	two hybrid	Corominas R (2014)	1
TP53	0	IL1A	0	genetic interference	Xie L (2013)	1
NDN	0	NUBP1	0	two hybrid	Taniguchi N (2000)	1
NDN	0	CERS2	2	affinity chromatography technology	Ewing RM (2007)	1
NDN	0	PPFIA1	5	two hybrid	Corominas R (2014)	1
NDN	0	EID1	1	affinity chromatography technology, two hybrid	Hudson JJ (2011), Corominas R (2014)	2
FXR2	2	GKAP1	0	two hybrid	Rual JF (2005)	1
IL1A	0	NDN	0	two hybrid, affinity chromatography technology	Hu B (2003), Hu B (2003)	2
EGFR	5	CERS2	2	affinity chromatography technology	Tong J (2014)	1
NDN	0	IFFO1	0	two hybrid	Corominas R (2014)	1
ARSE	2	NDN	0	two hybrid	Stelzl U (2005)	1
NDN	0	ZBTB1	4	two hybrid	Corominas R (2014)	1
NDN	0	FXR2	2	two hybrid	Corominas R (2014)	1
NDN	0	CDR2	1	two hybrid	Corominas R (2014)	1
NDN	0	BLOC1S6	0	two hybrid	Corominas R (2014)	1
NDN	0	HIF1A	1	affinity chromatography technology, two hybrid	Moon HE (2005), Moon HE (2005)	2
TRIM28	1	E2F1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang C (2007), Hu C (2012), Hu C (2012)	3
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
NDN	0	MAGEL2	6	bioid	Wijesuriya TM (2017)	1
NDN	0	SSX2IP	0	two hybrid	Corominas R (2014)	1
P4HA3	3	ZBTB7B	6	affinity chromatography technology	Huttlin EL (2017)	1
KPNB1	3	CERS2	2	affinity chromatography technology	Hein MY (2015)	1
NDN	0	SEC61A1	1	affinity chromatography technology	Ewing RM (2007)	1
FXR2	2	CALCOCO2	0	two hybrid	Rual JF (2005)	1
NGFR	3	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down	Zhou X (2016), Zhou X (2016), Zhou X (2016)	3
SIRT1	3	E2F1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Pediconi N (2009), Ji W (2014), Wang C (2006), Wang C (2006)	4